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Physiol."},{"key":"10.1016\/j.ceca.2006.04.025_bib84","first-page":"569","article-title":"T-type calcium current is expressed in dedifferentiated adult rat ventricular cells in primary culture","volume":"319","author":"Fares","year":"1996","journal-title":"CR Acad. Sci. III"},{"key":"10.1016\/j.ceca.2006.04.025_bib85","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cardiores.2005.05.009","article-title":"Aldosterone increases T-type calcium channel expression and in vitro beating frequency in neonatal rat cardiomyocytes","volume":"67","author":"Lalevee","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ceca.2006.04.025_bib86","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1161\/01.RES.85.12.1139","article-title":"Aldosterone upregulates Ca(2+) current in adult rat cardiomyocytes","volume":"85","author":"Benitah","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.ceca.2006.04.025_bib87","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1161\/01.RES.0000106134.69300.B7","article-title":"Angiotensin II signaling pathways mediate expression of cardiac T-type calcium channels","volume":"93","author":"Ferron","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.ceca.2006.04.025_bib88","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1254\/jphs.FMJ05002X4","article-title":"Pathophysiological significance of T-type Ca(2+) channels: transcriptional regulation of T-type Ca(2+) channel\u2014regulation of CACNA1H by neuron-restrictive silencer factor","volume":"99","author":"Kuwahara","year":"2005","journal-title":"J. Pharmacol. 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Biol."},{"key":"10.1016\/j.ceca.2006.04.025_bib92","first-page":"K37","article-title":"Possible functional significance of a novel type of cardiac Ca channel","volume":"45","author":"Nilius","year":"1986","journal-title":"Biomed. Biochim. Acta"},{"key":"10.1016\/j.ceca.2006.04.025_bib93","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/BF00581808","article-title":"Calcium currents in single SA nodal cells of the rabbit heart studied with action potential clamp","volume":"413","author":"Doerr","year":"1989","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.ceca.2006.04.025_bib94","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0022-2828(87)80590-4","article-title":"Abnormal pacemaking is modulated by sarcoplasmic reticulum in partially-depolarized myocardium from dilated right atria in humans","volume":"19","author":"Escande","year":"1987","journal-title":"J. Mol. 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Physiol."},{"key":"10.1016\/j.ceca.2006.04.025_bib107","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1016\/S0006-3495(98)77893-2","article-title":"Both T- and L-type Ca2+ channels can contribute to excitation-contraction coupling in cardiac Purkinje cells","volume":"74","author":"Zhou","year":"1998","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2006.04.025_bib108","first-page":"71","article-title":"Tetrodotoxin-sensitive Ca2+ and Ba2+ currents in human atrial cells","volume":"3","author":"Lemaire","year":"1995","journal-title":"Receptors Channels"},{"issue":"Pt 2","key":"10.1016\/j.ceca.2006.04.025_bib109","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1469-7793.1997.353bb.x","article-title":"Tetrodotoxin-blockable calcium currents in rat ventricular myocytes; a third type of cardiac cell sodium current","volume":"505","author":"Aggarwal","year":"1997","journal-title":"J. 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