{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:29:46Z","timestamp":1792042186710,"version":"4.4.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Cell Biology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.ceb.2020.01.015","type":"journal-article","created":{"date-parts":[[2020,2,22]],"date-time":"2020-02-22T05:37:44Z","timestamp":1582349864000},"page":"154-161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"special_numbering":"C","title":["Dissecting the signaling pathways involved in the function of sperm flagellum"],"prefix":"10.1016","volume":"63","author":[{"given":"Lenka","family":"Vyklicka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3140-2769","authenticated-orcid":false,"given":"Polina V.","family":"Lishko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceb.2020.01.015_bib1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1071\/BI9510581","article-title":"Observations on the penetration of the sperm in the mammalian egg","volume":"4","author":"Austin","year":"1951","journal-title":"Aust J Sci Res B"},{"key":"10.1016\/j.ceb.2020.01.015_bib2","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/168697b0","article-title":"Fertilizing capacity of spermatozoa deposited into the fallopian tubes","volume":"168","author":"Chang","year":"1951","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2020.01.015_bib3","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1242\/dev.121.4.1139","article-title":"Capacitation of mouse spermatozoa. II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway","volume":"121","author":"Visconti","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.ceb.2020.01.015_bib4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.anireprosci.2007.07.007","article-title":"Involvement of cholesterol, calcium and progesterone in the induction of capacitation and acrosome reaction of mammalian spermatozoa","volume":"102","author":"Witte","year":"2007","journal-title":"Anim Reprod Sci"},{"key":"10.1016\/j.ceb.2020.01.015_bib5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2307\/1538583","article-title":"Studies on the acrosome. III. Effect of calcium deficiency","volume":"107","author":"Dan","year":"1954","journal-title":"Biol Bull"},{"key":"10.1016\/j.ceb.2020.01.015_bib6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1085\/jgp.201611696","article-title":"Progress in ciliary ion channel physiology","volume":"149","author":"Pablo","year":"2016","journal-title":"J\u00a0Gen Physiol"},{"key":"10.1016\/j.ceb.2020.01.015_bib7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev-physiol-020911-153258","article-title":"The control of male fertility by spermatozoan ion channels","volume":"74","author":"Lishko","year":"2012","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.ceb.2020.01.015_bib8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.tcb.2016.10.002","article-title":"Signaling in sperm: more different than similar","volume":"27","author":"Kaupp","year":"2017","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.ceb.2020.01.015_bib9","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0015-0282(16)34633-7","article-title":"The pH and bicarbonate-ion content of the oviduct and uterine fluids","volume":"13","author":"Vishwakarma","year":"1962","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ceb.2020.01.015_bib10","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1073\/pnas.1322778111","article-title":"Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate","volume":"111","author":"Kleinboelting","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2020.01.015_bib11","first-page":"2325","article-title":"The tyrosine kinase FER is responsible for the capacitation associated increase in tyrosine phosphorylation in murine sperm","volume":"143","author":"Alvau","year":"2016","journal-title":"Dev"},{"key":"10.1016\/j.ceb.2020.01.015_bib12","doi-asserted-by":"crossref","first-page":"29202","DOI":"10.1074\/jbc.M115.698597","article-title":"Normal fertility requires the expression of carbonic anhydrases II and IV in sperm","volume":"290","author":"Wandernoth","year":"2015","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ceb.2020.01.015_bib13","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1007\/s00018-019-03170-w","article-title":"pH and male fertility: making sense on pH homeodynamics throughout the male reproductive tract","volume":"76","author":"Bernardino","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.ceb.2020.01.015_bib14","doi-asserted-by":"crossref","first-page":"14208","DOI":"10.1038\/s41598-017-14606-3","article-title":"A\u00a0missense mutation in SLC26A3 is associated with human male subfertility and impaired activation of CFTR","volume":"7","author":"Wedenoja","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ceb.2020.01.015_sref15","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/mrd.23055","article-title":"Slc26a3 deficiency is associated with epididymis dysplasia and impaired sperm fertilization potential in the mouse","volume":"85","author":"Khouri","year":"2018","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.ceb.2020.01.015_bib16","doi-asserted-by":"crossref","first-page":"36468","DOI":"10.1038\/srep36468","article-title":"A\u00a0critical role of solute carrier 22a14 in sperm motility and male fertility in mice","volume":"6","author":"Maruyama","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.ceb.2020.01.015_bib17","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1074\/jbc.M206284200","article-title":"Involvement of a Na+\/HCO3- cotransporter in mouse sperm capacitation","volume":"278","author":"Demarco","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ceb.2020.01.015_bib18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.devcel.2005.06.007","article-title":"The \u201csoluble\u201d adenylyl cyclase in sperm mediates multiple signaling events required for fertilization","volume":"9","author":"Hess","year":"2005","journal-title":"Dev Cell"},{"key":"10.1016\/j.ceb.2020.01.015_bib19","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1073\/pnas.0400050101","article-title":"Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect","volume":"101","author":"Esposito","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2020.01.015_bib20","doi-asserted-by":"crossref","first-page":"13483","DOI":"10.1073\/pnas.0405580101","article-title":"Sperm-specific protein kinase A catalytic subunit C\u03b12 orchestrates cAMP signaling for male fertility","volume":"101","author":"Nolan","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2020.01.015_bib21","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/mrd.1080250213","article-title":"Bovine oviductal fluid components and their potential role in sperm cholesterol efflux","volume":"25","author":"Ehrenwald","year":"1990","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.ceb.2020.01.015_bib22","doi-asserted-by":"crossref","first-page":"561","DOI":"10.4103\/1008-682X.153309","article-title":"New insights into the regulation of cholesterol efflux from the sperm membrane","volume":"17","author":"Leahy","year":"2015","journal-title":"Asian J Androl"},{"key":"10.1016\/j.ceb.2020.01.015_bib23","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/molehr\/5.11.1017","article-title":"Regulation of human sperm capacitation by a cholesterol efflux- stimulated signal transduction pathway leading to protein kinase A-mediated up-regulation of protein tyrosine phosphorylation","volume":"5","author":"Osheroff","year":"1999","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.ceb.2020.01.015_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.65","article-title":"Sodium\u2013hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility","volume":"7","author":"Chen","year":"2016","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ceb.2020.01.015_bib25","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/ncb1072","article-title":"A\u00a0new sperm-specific Na+\/H+ exchanger required for sperm motility and fertility","volume":"5","author":"Wang","year":"2003","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2020.01.015_bib26","doi-asserted-by":"crossref","first-page":"9325","DOI":"10.1073\/pnas.0611296104","article-title":"A\u00a0sperm-specific Na+\/H+ exchanger (sNHE) is critical for expression and in\u00a0vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC)","volume":"104","author":"Wang","year":"2007","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.ceb.2020.01.015_sref27","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1038\/s41467-018-05253-x","article-title":"The solute carrier SLC9C1 is a Na+\/H+-exchanger gated by an S4-type voltage-sensor and cyclic-nucleotide binding","volume":"9","author":"Windler","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.ceb.2020.01.015_bib28","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1126\/science.1122352","article-title":"A\u00a0voltage sensor-domain protein is a voltage-gated proton channel","volume":"312","author":"Sasaki","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.ceb.2020.01.015_bib29","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nature04700","article-title":"A\u00a0voltage-gated proton-selective channel lacking the pore domain","volume":"440","author":"Ramsey","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2020.01.015_bib30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cell.2009.12.053","article-title":"Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel","volume":"140","author":"Lishko","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ceb.2020.01.015_sref31","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1016\/j.celrep.2018.08.016","article-title":"Asymmetrically positioned flagellar control units regulate human sperm rotation","volume":"24","author":"Miller","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.ceb.2020.01.015_bib32","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35098027","article-title":"A\u00a0sperm ion channel required for sperm motility and male fertility","volume":"413","author":"Ren","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2020.01.015_bib33","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1007\/s00018-008-8056-8","article-title":"Voltage-gated proton channels","volume":"65","author":"DeCoursey","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.ceb.2020.01.015_bib34","doi-asserted-by":"crossref","first-page":"e4579","DOI":"10.1371\/journal.pone.0004579","article-title":"Localisation and function of the endocannabinoid system in the human ovary","volume":"4","author":"El-Talatini","year":"2009","journal-title":"PloS One"},{"key":"10.1016\/j.ceb.2020.01.015_bib35","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1113\/JP273189","article-title":"Post-translational cleavage of Hv1 in human sperm tunes pH- and voltage-dependent gating","volume":"595","author":"Berger","year":"2017","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.ceb.2020.01.015_bib36","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nature04417","article-title":"Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel","volume":"439","author":"Kirichok","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2020.01.015_bib37","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature09767","article-title":"Progesterone activates the principal Ca2+ channel of human sperm","volume":"471","author":"Lishko","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2020.01.015_bib38","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nature09769","article-title":"The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm","volume":"471","author":"Str\u00fcnker","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2020.01.015_bib39","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1126\/science.aad6887","article-title":"Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone","volume":"352","author":"Miller","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.ceb.2020.01.015_bib40","doi-asserted-by":"crossref","first-page":"20497","DOI":"10.1073\/pnas.1217018109","article-title":"Calaxin drives sperm chemotaxis by Ca2+-mediated direct modulation of a dynein motor","volume":"109","author":"Mizuno","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2020.01.015_bib41","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/s42003-019-0462-y","article-title":"Calaxin is required for cilia-driven determination of vertebrate laterality","volume":"2","author":"Sasaki","year":"2019","journal-title":"Commun Biol"},{"key":"10.1016\/j.ceb.2020.01.015_sref42","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.cell.2019.03.047","article-title":"Dual sensing of physiologic pH and calcium by EFCAB9 regulates sperm motility","volume":"177","author":"Hwang","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.ceb.2020.01.015_sref43","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.23082","article-title":"CatSper\u03b6 regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility","volume":"6","author":"Chung","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.ceb.2020.01.015_bib44","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.cell.2014.02.056","article-title":"Structurally distinct Ca2+ signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility","volume":"157","author":"Chung","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ceb.2020.01.015_bib45","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.repbio.2018.01.005","article-title":"Intramembranal disulfide cross-linking elucidates the super-quaternary structure of mammalian CatSpers","volume":"18","author":"Bystroff","year":"2018","journal-title":"Reprod Biol"},{"key":"10.1016\/j.ceb.2020.01.015_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7827-7-11","article-title":"Reduced levels of intracellular calcium releasing in spermatozoa from asthenozoospermic patients","volume":"7","author":"Espino","year":"2009","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.ceb.2020.01.015_bib47","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0015-0282(16)43348-0","article-title":"Sperm motility within the mammalian epididymis: species variation and correlation with free calcium levels in epididymal plasma","volume":"29","author":"Morton","year":"1978","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ceb.2020.01.015_bib48","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1085\/jgp.200308839","article-title":"Calcium clearance mechanisms of mouse sperm","volume":"122","author":"Wennemuth","year":"2003","journal-title":"J\u00a0Gen Physiol"},{"key":"10.1016\/j.ceb.2020.01.015_bib49","doi-asserted-by":"crossref","first-page":"28220","DOI":"10.1074\/jbc.M312599200","article-title":"Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility","volume":"279","author":"Schuh","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ceb.2020.01.015_bib50","doi-asserted-by":"crossref","first-page":"10676","DOI":"10.1073\/pnas.1831008100","article-title":"Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa","volume":"100","author":"Jaiswal","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2020.01.015_bib51","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1126\/science.aad0836","article-title":"Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive","volume":"350","author":"Miyata","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.ceb.2020.01.015_bib52","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/humrep\/dev057","article-title":"Twenty-four-hour monitoring of scrotal temperature in obese men and men with a varicocele as a mirror of spermatogenic function","volume":"30","author":"Garolla","year":"2015","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ceb.2020.01.015_sref53","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.35853","article-title":"TRPV4 is the temperature-sensitive ion channel of human sperm","volume":"7","author":"Mundt","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.ceb.2020.01.015_bib54","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1038\/emboj.2012.30","article-title":"The CatSper channel: a polymodal chemosensor in human sperm","volume":"31","author":"Brenker","year":"2012","journal-title":"EMBO J"},{"key":"10.1016\/j.ceb.2020.01.015_bib55","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1073\/pnas.1016902108","article-title":"K-ATPase \u03b14 isoform is essential for sperm fertility","volume":"108","author":"Jimenez","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2020.01.015_bib56","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/molehr\/gal062","article-title":"The Na,K-ATPase \u03b14 isoform from humans has distinct enzymatic properties and is important for sperm motility","volume":"12","author":"Sanchez","year":"2006","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.ceb.2020.01.015_sref57","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1021\/acs.jmedchem.7b00925","article-title":"Design, synthesis, and in\u00a0vitro and in\u00a0vivo evaluation of ouabain analogues as potent and selective Na,K-ATPase \u03b14 isoform inhibitors for male contraception","volume":"61","author":"Syeda","year":"2018","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.ceb.2020.01.015_bib58","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1074\/jbc.273.6.3509","article-title":"Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes","volume":"273","author":"Schreiber","year":"1998","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ceb.2020.01.015_bib59","doi-asserted-by":"crossref","first-page":"7688","DOI":"10.1073\/pnas.0702018104","article-title":"A\u00a0pH-sensitive K current that controls sperm membrane potential","volume":"104","author":"Navarro","year":"2007","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.ceb.2020.01.015_bib60","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.febslet.2010.02.005","article-title":"The Slo3 sperm-specific potassium channel plays a vital role in male fertility","volume":"584","author":"Santi","year":"2010","journal-title":"FEBS Lett"},{"key":"10.1016\/j.ceb.2020.01.015_bib61","doi-asserted-by":"crossref","first-page":"5879","DOI":"10.1073\/pnas.1100240108","article-title":"Deletion of the Slo3 gene abolishes alkalizationactivated K+ current in mouse spermatozoa","volume":"108","author":"Zeng","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2020.01.015_bib62","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1073\/pnas.1216588110","article-title":"Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient","volume":"110","author":"Smith","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2020.01.015_bib63","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.01009","article-title":"Slo1 is the principal potassium channel of human spermatozoa","volume":"2","author":"Mannowetz","year":"2013","journal-title":"Elife"},{"key":"10.1016\/j.ceb.2020.01.015_bib64","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.01438","article-title":"The Ca2+-activated K+ current of human sperm is mediated by Slo3","volume":"3","author":"Brenker","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.ceb.2020.01.015_bib65","doi-asserted-by":"crossref","first-page":"19274","DOI":"10.1073\/pnas.1215078109","article-title":"Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel","volume":"109","author":"Leonetti","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceb.2020.01.015_bib66","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1093\/humrep\/dew056","article-title":"Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF","volume":"31","author":"Brown","year":"2016","journal-title":"Hum Reprod"}],"container-title":["Current Opinion in Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955067420300223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955067420300223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:33:26Z","timestamp":1760621606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955067420300223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":66,"alternative-id":["S0955067420300223"],"URL":"https:\/\/doi.org\/10.1016\/j.ceb.2020.01.015","relation":{},"ISSN":["0955-0674"],"issn-type":[{"value":"0955-0674","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dissecting the signaling pathways involved in the function of sperm flagellum","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceb.2020.01.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}