{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:13:49Z","timestamp":1791422029394,"version":"4.3.3"},"reference-count":56,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Cell Biology"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.ceb.2005.12.003","type":"journal-article","created":{"date-parts":[[2005,12,19]],"date-time":"2005-12-19T10:52:07Z","timestamp":1134989527000},"page":"4-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":229,"title":["Protein complexes regulating Arp2\/3-mediated actin assembly"],"prefix":"10.1016","volume":"18","author":[{"given":"Theresia EB","family":"Stradal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Scita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceb.2005.12.003_bib1","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1242\/jcs.114.10.1801","article-title":"WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement","volume":"114","author":"Takenawa","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ceb.2005.12.003_bib2","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1126\/science.1059975","article-title":"Mechanism of actin-based motility","volume":"292","author":"Pantaloni","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ceb.2005.12.003_bib3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.tcb.2004.04.007","article-title":"Regulation of actin dynamics by WASP and WAVE family proteins","volume":"14","author":"Stradal","year":"2004","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib4","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1083\/jcb.142.5.1325","article-title":"SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development","volume":"142","author":"Bear","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib5","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0960-9822(98)00015-3","article-title":"Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2\/3 complex","volume":"8","author":"Machesky","year":"1998","journal-title":"Curr Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib6","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1083\/jcb.200403127","article-title":"Regulation of WASP\/WAVE proteins: making a long story short","volume":"166","author":"Bompard","year":"2004","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib7","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1126\/science.290.5492.801","article-title":"Integration of multiple signals through cooperative regulation of the N-WASP-Arp2\/3 complex","volume":"290","author":"Prehoda","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.ceb.2005.12.003_bib8","doi-asserted-by":"crossref","first-page":"11306","DOI":"10.1073\/pnas.211420498","article-title":"CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family","volume":"98","author":"Ho","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ceb.2005.12.003_bib9_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cell.2004.06.027","article-title":"Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex","volume":"118","author":"Ho","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ceb.2005.12.003_bib10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1074-7613(02)00268-6","article-title":"WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation","volume":"16","author":"Anton","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.ceb.2005.12.003_bib11","doi-asserted-by":"crossref","first-page":"37771","DOI":"10.1074\/jbc.M204145200","article-title":"Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2","volume":"277","author":"Benesch","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2005.12.003_bib12","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1242\/jcs.113.23.4165","article-title":"Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages","volume":"113","author":"Linder","year":"2000","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ceb.2005.12.003_bib13","doi-asserted-by":"crossref","first-page":"7854","DOI":"10.1074\/jbc.275.11.7854","article-title":"Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules","volume":"275","author":"Tian","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2005.12.003_bib14","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1091\/mbc.e03-10-0757","article-title":"AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus","volume":"15","author":"Larocca","year":"2004","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ceb.2005.12.003_bib15","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1091\/mbc.01-12-0579","article-title":"Regulation of protein transport from the Golgi complex to the endoplasmic reticulum by CDC42 and N-WASP","volume":"13","author":"Luna","year":"2002","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ceb.2005.12.003_bib16","doi-asserted-by":"crossref","first-page":"40091","DOI":"10.1074\/jbc.M404899200","article-title":"A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis","volume":"279","author":"Kamioka","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2005.12.003_bib17","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/35074551","article-title":"WIP regulates N-WASP-mediated actin polymerization and filopodium formation","volume":"3","author":"Martinez-Quiles","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib18","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S1357-2725(01)00162-5","article-title":"Restoration of podosomes and chemotaxis in Wiskott\u2013Aldrich syndrome macrophages following induced expression of WASp","volume":"34","author":"Jones","year":"2002","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib19","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1084\/jem.194.12.1777","article-title":"The intersectin 2 adaptor links Wiskott\u2013Aldrich syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis","volume":"194","author":"McGavin","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.ceb.2005.12.003_bib20","doi-asserted-by":"crossref","first-page":"6083","DOI":"10.1093\/emboj\/cdf604","article-title":"Syndapins integrate N-WASP in receptor-mediated endocytosis","volume":"21","author":"Kessels","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.ceb.2005.12.003_bib21","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/ncb1001-927","article-title":"Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP","volume":"3","author":"Hussain","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev.cellbio.19.111401.093127","article-title":"Actin assembly and endocytosis: from yeast to mammals","volume":"19","author":"Engqvist-Goldstein","year":"2003","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib23","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/ncb837","article-title":"Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits","volume":"4","author":"Merrifield","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1078\/0171-9335-00356","article-title":"Neural Wiskott\u2013Aldrich syndrome protein (N-WASP) and the Arp2\/3 complex are recruited to sites of clathrin-mediated endocytosis in cultured fibroblasts","volume":"83","author":"Merrifield","year":"2004","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib25_1","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1242\/jcs.02444","article-title":"N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pits","volume":"118","author":"Benesch","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ceb.2005.12.003_bib26_1","doi-asserted-by":"crossref","unstructured":"Innocenti M, Gerboth S, Rottner K, Lai FPL, Hertzog M, Stradal TEB, Frittoli E, Didry D, Polo S, Disanza A et al.: Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes. Nat Cell Biol 2005, 7:969\u2013976.","DOI":"10.1038\/ncb1304"},{"key":"10.1016\/j.ceb.2005.12.003_bib27","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0960-9822(98)70396-3","article-title":"The WASp homologue Las17p functions with the WIP homologue End5p\/verprolin and is essential for endocytosis in yeast","volume":"8","author":"Naqvi","year":"1998","journal-title":"Curr Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib28","doi-asserted-by":"crossref","first-page":"7889","DOI":"10.1128\/MCB.22.22.7889-7906.2002","article-title":"Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro","volume":"22","author":"Soulard","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.devcel.2005.04.014","article-title":"In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast","volume":"9","author":"Newpher","year":"2005","journal-title":"Dev Cell"},{"key":"10.1016\/j.ceb.2005.12.003_bib30","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1083\/jcb.200104094","article-title":"A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2\/3-activating motor complex in yeast","volume":"155","author":"Lechler","year":"2001","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib31","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S1097-2765(03)00172-2","article-title":"Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2\/3 complex and enhances actin polymerization by WASP","volume":"11","author":"Cory","year":"2003","journal-title":"Mol Cell"},{"key":"10.1016\/j.ceb.2005.12.003_bib32","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S1534-5807(02)00324-6","article-title":"Sustained activation of N-WASP through phosphorylation is essential for neurite extension","volume":"3","author":"Suetsugu","year":"2002","journal-title":"Dev Cell"},{"key":"10.1016\/j.ceb.2005.12.003_bib33","doi-asserted-by":"crossref","first-page":"45115","DOI":"10.1074\/jbc.M203346200","article-title":"Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott\u2013Aldrich syndrome protein","volume":"277","author":"Cory","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2005.12.003_bib34","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/S1097-2765(03)00139-4","article-title":"Contingent phosphorylation\/dephosphorylation provides a mechanism of molecular memory in WASP","volume":"11","author":"Torres","year":"2003","journal-title":"Mol Cell"},{"key":"10.1016\/j.ceb.2005.12.003_bib35","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35047107","article-title":"IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling","volume":"408","author":"Miki","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2005.12.003_bib36","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nature00859","article-title":"Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck","volume":"418","author":"Eden","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2005.12.003_bib37_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/ncb1105","article-title":"Abi1 is essential for the formation and activation of a WAVE2 signalling complex","volume":"6","author":"Innocenti","year":"2004","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib38","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1006\/bbrc.1996.0264","article-title":"Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck","volume":"219","author":"Kitamura","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ceb.2005.12.003_bib39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1074\/jbc.273.1.291","article-title":"p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase","volume":"273","author":"Kobayashi","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2005.12.003_bib40","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1101\/gad.9.21.2569","article-title":"Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity","volume":"9","author":"Dai","year":"1995","journal-title":"Genes Dev"},{"key":"10.1016\/j.ceb.2005.12.003_bib41_1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/sj.emboj.7600084","article-title":"Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation","volume":"23","author":"Steffen","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.ceb.2005.12.003_bib42","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2121-6-11","article-title":"Inclusion of Scar\/WAVE3 in a similar complex to Scar\/WAVE1 and 2","volume":"6","author":"Stovold","year":"2005","journal-title":"BMC Cell Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib43","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.1073\/pnas.0400628101","article-title":"Purification and architecture of the ubiquitous Wave complex","volume":"101","author":"Gautreau","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ceb.2005.12.003_bib44","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1105\/tpc.104.027987","article-title":"DISTORTED3\/SCAR2 is a putative Arabidopsis WAVE complex subunit that activates the Arp2\/3 complex and is required for epidermal morphogenesis","volume":"17","author":"Basu","year":"2005","journal-title":"Plant Cell"},{"key":"10.1016\/j.ceb.2005.12.003_bib45","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1242\/dev.01307","article-title":"Interchangeable functions of Arabidopsis PIROGI and the human WAVE complex subunit SRA1 during leaf epidermal development","volume":"131","author":"Basu","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ceb.2005.12.003_bib46","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.cub.2003.10.005","article-title":"Abi, Sra1, and Kette control the stability and localization of SCAR\/WAVE to regulate the formation of actin-based protrusions","volume":"13","author":"Kunda","year":"2003","journal-title":"Curr Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib47","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1083\/jcb.200303023","article-title":"Molecular requirements for actin-based lamella formation in Drosophila S2 cells","volume":"162","author":"Rogers","year":"2003","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib48","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/ncb1125","article-title":"PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia","volume":"6","author":"Oikawa","year":"2004","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib49","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1073\/pnas.0409120102","article-title":"Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation","volume":"102","author":"Leng","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ceb.2005.12.003_bib50","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pbi.2004.11.004","article-title":"Breaking the WAVE complex: the point of Arabidopsis trichomes","volume":"8","author":"Szymanski","year":"2005","journal-title":"Curr Opin Plant Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib51_1","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1105\/tpc.104.023739","article-title":"NAPP and PIRP encode subunits of a putative wave regulatory protein complex involved in plant cell morphogenesis","volume":"16","author":"Brembu","year":"2004","journal-title":"Plant Cell"},{"key":"10.1016\/j.ceb.2005.12.003_bib52","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/S0960-9822(03)00580-3","article-title":"PIR121 regulates pseudopod dynamics and SCAR activity in Dictyostelium","volume":"13","author":"Blagg","year":"2003","journal-title":"Curr Biol"},{"key":"10.1016\/j.ceb.2005.12.003_bib53","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1042\/BST0321113","article-title":"Control of SCAR activity in Dictyostelium discoideum","volume":"32","author":"Blagg","year":"2004","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.ceb.2005.12.003_bib54_1","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1091\/mbc.e04-09-0844","article-title":"A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis","volume":"16","author":"Myers","year":"2005","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ceb.2005.12.003_bib55","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1242\/dev.00663","article-title":"Kette regulates actin dynamics and genetically interacts with Wave and Wasp","volume":"130","author":"Bogdan","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ceb.2005.12.003_bib56_1","doi-asserted-by":"crossref","unstructured":"Bogdan S, Stephan R, L\u00f6bke C, Mertens A, Klambt C: Abi activates Wasp to promote sensory organ development. Nat Cell Biol 2005, 7:977\u2013984.","DOI":"10.1038\/ncb1305"}],"container-title":["Current Opinion in Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955067405001845?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955067405001845?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:05:27Z","timestamp":1760619927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955067405001845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0955067405001845"],"URL":"https:\/\/doi.org\/10.1016\/j.ceb.2005.12.003","relation":{},"ISSN":["0955-0674"],"issn-type":[{"value":"0955-0674","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protein complexes regulating Arp2\/3-mediated actin assembly","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceb.2005.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}