{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:36:56Z","timestamp":1789137416745,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.ceca.2013.01.004","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T19:05:53Z","timestamp":1361559953000},"page":"297-301","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts"],"prefix":"10.1016","volume":"53","author":[{"given":"Nanna","family":"Goldman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin","family":"Chandler-Militello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene M.","family":"Langevin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiken","family":"Nedergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceca.2013.01.004_bib0005","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nn.2562","article-title":"Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture","volume":"13","author":"Goldman","year":"2010","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.ceca.2013.01.004_bib0010","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.pain.2010.10.011","article-title":"Caffeine and pain","volume":"152","author":"Sawynok","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.ceca.2013.01.004_bib0015","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1748-1716.2009.01957.x","article-title":"Evolutionary origins of the purinergic signalling system","volume":"195","author":"Burnstock","year":"2009","journal-title":"Acta Physiologica (Oxford)"},{"key":"10.1016\/j.ceca.2013.01.004_bib0020","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.jpain.2012.09.012","article-title":"Traditional acupuncture triggers a local increase in adenosine in human subjects","volume":"13","author":"Takano","year":"2012","journal-title":"Journal of Pain"},{"key":"10.1016\/j.ceca.2013.01.004_bib0025","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s002100000309","article-title":"Extracellular metabolism of ATP and other nucleotides","volume":"362","author":"Zimmermann","year":"2000","journal-title":"Naunyn-Schmiedebergs Archives of Pharmacology"},{"key":"10.1016\/j.ceca.2013.01.004_bib0030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0304-3959(02)00419-0","article-title":"Intravenous adenosine alleviates neuropathic pain: a double blind placebo controlled crossover trial using an enriched enrolment design","volume":"103","author":"Lynch","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.ceca.2013.01.004_bib0035","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0301-0082(03)00050-9","article-title":"Adenosine in the spinal cord and periphery: release and regulation of pain","volume":"69","author":"Sawynok","year":"2003","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.ceca.2013.01.004_bib0040","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1254\/jphs.94.112","article-title":"ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4","volume":"94","author":"Inoue","year":"2004","journal-title":"Journal of Pharmacological Sciences"},{"key":"10.1016\/j.ceca.2013.01.004_bib0045","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nn0710-783","article-title":"Needling adenosine receptors for pain relief","volume":"13","author":"Zylka","year":"2010","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.ceca.2013.01.004_bib0050","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1089\/acm.2007.6351","article-title":"Connective tissue fibroblast response to acupuncture: dose-dependent effect of bidirectional needle rotation","volume":"13","author":"Langevin","year":"2007","journal-title":"Journal of Alternative and Complementary Medicine"},{"key":"10.1016\/j.ceca.2013.01.004_bib0055","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00418-005-0138-1","article-title":"Fibroblast spreading induced by connective tissue stretch involves intracellular redistribution of alpha- and beta-actin","volume":"125","author":"Langevin","year":"2006","journal-title":"Histochemistry and Cell Biology"},{"key":"10.1016\/j.ceca.2013.01.004_bib0060","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.bbrc.2009.12.184","article-title":"Coculture with BJ fibroblast cells inhibits the adipogenesis and lipogenesis in 3T3-L1 cells","volume":"392","author":"Jeong","year":"2010","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.ceca.2013.01.004_bib0065","doi-asserted-by":"crossref","first-page":"15735","DOI":"10.1073\/pnas.95.26.15735","article-title":"Connexins regulate calcium signaling by controlling ATP release","volume":"95","author":"Cotrina","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.ceca.2013.01.004_bib0070","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1523\/JNEUROSCI.3827-07.2008","article-title":"A central role of connexin 43 in hypoxic preconditioning","volume":"28","author":"Lin","year":"2008","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.ceca.2013.01.004_bib0075","doi-asserted-by":"crossref","first-page":"ra8","DOI":"10.1126\/scisignal.2002160","article-title":"Extracellular Ca(2)(+) acts as a mediator of communication from neurons to glia","volume":"5","author":"Torres","year":"2012","journal-title":"Science Signaling"},{"key":"10.1016\/j.ceca.2013.01.004_bib0080","doi-asserted-by":"crossref","first-page":"8794","DOI":"10.1523\/JNEUROSCI.18-21-08794.1998","article-title":"Cytoskeletal assembly and ATP release regulate astrocytic calcium signaling","volume":"18","author":"Cotrina","year":"1998","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.ceca.2013.01.004_bib0085","doi-asserted-by":"crossref","first-page":"44638","DOI":"10.1074\/jbc.M203012200","article-title":"Extracellular ATP is an autocrine\/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1\/2 and the Egr-1 transcription factor","volume":"277","author":"Gerasimovskaya","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.ceca.2013.01.004_bib0090","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s11302-005-8075-y","article-title":"Cell cycle regulation of astrocytes by extracellular nucleotides and fibroblast growth factor-2","volume":"1","author":"Neary","year":"2005","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.ceca.2013.01.004_bib0095","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1242\/jcs.02453","article-title":"Characteristics of subepithelial fibroblasts as a mechano-sensor in the intestine: cell-shape-dependent ATP release and P2Y1 signaling","volume":"118","author":"Furuya","year":"2005","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.ceca.2013.01.004_bib0100","doi-asserted-by":"crossref","first-page":"F62","DOI":"10.1152\/ajprenal.00473.2010","article-title":"P2X7 receptors mediate deleterious renal epithelial-fibroblast cross talk","volume":"300","author":"Ponnusamy","year":"2011","journal-title":"American Journal of Physiology. Renal Physiology"},{"key":"10.1016\/j.ceca.2013.01.004_bib0105","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/jcp.20623","article-title":"Subcutaneous tissue fibroblast cytoskeletal remodeling induced by acupuncture: evidence for a mechanotransduction-based mechanism","volume":"207","author":"Langevin","year":"2006","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.ceca.2013.01.004_bib0110","doi-asserted-by":"crossref","first-page":"ra26","DOI":"10.1126\/scisignal.2002334","article-title":"Astrocytes modulate neural network activity by Ca(2)+-dependent uptake of extracellular K+","volume":"5","author":"Wang","year":"2012","journal-title":"Science Signaling"},{"key":"10.1016\/j.ceca.2013.01.004_bib0115","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1096\/fj.01-0015hyp","article-title":"Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture","volume":"15","author":"Langevin","year":"2001","journal-title":"FASEB Journal"},{"key":"10.1016\/j.ceca.2013.01.004_bib0120","doi-asserted-by":"crossref","first-page":"C747","DOI":"10.1152\/ajpcell.00420.2004","article-title":"Dynamic fibroblast cytoskeletal response to subcutaneous tissue stretch ex vivo and in vivo","volume":"288","author":"Langevin","year":"2005","journal-title":"American Journal of Physiology \u2013 Cell Physiology"},{"key":"10.1016\/j.ceca.2013.01.004_bib0125","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1002\/jcp.22442","article-title":"Fibroblast cytoskeletal remodeling contributes to connective tissue tension","volume":"226","author":"Langevin","year":"2011","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.ceca.2013.01.004_bib0130","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrm809","article-title":"Myofibroblasts and mechano-regulation of connective tissue remodelling","volume":"3","author":"Tomasek","year":"2002","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"10.1016\/j.ceca.2013.01.004_bib0135","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s12195-010-0106-2","article-title":"Rho kinase regulation of fibroblast migratory mechanics in fibrillar collagen matrices","volume":"3","author":"Zhou","year":"2010","journal-title":"Cellular and Molecular Bioengineering"},{"key":"10.1016\/j.ceca.2013.01.004_bib0140","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/jcp.24102","article-title":"Stress and matrix-responsive cytoskeletal remodeling in fibroblasts","volume":"228","author":"Abbott","year":"2013","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.ceca.2013.01.004_bib0145","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1113\/jphysiol.2008.153015","article-title":"Fluid flow induces mechanosensitive ATP release, calcium signalling and Cl-transport in biliary epithelial cells through a PKCzeta-dependent pathway","volume":"586","author":"Woo","year":"2008","journal-title":"Journal of Physiology"},{"key":"10.1016\/j.ceca.2013.01.004_bib0150","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00418-004-0667-z","article-title":"Fibroblasts form a body-wide cellular network","volume":"122","author":"Langevin","year":"2004","journal-title":"Histochemistry and Cell Biology"},{"key":"10.1016\/j.ceca.2013.01.004_bib0155","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1524-4725.2011.02201.x","article-title":"The role of massage in scar management: a literature review","volume":"38","author":"Shin","year":"2012","journal-title":"Dermatologic Surgery"},{"key":"10.1016\/j.ceca.2013.01.004_bib0160","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/1471-2474-10-151","article-title":"Ultrasound evidence of altered lumbar connective tissue structure in human subjects with chronic low back pain","volume":"10","author":"Langevin","year":"2009","journal-title":"BMC Musculoskeletal Disorders"},{"key":"10.1016\/j.ceca.2013.01.004_bib0165","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/1471-2474-12-203","article-title":"Reduced thoracolumbar fascia shear strain in human chronic low back pain","volume":"12","author":"Langevin","year":"2011","journal-title":"BMC Musculoskeletal Disorders"},{"key":"10.1016\/j.ceca.2013.01.004_bib0170","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.mehy.2006.06.033","article-title":"Pathophysiological model for chronic low back pain integrating connective tissue and nervous system mechanisms","volume":"68","author":"Langevin","year":"2007","journal-title":"Medical Hypotheses"},{"key":"10.1016\/j.ceca.2013.01.004_bib0175","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s11302-012-9299-2","article-title":"Anti-inflammatory effects of purine nucleosides, adenosine and inosine, in a mouse model of pleurisy: evidence for the role of adenosine A2 receptors","volume":"8","author":"da Rocha Lapa","year":"2012","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.ceca.2013.01.004_bib0180","doi-asserted-by":"crossref","first-page":"e2107","DOI":"10.1371\/journal.pone.0002107","article-title":"Anti-inflammatory preconditioning by agonists of adenosine A1 receptor","volume":"3","author":"Nakav","year":"2008","journal-title":"PLoS ONE"}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416013000262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416013000262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T20:16:42Z","timestamp":1758917802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416013000262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0143416013000262"],"URL":"https:\/\/doi.org\/10.1016\/j.ceca.2013.01.004","relation":{},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceca.2013.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}