{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:50:12Z","timestamp":1774468212405,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.ceca.2006.11.010","type":"journal-article","created":{"date-parts":[[2007,1,23]],"date-time":"2007-01-23T07:58:09Z","timestamp":1169539089000},"page":"59-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Role of mitochondria in kainate-induced fast Ca2+ transients in cultured spinal motor neurons"],"prefix":"10.1016","volume":"42","author":[{"given":"Julian","family":"Grosskreutz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Haastert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten","family":"Dewil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Van Damme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert","family":"Callewaert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim","family":"Robberecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Dengler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludo","family":"Van Den Bosch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceca.2006.11.010_bib1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1056\/NEJM199403033300901","article-title":"A controlled trial of riluzole in amyotrophic lateral sclerosis","volume":"330","author":"Bensimon","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ceca.2006.11.010_bib2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35097565","article-title":"From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS","volume":"2","author":"Cleveland","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ceca.2006.11.010_bib3","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/12227","article-title":"SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter","volume":"2","author":"Trotti","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ceca.2006.11.010_bib4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0304-3940(03)00314-8","article-title":"The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis","volume":"343","author":"Van Damme","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ceca.2006.11.010_bib5","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0022-3565(24)29332-0","article-title":"RPR 119990, a novel alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis","volume":"299","author":"Canton","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ceca.2006.11.010_bib6","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/jnr.20715","article-title":"Glutamate AMPA receptors change in motor neurons of SOD1G93A transgenic mice and their inhibition by a noncompetitive antagonist ameliorates the progression of amytrophic lateral sclerosis-like disease","volume":"83","author":"Tortarolo","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ceca.2006.11.010_bib7","doi-asserted-by":"crossref","first-page":"9673","DOI":"10.1523\/JNEUROSCI.18-23-09673.1998","article-title":"Glutamate potentiates the toxicity of mutant Cu\/Zn-superoxide dismutase in motor neurons by postsynaptic calcium-dependent mechanisms","volume":"18","author":"Roy","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2006.11.010_bib8","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1046\/j.1460-9568.2003.02531.x","article-title":"Kinetic properties of human AMPA-type glutamate receptors expressed in HEK293 cells","volume":"17","author":"Grosskreutz","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ceca.2006.11.010_bib9","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1126\/science.1709304","article-title":"Ca2+ permeability of KA-AMPA\u2013gated glutamate receptor channels depends on subunit composition","volume":"252","author":"Hollmann","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.ceca.2006.11.010_bib10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0092-8674(91)90568-J","article-title":"RNA editing in brain controls a determinant of ion flow in glutamate-gated channels","volume":"67","author":"Sommer","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.ceca.2006.11.010_bib11","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1523\/JNEUROSCI.22-08-03005.2002","article-title":"A developmental switch of AMPA receptor subunits in neocortical pyramidal neurons","volume":"22","author":"Kumar","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2006.11.010_bib12","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1097\/00001756-200210070-00012","article-title":"Quantitative assessment of AMPA receptor mRNA in human spinal motor neurons isolated by laser capture microdissection","volume":"13","author":"Heath","year":"2002","journal-title":"Neuroreport"},{"key":"10.1016\/j.ceca.2006.11.010_bib13","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1152\/jn.2002.88.3.1279","article-title":"GluR2-dependent properties of AMPA receptors determine the selective vulnerability of motor neurons to excitotoxicity","volume":"88","author":"Van Damme","year":"2002","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ceca.2006.11.010_bib14","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1046\/j.1471-4159.2003.01703.x","article-title":"Human spinal motoneurons express low relative abundance of GluR2 mRNA: an implication for excitotoxicity in ALS","volume":"85","author":"Kawahara","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ceca.2006.11.010_bib15","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1093\/hmg\/ddh246","article-title":"Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model","volume":"13","author":"Tateno","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ceca.2006.11.010_bib16","doi-asserted-by":"crossref","first-page":"5826","DOI":"10.1073\/pnas.0501316102","article-title":"Late-onset motoneuron disease caused by a functionally modified AMPA receptor subunit","volume":"102","author":"Kuner","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.ceca.2006.11.010_bib17","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/01.jnen.0000171647.09589.07","article-title":"GluR2 deficiency accelerates motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis","volume":"64","author":"Van Damme","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.ceca.2006.11.010_bib18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0022-510X(00)00414-7","article-title":"Ca2+-permeable AMPA receptors and selective vulnerability of motor neurons","volume":"180","author":"Van Den Bosch","year":"2000","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.ceca.2006.11.010_bib19","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.1523\/JNEUROSCI.16-13-04069.1996","article-title":"Motor neurons are selectively vulnerable to AMPA\/kainate receptor-mediated injury in vitro","volume":"16","author":"Carriedo","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2006.11.010_bib20","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1523\/JNEUROSCI.20-01-00240.2000","article-title":"AMPA exposures induce mitochondrial Ca(2+) overload and ROS generation in spinal motor neurons in vitro","volume":"20","author":"Carriedo","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2006.11.010_bib21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1523\/JNEUROSCI.20-01-00123.2000","article-title":"AMPA receptor calcium permeability, GluR2 expression, and selective motoneuron vulnerability","volume":"20","author":"Vandenberghe","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2006.11.010_bib22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0143-4160(03)00141-6","article-title":"Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity","volume":"34","author":"Arundine","year":"2003","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2006.11.010_bib23","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1523\/JNEUROSCI.23-12-04942.2003","article-title":"Chloride influx aggravates Ca2+-dependent AMPA receptor-mediated motoneuron death","volume":"23","author":"Van Damme","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2006.11.010_bib24","doi-asserted-by":"crossref","first-page":"5688","DOI":"10.1523\/JNEUROSCI.16-18-05688.1996","article-title":"Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure","volume":"16","author":"White","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2006.11.010_bib25","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1523\/JNEUROSCI.21-06-01893.2001","article-title":"Mitochondria control AMPA\/kainate receptor-induced cytoplasmic calcium deregulation in rat cerebellar granule cells","volume":"21","author":"Rego","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2006.11.010_bib26","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1006\/exnr.2001.7858","article-title":"Protective effect of parvalbumin on excitotoxic motor neuron death","volume":"174","author":"Van Den Bosch","year":"2002","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ceca.2006.11.010_bib27","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jneumeth.2004.09.003","article-title":"Rat embryonic motoneurons in long-term co-culture with Schwann cells-a system to investigate motoneuron diseases on a cellular level in vitro","volume":"142","author":"Haastert","year":"2005","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ceca.2006.11.010_bib28","doi-asserted-by":"crossref","first-page":"5840","DOI":"10.1523\/JNEUROSCI.22-14-05840.2002","article-title":"Presynaptic mitochondrial calcium sequestration influences transmission at mammalian central synapses","volume":"22","author":"Billups","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2006.11.010_bib29","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.neuroscience.2006.07.034","article-title":"Temporospatial coupling of networked synaptic activation of AMPA-type glutamate receptor channels and calcium transients in cultured motoneurons","volume":"142","author":"Jahn","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.ceca.2006.11.010_bib30","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2006.11.010_bib31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tins.2003.11.001","article-title":"Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis","volume":"27","author":"Rao","year":"2004","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ceca.2006.11.010_bib32","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.bbadis.2006.05.002","article-title":"The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis","volume":"1762","author":"Van Den Bosch","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ceca.2006.11.010_bib33","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1097\/00001756-199504190-00030","article-title":"In vitro kainate injury to large SMI-32(+) spinal neurons is Ca2+ dependent","volume":"6","author":"Carriedo","year":"1995","journal-title":"Neuroreport"},{"key":"10.1016\/j.ceca.2006.11.010_bib34","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0361-9230(00)00371-3","article-title":"Different receptors mediate motor neuron death induced by short and long exposures to excitotoxicity","volume":"53","author":"Van Den Bosch","year":"2000","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ceca.2006.11.010_bib35","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0896-6273(00)80038-0","article-title":"Dominant role of mitochondria in clearance of large Ca2+ loads from rat adrenal chromaffin cells","volume":"16","author":"Herrington","year":"1996","journal-title":"Neuron"},{"issue":"Pt 1","key":"10.1016\/j.ceca.2006.11.010_bib36","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1469-7793.1998.103bo.x","article-title":"The role of intracellular Na+ and mitochondria in buffering of kainate-induced intracellular free Ca2+ changes in rat forebrain neurones","volume":"509","author":"Hoyt","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2006.11.010_bib37","doi-asserted-by":"crossref","first-page":"7495","DOI":"10.1523\/JNEUROSCI.19-17-07495.1999","article-title":"Mitochondrial clearance of cytosolic Ca(2+) in stimulated lizard motor nerve terminals proceeds without progressive elevation of mitochondrial matrix [Ca2+]","volume":"19","author":"David","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2006.11.010_bib38","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nature02246","article-title":"The mitochondrial calcium uniporter is a highly selective ion channel","volume":"427","author":"Kirichok","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2006.11.010_bib39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1054\/ceca.1999.0095","article-title":"Chemical and physiological characterization of fluo-4 Ca2+-indicator dyes","volume":"27","author":"Gee","year":"2000","journal-title":"Cell Calcium"},{"issue":"Pt 2","key":"10.1016\/j.ceca.2006.11.010_bib40","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1469-7793.1999.00485.x","article-title":"Calcium dynamics and buffering in motoneurones of the mouse spinal cord","volume":"520","author":"Palecek","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2006.11.010_bib41","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0143-4160(03)00142-8","article-title":"Neuronal ageing from an intraneuronal perspective: roles of endoplasmic reticulum and mitochondria","volume":"34","author":"Toescu","year":"2003","journal-title":"Cell Calcium"},{"issue":"Pt 2","key":"10.1016\/j.ceca.2006.11.010_bib42","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1469-7793.2000.t01-1-00433.x","article-title":"Calcium dynamics and buffering in oculomotor neurones from mouse that are particularly resistant during amyotrophic lateral sclerosis (ALS)-related motoneurone disease","volume":"525","author":"Vanselow","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2006.11.010_bib43","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1046\/j.1471-4159.2001.00582.x","article-title":"Parvalbumin overexpression alters immune-mediated increases in intracellular calcium, and delays disease onset in a transgenic model of familial amyotrophic lateral sclerosis","volume":"79","author":"Beers","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ceca.2006.11.010_bib44","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/427801a","article-title":"Glutamate receptors: RNA editing and death of motor neurons","volume":"427","author":"Kawahara","year":"2004","journal-title":"Nature"}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416006002156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416006002156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T20:05:40Z","timestamp":1758917140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416006002156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0143416006002156"],"URL":"https:\/\/doi.org\/10.1016\/j.ceca.2006.11.010","relation":{},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of mitochondria in kainate-induced fast Ca2+ transients in cultured spinal motor neurons","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceca.2006.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}