{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:05:37Z","timestamp":1793333137336,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM151682"],"award-info":[{"award-number":["R01GM151682"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Cell Biology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ceb.2026.102623","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T04:08:47Z","timestamp":1772078927000},"page":"102623","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Chemical biology approaches for revealing interorganelle lipid transport pathways"],"prefix":"10.1016","volume":"99","author":[{"given":"Yuan-Ting","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2939-3138","authenticated-orcid":false,"given":"Jeremy M.","family":"Baskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceb.2026.102623_bib1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41580-025-00864-x","article-title":"Key challenges and recommendations for defining organelle membrane contact sites","volume":"26","author":"Cal\u00ec","year":"2025","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ceb.2026.102623_bib2","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1038\/s44318-024-00063-y","article-title":"MemPrep, a new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress","volume":"43","author":"Reinhard","year":"2024","journal-title":"EMBO J"},{"key":"10.1016\/j.ceb.2026.102623_bib3","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202310095","article-title":"Recombinant biosensors for multiplex and super-resolution imaging of phosphoinositides","volume":"223","author":"Maib","year":"2024","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ceb.2026.102623_bib4","doi-asserted-by":"crossref","first-page":"tp2","DOI":"10.1091\/mbc.E21-07-0363","article-title":"An update on genetically encoded lipid biosensors","volume":"33","author":"Hammond","year":"2022","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ceb.2026.102623_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.110441","article-title":"Lipid asymmetry and membrane trafficking: transbilayer distribution of structural phospholipids as regulators of exocytosis and endocytosis","volume":"301","author":"Caputo","year":"2025","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceb.2026.102623_bib6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.tibs.2024.01.007","article-title":"Exploring membrane asymmetry and its effects on membrane proteins","volume":"49","author":"Pabst","year":"2024","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.ceb.2026.102623_bib7","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s43586-021-00028-z","article-title":"Bioorthogonal chemistry","volume":"1","author":"Scinto","year":"2021","journal-title":"Nat Rev Methods Primers"},{"key":"10.1016\/j.ceb.2026.102623_bib8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1021\/acschembio.2c00813","article-title":"Cellular labeling of phosphatidylserine using clickable serine probes","volume":"18","author":"Ancajas","year":"2023","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.ceb.2026.102623_bib9","doi-asserted-by":"crossref","first-page":"15332","DOI":"10.1073\/pnas.0907864106","article-title":"Metabolic labeling and direct imaging of choline phospholipids in vivo","volume":"106","author":"Jao","year":"2009","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.ceb.2026.102623_bib10","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1021\/acscentsci.7b00222","article-title":"Clickable substrate mimics enable imaging of phospholipase D activity","volume":"3","author":"Bumpus","year":"2017","journal-title":"ACS Cent Sci"},{"key":"10.1016\/j.ceb.2026.102623_bib11","article-title":"Super-resolution microscopy: methods and protocols","volume":"vol. 1663","year":"2017"},{"key":"10.1016\/j.ceb.2026.102623_bib12","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1126\/science.1260088","article-title":"Expansion microscopy","volume":"347","author":"Chen","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.ceb.2026.102623_bib13","doi-asserted-by":"crossref","first-page":"18212","DOI":"10.1021\/jacs.2c03743","article-title":"Lipid expansion microscopy","volume":"144","author":"White","year":"2022","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.ceb.2026.102623_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.1051","article-title":"Super-resolution imaging of clickable lipids with lipid expansion microscopy (LExM)","volume":"4","author":"White-Mathieu","year":"2024","journal-title":"Curr Protoc"},{"key":"10.1016\/j.ceb.2026.102623_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.gde.2020.05.027","article-title":"Role of VPS13, a protein with similarity to ATG2, in physiology and disease","volume":"65","author":"Ugur","year":"2020","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.ceb.2026.102623_bib16","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1080\/10409230903193307","article-title":"The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease","volume":"44","author":"Fadeel","year":"2009","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.ceb.2026.102623_bib17","article-title":"Sphingolipid imbalance aggravates Tau pathology by endomembrane rigidification and rupture","volume":"14","author":"Tittelmeier","year":"2025","journal-title":"eLife"},{"key":"10.1016\/j.ceb.2026.102623_bib18","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1021\/acs.chemrev.4c00761","article-title":"Synthetic lipid biology","volume":"125","author":"Chen","year":"2025","journal-title":"Chem Rev"},{"key":"10.1016\/j.ceb.2026.102623_bib19","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1021\/acs.accounts.2c00510","article-title":"Imaging and editing the phospholipidome","volume":"55","author":"Chiu","year":"2022","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.ceb.2026.102623_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/acs.accounts.2c00586","article-title":"Fluorescent probes for lipid membranes: from the cell surface to organelles","volume":"56","author":"Klymchenko","year":"2023","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.ceb.2026.102623_sref21","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41586-025-09432-x","article-title":"Quantitative imaging of lipid transport in mammalian cells","volume":"646","author":"Iglesias-Artola","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2026.102623_bib22","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/j.cell.2015.05.045","article-title":"A global map of lipid-binding proteins and their ligandability in cells","volume":"161","author":"Niphakis","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.ceb.2026.102623_bib23","doi-asserted-by":"crossref","first-page":"33386","DOI":"10.1021\/jacs.5c03851","article-title":"Photoaffinity labeling reveals a role for the unusual triply acylated phospholipid N-Acylphosphatidylethanolamine in lactate homeostasis","volume":"147","author":"Chiu","year":"2025","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.ceb.2026.102623_bib24","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1073\/pnas.1611096114","article-title":"Trifunctional lipid probes for comprehensive studies of single lipid species in living cells","volume":"114","author":"H\u00f6glinger","year":"2017","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.ceb.2026.102623_bib25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41580-018-0071-5","article-title":"Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes","volume":"20","author":"Wong","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ceb.2026.102623_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202513360","article-title":"Bifunctional probes reveal the rules of intracellular ether lipid transport","volume":"64","author":"B\u00f6hlig","year":"2025","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.ceb.2026.102623_bib27","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2213886120","article-title":"Lysosome-targeted multifunctional lipid probes reveal the sterol transporter NPC1 as a sphingosine interactor","volume":"120","author":"Altuzar","year":"2023","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.ceb.2026.102623_bib28","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/cbic.201402149","article-title":"Biosynthetic labeling and two-color imaging of phospholipids in cells","volume":"16","author":"Jao","year":"2015","journal-title":"Chembiochem"},{"key":"10.1016\/j.ceb.2026.102623_bib29","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/j.chempr.2023.05.016","article-title":"Bioorthogonal chemistry: bridging chemistry, biology, and medicine","volume":"9","author":"Hartung","year":"2023","journal-title":"Chem"},{"key":"10.1016\/j.ceb.2026.102623_sref30","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/s41589-020-00651-z","article-title":"Organelle membrane-specific chemical labeling and dynamic imaging in living cells","volume":"16","author":"Tamura","year":"2020","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.ceb.2026.102623_sref31","doi-asserted-by":"crossref","first-page":"22284","DOI":"10.1021\/jacs.5c02871","article-title":"Subcellular analysis of fatty acid metabolism using organelle-selective click chemistry","volume":"147","author":"Kimura","year":"2025","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.ceb.2026.102623_sref32","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1021\/jacsau.2c00419","article-title":"Organelle-selective membrane labeling through phospholipase D-Mediated transphosphatidylation","volume":"2","author":"Chiu","year":"2022","journal-title":"JACS Au"},{"key":"10.1016\/j.ceb.2026.102623_bib33","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.tips.2004.05.005","article-title":"Polyspecific organic cation transporters: their functions and interactions with drugs","volume":"25","author":"Koepsell","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.ceb.2026.102623_bib34","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.chembiol.2024.03.012","article-title":"Current advances in photocatalytic proximity labeling","volume":"31","author":"Knutson","year":"2024","journal-title":"Cell Chem Biol"},{"key":"10.1016\/j.ceb.2026.102623_bib35","doi-asserted-by":"crossref","DOI":"10.1126\/science.adl5763","article-title":"Multiscale photocatalytic proximity labeling reveals cell surface neighbors on and between cells","volume":"385","author":"Lin","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.ceb.2026.102623_bib36","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1126\/science.aay4106","article-title":"Microenvironment mapping via dexter energy transfer on immune cells","volume":"367","author":"Geri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ceb.2026.102623_bib37","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1021\/jacsau.1c00172","article-title":"Selective mitochondrial protein labeling enabled by biocompatible photocatalytic reactions inside live cells","volume":"1","author":"Wang","year":"2021","journal-title":"JACS Au"},{"key":"10.1016\/j.ceb.2026.102623_sref38","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/s41557-025-01886-w","article-title":"Quantitative profiling of lipid transport between organelles enabled by subcellular photocatalytic labelling","volume":"17","author":"Chen","year":"2025","journal-title":"Nat Chem"},{"key":"10.1016\/j.ceb.2026.102623_sref39","article-title":"Leaflet specific phospholipid imaging using genetically encoded proximity sensors","author":"Moore","year":"2025","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.ceb.2026.102623_bib40","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/s41586-024-07374-4","article-title":"Structural basis of lipid head group entry to the kennedy pathway by FLVCR1","volume":"629","author":"Son","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.ceb.2026.102623_bib41","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202012058","article-title":"Mechanisms of nonvesicular lipid transport","volume":"220","author":"Reinisch","year":"2021","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ceb.2026.102623_sref42","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/s41556-022-00917-9","article-title":"METALIC reveals interorganelle lipid flux in live cells by enzymatic mass tagging","volume":"24","author":"John Peter","year":"2022","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ceb.2026.102623_sref43","doi-asserted-by":"crossref","DOI":"10.1038\/s41589-025-02104-x","article-title":"Membrane editing with proximity labeling reveals regulators of lipid homeostasis","author":"Tei","year":"2026","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.ceb.2026.102623_bib44","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/s41557-023-01214-0","article-title":"Activity-based directed evolution of a membrane editor in mammalian cells","volume":"15","author":"Tei","year":"2023","journal-title":"Nat Chem"},{"key":"10.1016\/j.ceb.2026.102623_bib45","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00018-002-8416-8","article-title":"Sterol carrier Protein-2: structure reveals function","volume":"59","author":"Stolowich","year":"2002","journal-title":"Cell Mol Life Sci CMLS"},{"key":"10.1016\/j.ceb.2026.102623_bib46","doi-asserted-by":"crossref","first-page":"7729","DOI":"10.1073\/pnas.1912684117","article-title":"Live-cell lipid biochemistry reveals a role of diacylglycerol side-chain composition for cellular lipid dynamics and protein affinities","volume":"117","author":"Schuhmacher","year":"2020","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.ceb.2026.102623_bib47","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1021\/acscentsci.3c01105","article-title":"Ultralow background membrane editors for spatiotemporal control of phosphatidic acid metabolism and signaling","volume":"10","author":"Li","year":"2024","journal-title":"ACS Cent Sci"},{"key":"10.1016\/j.ceb.2026.102623_bib48","doi-asserted-by":"crossref","first-page":"15453","DOI":"10.1073\/pnas.1903949116","article-title":"Real-time, click chemistry imaging approach reveals stimulus-specific subcellular locations of phospholipase D activity","volume":"116","author":"Liang","year":"2019","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.ceb.2026.102623_bib49","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1021\/acschembio.4c00345","article-title":"Imaging interorganelle phospholipid transport by extended synaptotagmins using bioorthogonally tagged lipids","volume":"19","author":"Luan","year":"2024","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.ceb.2026.102623_bib50","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.bbamcr.2017.03.013","article-title":"The extended-synaptotagmins","volume":"1864","author":"Saheki","year":"2017","journal-title":"Biochim Biophys Acta BBA - Mol Cell Res"}],"container-title":["Current Opinion in Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955067426000116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955067426000116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:22:26Z","timestamp":1773148946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955067426000116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":50,"alternative-id":["S0955067426000116"],"URL":"https:\/\/doi.org\/10.1016\/j.ceb.2026.102623","relation":{},"ISSN":["0955-0674"],"issn-type":[{"value":"0955-0674","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemical biology approaches for revealing interorganelle lipid transport pathways","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceb.2026.102623","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102623"}}