{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:06:38Z","timestamp":1768284398181,"version":"3.49.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL16152"],"award-info":[{"award-number":["R01 HL16152"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.ceca.2015.12.002","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T06:22:01Z","timestamp":1450419721000},"page":"98-107","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Calcium signaling in human stem cell-derived cardiomyocytes: Evidence from normal subjects and CPVT afflicted patients"],"prefix":"10.1016","volume":"59","author":[{"given":"Xiao-Hua","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Morad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceca.2015.12.002_bib0350","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF00362542","article-title":"The effect of the duration of the action potential on contraction in the mammalian heart muscle","volume":"299","author":"Morad","year":"1968","journal-title":"Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere"},{"key":"10.1016\/j.ceca.2015.12.002_bib0355","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1113\/jphysiol.1971.sp009656","article-title":"Excitation-concentration coupling in frog ventricle: evidence from voltage clamp studies","volume":"219","author":"Morad","year":"1971","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0360","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.ceca.2015.12.002_bib0365","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00656997","article-title":"Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches","volume":"391","author":"Hamill","year":"1981","journal-title":"Pflugers Archiv: European Journal of Physiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0370","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1126\/science.2543067","article-title":"Regulation of calcium release is gated by calcium current, not gating charge, in cardiac myocytes","volume":"244","author":"Nabauer","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.ceca.2015.12.002_bib0375","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.1983.245.1.C1","article-title":"Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum","volume":"245","author":"Fabiato","year":"1983","journal-title":"The American Journal of Physiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0380","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1126\/science.8235594","article-title":"Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle","volume":"262","author":"Cheng","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.ceca.2015.12.002_bib0385","doi-asserted-by":"crossref","first-page":"10984","DOI":"10.1073\/pnas.95.18.10984","article-title":"Two-dimensional confocal images of organization, density, and gating of focal Ca2+ release sites in rat cardiac myocytes","volume":"95","author":"Cleemann","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.ceca.2015.12.002_bib0390","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1161\/01.RES.61.1.148","article-title":"Voltage dependence of intracellular [Ca2+]i transients in guinea pig ventricular myocytes","volume":"61","author":"Barcenas-Ruiz","year":"1987","journal-title":"Circulation Research"},{"key":"10.1016\/j.ceca.2015.12.002_bib0395","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1085\/jgp.108.5.435","article-title":"Cross-signaling between L-type Ca2+ channels and ryanodine receptors in rat ventricular myocytes","volume":"108","author":"Adachi-Akahane","year":"1996","journal-title":"The Journal of General Physiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0400","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/01.RES.0000051887.97625.07","article-title":"Spatiotemporal characteristics of junctional and nonjunctional focal Ca2+ release in rat atrial myocytes","volume":"92","author":"Woo","year":"2003","journal-title":"Circulation Research"},{"key":"10.1016\/j.ceca.2015.12.002_bib0405","first-page":"3188","article-title":"Tunicate heart as a possible model for the vertebrate heart","volume":"39","author":"Morad","year":"1980","journal-title":"Federation Proceedings"},{"key":"10.1016\/j.ceca.2015.12.002_bib0410","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.physiol.70.113006.100455","article-title":"Calcium cycling and signaling in cardiac myocytes","volume":"70","author":"Bers","year":"2008","journal-title":"Annual Review of Physiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0415","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1083\/jcb.120.5.1137","article-title":"Inositol 1,4,5-trisphosphate receptor expression in cardiac myocytes","volume":"120","author":"Moschella","year":"1993","journal-title":"The Journal of Cell Biology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0420","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.ceca.2005.06.016","article-title":"Ca2+ signalling in cardiogenesis","volume":"38","author":"Puceat","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2015.12.002_bib0425","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrm1149","article-title":"Calcium signalling during embryonic development","volume":"4","author":"Webb","year":"2003","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0430","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1006\/dbio.1996.8479","article-title":"Developmental expression of the inositol 1,4,5-trisphosphate receptor and structural changes in the endoplasmic reticulum during oogenesis and meiotic maturation of Xenopus laevis","volume":"182","author":"Kume","year":"1997","journal-title":"Developmental Biology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0435","doi-asserted-by":"crossref","first-page":"H1939","DOI":"10.1152\/ajpheart.00607.2009","article-title":"Developmental aspects of cardiac Ca(2+) signaling: interplay between RyR- and IP(3)R-gated Ca(2+) stores","volume":"298","author":"Janowski","year":"2010","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0440","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1161\/CIRCRESAHA.110.220038","article-title":"The IP3 receptor regulates cardiac hypertrophy in response to select stimuli","volume":"107","author":"Nakayama","year":"2010","journal-title":"Circulation Research"},{"key":"10.1016\/j.ceca.2015.12.002_bib0445","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1172\/JCI117739","article-title":"Differential regulation of two types of intracellular calcium release channels during end-stage heart failure","volume":"95","author":"Go","year":"1995","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.ceca.2015.12.002_bib0450","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cardiores.2005.05.015","article-title":"The 1,4,5-inositol trisphosphate pathway is a key component in Fas-mediated hypertrophy in neonatal rat ventricular myocytes","volume":"68","author":"Barac","year":"2005","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.ceca.2015.12.002_bib0455","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0006-291X(64)90212-8","article-title":"Binding of adenine nucleotides by mitochondria during active uptake of CA++","volume":"16","author":"Carafoli","year":"1964","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.ceca.2015.12.002_bib0460","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ceca.2007.11.002","article-title":"Mitochondrial Ca2+ and the heart","volume":"44","author":"Dedkova","year":"2008","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2015.12.002_bib0465","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0022-2828(92)93381-S","article-title":"Ultrastructural quantitation of mitochondria and myofilaments in cardiac muscle from 10 different animal species including man","volume":"24","author":"Barth","year":"1992","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0470","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1113\/jphysiol.2007.149294","article-title":"\u2018Pressure-flow\u2019-triggered intracellular Ca2+ transients in rat cardiac myocytes: possible mechanisms and role of mitochondria","volume":"586","author":"Belmonte","year":"2008","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0475","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ceca.2014.06.001","article-title":"Diversity of mitochondrial Ca(2)(+) signaling in rat neonatal cardiomyocytes: evidence from a genetically directed Ca(2)(+) probe, mitycam-E31Q","volume":"56","author":"Haviland","year":"2014","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2015.12.002_bib0480","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1159\/000335753","article-title":"In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells","volume":"28","author":"Fatima","year":"2011","journal-title":"Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0485","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/s12015-011-9273-3","article-title":"Calcium homeostasis in human induced pluripotent stem cell-derived cardiomyocytes","volume":"7","author":"Lee","year":"2011","journal-title":"Stem Cell Reviews"},{"key":"10.1016\/j.ceca.2015.12.002_bib0490","doi-asserted-by":"crossref","first-page":"e55266","DOI":"10.1371\/journal.pone.0055266","article-title":"Identification and characterization of calcium sparks in cardiomyocytes derived from human induced pluripotent stem cells","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ceca.2015.12.002_bib0495","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1089\/scd.2012.0490","article-title":"Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells","volume":"22","author":"Lundy","year":"2013","journal-title":"Stem Cells and Development"},{"key":"10.1016\/j.ceca.2015.12.002_bib0500","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1111\/j.1582-4934.2011.01417.x","article-title":"Cardiomyocytes derived from human embryonic and induced pluripotent stem cells: comparative ultrastructure","volume":"15","author":"Gherghiceanu","year":"2011","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10.1016\/j.ceca.2015.12.002_bib0505","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1089\/scd.2009.0052","article-title":"Absence of transverse tubules contributes to non-uniform Ca(2+) wavefronts in mouse and human embryonic stem cell-derived cardiomyocytes","volume":"18","author":"Lieu","year":"2009","journal-title":"Stem Cells and Development"},{"key":"10.1016\/j.ceca.2015.12.002_bib0510","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ceca.2013.04.004","article-title":"Ca2+ signaling in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CM) from normal and catecholaminergic polymorphic ventricular tachycardia (CPVT)-afflicted subjects","volume":"54","author":"Zhang","year":"2013","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2015.12.002_bib0515","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.yjmcc.2015.05.003","article-title":"Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories","volume":"85","author":"Hwang","year":"2015","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0520","doi-asserted-by":"crossref","first-page":"H2006","DOI":"10.1152\/ajpheart.00694.2011","article-title":"High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents","volume":"301","author":"Ma","year":"2011","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0525","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0079-6107(73)90008-4","article-title":"Excitation-contraction coupling in heart muscle: membrane control of development of tension","volume":"27","author":"Morad","year":"1973","journal-title":"Progress in Biophysics and Molecular Biology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0530","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0022-2828(87)80360-7","article-title":"Role of Ca2+ channel in development of tension in heart muscle","volume":"19","author":"Morad","year":"1987","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0535","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1113\/jphysiol.1991.sp018385","article-title":"Role of Ca2+ channel in cardiac excitation-contraction coupling in the rat: evidence from Ca2+ transients and contraction","volume":"432","author":"Cleemann","year":"1991","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0540","doi-asserted-by":"crossref","first-page":"C1126","DOI":"10.1152\/ajpcell.1995.268.5.C1126","article-title":"Distribution of the Na+\/Ca2+ exchange protein in developing rabbit myocytes","volume":"268","author":"Chen","year":"1995","journal-title":"The American Journal of Physiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0545","doi-asserted-by":"crossref","first-page":"e18037","DOI":"10.1371\/journal.pone.0018037","article-title":"Calcium handling in human induced pluripotent stem cell derived cardiomyocytes","volume":"6","author":"Itzhaki","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ceca.2015.12.002_bib0550","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1582-4934.2009.00996.x","article-title":"Molecular characterization and functional properties of cardiomyocytes derived from human inducible pluripotent stem cells","volume":"15","author":"Germanguz","year":"2011","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"Pt 3","key":"10.1016\/j.ceca.2015.12.002_bib0555","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1113\/jphysiol.1995.sp021078","article-title":"Calcium-induced calcium release in rat sensory neurons","volume":"489","author":"Shmigol","year":"1995","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0560","doi-asserted-by":"crossref","first-page":"e44660","DOI":"10.1371\/journal.pone.0044660","article-title":"Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations","volume":"7","author":"Kujala","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ceca.2015.12.002_bib0565","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1111\/jcmm.12581","article-title":"Functional abnormalities in iPSC-derived cardiomyocytes generated from CPVT1 and CPVT2 patients carrying ryanodine or calsequestrin mutations","volume":"19","author":"Novak","year":"2015","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10.1016\/j.ceca.2015.12.002_bib0570","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ceca.2015.02.003","article-title":"Regionally diverse mitochondrial calcium signaling regulates spontaneous pacing in developing cardiomyocytes","volume":"57","author":"Zhang","year":"2015","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2015.12.002_bib0575","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/dbio.1998.9120","article-title":"Intracellular calcium release channel expression during embryogenesis","volume":"206","author":"Rosemblit","year":"1999","journal-title":"Developmental Biology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0580","first-page":"H597","article-title":"Intracellular calcium-release channels: regulators of cell life and death","volume":"272","author":"Marks","year":"1997","journal-title":"The American Journal of Physiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0585","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1152\/physrev.00004.2005","article-title":"Microdomains of intracellular Ca2+: molecular determinants and functional consequences","volume":"86","author":"Rizzuto","year":"2006","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.ceca.2015.12.002_bib0590","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ceca.2007.04.017","article-title":"Nuclear Ca2+ sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes","volume":"43","author":"Luo","year":"2008","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2015.12.002_bib0595","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1634\/stemcells.2008-0777","article-title":"1,4,5-Inositol trisphosphate-operated intracellular Ca(2+) stores and angiotensin-II\/endothelin-1 signaling pathway are functional in human embryonic stem cell-derived cardiomyocytes","volume":"26","author":"Sedan","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.ceca.2015.12.002_bib0600","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1634\/stemcells.2007-0591","article-title":"Calcium handling in human embryonic stem cell-derived cardiomyocytes","volume":"26","author":"Satin","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.ceca.2015.12.002_bib0605","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pbiomolbio.2010.02.002","article-title":"Atrial local Ca2+ signaling and inositol 1,4,5-trisphosphate receptors","volume":"103","author":"Kim","year":"2010","journal-title":"Progress in Biophysics and Molecular Biology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0610","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1085\/jgp.200609575","article-title":"Intracellular Ca2+ oscillations, a potential pacemaking mechanism in early embryonic heart cells","volume":"130","author":"Sasse","year":"2007","journal-title":"The Journal of General Physiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0615","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1113\/jphysiol.2006.125955","article-title":"Inositol-1,4,5-trisphosphate-mediated spontaneous activity in mouse embryonic stem cell-derived cardiomyocytes","volume":"581","author":"Kapur","year":"2007","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0620","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1091\/mbc.e04-10-0883","article-title":"Initiation of embryonic cardiac pacemaker activity by inositol 1,4,5-trisphosphate-dependent calcium signaling","volume":"16","author":"Mery","year":"2005","journal-title":"Molecular Biology of the Cell"},{"key":"10.1016\/j.ceca.2015.12.002_bib0625","doi-asserted-by":"crossref","first-page":"e83715","DOI":"10.1371\/journal.pone.0083715","article-title":"Spatially defined InsP3-mediated signaling in embryonic stem cell-derived cardiomyocytes","volume":"9","author":"Kapoor","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ceca.2015.12.002_bib0630","doi-asserted-by":"crossref","first-page":"C1048","DOI":"10.1152\/ajpcell.00004.2004","article-title":"Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice","volume":"287","author":"Garcia","year":"2004","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0635","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1161\/01.CIR.103.2.196","article-title":"Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia","volume":"103","author":"Priori","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ceca.2015.12.002_bib0640","doi-asserted-by":"crossref","first-page":"e0015","DOI":"10.5041\/RMMJ.10086","article-title":"Modeling catecholaminergic polymorphic ventricular tachycardia using induced pluripotent stem cell-derived cardiomyocytes","volume":"3","author":"Novak","year":"2012","journal-title":"Rambam Maimonides Medical Journal"},{"key":"10.1016\/j.ceca.2015.12.002_bib0645","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1161\/01.RES.0000038886.18992.6B","article-title":"Absence of calsequestrin 2 causes severe forms of catecholaminergic polymorphic ventricular tachycardia","volume":"91","author":"Postma","year":"2002","journal-title":"Circulation Research"},{"key":"10.1016\/j.ceca.2015.12.002_bib0650","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0092-8674(03)00434-3","article-title":"FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death","volume":"113","author":"Wehrens","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.ceca.2015.12.002_bib0655","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1161\/01.RES.0000192146.85173.4b","article-title":"Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death","volume":"97","author":"Jiang","year":"2005","journal-title":"Circulation Research"},{"key":"10.1016\/j.ceca.2015.12.002_bib0660","first-page":"2230","article-title":"Leaky Ca2+ release channel\/ryanodine receptor 2 causes seizures and sudden cardiac death in mice","volume":"118","author":"Lehnart","year":"2008","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.ceca.2015.12.002_bib0665","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/emmm.201100194","article-title":"Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia","volume":"4","author":"Jung","year":"2012","journal-title":"EMBO Molecular Medicine"},{"key":"10.1016\/j.ceca.2015.12.002_bib0670","doi-asserted-by":"crossref","first-page":"e843","DOI":"10.1038\/cddis.2013.369","article-title":"CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia","volume":"4","author":"Di Pasquale","year":"2013","journal-title":"Cell Death & Disease"},{"key":"10.1016\/j.ceca.2015.12.002_bib0675","doi-asserted-by":"crossref","first-page":"e0125366","DOI":"10.1371\/journal.pone.0125366","article-title":"Antiarrhythmic effects of dantrolene in patients with catecholaminergic polymorphic ventricular tachycardia and replication of the responses using iPSC Models","volume":"10","author":"Penttinen","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ceca.2015.12.002_bib0680","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.jacc.2012.02.066","article-title":"Modeling of catecholaminergic polymorphic ventricular tachycardia with patient-specific human-induced pluripotent stem cells","volume":"60","author":"Itzhaki","year":"2012","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.ceca.2015.12.002_bib0685","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.str.2011.03.016","article-title":"The deletion of exon 3 in the cardiac ryanodine receptor is rescued by beta strand switching","volume":"19","author":"Lobo","year":"2011","journal-title":"Structure"},{"key":"10.1016\/j.ceca.2015.12.002_bib0690","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1471-213X-10-98","article-title":"Global transcriptional profiles of beating clusters derived from human induced pluripotent stem cells and embryonic stem cells are highly similar","volume":"10","author":"Gupta","year":"2010","journal-title":"BMC Developmental Biology"}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416015001736?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416015001736?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T20:21:45Z","timestamp":1758918105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416015001736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":69,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0143416015001736"],"URL":"https:\/\/doi.org\/10.1016\/j.ceca.2015.12.002","relation":{},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Calcium signaling in human stem cell-derived cardiomyocytes: Evidence from normal subjects and CPVT afflicted patients","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceca.2015.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}