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The aim of this study was to compare the metabolic features of pitCS and adrCS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review including 114 patients (64 adrCS and 50 pitCS) diagnosed with CS in 2009\u20132019 was performed. Metabolic factors were then compared between pitCS and adrCS groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regarding sex, females suffered both adrCs (92.2%) and pitCS (88.0%) more frequently than males. Regarding age, patients with pitCS were diagnosed at a younger age (35.40\u2009\u00b1\u200911.94 vs. 39.65\u2009\u00b1\u200911.37 years, <jats:italic>p<\/jats:italic>\u2009=\u20090.056) than those with adrCS, although the difference was not statistically significant. Moreover, pitCS patients had much higher ACTH levels and more serious occurrences of hypercortisolemia at all time points (8 AM, 4 PM, 12 AM) than that in adrCS patients. Conversely, indexes, including body weight, BMI, blood pressure, serum total cholesterol, low density lipoprotein cholesterol (LDL\u2010C), high density lipoprotein cholesterol (HDL\u2010C), triglycerides, fasting plasma glucose, and uric acid, showed no differences between adrCS and pitCS patients. Furthermore, diabetes prevalence was higher in pitCS patients than in adrCS patients; however, there were no significant differences in hypertension or dyslipidemia prevalence between the two.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although adrCS and pitCS had different pathogenetic mechanisms, different severities of hypercortisolemia, and different diabetes prevalences, both etiologies had similar metabolic characteristics.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.cdtm.2021.08.004","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T11:48:17Z","timestamp":1631533697000},"page":"36-40","source":"Crossref","is-referenced-by-count":2,"title":["Metabolic profile differences in ACTH\u2010dependent and ACTH\u2010independent Cushing syndrome"],"prefix":"10.1002","volume":"8","author":[{"given":"Zhengyang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong 250021 China"},{"name":"Institute of Endocrinology and metabolism Shandong Academy of Clinical Medicine  Jinan Shandong 250021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong 250021 China"},{"name":"Institute of Endocrinology and metabolism Shandong Academy of Clinical Medicine  Jinan Shandong 250021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong 250021 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfeng","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong 250021 China"},{"name":"Institute of Endocrinology and metabolism Shandong Academy of Clinical Medicine  Jinan Shandong 250021 China"},{"name":"Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong University  Jinan Shandong 250021 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