{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:09:53Z","timestamp":1762506593844},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T00:00:00Z","timestamp":1426636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chronic Diseases and Translational Medicine"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study explores the correlation between plasma lipoprotein\u2010associated phospholipase A2 (Lp\u2010PLA2) and coronary heart disease (CHD) by comparing the level of plasma Lp\u2010PLA2 in the plasma of patients with different types of CHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blood samples were collected from 56 patients diagnosed with CHD by the Department of Cardiology of the First People's Hospital of Foshan and 34 healthy subjects from February 2013 to January 2014. We measured the concentration of plasma Lp\u2010PLA2 and determined the levels of total cholesterol (Tch), triglyceride (TG), apolipoprotein A1 (Apo\u2010A1), apolipoprotein B (Apo\u2010B), high density lipoprotein\u2010cholesterol (HDL\u2010c), low density lipoprotein\u2010cholesterol (LDL\u2010c), lipoprotein a (Lp(a)), glucose (Glu), and high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP). The concentration of plasma Lp\u2010PLA2 in the healthy control group and each subgroup of CHD patients were compared and analyzed for correlations of plasma Lp\u2010PLA2 between the patients in different CHD subgroups and several laboratory indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The concentration of plasma Lp\u2010PLA2 in each subgroup of CHD was significantly higher than in the control group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The concentration of Lp\u2010PLA2 in the unstable angina pectoris (UAP) group and acute myocardial infarction (AMI) group were significantly higher than in the stable angina pectoris (SAP) group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), and the concentration of plasma Lp\u2010PLA2 in the AMI group was significantly higher than in the UAP group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The concentration of plasma Lp\u2010PLA2 in the CHD group merely showed a positive correlation (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.493, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) with the hs\u2010CRP group, but the levels of Tch, TG, Apo\u2010A1, Apo\u2010B, HDL\u2010c, LDL\u2010c, Lp(a) and Glu did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The concentration of plasma Lp\u2010PLA2 in patients with CHD was higher than that in the control group. The concentration of plasma Lp\u2010PLA2 in the subgroups of CHD patients varied greatly from each other. The inflammatory response of\u00a0atherosclerosis might be resulted from the synergy of plasma Lp\u2010PLA2 and hs\u2010CRP.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.cdtm.2015.02.009","type":"journal-article","created":{"date-parts":[[2015,6,27]],"date-time":"2015-06-27T20:05:40Z","timestamp":1435435540000},"page":"105-109","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Study on the correlation between the concentration of plasma lipoprotein\u2010associated phospholipase A2 and coronary heart disease"],"prefix":"10.1002","volume":"1","author":[{"given":"Jin\u2010Ming","family":"Cen","sequence":"first","affiliation":[{"name":"Department of Cardiology Foshan Municipal First People's Hospital Foshan Guangdong 528000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry &amp; Molecular Biology Guangdong Medical College Dongguan Guangdong 523808 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing\u2010Yuan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The Chancheng District Central Hospital of Foshan Guangdong 528000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bai\u2010Qiang","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Cardiology Foshan Municipal First People's Hospital Foshan Guangdong 528000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Biao","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Foshan Municipal First People's Hospital Foshan Guangdong 528000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi\u2010Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Foshan Municipal First People's Hospital Foshan Guangdong 528000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6]]},"reference":[{"key":"e_1_2_2_2_1","first-page":"274","volume-title":"Internal Medicine","author":"Lu Zaiying","year":"2010"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-014-0401-9"},{"key":"e_1_2_2_4_1","first-page":"21","article-title":"The relationship between plasma lipoprotein\u2010associated phospholipase A2 and coronary heart disease","volume":"2","author":"Weiwei Hu","year":"2010","journal-title":"Chin J Evidence\u2010based Cardiovasc 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