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Biol."},{"issue":"7","key":"10.1016\/j.cdev.2026.204099_bb0455","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1091\/mbc.e08-12-1248","article-title":"Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy","volume":"20","author":"Hosokawa","year":"2009","journal-title":"Mol. Biol. Cell"},{"issue":"5","key":"10.1016\/j.cdev.2026.204099_bb0460","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1083\/jcb.200212114","article-title":"Differential regulation of cell motility and invasion by FAK","volume":"160","author":"Hsia","year":"2003","journal-title":"J. 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A."},{"key":"10.1016\/j.cdev.2026.204099_bb0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154567","article-title":"Brusatol suppresses the tumor growth and metastasis of colorectal cancer via upregulating ARRDC4 expression through modulating PI3K\/YAP1\/TAZ pathway","volume":"109","author":"Huang","year":"2023","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.cdev.2026.204099_bb0490","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0092-8674(01)00336-1","article-title":"beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin","volume":"105","author":"Huelsken","year":"2001","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.cdev.2026.204099_bb0495","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1073\/pnas.0908682107","article-title":"Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment","volume":"107","author":"Hung","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"49","key":"10.1016\/j.cdev.2026.204099_bb0500","doi-asserted-by":"crossref","first-page":"48805","DOI":"10.1074\/jbc.M305472200","article-title":"Smad4 and beta-catenin co-activators functionally interact with lymphoid-enhancing factor to regulate graded expression of Msx2","volume":"278","author":"Hussein","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.cdev.2026.204099_bb0505","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1093\/emboj\/17.5.1371","article-title":"Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin","volume":"17","author":"Ikeda","year":"1998","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb0510","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/ncb3084","article-title":"Dual role of YAP and TAZ in renewal of the intestinal epithelium","volume":"17","author":"Imajo","year":"2015","journal-title":"Nat. Cell Biol."},{"issue":"9","key":"10.1016\/j.cdev.2026.204099_bb0515","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ncb839","article-title":"TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling","volume":"4","author":"Inoki","year":"2002","journal-title":"Nat. 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Sci."},{"issue":"4","key":"10.1016\/j.cdev.2026.204099_bb0550","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1053\/j.gastro.2006.08.011","article-title":"APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression","volume":"131","author":"Janssen","year":"2006","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.cdev.2026.204099_bb0555","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1387\/ijdb.092985sj","article-title":"Direct control of Hoxd1 and Irx3 expression by Wnt\/beta-catenin signaling during anteroposterior patterning of the neural axis in Xenopus","volume":"54","author":"Janssens","year":"2010","journal-title":"Int. J. Dev. Biol."},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb0560","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41698-018-0049-y","article-title":"Interaction between Wnt\/\u03b2-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of \u03b2-catenin and RAS by targeting the Wnt\/\u03b2-catenin pathway","volume":"2","author":"Jeong","year":"2018","journal-title":"NPJ Precis. Oncol."},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb0565","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41698-018-0049-y","article-title":"Interaction between Wnt\/\u03b2-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of \u03b2-catenin and RAS by targeting the Wnt\/\u03b2-catenin pathway","volume":"2","author":"Jeong","year":"2018","journal-title":"NPJ Precis. Oncol."},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb0570","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cub.2014.10.051","article-title":"Nuclear size scaling during Xenopus early development contributes to midblastula transition timing","volume":"25","author":"Jevtic","year":"2015","journal-title":"Curr Biol: CB."},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb0575","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/bbrc.1999.1760","article-title":"A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression","volume":"266","author":"Jho","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.cdev.2026.204099_bb0580","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.devcel.2017.07.026","article-title":"Zygotic genome activation in vertebrates","volume":"42","author":"Jukam","year":"2017","journal-title":"Dev. 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A."},{"issue":"9","key":"10.1016\/j.cdev.2026.204099_bb0590","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.stem.2023.08.005","article-title":"3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages","volume":"30","author":"Karvas","year":"2023","journal-title":"Cell Stem Cell"},{"issue":"23","key":"10.1016\/j.cdev.2026.204099_bb0595","doi-asserted-by":"crossref","first-page":"7054","DOI":"10.1093\/emboj\/16.23.7054","article-title":"BMK1\/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C","volume":"16","author":"Kato","year":"1997","journal-title":"EMBO J."},{"issue":"2","key":"10.1016\/j.cdev.2026.204099_bb0600","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.stem.2010.12.010","article-title":"\u03b2-Catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism","volume":"8","author":"Kelly","year":"2011","journal-title":"Cell Stem Cell"},{"issue":"21","key":"10.1016\/j.cdev.2026.204099_bb0605","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1242\/dev.128.21.4189","article-title":"A morphogen gradient of Wnt\/beta-catenin signalling regulates anteroposterior neural patterning in Xenopus","volume":"128","author":"Kiecker","year":"2001","journal-title":"Development"},{"issue":"6806","key":"10.1016\/j.cdev.2026.204099_bb0610","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/35038097","article-title":"Repressor activity of headless\/Tcf3 is essential for vertebrate head formation","volume":"407","author":"Kim","year":"2000","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.cdev.2026.204099_bb0615","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.cellsig.2006.08.008","article-title":"The PI3 kinase-Akt pathway mediates Wnt3a-induced proliferation","volume":"19","author":"Kim","year":"2007","journal-title":"Cell. 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Genet."},{"issue":"5307","key":"10.1016\/j.cdev.2026.204099_bb0630","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1126\/science.275.5307.1784","article-title":"Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC\u2212\/\u2212 colon carcinoma","volume":"275","author":"Korinek","year":"1997","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.cdev.2026.204099_bb0635","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1128\/MCB.18.3.1248","article-title":"Two members of the Tcf family implicated in Wnt\/beta-catenin signaling during embryogenesis in the mouse","volume":"18","author":"Korinek","year":"1998","journal-title":"Mol. Cell. 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Engl. J. Med."},{"issue":"10","key":"10.1016\/j.cdev.2026.204099_bb0675","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1158\/0008-5472.CAN-12-4562","article-title":"A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth","volume":"73","author":"Lau","year":"2013","journal-title":"Cancer Res."},{"issue":"23","key":"10.1016\/j.cdev.2026.204099_bb0680","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1242\/dev.124.23.4905","article-title":"The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann\u2019s organizer","volume":"124","author":"Laurent","year":"1997","journal-title":"Development"},{"issue":"34","key":"10.1016\/j.cdev.2026.204099_bb0685","doi-asserted-by":"crossref","first-page":"20608","DOI":"10.1074\/jbc.271.34.20608","article-title":"Cyclin D1 expression is regulated positively by the p42\/p44MAPK and negatively by the p38\/HOGMAPK pathway","volume":"271","author":"Lavoie","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.cdev.2026.204099_bb0690","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1083\/jcb.122.5.1079","article-title":"Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts","volume":"122","author":"Lenormand","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cdev.2026.204099_bb0695","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-11-49","article-title":"Activation of \u03b2-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters","volume":"11","author":"Li","year":"2011","journal-title":"BMC Cancer"},{"issue":"5308","key":"10.1016\/j.cdev.2026.204099_bb0700","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1126\/science.275.5308.1943","article-title":"PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer","volume":"275","author":"Li","year":"1997","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb0705","first-page":"13","article-title":"Significance of vascular endothelial growth factor mRNA expression in invasion and metastasis of hepatocellular carcinoma","volume":"17","author":"Li","year":"1998","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb0710","doi-asserted-by":"crossref","first-page":"10028","DOI":"10.1038\/s41467-024-54450-4","article-title":"A Huluwa phosphorylation switch regulates embryonic axis induction","volume":"15","author":"Li","year":"2024","journal-title":"Nat. Commun."},{"issue":"17","key":"10.1016\/j.cdev.2026.204099_bb0715","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1242\/dev.127.17.3805","article-title":"Wnt\/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine","volume":"127","author":"Lickert","year":"2000","journal-title":"Development"},{"issue":"6","key":"10.1016\/j.cdev.2026.204099_bb0720","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0092-8674(02)00685-2","article-title":"Control of beta-catenin phosphorylation\/degradation by a dual-kinase mechanism","volume":"108","author":"Liu","year":"2002","journal-title":"Cell"},{"issue":"17","key":"10.1016\/j.cdev.2026.204099_bb0725","doi-asserted-by":"crossref","first-page":"28614","DOI":"10.18632\/oncotarget.15603","article-title":"TCF7L2 polymorphisms and the risk of schizophrenia in the Chinese Han population","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.cdev.2026.204099_bb0730","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1242\/dev.126.2.345","article-title":"Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo","volume":"126","author":"Logan","year":"1999","journal-title":"Development"},{"issue":"5","key":"10.1016\/j.cdev.2026.204099_bb0735","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1365-2613.2009.00667.x","article-title":"Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways","volume":"90","author":"Luo","year":"2009","journal-title":"Int. J. Exp. Pathol."},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb0740","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: components, mechanisms, and diseases","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev. Cell"},{"issue":"21","key":"10.1016\/j.cdev.2026.204099_bb0745","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1038\/emboj.2009.285","article-title":"The kinase TNIK is an essential activator of Wnt target genes","volume":"28","author":"Mahmoudi","year":"2009","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.cdev.2026.204099_bb0750","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1073\/pnas.96.4.1603","article-title":"Target genes of beta-catenin-T cell-factor\/lymphoid-enhancer-factor signaling in human colorectal carcinomas","volume":"96","author":"Mann","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.cdev.2026.204099_bb0755","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S1097-2765(01)00224-6","article-title":"Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway","volume":"7","author":"Mao","year":"2001","journal-title":"Mol. Cell"},{"issue":"7","key":"10.1016\/j.cdev.2026.204099_bb0760","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1074\/jbc.272.7.4378","article-title":"Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases","volume":"272","author":"Marais","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.cdev.2026.204099_bb0765","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1093\/emboj\/18.8.2137","article-title":"Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation","volume":"18","author":"Mason","year":"1999","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb0770","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s13059-021-02498-6","article-title":"KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells","volume":"22","author":"Mathison","year":"2021","journal-title":"Genome Biol."},{"issue":"20","key":"10.1016\/j.cdev.2026.204099_bb0775","doi-asserted-by":"crossref","first-page":"11598","DOI":"10.1073\/pnas.181181198","article-title":"A phosphatidylinositol 3-kinase\/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus","volume":"98","author":"Mayo","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb0780","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/leu.2013.184","article-title":"Multifaceted roles of GSK-3 and Wnt\/\u03b2-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention","volume":"28","author":"McCubrey","year":"2014","journal-title":"Leukemia"},{"issue":"2","key":"10.1016\/j.cdev.2026.204099_bb0785","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1006\/dbio.1997.8797","article-title":"LEF-1\/TCF proteins mediate wnt-inducible transcription from the Xenopus nodal-related 3 promoter","volume":"192","author":"McKendry","year":"1997","journal-title":"Dev. Biol."},{"issue":"11","key":"10.1016\/j.cdev.2026.204099_bb0790","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.1091\/mbc.e08-05-0506","article-title":"Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3","volume":"19","author":"Medici","year":"2008","journal-title":"Mol. Biol. Cell"},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb0795","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41598-018-36447-4","article-title":"A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4\/6 inhibitors","volume":"9","author":"Menon","year":"2019","journal-title":"Sci. Rep."},{"issue":"7948","key":"10.1016\/j.cdev.2026.204099_bb0800","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/s41586-022-05655-4","article-title":"Reconstruction and deconstruction of human somitogenesis in vitro","volume":"614","author":"Miao","year":"2023","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.cdev.2026.204099_bb0805","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0092-8674(05)80019-4","article-title":"Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs","volume":"81","author":"Minden","year":"1995","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.cdev.2026.204099_bb0810","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1111\/cas.13805","article-title":"RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model","volume":"109","author":"Mizutani","year":"2018","journal-title":"Cancer Sci."},{"issue":"5114","key":"10.1016\/j.cdev.2026.204099_bb0815","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1126\/science.8503013","article-title":"Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase","volume":"260","author":"Moodie","year":"1993","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.cdev.2026.204099_bb0820","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djt373","article-title":"Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt\/\u03b2-catenin signaling","volume":"106","author":"Moon","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"issue":"5307","key":"10.1016\/j.cdev.2026.204099_bb0825","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1126\/science.275.5307.1787","article-title":"Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC","volume":"275","author":"Morin","year":"1997","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.cdev.2026.204099_bb0830","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nrc2899","article-title":"KRAS, hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma","volume":"10","author":"Morris","year":"2010","journal-title":"Nat. Rev. Cancer"},{"issue":"7","key":"10.1016\/j.cdev.2026.204099_bb0835","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1158\/2159-8290.CD-13-0070","article-title":"Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors","volume":"3","author":"Morris","year":"2013","journal-title":"Cancer Discov."},{"issue":"8","key":"10.1016\/j.cdev.2026.204099_bb0840","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.4161\/cc.7.8.5739","article-title":"The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry","volume":"7","author":"Morrish","year":"2008","journal-title":"Cell Cycle"},{"issue":"6","key":"10.1016\/j.cdev.2026.204099_bb0845","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s00280-012-1869-z","article-title":"Selective PI3K inhibition by BKM120 and BEZ235 alone or in combination with chemotherapy in wild-type and mutated human gastrointestinal cancer cell lines","volume":"69","author":"Mueller","year":"2012","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"5","key":"10.1016\/j.cdev.2026.204099_bb0850","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ncb1399","article-title":"Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos","volume":"8","author":"Mu\u00f1oz","year":"2006","journal-title":"Nat. Cell Biol."},{"issue":"7056","key":"10.1016\/j.cdev.2026.204099_bb0855","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nature03914","article-title":"Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development","volume":"437","author":"Nateri","year":"2005","journal-title":"Nature"},{"issue":"5663","key":"10.1016\/j.cdev.2026.204099_bb0860","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1126\/science.1094291","article-title":"Convergence of Wnt, beta-catenin, and cadherin pathways","volume":"303","author":"Nelson","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.cdev.2026.204099_bb0865","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0092-8674(82)90272-0","article-title":"A major developmental transition in early Xenopus embryos I: characterization and timing of cellular changes at the midblastula stage","author":"Newport","year":"1982","journal-title":"Cell"},{"issue":"51","key":"10.1016\/j.cdev.2026.204099_bb0870","doi-asserted-by":"crossref","first-page":"35308","DOI":"10.1074\/jbc.M109.078261","article-title":"Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade","volume":"284","author":"Ng","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.cdev.2026.204099_bb0875","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrg1347","article-title":"Regionally specific induction by the Spemann-Mangold organizer","volume":"5","author":"Niehrs","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cdev.2026.204099_bb0880","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2021.11.006","article-title":"The role of Xenopus developmental biology in unraveling Wnt signalling and antero-posterior axis formation","volume":"482","author":"Niehrs","year":"2022","journal-title":"Dev. Biol."},{"issue":"12","key":"10.1016\/j.cdev.2026.204099_bb0885","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1038\/emboj.2012.124","article-title":"Mitotic and mitogenic Wnt signalling","volume":"31","author":"Niehrs","year":"2012","journal-title":"EMBO J."},{"issue":"6724","key":"10.1016\/j.cdev.2026.204099_bb0890","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/18465","article-title":"The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway","volume":"398","author":"Ninomiya-Tsuji","year":"1999","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb0895","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.stem.2007.10.011","article-title":"Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood","volume":"2","author":"Nostro","year":"2008","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.cdev.2026.204099_bb0900","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/\u03b2-catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb0905","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0092-8674(82)90409-3","article-title":"Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome","volume":"31","author":"Nusse","year":"1982","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.cdev.2026.204099_bb0910","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/72761","article-title":"Gene-target recognition among members of the myc superfamily and implications for oncogenesis","volume":"24","author":"O\u2019Hagan","year":"2000","journal-title":"Nat. Genet."},{"issue":"5583","key":"10.1016\/j.cdev.2026.204099_bb0915","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1126\/science.1073560","article-title":"Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice","volume":"297","author":"Okkenhaug","year":"2002","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.cdev.2026.204099_bb0920","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1158\/0008-5472.CAN-05-2925","article-title":"mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt","volume":"66","author":"O\u2019Reilly","year":"2006","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.cdev.2026.204099_bb0925","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1399-3011.1995.tb01067.x","article-title":"In vitro association of the phosphatidylinositol 3-kinase regulatory subunit (p85) with the human insulin receptor","volume":"46","author":"Ottinger","year":"1995","journal-title":"Int. J. Pept. Protein Res."},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb0930","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/ncb716","article-title":"The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos","volume":"4","author":"Park","year":"2002","journal-title":"Nat. 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Mol. Gastroenterol. Hepatol."},{"issue":"11","key":"10.1016\/j.cdev.2026.204099_bb0980","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nrc3106","article-title":"RAS oncogenes: weaving a tumorigenic web","volume":"11","author":"Pylayeva-Gupta","year":"2011","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.cdev.2026.204099_bb0985","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1128\/MCB.16.3.1247","article-title":"MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway","volume":"16","author":"Raingeaud","year":"1996","journal-title":"Mol. Cell. Biol."},{"issue":"7263","key":"10.1016\/j.cdev.2026.204099_bb0990","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nature08314","article-title":"A dimerization-dependent mechanism drives RAF catalytic activation","volume":"461","author":"Rajakulendran","year":"2009","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.cdev.2026.204099_bb0995","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141753","article-title":"The anti-tumor activity of succinyl macrolactin a is mediated through the \u03b2-catenin destruction complex via the suppression of tankyrase and PI3K\/Akt","volume":"10","author":"Regmi","year":"2015","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.cdev.2026.204099_bb1000","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1387\/ijdb.11934150","article-title":"Multiple interactions between maternally-activated signalling pathways control Xenopus nodal-related genes","volume":"46","author":"Rex","year":"2002","journal-title":"Int. J. Dev. Biol."},{"issue":"6938","key":"10.1016\/j.cdev.2026.204099_bb1005","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nature01593","article-title":"A role for Wnt signalling in self-renewal of haematopoietic stem cells","volume":"423","author":"Reya","year":"2003","journal-title":"Nature"},{"issue":"6938","key":"10.1016\/j.cdev.2026.204099_bb1010","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nature01593","article-title":"A role for Wnt signalling in self-renewal of haematopoietic stem cells","volume":"423","author":"Reya","year":"2003","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.cdev.2026.204099_bb1015","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1083\/jcb.201610058","article-title":"Oncogenic \u03b2-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids","volume":"216","author":"Riemer","year":"2017","journal-title":"J. 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Cell Sci."},{"issue":"7","key":"10.1016\/j.cdev.2026.204099_bb1030","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.cell.2012.11.026","article-title":"\u03b2-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis","volume":"151","author":"Rosenbluh","year":"2012","journal-title":"Cell"},{"issue":"51","key":"10.1016\/j.cdev.2026.204099_bb1035","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.274.51.36734","article-title":"Regulation of E-cadherin\/catenin association by tyrosine phosphorylation","volume":"274","author":"Roura","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.cdev.2026.204099_bb1040","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1128\/MMBR.68.2.320-344.2004","article-title":"ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions","volume":"68","author":"Roux","year":"2004","journal-title":"Microbiol. 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Med."},{"issue":"7","key":"10.1016\/j.cdev.2026.204099_bb1090","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/10533","article-title":"Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo","volume":"5","author":"Sebolt-Leopold","year":"1999","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb1095","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1006\/dbio.2002.0633","article-title":"Zygotic Wnt\/beta-catenin signaling preferentially regulates the expression of Myf5 gene in the mesoderm of Xenopus","volume":"245","author":"Shi","year":"2002","journal-title":"Dev. Biol."},{"issue":"12","key":"10.1016\/j.cdev.2026.204099_bb1100","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.1158\/0008-5472.CAN-10-0306","article-title":"Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth","volume":"70","author":"Shitashige","year":"2010","journal-title":"Cancer Res."},{"issue":"10","key":"10.1016\/j.cdev.2026.204099_bb1105","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1073\/pnas.96.10.5522","article-title":"The cyclin D1 gene is a target of the beta-catenin\/LEF-1 pathway","volume":"96","author":"Shtutman","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.cdev.2026.204099_bb1110","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35010517","article-title":"FAK integrates growth-factor and integrin signals to promote cell migration","volume":"2","author":"Sieg","year":"2000","journal-title":"Nat. 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Genet."},{"issue":"37","key":"10.1016\/j.cdev.2026.204099_bb1145","doi-asserted-by":"crossref","first-page":"5075","DOI":"10.1038\/onc.2008.140","article-title":"Snail promotes Wnt target gene expression and interacts with beta-catenin","volume":"27","author":"Stemmer","year":"2008","journal-title":"Oncogene"},{"issue":"17","key":"10.1016\/j.cdev.2026.204099_bb1150","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1242\/dev.021121","article-title":"Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt\/beta-catenin, Activin\/Nodal and BMP signaling","volume":"135","author":"Sumi","year":"2008","journal-title":"Development"},{"issue":"Pt1","key":"10.1016\/j.cdev.2026.204099_bb1155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/bj2960015","article-title":"Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling","volume":"296","author":"Sutherland","year":"1993","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.cdev.2026.204099_bb1160","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1530\/ERC-16-0536","article-title":"Apc inactivation, but not obesity, synergizes with Pten deficiency to drive intestinal stem cell-derived tumorigenesis","volume":"24","author":"Tabrizian","year":"2017","journal-title":"Endocr. Relat. 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Cell Biol."},{"issue":"6","key":"10.1016\/j.cdev.2026.204099_bb1200","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.cell.2005.01.013","article-title":"Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos","volume":"120","author":"Tao","year":"2005","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.cdev.2026.204099_bb1205","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1002\/hep.28975","article-title":"Targeting \u03b2-catenin in hepatocellular cancers induced by coexpression of mutant \u03b2-catenin and K-Ras in mice","volume":"65","author":"Tao","year":"2017","journal-title":"Hepatology"},{"issue":"15","key":"10.1016\/j.cdev.2026.204099_bb1210","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0960-9822(03)00506-2","article-title":"Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb","volume":"13","author":"Tee","year":"2003","journal-title":"Curr. 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A."},{"issue":"5","key":"10.1016\/j.cdev.2026.204099_bb1220","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.stem.2008.09.013","article-title":"Wnt signaling mediates self-organization and axis formation in embryoid bodies","volume":"3","author":"ten Berge","year":"2008","journal-title":"Cell Stem Cell"},{"issue":"6726","key":"10.1016\/j.cdev.2026.204099_bb1225","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/18884","article-title":"Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells","volume":"398","author":"Tetsu","year":"1999","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.cdev.2026.204099_bb1230","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1158\/1541-7786.MCR-15-0125","article-title":"Structure, dynamics, and functionality of tankyrase inhibitor-induced degradasomes","volume":"13","author":"Thorvaldsen","year":"2015","journal-title":"Mol. 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Biol."},{"issue":"9","key":"10.1016\/j.cdev.2026.204099_bb1245","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0046-8177(98)90205-2","article-title":"Increased expression of vascular endothelial growth factor is associated with tumor progression in hepatocellular carcinoma","volume":"29","author":"Torimura","year":"1998","journal-title":"Hum. Pathol."},{"issue":"24","key":"10.1016\/j.cdev.2026.204099_bb1250","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1038\/sj.onc.1210133","article-title":"Physical and functional cooperation between AP-1 and beta-catenin for the regulation of TCF-dependent genes","volume":"26","author":"Toualbi","year":"2007","journal-title":"Oncogene"},{"issue":"Pt2","key":"10.1016\/j.cdev.2026.204099_bb1255","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/bj2880351","article-title":"Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor","volume":"288","author":"Traverse","year":"1992","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.cdev.2026.204099_bb1260","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0092-8674(02)01014-0","article-title":"The beta-catenin\/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells","volume":"111","author":"van de Wetering","year":"2002","journal-title":"Cell"},{"issue":"22","key":"10.1016\/j.cdev.2026.204099_bb1265","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1242\/dev.113001","article-title":"Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells","volume":"141","author":"van den Brink","year":"2014","journal-title":"Development"},{"issue":"4","key":"10.1016\/j.cdev.2026.204099_bb1270","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/ncb1240","article-title":"Wnt signalling induces maturation of Paneth cells in intestinal crypts","volume":"7","author":"van Es","year":"2005","journal-title":"Nat. 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A."},{"issue":"11","key":"10.1016\/j.cdev.2026.204099_bb1285","doi-asserted-by":"crossref","DOI":"10.1242\/dev.161471","article-title":"The maternal-to-zygotic transition revisited","volume":"146","author":"Vastenhouw","year":"2019","journal-title":"Development"},{"issue":"34","key":"10.1016\/j.cdev.2026.204099_bb1290","doi-asserted-by":"crossref","first-page":"15157","DOI":"10.1073\/pnas.1003822107","article-title":"TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions","volume":"107","author":"Verzi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb1295","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1006\/dbio.2002.0786","article-title":"Zygotic Wnt activity is required for Brachyury expression in the early Xenopus laevis embryo","volume":"250","author":"Vonica","year":"2002","journal-title":"Dev. Biol."},{"issue":"6782","key":"10.1016\/j.cdev.2026.204099_bb1300","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/35011077","article-title":"Dishevelled controls cell polarity during Xenopus gastrulation","volume":"405","author":"Wallingford","year":"2000","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.cdev.2026.204099_bb1305","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/1097-010X(20000701)287:2<128::AID-JEZ3>3.0.CO;2-G","article-title":"Transition of the blastomere cell cycle from cell size-independent to size-dependent control at the midblastula stage in Xenopus laevis","volume":"287","author":"Wang","year":"2000","journal-title":"J. Exp. 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Pharmacol."},{"issue":"6835","key":"10.1016\/j.cdev.2026.204099_bb1330","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/35077115","article-title":"The status of Wnt signalling regulates neural and epidermal fates in the chick embryo","volume":"411","author":"Wilson","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cdev.2026.204099_bb1335","doi-asserted-by":"crossref","DOI":"10.1186\/1471-213X-9-53","article-title":"Ras promotes cell survival by antagonizing both JNK and hid signals in the Drosophila eye","volume":"9","author":"Wu","year":"2009","journal-title":"BMC Dev. Biol."},{"issue":"5240","key":"10.1016\/j.cdev.2026.204099_bb1340","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.270.5240.1326","article-title":"Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis","volume":"270","author":"Xia","year":"1995","journal-title":"Science"},{"issue":"42","key":"10.1016\/j.cdev.2026.204099_bb1345","doi-asserted-by":"crossref","first-page":"E6382","DOI":"10.1073\/pnas.1613849113","article-title":"Wnt\/beta-catenin signaling promotes self-renewal and inhibits the primed state transition in naive human embryonic stem cells","volume":"113","author":"Xu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb1350","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1038\/s41467-021-23653-4","article-title":"Construction of a mammalian embryo model from stem cells organized by a morphogen signalling Centre","volume":"12","author":"Xu","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.cdev.2026.204099_bb1355","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41392-025-02142-w","article-title":"Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances","volume":"10","author":"Xue","year":"2025","journal-title":"Signal Transduct. Target. 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