{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:30:13Z","timestamp":1791412213726,"version":"4.3.3"},"reference-count":84,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Cell Biology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.ceb.2010.07.002","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T06:28:12Z","timestamp":1280816892000},"page":"772-780","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Epigenomics of centromere assembly and function"],"prefix":"10.1016","volume":"22","author":[{"given":"Kaitlin M","family":"Stimpson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth A","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceb.2010.07.002_bib0005","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1083\/jcb.104.4.805","article-title":"A 17-kD centromere protein (CENP-A) copurifies with nucleosome core particles and with histones","volume":"104","author":"Palmer","year":"1987","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ceb.2010.07.002_bib0010","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ceb.2007.11.007","article-title":"The histone variant CENP-A and centromere specification","volume":"20","author":"Black","year":"2008","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.ceb.2010.07.002_bib0015","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.ceb.2010.02.005","article-title":"Down the rabbit hole of centromere assembly and dynamics","volume":"22","author":"Dalal","year":"2010","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.ceb.2010.07.002_bib0020","doi-asserted-by":"crossref","first-page":"14706","DOI":"10.1073\/pnas.0706985104","article-title":"Centromere identity is specified by a single centromeric nucleosome in budding yeast","volume":"104","author":"Furuyama","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2010.07.002_bib0025","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S1673-8527(08)60144-7","article-title":"An overview of plant centromeres","volume":"36","author":"Wang","year":"2009","journal-title":"J Genet Genomics"},{"key":"10.1016\/j.ceb.2010.07.002_bib0030","first-page":"524","article-title":"Chromosome-specific organization of human alpha satellite DNA","volume":"37","author":"Willard","year":"1985","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ceb.2010.07.002_bib0035","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s004390050508","article-title":"Human centromeric DNAs","volume":"100","author":"Lee","year":"1997","journal-title":"Hum Genet"},{"key":"10.1016\/j.ceb.2010.07.002_bib0040","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s004120050324","article-title":"Assay of centromere function using a human artificial chromosome","volume":"107","author":"Masumoto","year":"1998","journal-title":"Chromosoma"},{"key":"10.1016\/j.ceb.2010.07.002_bib0045","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0960-9822(06)00382-4","article-title":"Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres","volume":"7","author":"Warburton","year":"1997","journal-title":"Curr Biol"},{"key":"10.1016\/j.ceb.2010.07.002_bib0050","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1023\/B:CHRO.0000036607.74671.db","article-title":"Plant neocentromeres: fast, focused, and driven","volume":"12","author":"Dawe","year":"2004","journal-title":"Chromosome Res"},{"key":"10.1016\/j.ceb.2010.07.002_bib0055_1","doi-asserted-by":"crossref","first-page":"e1000400","DOI":"10.1371\/journal.pgen.1000400","article-title":"Neocentromeres form efficiently at multiple possible loci in Candida albicans","volume":"5","author":"Ketel","year":"2009","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ceb.2010.07.002_bib0060","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/ng0198-30","article-title":"Neocentromere activity of structurally acentric mini-chromosomes in Drosophila","volume":"18","author":"Williams","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.ceb.2010.07.002_bib0065","first-page":"1153","article-title":"A functional marker centromere with no detectable alpha-satellite, satellite III, or CENP-B protein: activation of a latent centromere?","volume":"52","author":"Voullaire","year":"1993","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ceb.2010.07.002_bib0070","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1023\/B:CHRO.0000036585.44138.4b","article-title":"Chromosomal dynamics of human neocentromere formation","volume":"12","author":"Warburton","year":"2004","journal-title":"Chromosome Res"},{"key":"10.1016\/j.ceb.2010.07.002_bib0075","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1006\/mthe.2002.0612","article-title":"alpha-Satellite DNA and vector composition influence rates of human artificial chromosome formation","volume":"5","author":"Grimes","year":"2002","journal-title":"Mol Ther"},{"key":"10.1016\/j.ceb.2010.07.002_bib0080","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ng0497-345","article-title":"Formation of de novo centromeres and construction of first-generation human artificial microchromosomes","volume":"15","author":"Harrington","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.ceb.2010.07.002_bib0085","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nbt0598-431","article-title":"Construction of YAC-based mammalian artificial chromosomes","volume":"16","author":"Ikeno","year":"1998","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.ceb.2010.07.002_bib0090","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1083\/jcb.109.5.1963","article-title":"A human centromere antigen (CENP-B) interacts with a short specific sequence in alphoid DNA, a human centromeric satellite","volume":"109","author":"Masumoto","year":"1989","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ceb.2010.07.002_bib0095","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1023\/B:CHRO.0000036593.72788.99","article-title":"The role of CENP-B and alpha-satellite DNA: de novo assembly and epigenetic maintenance of human centromeres","volume":"12","author":"Masumoto","year":"2004","journal-title":"Chromosome Res"},{"key":"10.1016\/j.ceb.2010.07.002_bib0100","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1093\/hmg\/4.12.2189","article-title":"Identification of centromeric antigens in dicentric Robertsonian translocations: CENP-C and CENP-E are necessary components of functional centromeres","volume":"4","author":"Sullivan","year":"1995","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ceb.2010.07.002_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00293329","article-title":"Visualization of centromere proteins CENP-B and CENP-C on a stable dicentric chromosome in cytological spreads","volume":"98","author":"Earnshaw","year":"1989","journal-title":"Chromosoma"},{"key":"10.1016\/j.ceb.2010.07.002_bib0110","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1534-5807(01)00028-4","article-title":"Domain organization at the centromere and neocentromere","volume":"1","author":"Choo","year":"2001","journal-title":"Dev Cell"},{"key":"10.1016\/j.ceb.2010.07.002_bib0115","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1083\/jcb.200207112","article-title":"CENP-B box is required for de novo centromere chromatin assembly on human alphoid DNA","volume":"159","author":"Ohzeki","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ceb.2010.07.002_bib0120","doi-asserted-by":"crossref","first-page":"14877","DOI":"10.1073\/pnas.0606958103","article-title":"Formation of functional centromeric chromatin is specified epigenetically in Candida albicans","volume":"103","author":"Baum","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2010.07.002_bib0125","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1093\/emboj\/cdf511","article-title":"Co-localization of centromere activity, proteins and topoisomerase II within a subdomain of the major human X alpha-satellite array","volume":"21","author":"Spence","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.ceb.2010.07.002_bib0130","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1073\/pnas.0507947103","article-title":"Human centromeric chromatin is a dynamic chromosomal domain that can spread over noncentromeric DNA","volume":"103","author":"Lam","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2010.07.002_bib0135","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1534-5807(02)00135-1","article-title":"Conserved organization of centromeric chromatin in flies and humans","volume":"2","author":"Blower","year":"2002","journal-title":"Dev Cell"},{"key":"10.1016\/j.ceb.2010.07.002_bib0140","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/nsmb845","article-title":"Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin","volume":"11","author":"Sullivan","year":"2004","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.ceb.2010.07.002_bib0145","doi-asserted-by":"crossref","first-page":"10484","DOI":"10.1073\/pnas.1002325107","article-title":"A super-resolution map of the vertebrate kinetochore","volume":"107","author":"Ribeiro","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2010.07.002_bib0150","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1534\/genetics.106.056853","article-title":"Partitioning of the maize epigenome by the number of methyl groups on histone H3 lysines 9 and 27","volume":"173","author":"Shi","year":"2006","journal-title":"Genetics"},{"key":"10.1016\/j.ceb.2010.07.002_bib0155","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s10577-008-1269-8","article-title":"Histone modifications associated with both A and B chromosomes of maize","volume":"16","author":"Jin","year":"2008","journal-title":"Chromosome Res"},{"key":"10.1016\/j.ceb.2010.07.002_bib0160","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1105\/tpc.105.037945","article-title":"Transcription and histone modifications in the recombination-free region spanning a rice centromere","volume":"17","author":"Yan","year":"2005","journal-title":"Plant Cell"},{"key":"10.1016\/j.ceb.2010.07.002_bib0165","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.cub.2005.11.065","article-title":"A heterochromatin barrier partitions the fission yeast centromere into discrete chromatin domains","volume":"16","author":"Scott","year":"2006","journal-title":"Curr Biol"},{"key":"10.1016\/j.ceb.2010.07.002_bib0170","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1101\/gad.14.7.783","article-title":"Distinct protein interaction domains and protein spreading in a complex centromere","volume":"14","author":"Partridge","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.ceb.2010.07.002_bib0175","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1093\/hmg\/ddg282","article-title":"Genomic microarray analysis reveals distinct locations for CENP-A binding domains in three human chromosome 13q32 neocentromeres","volume":"12","author":"Alonso","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ceb.2010.07.002_bib0180","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/hmg\/ddi008","article-title":"Variable and hierarchical size distribution of L1-retroelement-enriched CENP-A clusters within a functional human neocentromere","volume":"14","author":"Chueh","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ceb.2010.07.002_bib0185","doi-asserted-by":"crossref","first-page":"R148","DOI":"10.1186\/gb-2007-8-7-r148","article-title":"Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres","volume":"8","author":"Alonso","year":"2007","journal-title":"Genome Biol"},{"key":"10.1016\/j.ceb.2010.07.002_bib0190_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1756-8935-3-6","article-title":"A paucity of heterochromatin at functional human neocentromeres","volume":"3","author":"Alonso","year":"2010","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.ceb.2010.07.002_bib0195","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S1097-2765(03)00279-X","article-title":"Transcription within a functional human centromere","volume":"12","author":"Saffery","year":"2003","journal-title":"Mol Cell"},{"key":"10.1016\/j.ceb.2010.07.002_bib0200_1","doi-asserted-by":"crossref","first-page":"e1000354","DOI":"10.1371\/journal.pgen.1000354","article-title":"LINE retrotransposon RNA is an essential structural and functional epigenetic component of a core neocentromeric chromatin","volume":"5","author":"Chueh","year":"2009","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ceb.2010.07.002_bib0205","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1371\/journal.pgen.0020017","article-title":"Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation","volume":"2","author":"Wong","year":"2006","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ceb.2010.07.002_bib0210","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1023\/A:1022815931524","article-title":"RNA interference is required for normal centromere function in fission yeast","volume":"11","author":"Volpe","year":"2003","journal-title":"Chromosome Res"},{"key":"10.1016\/j.ceb.2010.07.002_bib0215","doi-asserted-by":"crossref","first-page":"8709","DOI":"10.1073\/pnas.0508006103","article-title":"Accumulation of small murine minor satellite transcripts leads to impaired centromeric architecture and function","volume":"103","author":"Bouzinba-Segard","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2010.07.002_bib0220","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/ncb1155","article-title":"Dicer is essential for formation of the heterochromatin structure in vertebrate cells","volume":"6","author":"Fukagawa","year":"2004","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2010.07.002_bib0225","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.1150944","article-title":"Heterochromatin and RNAi are required to establish CENP-A chromatin at centromeres","volume":"319","author":"Folco","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.ceb.2010.07.002_bib0230","doi-asserted-by":"crossref","first-page":"15986","DOI":"10.1073\/pnas.0407154101","article-title":"Centromere-encoded RNAs are integral components of the maize kinetochore","volume":"101","author":"Topp","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2010.07.002_bib0235","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1371\/journal.pgen.0010079","article-title":"Differential regulation of strand-specific transcripts from Arabidopsis centromeric satellite repeats","volume":"1","author":"May","year":"2005","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ceb.2010.07.002_bib0240","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1101\/gr.6022807","article-title":"Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere","volume":"17","author":"Wong","year":"2007","journal-title":"Genome Res"},{"key":"10.1016\/j.ceb.2010.07.002_bib0245_1","doi-asserted-by":"crossref","first-page":"e1000835","DOI":"10.1371\/journal.pgen.1000835","article-title":"DNA binding of centromere protein C (CENPC) is stabilized by single-stranded RNA","volume":"6","author":"Du","year":"2010","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ceb.2010.07.002_bib0250","first-page":"2397","article-title":"Genetic manipulation of centromere function","volume":"7","author":"Hill","year":"1987","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ceb.2010.07.002_bib0255_1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.devcel.2008.02.001","article-title":"Inactivation of a human kinetochore by specific targeting of chromatin modifiers","volume":"14","author":"Nakano","year":"2008","journal-title":"Dev Cell"},{"key":"10.1016\/j.ceb.2010.07.002_bib0260","doi-asserted-by":"crossref","first-page":"5885","DOI":"10.1242\/jcs.02702","article-title":"Assembly of additional heterochromatin distinct from centromere\u2013kinetochore chromatin is required for de novo formation of human artificial chromosome","volume":"118","author":"Nakashima","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ceb.2010.07.002_bib0265","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/genetics\/26.2.234","article-title":"The stability of broken ends of chromosomes in Zea mays","volume":"26","author":"McClintock","year":"1941","journal-title":"Genetics"},{"key":"10.1016\/j.ceb.2010.07.002_bib0270","first-page":"1368","article-title":"Acquisition and processing of a conditional dicentric chromosome in Saccharomyces cerevisiae","volume":"9","author":"Hill","year":"1989","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ceb.2010.07.002_bib0275","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1091\/mbc.12.9.2800","article-title":"Dicentric chromosome stretching during anaphase reveals roles of Sir2\/Ku in chromatin compaction in budding yeast","volume":"12","author":"Thrower","year":"2001","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ceb.2010.07.002_bib0280","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1242\/jcs.00251","article-title":"Nuclear oscillations and nuclear filament formation accompany single-strand annealing repair of a dicentric chromosome in Saccharomyces cerevisiae","volume":"116","author":"Thrower","year":"2003","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ceb.2010.07.002_bib0285","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s004120050427","article-title":"A dicentric chromosome of Drosophila melanogaster showing alternate centromere inactivation","volume":"109","author":"Agudo","year":"2000","journal-title":"Chromosoma"},{"key":"10.1016\/j.ceb.2010.07.002_bib0290","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1073\/pnas.0509650103","article-title":"High frequency of centromere inactivation resulting in stable dicentric chromosomes","volume":"103","author":"Han","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2010.07.002_bib0295","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/BF00329812","article-title":"Three related centromere proteins are absent from the inactive centromere of a stable isodicentric chromosome","volume":"92","author":"Earnshaw","year":"1985","journal-title":"Chromosoma"},{"key":"10.1016\/j.ceb.2010.07.002_bib0300","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/hmg\/4.2.289","article-title":"Further evidence that CENP-C is a necessary component of active centromeres: studies of a dic(X; 15) with simultaneous immunofluorescence and FISH","volume":"4","author":"Page","year":"1995","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ceb.2010.07.002_bib0305","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s10577-005-1009-2","article-title":"Engineered human dicentric chromosomes show centromere plasticity","volume":"13","author":"Higgins","year":"2005","journal-title":"Chromosome Res"},{"key":"10.1016\/j.ceb.2010.07.002_bib0310","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1023\/A:1009286929145","article-title":"Chromosome stability is maintained by short intercentromeric distance in functionally dicentric human Robertsonian translocations","volume":"6","author":"Page","year":"1998","journal-title":"Chromosome Res"},{"key":"10.1016\/j.ceb.2010.07.002_bib0315_1","unstructured":"Stimpson KM, Song IY, Jauch A, Holtgreve-Grez H, Hayden KE, Bridger JM, Sullivan BA: Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosome. PLoS Genet, in press."},{"key":"10.1016\/j.ceb.2010.07.002_bib0320","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0092-8674(87)90077-8","article-title":"A genetic analysis of dicentric minichromosomes in Saccharomyces cerevisiae","volume":"48","author":"Koshland","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.ceb.2010.07.002_bib0325","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/3024","article-title":"Stable dicentric X chromosomes with two functional centromeres","volume":"20","author":"Sullivan","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.ceb.2010.07.002_bib0330","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s004120050376","article-title":"Chromosome engineering: generation of mono- and dicentric isochromosomes in a somatic cell hybrid system","volume":"108","author":"Higgins","year":"1999","journal-title":"Chromosoma"},{"key":"10.1016\/j.ceb.2010.07.002_bib0335_1","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1091\/mbc.e09-06-0489","article-title":"Hierarchical inactivation of a synthetic human kinetochore by a chromatin modifier","volume":"20","author":"Cardinale","year":"2009","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ceb.2010.07.002_bib0340","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/sj.emboj.7601584","article-title":"A minimal CENP-A core is required for nucleation and maintenance of a functional human centromere","volume":"26","author":"Okamoto","year":"2007","journal-title":"EMBO J"},{"key":"10.1016\/j.ceb.2010.07.002_bib0345","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1242\/jcs.00697","article-title":"Epigenetic assembly of centromeric chromatin at ectopic alpha-satellite sites on human chromosomes","volume":"116","author":"Nakano","year":"2003","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ceb.2010.07.002_bib0350_1","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.cell.2007.10.045","article-title":"CENP-B controls centromere formation depending on chromatin context","volume":"131","author":"Okada","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.ceb.2010.07.002_bib0355_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00412-010-0278-5","article-title":"Centromere inactivation and epigenetic modifications of a plant chromosome with three functional centromeres","volume":"119","author":"Zhang","year":"2010","journal-title":"Chromosoma"},{"key":"10.1016\/j.ceb.2010.07.002_bib0360_1","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1105\/tpc.109.066662","article-title":"Reactivation of an inactive centromere reveals epigenetic and structural components for centromere specification in maize","volume":"21","author":"Han","year":"2009","journal-title":"Plant Cell"},{"key":"10.1016\/j.ceb.2010.07.002_bib0365","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/BF00337384","article-title":"Analysis of centromeric activity in Robertsonian translocations: implications for a functional acrocentric hierarchy","volume":"103","author":"Sullivan","year":"1994","journal-title":"Chromosoma"},{"key":"10.1016\/j.ceb.2010.07.002_bib0370","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s004120050240","article-title":"Centromeric inactivation in a dicentric human Y;21 translocation chromosome","volume":"106","author":"Fisher","year":"1997","journal-title":"Chromosoma"},{"key":"10.1016\/j.ceb.2010.07.002_bib0375","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/BF00194222","article-title":"Deletion of specific sequences or modification of centromeric chromatin are responsible for Y chromosome centromere inactivation","volume":"85","author":"Maraschio","year":"1990","journal-title":"Hum Genet"},{"key":"10.1016\/j.ceb.2010.07.002_bib0380","doi-asserted-by":"crossref","first-page":"15762","DOI":"10.1073\/pnas.0908233106","article-title":"Double-strand DNA breaks recruit the centromeric histone CENP-A","volume":"106","author":"Zeitlin","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2010.07.002_bib0385","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1073\/pnas.0912143106","article-title":"Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle","volume":"107","author":"Guerrero","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2010.07.002_bib0390_1","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1083\/jcb.200803042","article-title":"Centromere mitotic recombination in mammalian cells","volume":"181","author":"Jaco","year":"2008","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ceb.2010.07.002_bib0395","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.3137657","article-title":"Mitotic recombination within the centromere of a yeast chromosome","volume":"241","author":"Liebman","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.ceb.2010.07.002_bib0400_1","doi-asserted-by":"crossref","first-page":"e1000327","DOI":"10.1371\/journal.pbio.1000327","article-title":"Widespread gene conversion in centromere cores","volume":"8","author":"Shi","year":"2010","journal-title":"PLoS Biol"},{"key":"10.1016\/j.ceb.2010.07.002_bib0405","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1111\/j.1742-4658.2005.04759.x","article-title":"Death inducer obliterator protein 1 in the context of DNA regulation. Sequence analyses of distant homologues point to a novel functional role","volume":"272","author":"Rojas","year":"2005","journal-title":"FEBS J"},{"key":"10.1016\/j.ceb.2010.07.002_bib0410_1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cell.2009.02.040","article-title":"HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres","volume":"137","author":"Dunleavy","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ceb.2010.07.002_bib0415_1","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cell.2009.02.039","article-title":"Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP","volume":"137","author":"Foltz","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ceb.2010.07.002_bib0420","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.cell.2009.06.010","article-title":"Common ancestry of the CENP-A chaperones Scm3 and HJURP","volume":"137","author":"Sanchez-Pulido","year":"2009","journal-title":"Cell"}],"container-title":["Current Opinion in Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095506741000102X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095506741000102X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:18:03Z","timestamp":1760620683000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095506741000102X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":84,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S095506741000102X"],"URL":"https:\/\/doi.org\/10.1016\/j.ceb.2010.07.002","relation":{},"ISSN":["0955-0674"],"issn-type":[{"value":"0955-0674","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenomics of centromere assembly and function","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceb.2010.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}