{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:48:04Z","timestamp":1789469284582,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010814","name":"Department of Education of Anhui Province","doi-asserted-by":"publisher","award":["2022AH010072"],"award-info":[{"award-number":["2022AH010072"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301812"],"award-info":[{"award-number":["82301812"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501948"],"award-info":[{"award-number":["82501948"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Anhui Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2408085QH287"],"award-info":[{"award-number":["2408085QH287"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016106","name":"Science and Technology Bureau of Zhenjiang","doi-asserted-by":"publisher","award":["SH2025028"],"award-info":[{"award-number":["SH2025028"]}],"id":[{"id":"10.13039\/501100016106","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016106","name":"Science and Technology Bureau of Zhenjiang","doi-asserted-by":"publisher","award":["JC2024039"],"award-info":[{"award-number":["JC2024039"]}],"id":[{"id":"10.13039\/501100016106","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cells &amp; Development"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cdev.2026.204098","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:16:19Z","timestamp":1784733379000},"page":"204098","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Samd7 is dispensable for spermatogenesis and male fertility in mice"],"prefix":"10.1016","volume":"187","author":[{"given":"Dan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cdev.2026.204098_bb0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/rmb2.12067","article-title":"Revolutionizing male fertility factor research in mice by using the genome editing tool CRISPR\/Cas9","volume":"17","author":"Abbasi","year":"2018","journal-title":"Reprod. Med. Biol."},{"key":"10.1016\/j.cdev.2026.204098_bb0010","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/978-1-60761-103-5_16","article-title":"Staging of mouse seminiferous tubule cross-sections","volume":"558","author":"Ahmed","year":"2009","journal-title":"Methods Mol. Biol."},{"issue":"8","key":"10.1016\/j.cdev.2026.204098_bb0015","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/nsb956","article-title":"The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators","volume":"10","author":"Aviv","year":"2003","journal-title":"Nat. Struct. Biol."},{"issue":"5760","key":"10.1016\/j.cdev.2026.204098_bb0020","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1126\/science.1118995","article-title":"An architectural framework that may lie at the core of the postsynaptic density","volume":"311","author":"Baron","year":"2006","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.cdev.2026.204098_bb0025","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ajhg.2024.01.001","article-title":"Mutations in SAMD7 cause autosomal-recessive macular dystrophy with or without cone dysfunction","volume":"111","author":"Bauwens","year":"2024","journal-title":"Am. J. Hum. Genet."},{"issue":"27","key":"10.1016\/j.cdev.2026.204098_bb0030","doi-asserted-by":"crossref","first-page":"E5370","DOI":"10.1073\/pnas.1621279114","article-title":"TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa","volume":"114","author":"Castaneda","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.cdev.2026.204098_bb0035","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/cbin.70014","article-title":"PRKCQ is dispensable for spermatogenesis in mice","volume":"49","author":"Chen","year":"2025","journal-title":"Cell Biol. Int."},{"issue":"10","key":"10.1016\/j.cdev.2026.204098_bb0040","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrg911","article-title":"Mouse models of male infertility","volume":"3","author":"Cooke","year":"2002","journal-title":"Nat. Rev. Genet."},{"issue":"7","key":"10.1016\/j.cdev.2026.204098_bb0045","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.cell.2019.11.022","article-title":"A translation-activating function of MIWI\/piRNA during mouse spermiogenesis","volume":"179","author":"Dai","year":"2019","journal-title":"Cell"},{"issue":"19","key":"10.1016\/j.cdev.2026.204098_bb0050","doi-asserted-by":"crossref","first-page":"6289","DOI":"10.1074\/jbc.RA119.012375","article-title":"The testis-specific LINC component SUN3 is essential for sperm head shaping during mouse spermiogenesis","volume":"295","author":"Gao","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.cdev.2026.204098_bb0055","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/S1097-2765(03)00178-3","article-title":"RNA recognition via the SAM domain of Smaug","volume":"11","author":"Green","year":"2003","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.cdev.2026.204098_bb0060","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.str.2007.12.017","article-title":"Regulation of enzyme localization by polymerization: polymer formation by the SAM domain of diacylglycerol kinase delta1","volume":"16","author":"Harada","year":"2008","journal-title":"Structure (London, England: 1993)"},{"issue":"4","key":"10.1016\/j.cdev.2026.204098_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060633","article-title":"Sterile alpha motif containing 7 (samd7) is a novel crx-regulated transcriptional repressor in the retina","volume":"8","author":"Hlawatsch","year":"2013","journal-title":"PLoS One"},{"issue":"22","key":"10.1016\/j.cdev.2026.204098_bb0070","first-page":"11755","article-title":"FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis","volume":"47","author":"Hua","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cdev.2026.204098_bb0075","first-page":"11755","article-title":"FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis","volume":"47","author":"Hua","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.cdev.2026.204098_bb0080","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/emboj\/16.1.69","article-title":"A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein","volume":"16","author":"Jousset","year":"1997","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.cdev.2026.204098_bb0085","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1038\/s41598-018-23176-x","article-title":"The evolutionarily conserved genes: Tex37, Ccdc73, Prss55 and Nxt2 are dispensable for fertility in mice","volume":"8","author":"Khan","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cdev.2026.204098_bb0090","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.1038\/s41598-021-83781-1","article-title":"Functional analysis of Samd11, a retinal photoreceptor PRC1 component, in establishing rod photoreceptor identity","volume":"11","author":"Kubo","year":"2021","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.cdev.2026.204098_bb0095","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.tree.2020.04.009","article-title":"The importance of genetic redundancy in evolution","volume":"35","author":"L\u00e1ruson","year":"2020","journal-title":"Trends Ecol. Evol."},{"issue":"2","key":"10.1016\/j.cdev.2026.204098_bb0100","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/biolre\/ioz103","article-title":"CRISPR\/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice","volume":"101","author":"Lu","year":"2019","journal-title":"Biol. Reprod."},{"issue":"17","key":"10.1016\/j.cdev.2026.204098_bb0105","doi-asserted-by":"crossref","first-page":"10255","DOI":"10.1093\/nar\/gkae701","article-title":"Meiotic chromatin-associated HSF5 is indispensable for pachynema progression and male fertility","volume":"52","author":"Luo","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"28","key":"10.1016\/j.cdev.2026.204098_bb0110","doi-asserted-by":"crossref","first-page":"7704","DOI":"10.1073\/pnas.1608458113","article-title":"Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice","volume":"113","author":"Miyata","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"39","key":"10.1016\/j.cdev.2026.204098_bb0115","doi-asserted-by":"crossref","first-page":"E8264","DOI":"10.1073\/pnas.1707021114","article-title":"Samd7 is a cell type-specific PRC1 component essential for establishing retinal rod photoreceptor identity","volume":"114","author":"Omori","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"286","key":"10.1016\/j.cdev.2026.204098_bb0120","doi-asserted-by":"crossref","DOI":"10.1126\/stke.2862005re7","article-title":"The many faces of SAM","volume":"2005","author":"Qiao","year":"2005","journal-title":"Sci. STKE"},{"key":"10.1016\/j.cdev.2026.204098_bb0125","doi-asserted-by":"crossref","DOI":"10.1111\/andr.70144","article-title":"CRISPR\/Cas9-mediated genome-editing reveals 10 testis-enriched genes and one non-testis-enriched gene are dispensable for male fecundity in mice","author":"Qiu","year":"2025","journal-title":"Andrology"},{"issue":"12","key":"10.1016\/j.cdev.2026.204098_bb0130","doi-asserted-by":"crossref","first-page":"8702","DOI":"10.1074\/jbc.M111.336115","article-title":"The growth-suppressive function of the polycomb group protein polyhomeotic is mediated by polymerization of its sterile alpha motif (SAM) domain","volume":"287","author":"Robinson","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"5576","key":"10.1016\/j.cdev.2026.204098_bb0135","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1126\/science.1070963","article-title":"Unique chromatin remodeling and transcriptional regulation in spermatogenesis","volume":"296","author":"Sassone-Corsi","year":"2002","journal-title":"Science"},{"issue":"21","key":"10.1016\/j.cdev.2026.204098_bb0140","doi-asserted-by":"crossref","first-page":"12201","DOI":"10.1073\/pnas.1635054100","article-title":"A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets","volume":"100","author":"Schultz","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.cdev.2026.204098_bb0145","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s00335-021-09879-z","article-title":"Inactivation of testis-specific gene C4orf46 is dispensable for spermatogenesis and fertility in mouse","volume":"32","author":"Shah","year":"2021","journal-title":"Mamm. Genome."},{"key":"10.1016\/j.cdev.2026.204098_bb0150","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.28199","article-title":"Essential role for SUN5 in anchoring sperm head to the tail","volume":"6","author":"Shang","year":"2017","journal-title":"Elife"},{"issue":"5","key":"10.1016\/j.cdev.2026.204098_bb0155","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/cr.2013.46","article-title":"Generation of gene-modified mice via Cas9\/RNA-mediated gene targeting","volume":"23","author":"Shen","year":"2013","journal-title":"Cell Res."},{"issue":"4","key":"10.1016\/j.cdev.2026.204098_bb0160","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4103\/aja.aja_65_18","article-title":"Strawberry notch 1 (SBNO1) promotes proliferation of spermatogonial stem cells via the noncanonical Wnt pathway in mice","volume":"21","author":"Shen","year":"2019","journal-title":"Asian J. Androl."},{"issue":"5","key":"10.1016\/j.cdev.2026.204098_bb0165","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.cell.2015.10.030","article-title":"MAJIN links telomeric DNA to the nuclear membrane by exchanging telomere cap","volume":"163","author":"Shibuya","year":"2015","journal-title":"Cell"},{"issue":"21","key":"10.1016\/j.cdev.2026.204098_bb0170","doi-asserted-by":"crossref","first-page":"12129","DOI":"10.1073\/pnas.95.21.12129","article-title":"Structure of the Ets-1 pointed domain and mitogen-activated protein kinase phosphorylation site","volume":"95","author":"Slupsky","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.cdev.2026.204098_bb0175","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s004290050245","article-title":"Transcriptional and translational regulation of gene expression in haploid spermatids","volume":"199","author":"Steger","year":"1999","journal-title":"Anat. Embryol. (Berl.)"},{"issue":"10","key":"10.1016\/j.cdev.2026.204098_bb0180","doi-asserted-by":"crossref","first-page":"5876","DOI":"10.1128\/MCB.17.10.5876","article-title":"Multiple regulatory domains on the Byr2 protein kinase","volume":"17","author":"Tu","year":"1997","journal-title":"Mol. Cell. Biol."},{"issue":"47","key":"10.1016\/j.cdev.2026.204098_bb0185","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2402121121","article-title":"Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity","volume":"121","author":"Volkov","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.cdev.2026.204098_bb0190","doi-asserted-by":"crossref","DOI":"10.1530\/REP-25-0310","article-title":"ZDHHC5 deficiency impairs spermatogenesis and causes male infertility in mice","volume":"170","author":"Wang","year":"2025","journal-title":"Reproduction"},{"key":"10.1016\/j.cdev.2026.204098_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2019.06.015","article-title":"The testis-specifically expressed Dpep3 is not essential for male fertility in mice","volume":"711","author":"Xie","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.cdev.2026.204098_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygcen.2022.114148","article-title":"Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene","volume":"330","author":"Xu","year":"2023","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.cdev.2026.204098_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.cdev.2025.204032","article-title":"AKAP14 is dispensable for mouse fertility","volume":"182","author":"Xu","year":"2025","journal-title":"Cells Dev."},{"key":"10.1016\/j.cdev.2026.204098_bb0210","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12964-026-02709-2","article-title":"Protein disulfide isomerase A6 (PDIA6) is essential for acrosome biogenesis and male fertility in mice","volume":"24","author":"Yan","year":"2026","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.cdev.2026.204098_bb0215","doi-asserted-by":"crossref","DOI":"10.4103\/aja202585","article-title":"Loss-of-function mutations in Ccdc113 cause male infertility in both humans and mice","author":"Yu","year":"2026","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.cdev.2026.204098_bb0220","article-title":"Normal spermatogenesis in Fank1 (fibronectin type 3 and ankyrin repeat domains 1) mutant mice","volume":"7","author":"Zhang","year":"2019","journal-title":"PeerJ"},{"key":"10.1016\/j.cdev.2026.204098_bb0225","article-title":"Forkhead-associated phosphopeptide binding domain 1 (FHAD1) deficiency impaired murine sperm motility","volume":"12","author":"Zhang","year":"2024","journal-title":"PeerJ"},{"key":"10.1016\/j.cdev.2026.204098_bb0230","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1074\/mcp.M115.049569","article-title":"Quantitative proteomics reveals the essential roles of stromal interaction molecule 1 (STIM1) in the testicular cord formation in mouse testis","author":"Zheng","year":"2015","journal-title":"Mol. Cell. Proteomics"}],"container-title":["Cells &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667290126000288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667290126000288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:01:39Z","timestamp":1789466499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667290126000288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":46,"alternative-id":["S2667290126000288"],"URL":"https:\/\/doi.org\/10.1016\/j.cdev.2026.204098","relation":{},"ISSN":["2667-2901"],"issn-type":[{"value":"2667-2901","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Samd7 is dispensable for spermatogenesis and male fertility in mice","name":"articletitle","label":"Article Title"},{"value":"Cells & Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cdev.2026.204098","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"204098"}}