{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T07:10:50Z","timestamp":1763968250699},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T00:00:00Z","timestamp":1480032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chronic Diseases and Translational Medicine"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunoglobulin G4\u2010related disease (IgG4\u2010RD) is a recently recognized clinical entity that often involves multiple organs; it is characterized by high levels of serum immunoglobulin G4 (IgG4), dense infiltration of IgG4+ cells, and storiform fibrosis. Cellular immunity, particularly T cell\u2010mediated immunity, has been implicated in the pathogenesis of IgG4\u2010RD. The most frequent renal manifestations of IgG4\u2010RD are IgG4\u2010related tubulointerstitial nephritis, membranous glomerulonephropathy (MGN), and obstructive nephropathy secondary to urinary tract obstruction due to IgG4\u2010related retroperitoneal fibrosis, prostatitis, or ureter inflammation. Kidney function impairment can be acute or chronic. In IgG4\u2010MGN, proteinuria can be in the nephrotic range. The diagnosis of IgG4\u2010related kidney disease should not be based solely on serum IgG4 levels or the number of tissue\u2010infiltrating IgG4+ plasma cells. Diagnosis should be based on specific histopathological findings, confirmed by tissue immunostaining and an appropriate clinical context. Steroid treatment is the first\u2010line therapy. For relapsing or refractory cases, immunosuppressants could be combined with steroids. In hydronephrosis patients, appropriate immunosuppressive therapy could preclude the implantation of a double J ureteral catheter.<\/jats:p>","DOI":"10.1016\/j.cdtm.2017.05.003","type":"journal-article","created":{"date-parts":[[2017,7,8]],"date-time":"2017-07-08T11:32:10Z","timestamp":1499513530000},"page":"138-147","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Immunoglobulin G4\u2010related kidney disease: Pathogenesis, diagnosis, and treatment"],"prefix":"10.1002","volume":"3","author":[{"given":"Ke","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Nephrology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Nephrology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue\u2010Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103083441005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.3948"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000102"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34593"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.271"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev203"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03207.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283412fd4"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(93)90432-B"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12641"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.1.127"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-016-0331-0"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1330"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.1"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.03.034"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12342"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2014.10.008"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33386"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.049064"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpa.0000226881.48204.fd"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903068"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130678"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-5-201203060-00025"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP73385"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2014.1001474"},{"key":"e_1_2_11_27_1","first-page":"937","article-title":"Analysis on urinary system lesions of IgG4\u2010related disease","volume":"28","author":"Zheng K.","year":"2012","journal-title":"Chin J Nephrol"},{"key":"e_1_2_11_28_1","first-page":"7","article-title":"Clinical feature of renal impairment caused by IgG4 related disease with renal and urinary lesions","volume":"31","author":"Chen G.","year":"2015","journal-title":"Chin J Nephrol"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32835265ac"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.05.002"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfs180"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.382"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011010062"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-011-0521-2"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/139409"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sft062"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2423060003"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2014.03.033"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000001153"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2729-3"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2490-14-54"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.72"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr761"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204907"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.95"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2015.1117171"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283413469"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39205"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205233"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/580814"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2012.08.001"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1104650"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3182431ef6"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-016-0279-4"}],"container-title":["Chronic Diseases and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095882X1630130X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095882X1630130X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.cdtm.2017.05.003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.cdtm.2017.05.003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.cdtm.2017.05.003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T12:40:47Z","timestamp":1693140047000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.cdtm.2017.05.003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1016\/j.cdtm.2017.05.003"],"URL":"https:\/\/doi.org\/10.1016\/j.cdtm.2017.05.003","archive":["Portico"],"relation":{},"ISSN":["2589-0514","2589-0514"],"issn-type":[{"value":"2589-0514","type":"print"},{"value":"2589-0514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunoglobulin G4-related kidney disease: Pathogenesis, diagnosis, and treatment","name":"articletitle","label":"Article Title"},{"value":"Chronic Diseases and Translational Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cdtm.2017.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Chinese Medical Association. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.","name":"copyright","label":"Copyright"}]}}