{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:35:58Z","timestamp":1791286558831,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006251","name":"University of Bordeaux","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006251","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Cell Biology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.ceb.2016.01.008","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T20:34:09Z","timestamp":1453926849000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"special_numbering":"C","title":["Autophagy and primary cilia: dual interplay"],"prefix":"10.1016","volume":"39","author":[{"given":"Olatz","family":"Pampliega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Cuervo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceb.2016.01.008_bib0230","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.tcb.2015.03.001","article-title":"Eaten alive: novel insights into autophagy from multicellular model systems","volume":"25","author":"Zhang","year":"2015","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.ceb.2016.01.008_bib0235","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1038\/sj.cdd.4401728","article-title":"The pleiotropic role of autophagy: from protein metabolism to bactericide","volume":"12","author":"Mizushima","year":"2005","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.ceb.2016.01.008_bib0240","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1056\/NEJMra1205406","article-title":"Autophagy in human health and disease","volume":"368","author":"Choi","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ceb.2016.01.008_bib0245","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.tibs.2013.12.001","article-title":"At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy","volume":"39","author":"Shen","year":"2014","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.ceb.2016.01.008_bib0250","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nrm4024","article-title":"Autophagy at the crossroads of catabolism and anabolism","volume":"16","author":"Kaur","year":"2015","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ceb.2016.01.008_bib0255","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nature14190","article-title":"Nutrient-sensing mechanisms and pathways","volume":"517","author":"Efeyan","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2016.01.008_bib0260","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0465","article-title":"How do cilia organize signalling cascades?","volume":"369","author":"Nachury","year":"2014","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.ceb.2016.01.008_bib0265","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1600-0854.2006.00516.x","article-title":"Sensory cilia and integration of signal transduction in human health and disease","volume":"8","author":"Christensen","year":"2007","journal-title":"Traffic"},{"key":"10.1016\/j.ceb.2016.01.008_bib0270","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrg2774","article-title":"The primary cilium: a signalling centre during vertebrate development","volume":"5","author":"Goetz","year":"2010","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.ceb.2016.01.008_bib0275","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nrm3598","article-title":"The mechanisms of Hedgehog signalling and its roles in development and disease","volume":"14","author":"Briscoe","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ceb.2016.01.008_bib0280","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0070-2153(08)00807-7","article-title":"Ciliary function and Wnt signal modulation","volume":"85","author":"Gerdes","year":"2008","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.ceb.2016.01.008_bib0285","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0070-2153(08)00812-0","article-title":"Olfactory cilia: our direct neuronal connection to the external world","volume":"85","author":"McEwen","year":"2008","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.ceb.2016.01.008_bib0290","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nature12832","article-title":"Direct recording and molecular identification of the calcium channel of primary cilia","volume":"504","author":"DeCaen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2016.01.008_bib0295","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature12833","article-title":"Primary cilia are specialized calcium signalling organelles","volume":"504","author":"Delling","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2016.01.008_sbref0300","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature12639","article-title":"Functional interaction between autophagy and ciliogenesis","volume":"502","author":"Pampliega","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2016.01.008_sbref0305","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/nature12606","article-title":"Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites","volume":"502","author":"Tang","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2016.01.008_sbref0310","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature02061","article-title":"Hedgehog signalling in the mouse requires intraflagellar transport proteins","volume":"426","author":"Huangfu","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2016.01.008_bib0315","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/cm.20346","article-title":"Characterization of mouse IFT complex B","volume":"66","author":"Follit","year":"2009","journal-title":"Cell Motil Cytoskeleton"},{"key":"10.1016\/j.ceb.2016.01.008_bib0320","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/cr.2013.168","article-title":"The machinery of macroautophagy","volume":"24","author":"Feng","year":"2014","journal-title":"Cell Res"},{"key":"10.1016\/j.ceb.2016.01.008_bib0325","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ceb.2013.03.004","article-title":"Up-to-date membrane biogenesis in the autophagosome formation","volume":"25","author":"Hamasaki","year":"2013","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.ceb.2016.01.008_bib0330","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ceb.2012.10.011","article-title":"The ciliary pocket","volume":"25","author":"Benmerah","year":"2013","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.ceb.2016.01.008_bib0335","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/ncb2078","article-title":"Plasma membrane contributes to the formation of pre-autophagosomal structures","volume":"12","author":"Ravikumar","year":"2010","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2016.01.008_bib0340","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.cell.2013.08.044","article-title":"Diverse autophagosome membrane sources coalesce in recycling endosomes","volume":"154","author":"Puri","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.ceb.2016.01.008_bib0345","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.molcel.2015.07.021","article-title":"Organelle-specific initiation of autophagy","volume":"59","author":"Sica","year":"2015","journal-title":"Mol Cell"},{"key":"10.1016\/j.ceb.2016.01.008_bib0350","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/15548627.2015.1023983","article-title":"Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways","volume":"11","author":"Wang","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.ceb.2016.01.008_bib0355","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/ncomms2212","article-title":"The Hedgehog signalling pathway regulates autophagy","volume":"3","author":"Jimenez-Sanchez","year":"2012","journal-title":"Nat Commun"},{"key":"10.1016\/j.ceb.2016.01.008_bib0360","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.devcel.2009.12.022","article-title":"Ofd1, a human disease gene, regulates the length and distal structure of centrioles","volume":"18","author":"Singla","year":"2010","journal-title":"Dev Cell"},{"key":"10.1016\/j.ceb.2016.01.008_bib0365","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/ng1684","article-title":"Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification","volume":"38","author":"Ferrante","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.ceb.2016.01.008_sbref0370","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.molcel.2015.05.010","article-title":"Skp2-mediated RagA ubiquitination elicits a negative feedback to prevent amino-acid-dependent mTORC1 hyperactivation by recruiting GATOR1","volume":"58","author":"Jin","year":"2015","journal-title":"Mol Cell"},{"key":"10.1016\/j.ceb.2016.01.008_sbref0375","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2010.02.024","article-title":"Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids","volume":"141","author":"Sancak","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ceb.2016.01.008_bib0380","doi-asserted-by":"crossref","first-page":"e0118190","DOI":"10.1371\/journal.pone.0118190","article-title":"Inhibition of autophagy suppresses sertraline-mediated primary ciliogenesis in retinal pigment epithelium cells","volume":"10","author":"Kim","year":"2015","journal-title":"PLOS ONE"},{"key":"10.1016\/j.ceb.2016.01.008_bib0385","doi-asserted-by":"crossref","first-page":"327","DOI":"10.4062\/biomolther.2015.025","article-title":"Autophagy regulates formation of primary cilia in mefloquine-treated cells","volume":"23","author":"Shin","year":"2015","journal-title":"Biomol Ther (Seoul)"},{"key":"10.1016\/j.ceb.2016.01.008_sbref0390","doi-asserted-by":"crossref","DOI":"10.1172\/JCI69636","article-title":"Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction","volume":"123","author":"Lam","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ceb.2016.01.008_bib0395","doi-asserted-by":"crossref","first-page":"532","DOI":"10.4161\/auto.27641","article-title":"\u201cCiliophagy\u201d: the consumption of cilia components by autophagy","volume":"10","author":"Cloonan","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.ceb.2016.01.008_bib0400","doi-asserted-by":"crossref","first-page":"6404","DOI":"10.1074\/jbc.M113.501205","article-title":"Polycystin-1 negatively regulates polycystin-2 expression via the aggresome\/autophagosome pathway","volume":"289","author":"Cebotaru","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2016.01.008_bib0405","doi-asserted-by":"crossref","first-page":"F1235","DOI":"10.1152\/ajprenal.00348.2010","article-title":"Hypoxia-inducible factor-1alpha (HIF-1alpha) and autophagy in polycystic kidney disease (PKD)","volume":"300","author":"Belibi","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ceb.2016.01.008_bib0410","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.semnephrol.2013.11.005","article-title":"Polycystic kidney disease: a case of suppressed autophagy?","volume":"34","author":"Ravichandran","year":"2014","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.ceb.2016.01.008_bib0415","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1073\/pnas.0509694103","article-title":"The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease","volume":"103","author":"Shillingford","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2016.01.008_sbref0420","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/ncb2117","article-title":"Primary cilia regulate mTORC1 activity and cell size through Lkb1","volume":"12","author":"Boehlke","year":"2010","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2016.01.008_bib0425","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1073\/pnas.1112834109","article-title":"Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation","volume":"109","author":"Yuan","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2016.01.008_bib0430","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/cdd.2015.80","article-title":"Primary cilia and autophagic dysfunction in Huntington's disease","volume":"22","author":"Kaliszewski","year":"2015","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.ceb.2016.01.008_bib0435","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.tins.2014.09.003","article-title":"Autophagy in Huntington disease and huntingtin in autophagy","volume":"38","author":"Martin","year":"2015","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.ceb.2016.01.008_sbref0440","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nn.2528","article-title":"Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease","volume":"13","author":"Martinez-Vicente","year":"2010","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.ceb.2016.01.008_sbref0445","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/ncb3101","article-title":"Huntingtin functions as a scaffold for selective macroautophagy","volume":"17","author":"Rui","year":"2015","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2016.01.008_sbref0450","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1172\/JCI57552","article-title":"Ciliogenesis is regulated by a huntingtin-hap1-pcm1 pathway and is altered in Huntington disease","volume":"121","author":"Keryer","year":"2011","journal-title":"J Clin Invest"}],"container-title":["Current Opinion in Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955067416000090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955067416000090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:24:18Z","timestamp":1760621058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955067416000090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":45,"alternative-id":["S0955067416000090"],"URL":"https:\/\/doi.org\/10.1016\/j.ceb.2016.01.008","relation":{},"ISSN":["0955-0674"],"issn-type":[{"value":"0955-0674","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autophagy and primary cilia: dual interplay","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceb.2016.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}