{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:14:13Z","timestamp":1791029653595,"version":"4.1.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1016\/j.ceca.2004.08.001","type":"journal-article","created":{"date-parts":[[2004,10,5]],"date-time":"2004-10-05T11:09:06Z","timestamp":1096974546000},"page":"121-127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Intracellular Ca2+ dynamics in malignant hyperthermia and central core disease: established concepts, new cellular mechanisms involved"],"prefix":"10.1016","volume":"37","author":[{"given":"Guillermo","family":"Avila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceca.2004.08.001_bib1","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1086\/515454","article-title":"Malignant-hyperthermia susceptibility is associated with a mutation of the alpha 1-subunit of the human dihydropyridine-sensitive L-type voltage-dependent calcium-channel receptor in skeletal muscle","volume":"60","author":"Monnier","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ceca.2004.08.001_bib2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/(SICI)1096-8628(19980226)76:1<21::AID-AJMG3>3.0.CO;2-S","article-title":"Linkage of malignant hyperthermia and hyperkalemic periodic paralysis to the adult skeletal muscle sodium channel (SCN4A) gene in a large pedigree","volume":"76","author":"Moslehi","year":"1998","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ceca.2004.08.001_bib3","series-title":"Molecular Biology of Membrane Transport Disorders","first-page":"181","article-title":"The genetic and physiological basis of malignant hyperthermia","author":"MacLennan","year":"1996"},{"key":"10.1016\/j.ceca.2004.08.001_bib4","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1152\/physrev.1996.76.2.537","article-title":"Malignant hyperthermia: excitation\u2013contraction coupling, Ca2+ release channel, and cell Ca2+ regulation defects","volume":"76","author":"Mickelson","year":"1996","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ceca.2004.08.001_bib5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/(SICI)1097-4598(200001)23:1<4::AID-MUS3>3.0.CO;2-D","article-title":"Genetics and pathogenesis of malignant hyperthermia","volume":"23","author":"Jurkat-Rott","year":"2000","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.ceca.2004.08.001_bib6","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/(SICI)1098-1004(200005)15:5<410::AID-HUMU2>3.0.CO;2-D","article-title":"Ryanodine receptor mutations in malignant hyperthermia and central core disease","volume":"15","author":"McCarthy","year":"2000","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ceca.2004.08.001_bib7","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/00003643-200110000-00002","article-title":"Malignant hyperthermia","volume":"18","author":"Wappler","year":"2001","journal-title":"Eur. J. Anaesthesiol."},{"key":"10.1016\/j.ceca.2004.08.001_bib8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1023\/A:1013644107519","article-title":"Malignant hyperthermia: an inherited disorder of skeletal muscle Ca2+ regulation","volume":"21","author":"Louis","year":"2001","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.ceca.2004.08.001_bib9","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1046\/j.1365-201x.2001.00840.x","article-title":"Malignant hyperthermia and excitation\u2013contraction coupling","volume":"171","author":"Melzer","year":"2001","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.ceca.2004.08.001_bib10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S1050-1738(02)00163-9","article-title":"Altered ryanodine receptor function in central core disease: leaky or uncoupled Ca(2+) release channels?","volume":"12","author":"Dirksen","year":"2002","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.ceca.2004.08.001_bib11","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/00019052-200210000-00006","article-title":"Congenital myopathies and related disorders","volume":"15","author":"Taratuto","year":"2002","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.ceca.2004.08.001_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1090-3798(02)00136-8","article-title":"What's new in neuromuscular disorders? The congenital myopathies","volume":"7","author":"Jungbluth","year":"2003","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"10.1016\/j.ceca.2004.08.001_bib13","unstructured":"J.D. Lueck, S.A. Goonasekera, R.T. Dirksen, Ryanodinopathies: muscle disorders linked to mutations in ryanodine receptors, Basic Appl. Myol., in press."},{"key":"10.1016\/j.ceca.2004.08.001_bib14","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/jmg.37.10.729","article-title":"Channelopathies: ion channel defects linked to heritable clinical disorders","volume":"37","author":"Felix","year":"2000","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ceca.2004.08.001_bib15","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1046\/j.1523-1755.2000.00917.x","article-title":"Calcium channelopathies","volume":"57","author":"Lorenzon","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.ceca.2004.08.001_bib16","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s00415-002-0871-5","article-title":"Skeletal muscle channelopathies","volume":"249","author":"Jurkat-Rott","year":"2002","journal-title":"J. Neurol."},{"key":"10.1016\/j.ceca.2004.08.001_bib17","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/brain\/79.4.610","article-title":"A new congenital non-progressive myopathy","volume":"79","author":"Shy","year":"1956","journal-title":"Brain"},{"key":"10.1016\/j.ceca.2004.08.001_bib18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0140-6736(60)92690-8","article-title":"Anesthetic deaths in a family","volume":"2","author":"Denborough","year":"1960","journal-title":"Lancet"},{"key":"10.1016\/j.ceca.2004.08.001_bib19","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/00000542-196904000-00022","article-title":"Hyperthermia under anesthesia with regional muscle flaccidity","volume":"30","author":"Satnik","year":"1969","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ceca.2004.08.001_bib20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0143-4160(88)90006-1","article-title":"SR function in malignant hyperthermia","volume":"9","author":"Nelson","year":"1988","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2004.08.001_bib21","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2220\/biomedres.4.83","article-title":"Changes in the Ca-induced Ca release mechanism in sarcoplasmic reticulum from a patient with malignant hyperthermia","volume":"4","author":"Endo","year":"1983","journal-title":"Biomed. Res."},{"key":"10.1016\/j.ceca.2004.08.001_bib22","doi-asserted-by":"crossref","first-page":"9310","DOI":"10.1016\/S0021-9258(19)76541-7","article-title":"Abnormal sarcoplasmic reticulum ryanodine receptor in malignant hyperthermia","volume":"263","author":"Mickelson","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2004.08.001_bib23","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0006-3495(90)82563-7","article-title":"Abnormal ryanodine receptor channels in malignant hyperthermia","volume":"57","author":"Fill","year":"1990","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2004.08.001_bib24","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0006-3495(91)82323-2","article-title":"Abnormal human sarcoplasmic reticulum Ca2+ release channels in malignant hyperthermic skeletal muscle","volume":"59","author":"Fill","year":"1991","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2004.08.001_bib25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0888-7543(90)90278-3","article-title":"Assignment of the porcine calcium release channel gene, a candidate for the malignant hyperthermia locus, to the 6p11\u2013q21 segment of chromosome 6","volume":"8","author":"Harbitz","year":"1990","journal-title":"Genomics"},{"key":"10.1016\/j.ceca.2004.08.001_bib26","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/343559a0","article-title":"Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia","volume":"343","author":"MacLennan","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2004.08.001_bib27","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/343562a0","article-title":"Localization of the malignant hyperthermia susceptibility locus to human chromosome 19q12\u201313.2","volume":"343","author":"McCarthy","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2004.08.001_bib28","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1126\/science.1862346","article-title":"Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia","volume":"253","author":"Fujii","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.ceca.2004.08.001_bib29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF00197703","article-title":"Assignment of the gene for central core disease to chromosome 19","volume":"86","author":"Haan","year":"1990","journal-title":"Hum. Genet."},{"key":"10.1016\/j.ceca.2004.08.001_bib30","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/0888-7543(91)90461-M","article-title":"Evidence for linkage of the central core disease locus to the proximal long arm of human chromosome 19","volume":"10","author":"Kausch","year":"1991","journal-title":"Genomics"},{"key":"10.1016\/j.ceca.2004.08.001_bib31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/ng0993-51","article-title":"Mutations in the ryanodine receptor gene in central core disease and malignant hyperthermia","volume":"5","author":"Quane","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ceca.2004.08.001_bib32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ng0993-46","article-title":"A mutation in the human ryanodine receptor gene associated with central core disease","volume":"5","author":"Zhang","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ceca.2004.08.001_bib33","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/ana.10231","article-title":"A recessive form of central core disease, transiently presenting as multi-minicore disease, is associated with a homozygous mutation in the ryanodine receptor type 1 gene","volume":"51","author":"Ferreiro","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ceca.2004.08.001_bib34","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1212\/WNL.59.2.284","article-title":"Autosomal recessive inheritance of RYR1 mutations in a congenital myopathy with cores","volume":"59","author":"Jungbluth","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.ceca.2004.08.001_bib35","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/hmg\/ddg121","article-title":"A homozygous splicing mutation causing a depletion of skeletal muscle RYR1 is associated with multi-minicore disease congenital myopathy with ophthalmoplegia","volume":"12","author":"Monnier","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ceca.2004.08.001_bib36","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1093\/hmg\/9.18.2599","article-title":"An autosomal dominant congenital myopathy with cores and rods is associated with a neomutation in the RYR1 gene encoding the skeletal muscle ryanodine receptor","volume":"9","author":"Monnier","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ceca.2004.08.001_bib37","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1212\/WNL.55.11.1689","article-title":"A novel ryanodine receptor gene mutation causing both cores and rods in congenital myopathy","volume":"55","author":"Scacheri","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.ceca.2004.08.001_bib38","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0960-8966(02)00218-3","article-title":"Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region oftheRYR1 gene","volume":"13","author":"Davis","year":"2003","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.ceca.2004.08.001_bib39","first-page":"85","article-title":"[Ca2+]i in muscles of malignant hyperthermia susceptible pigs determined in vivo with Ca2+ selective microelectrodes","volume":"9","author":"Lopez","year":"1986","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.ceca.2004.08.001_bib40","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1034\/j.1399-0004.2002.620206.x","article-title":"Increased sensitivity to 4-chloro-m-cresol and caffeine in primary myotubes from malignant hyperthermia susceptible individuals carrying the ryanodine receptor 1 Thr2206Met (C6617T) mutation","volume":"62","author":"Wehner","year":"2002","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ceca.2004.08.001_bib41","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/BF00580861","article-title":"Fura-2 detected myoplasmic calcium and its correlation with contracture force in skeletal muscle from normal and malignant hyperthermia susceptible pigs","volume":"411","author":"Iaizzo","year":"1988","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.ceca.2004.08.001_bib42","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1172\/JCI993","article-title":"Intracellular calcium homeostasis in human primary muscle cells from malignant hyperthermia-susceptible and normal individuals. Effect of overexpression of recombinant wild-type and Arg163Cys mutated ryanodine receptors","volume":"101","author":"Censier","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ceca.2004.08.001_bib43","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1074\/jbc.274.2.693","article-title":"Measurement of resting cytosolic Ca2+ concentrations and Ca2+ store size in HEK-293 cells transfected with malignant hyperthermia or central core disease mutant Ca2+ release channels","volume":"274","author":"Tong","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2004.08.001_bib44","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1093\/brain\/awg244","article-title":"Dominant and recessive central core disease associated with RYR1 mutations and fetal akinesia","volume":"136","author":"Romero","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.ceca.2004.08.001_bib45","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1085\/jgp.118.3.277","article-title":"Functional effects of central core disease mutations in the cytoplasmic region of the skeletal muscle ryanodine receptor","volume":"118","author":"Avila","year":"2001","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ceca.2004.08.001_bib46","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1085\/jgp.200308791","article-title":"The pore region of the skeletal muscle ryanodine receptor is a primary locus for excitation\u2013contraction uncoupling in central core disease","volume":"121","author":"Avila","year":"2003","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ceca.2004.08.001_bib47","doi-asserted-by":"crossref","first-page":"25971","DOI":"10.1074\/jbc.274.37.25971","article-title":"Molecular identification of the ryanodine receptor pore-forming segment","volume":"274","author":"Zhao","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2004.08.001_bib48","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S0006-3495(00)76339-9","article-title":"Evidence for a role of the lumenal M3\u2013M4 loop in skeletal muscle Ca(2+) release channel (ryanodine receptor) activity and conductance","volume":"79","author":"Gao","year":"2000","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2004.08.001_bib49","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1093\/hmg\/10.25.2879","article-title":"Identification of four novel mutations in the C-terminal membrane spanning domain of the ryanodine receptor 1: association with central core disease and alteration of calcium homeostasis","volume":"10","author":"Tilgen","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ceca.2004.08.001_bib50","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/hmg\/ddg032","article-title":"Clinical and functional effects of a deletion in a COOH-terminal lumenal loop of the skeletal muscle ryanodine receptor","volume":"12","author":"Zorzato","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ceca.2004.08.001_bib51","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1073\/pnas.071048198","article-title":"Excitation\u2013contraction uncoupling by a human central core disease mutation in the ryanodine receptor","volume":"98","author":"Avila","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ceca.2004.08.001_bib52","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/brain\/96.3.527","article-title":"Central core disease or not? Observations on a family with a non-progressive myopathy","volume":"96","author":"Morgan-Hughes","year":"1973","journal-title":"Brain"},{"key":"10.1016\/j.ceca.2004.08.001_bib53","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/00005792-198709000-00004","article-title":"Central core disease. Clinical features in 13 patients","volume":"66","author":"Shuaib","year":"1987","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ceca.2004.08.001_bib54","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/242244a0","article-title":"Voltage dependent charge movement of skeletal muscle: a possible step in excitation\u2013contraction coupling","volume":"242","author":"Schneider","year":"1973","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2004.08.001_bib55","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/336134a0","article-title":"Restoration of excitation\u2013contraction coupling and slow calcium current in dysgenic muscle by dihydropyridine receptor complementary DNA","volume":"336","author":"Tanabe","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2004.08.001_bib56","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/325717a0","article-title":"Involvement of dihydropyridine receptors in excitation\u2013contraction coupling in skeletal muscle","volume":"325","author":"Rios","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2004.08.001_bib57","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1113\/jphysiol.1996.sp021689","article-title":"Absence of Ca2+ current facilitation in skeletal muscle of transgenic mice lacking the type 1 ryanodine receptor","volume":"496","author":"Fleig","year":"1996","journal-title":"J. Physiol"},{"key":"10.1016\/j.ceca.2004.08.001_bib58","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/380072a0","article-title":"Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor","volume":"380","author":"Nakai","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2004.08.001_bib59","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1152\/ajpcell.1992.262.2.C422","article-title":"Excitation\u2013contraction coupling in pigs heterozygous for malignant hyperthermia","volume":"262","author":"Gallant","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ceca.2004.08.001_bib60","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/(SICI)1097-4598(199601)19:1<68::AID-MUS9>3.0.CO;2-6","article-title":"Porcine malignant hyperthermia: genotype and contractile threshold of immature muscles","volume":"19","author":"Gallant","year":"1996","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.ceca.2004.08.001_bib61","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1469-7793.2000.t01-1-00507.x","article-title":"Malignant hyperthermia mutation Arg615Cys in the porcine ryanodine receptor alters voltage dependence of Ca2+ release","volume":"526","author":"Dietze","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2004.08.001_bib62","doi-asserted-by":"crossref","first-page":"25722","DOI":"10.1074\/jbc.M302165200","article-title":"Functional defects in six ryanodine receptor isoform-1 (RyR1) mutations associated with malignant hyperthermia and their impact on skeletal excitation\u2013contraction coupling","volume":"278","author":"Yang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2004.08.001_bib63","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1073\/pnas.96.7.4164","article-title":"A mutation in the transmembrane\/luminal domain of the ryanodine receptor is associated with abnormal Ca2+ release channel function and severe central core disease","volume":"96","author":"Lynch","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ceca.2004.08.001_bib64","doi-asserted-by":"crossref","first-page":"31867","DOI":"10.1074\/jbc.273.48.31867","article-title":"Functional consequences of mutations of conserved, polar amino acids in transmembrane sequences of the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum","volume":"273","author":"Du","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2004.08.001_bib65","doi-asserted-by":"crossref","first-page":"17732","DOI":"10.1074\/jbc.M009685200","article-title":"Ca2+ release through ryanodine receptors regulates skeletal muscle L-type Ca2+ channel expression","volume":"276","author":"Avila","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2004.08.001_bib66","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1016\/S0006-3495(02)75586-0","article-title":"Ca2+ activation of RyR1 is not necessary for the initiation of skeletal-type excitation\u2013contraction coupling","volume":"82","author":"O\u2019Brien","year":"2002","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2004.08.001_bib67","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1042\/BJ20040580","article-title":"Central core disease mutations R4892W, I4897T and G4898E in the ryanodine receptor isoform 1 (RyR1) reduce the Ca2+ sensitivity and amplitude of Ca2+-dependent Ca2+ release","volume":"382","author":"Du","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.ceca.2004.08.001_bib68","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1091\/mbc.e03-09-0688","article-title":"Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains","volume":"15","author":"George","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ceca.2004.08.001_bib69","doi-asserted-by":"crossref","first-page":"14675","DOI":"10.1074\/jbc.273.24.14675","article-title":"Molecular identification of the ryanodine receptor Ca2+ sensor","volume":"273","author":"Chen","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2004.08.001_bib70","doi-asserted-by":"crossref","first-page":"37566","DOI":"10.1074\/jbc.M406637200","article-title":"Role of the sequence surrounding predicted transmembrane helix M4 in membrane association and function of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum (Ryanodine Receptor Isoform 1)","volume":"279","author":"Du","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2004.08.001_bib71","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S1050-1738(01)00067-6","article-title":"Postulated role of inter-domain interaction within the ryanodine receptor in Ca(2+) channel regulation","volume":"10","author":"Ikemoto","year":"2000","journal-title":"Trends Cardiovasc. Med."}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416004001344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416004001344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T20:02:36Z","timestamp":1758916956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416004001344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S0143416004001344"],"URL":"https:\/\/doi.org\/10.1016\/j.ceca.2004.08.001","relation":{},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intracellular Ca2+ dynamics in malignant hyperthermia and central core disease: established concepts, new cellular mechanisms involved","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceca.2004.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}