{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:21:03Z","timestamp":1789611663210,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"NIH","award":["P01HL70687"],"award-info":[{"award-number":["P01HL70687"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.ceca.2012.10.006","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T23:17:16Z","timestamp":1353539836000},"page":"112-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ryanodine receptors are uncoupled from contraction in rat vena cava"],"prefix":"10.1016","volume":"53","author":[{"given":"N.R.","family":"Tykocki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.F.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.W.","family":"Watts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3\u20134","key":"10.1016\/j.ceca.2012.10.006_bib0005","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ceca.2005.06.037","article-title":"Ryanodine receptors","volume":"38","author":"Hamilton","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2012.10.006_bib0010","first-page":"1","article-title":"Role of ryanodine receptor subtypes in initiation and formation of calcium sparks in arterial smooth muscle: comparison with striated muscle","volume":"2009","author":"Essin","year":"2009","journal-title":"Journal of Biomedicine and Biotechnology"},{"issue":"17","key":"10.1016\/j.ceca.2012.10.006_bib0015","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1093\/emboj\/cdg432","article-title":"Ca2+ channel\u2013sarcoplasmic reticulum coupling: a mechanism of arterial myocyte contraction without Ca2+ influx","volume":"22","author":"del Valle-Rodr\u00edguez","year":"2003","journal-title":"The EMBO Journal"},{"issue":"12","key":"10.1016\/j.ceca.2012.10.006_bib0020","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1161\/01.RES.0000172556.05576.4c","article-title":"Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice","volume":"96","author":"Li","year":"2005","journal-title":"Circulation Research"},{"issue":"4","key":"10.1016\/j.ceca.2012.10.006_bib0025","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1085\/jgp.200308999","article-title":"RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle","volume":"123","author":"Ji","year":"2004","journal-title":"The Journal of General Physiology"},{"issue":"5236","key":"10.1016\/j.ceca.2012.10.006_bib0030","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1126\/science.270.5236.633","article-title":"Relaxation of arterial smooth muscle by calcium sparks","volume":"270","author":"Nelson","year":"1995","journal-title":"Science (New York, NY)"},{"issue":"5","key":"10.1016\/j.ceca.2012.10.006_bib0035","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1001\/archinte.1986.00360170223028","article-title":"Physiology of venous return: an unappreciated boost to the heart","volume":"146","author":"Rothe","year":"1986","journal-title":"Archives of Internal Medicine"},{"issue":"2","key":"10.1016\/j.ceca.2012.10.006_bib0040","doi-asserted-by":"crossref","first-page":"L213","DOI":"10.1152\/ajplung.00103.2004","article-title":"Role of veins in regulation of pulmonary circulation","volume":"288","author":"Gao","year":"2005","journal-title":"American Journal of Physiology, Lung Cellular and Molecular Physiology"},{"issue":"1 Pt 2","key":"10.1016\/j.ceca.2012.10.006_bib0045","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1161\/01.HYP.35.1.464","article-title":"Mechanisms of increased venous smooth muscle tone in desoxycorticosterone acetate\u2013salt hypertension","volume":"35","author":"Fink","year":"2000","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.ceca.2012.10.006_bib0050","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1152\/ajpregu.00465.2009","article-title":"Sex-related decrease in [Ca2+]i signaling and Ca2+-dependent contraction in inferior vena cava of female rat","volume":"298","author":"Xia","year":"2010","journal-title":"American Journal of Physiology, Regulatory, Integrative and Comparative Physiology"},{"issue":"4","key":"10.1016\/j.ceca.2012.10.006_bib0055","doi-asserted-by":"crossref","first-page":"E72","DOI":"10.1161\/01.RES.86.4.e72","article-title":"Asynchronous Ca(2+) waves in intact venous smooth muscle","volume":"86","author":"Ruehlmann","year":"2000","journal-title":"Circulation Research"},{"issue":"1","key":"10.1016\/j.ceca.2012.10.006_bib0060","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2210-12-4","article-title":"5-Hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved","volume":"12","author":"Davis","year":"2012","journal-title":"BMC Pharmacology"},{"issue":"3","key":"10.1016\/j.ceca.2012.10.006_bib0065","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ceca.2011.01.007","article-title":"Calcium entry-calcium refilling (CECR) coupling between store-operated Ca(2+) entry and sarco\/endoplasmic reticulum Ca(2+)-ATPase","volume":"49","author":"Manjarr\u00e9s","year":"2011","journal-title":"Cell Calcium"},{"issue":"2","key":"10.1016\/j.ceca.2012.10.006_bib0070","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1161\/HYPERTENSIONAHA.108.119990","volume":"53","year":"2009","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.ceca.2012.10.006_bib0075","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1159\/000106553","article-title":"Endothelin-1-mediated wave-like [Ca2+]i oscillations in intact rabbit inferior vena cava","volume":"44","author":"Dai","year":"2007","journal-title":"Journal of Vascular Research"},{"issue":"2","key":"10.1016\/j.ceca.2012.10.006_bib0080","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1161\/01.HYP.10.2.133","article-title":"Arterial and venous compliance in sustained essential hypertension","volume":"10","author":"Safar","year":"1987","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.ceca.2012.10.006_bib0085","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/ki.1975.74","article-title":"Altered blood volume regulation in sustained essential hypertension: a hemodynamic study","volume":"8","author":"Safar","year":"1975","journal-title":"Kidney International"},{"issue":"25","key":"10.1016\/j.ceca.2012.10.006_bib0090","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1161\/01.CIR.0000132472.98675.EC","article-title":"Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak","volume":"109","author":"Lehnart","year":"2004","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.ceca.2012.10.006_bib0095","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1161\/HYPERTENSIONAHA.109.147991","article-title":"A leakage leads to failure: roles of sarcoplasmic reticulum Ca2+ leak via RyR2 in heart failure progression","volume":"55","author":"Duan","year":"2010","journal-title":"Hypertension"},{"issue":"7","key":"10.1016\/j.ceca.2012.10.006_bib0100","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1074\/jbc.R800054200","article-title":"Ryanodine receptor structure: progress and challenges","volume":"284","author":"Hamilton","year":"2009","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.ceca.2012.10.006_bib0105","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/978-1-59745-542-8_38","article-title":"A brief review of other notable protein blotting methods","volume":"536","author":"Kurien","year":"2009","journal-title":"Methods in Molecular Biology (Clifton, NJ)"},{"issue":"26","key":"10.1016\/j.ceca.2012.10.006_bib0110","doi-asserted-by":"crossref","first-page":"19785","DOI":"10.1016\/S0021-9258(19)36582-2","article-title":"Characterization of the major brain form of the ryanodine receptor\/Ca2+ release channel","volume":"268","author":"McPherson","year":"1993","journal-title":"The Journal of Biological Chemistry"},{"issue":"2","key":"10.1016\/j.ceca.2012.10.006_bib0115","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1042\/BJ20071257","article-title":"Localization of PKA phosphorylation site, Ser(2030), in the three-dimensional structure of cardiac ryanodine receptor","volume":"410","author":"Jones","year":"2008","journal-title":"The Biochemical Journal"},{"issue":"3","key":"10.1016\/j.ceca.2012.10.006_bib0120","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1161\/CIRCRESAHA.111.244970","article-title":"A novel ryanodine receptor mutation linked to sudden death increases sensitivity to cytosolic calcium","volume":"109","author":"Meli","year":"2011","journal-title":"Circulation Research"},{"issue":"2","key":"10.1016\/j.ceca.2012.10.006_bib0125","doi-asserted-by":"crossref","first-page":"C264","DOI":"10.1152\/ajpcell.00318.2009","article-title":"Subtype identification and functional characterization of ryanodine receptors in rat cerebral artery myocytes","volume":"299","author":"Vaithianathan","year":"2010","journal-title":"American Journal of Physiology Cell Physiology"},{"issue":"Pt 8","key":"10.1016\/j.ceca.2012.10.006_bib0130","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1113\/jphysiol.2011.222083","article-title":"Function and expression of ryanodine receptors and inositol 1,4,5-trisphosphate receptors in smooth muscle cells of murine feed arteries and arterioles","volume":"590","author":"Westcott","year":"2012","journal-title":"The Journal of Physiology"},{"issue":"5","key":"10.1016\/j.ceca.2012.10.006_bib0135","doi-asserted-by":"crossref","first-page":"H1616","DOI":"10.1152\/ajpheart.00728.2010","article-title":"Heterogeneous function of ryanodine receptors, but not IP3 receptors, in hamster cremaster muscle feed arteries and arterioles","volume":"300","author":"Westcott","year":"2011","journal-title":"American Journal of Physiology Heart and Circulatory Physiology"},{"issue":"6","key":"10.1016\/j.ceca.2012.10.006_bib0140","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ceca.2007.09.002","article-title":"FK506-binding protein (FKBP12) regulates ryanodine receptor-evoked Ca2+ release in colonic but not aortic smooth muscle","volume":"43","author":"Macmillan","year":"2008","journal-title":"Cell Calcium"},{"issue":"1","key":"10.1016\/j.ceca.2012.10.006_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-6997(24)01312-7","article-title":"The sarcoplasmic reticulum Ca2+ channel\/ryanodine receptor: modulation by endogenous effectors, drugs and disease states","volume":"49","author":"Zucchi","year":"1997","journal-title":"Pharmacological Reviews"},{"issue":"4","key":"10.1016\/j.ceca.2012.10.006_bib0150","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1152\/physrev.00013.2002","article-title":"Ryanodine receptor calcium release channels","volume":"82","author":"Fill","year":"2002","journal-title":"Physiological Reviews"},{"issue":"3\u20134","key":"10.1016\/j.ceca.2012.10.006_bib0155","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ceca.2005.06.018","article-title":"Calcium signalling in smooth muscle","volume":"38","author":"Wray","year":"2005","journal-title":"Cell Calcium"},{"issue":"1","key":"10.1016\/j.ceca.2012.10.006_bib0160","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/FJC.0b013e318233614c","article-title":"Requirement for functional BK channels in maintaining oscillation in venomotor tone revealed by species differences in expression of the \u03b21 accessory subunits","volume":"59","author":"Xu","year":"2012","journal-title":"Journal of Cardiovascular Pharmacology"},{"issue":"2","key":"10.1016\/j.ceca.2012.10.006_bib0165","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jvs.2006.10.041","article-title":"Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formation","volume":"45","author":"Raffetto","year":"2007","journal-title":"Journal of Vascular Surgery: Official Publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter"},{"issue":"3","key":"10.1016\/j.ceca.2012.10.006_bib0170","first-page":"289","article-title":"Effect of inhibiting the sarcoplasmic reticulum on spontaneous and oxytocin-induced contractions of human myometrium","volume":"109","author":"Kupittayanant","year":"2002","journal-title":"BJOG: an International Journal of Obstetrics and Gynaecology"},{"issue":"Pt 1","key":"10.1016\/j.ceca.2012.10.006_bib0175","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1469-7793.1998.133bi.x","article-title":"Contribution of sarcoplasmic reticular calcium to smooth muscle contractile activation: gestational dependence in isolated rat uterus","volume":"511","author":"Taggart","year":"1998","journal-title":"The Journal of Physiology"},{"issue":"3","key":"10.1016\/j.ceca.2012.10.006_bib0180","doi-asserted-by":"crossref","first-page":"C848","DOI":"10.1152\/ajpcell.00069.2007","article-title":"Role of RYR3 splice variants in calcium signaling in mouse nonpregnant and pregnant myometrium","volume":"293","author":"Dabertrand","year":"2007","journal-title":"American Journal of Physiology Cell Physiology"}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416012001777?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416012001777?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T20:15:36Z","timestamp":1758917736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416012001777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0143416012001777"],"URL":"https:\/\/doi.org\/10.1016\/j.ceca.2012.10.006","relation":{},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ryanodine receptors are uncoupled from contraction in rat vena cava","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceca.2012.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}