{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:13:24Z","timestamp":1779120804867,"version":"3.51.4"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chronic Diseases and Translational Medicine"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Coronavirus disease 2019 is a major threat to public health globally. Though its pathogenesis has not been fully elucidated, angiotensin\u2010converting enzyme 2 (ACE2) has been recently identified as a receptor for the entry of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) into the cell. Here, we aimed to clarify the potential role of ACE2 in SARS\u2010CoV\u20102\u2010induced acute lung injury and its underlying mechanism. As a receptor for coronavirus, ACE2 mediates the entry of SARS\u2010CoV\u20102 into cells in a similar way as for severe acute respiratory syndrome coronavirus (SARS\u2010CoV). The high binding affinity of SARS\u2010CoV\u20102 to ACE2 correlates with its efficient spread among humans. On the other hand, ACE2 negatively regulates the renin\u2010angiotensin\u2010aldosterone system (RAAS) primarily by converting angiotensin II to angiotensin 1\u20137, which exerts a beneficial effect on coronavirus\u2010induced acute lung injury. Human recombinant ACE2 has been considered as a potential therapy for SARS\u2010CoV\u20102 by blocking virus entry and redressing the imbalance of RAAS in SARS\u2010CoV\u20102 infection. The level of ACE2 expression can be upregulated by treatment with an ACE inhibitor (ACEI) or angiotensin \u2161 type 1 receptor blocker (ARB). To date, no evidence shows that ACEIs or ARBs increase the susceptibility and mortality of patients infected with SARS\u2010CoV\u20102, and hence, it is not advisable to discontinue such drugs in patients with cardiovascular disease.<\/jats:p>","DOI":"10.1016\/j.cdtm.2020.05.003","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T13:28:21Z","timestamp":1589894901000},"page":"98-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Role and mechanism of angiotensin\u2010converting enzyme 2 in acute lung injury in coronavirus disease 2019"],"prefix":"10.1002","volume":"6","author":[{"given":"Meng\u2010Yuan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology Peking University First Hospital Beijing 100034 China"},{"name":"NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Beijing 100034 China"},{"name":"Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education Health Science Center Peking University Beijing 100034 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology Peking University First Hospital Beijing 100034 China"},{"name":"NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Beijing 100034 China"},{"name":"Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education Health Science Center Peking University Beijing 100034 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Peking University First Hospital Beijing 100034 China"},{"name":"NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Beijing 100034 China"},{"name":"Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education Health Science Center Peking University Beijing 100034 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Peking University First Hospital Beijing 100034 China"},{"name":"NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Beijing 100034 China"},{"name":"Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education Health Science Center Peking University Beijing 100034 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6]]},"reference":[{"key":"e_1_2_3_2_1","unstructured":"Coronavirus disease (COVID\u20102019) situation reports. 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