{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T20:40:06Z","timestamp":1758919206288,"version":"3.44.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T00:00:00Z","timestamp":1545782400000},"content-version":"am","delay-in-days":239,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Institutional Development Award"},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM103527"],"award-info":[{"award-number":["P20GM103527"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIH\/NIGMS","doi-asserted-by":"publisher","award":["R35GM124977"],"award-info":[{"award-number":["R35GM124977"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NIH National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R56HL131782"],"award-info":[{"award-number":["R56HL131782"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL118474","R01HL109501"],"award-info":[{"award-number":["R01HL118474","R01HL109501"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CBET 1357600"],"award-info":[{"award-number":["CBET 1357600"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.ceca.2017.11.006","type":"journal-article","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T17:33:06Z","timestamp":1512754386000},"page":"65-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Computational modeling of amylin-induced calcium dysregulation in rat ventricular cardiomyocytes"],"prefix":"10.1016","volume":"71","author":[{"given":"Bradley D.","family":"Stewart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin E.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas P.","family":"McCoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florin","family":"Despa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanda","family":"Despa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Kekenes-Huskey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceca.2017.11.006_bib0005","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1152\/physrev.00042.2009","article-title":"Islet amyloid polypeptide, islet amyloid, and diabetes mellitus","volume":"91","author":"Westermark","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ceca.2017.11.006_bib0010","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3233\/JAD-160047","article-title":"Intraneuronal amylin deposition, peroxidative membrane injury and increased IL-1\u03b2 synthesis in brains of Alzheimer's disease patients with type-2 diabetes and in diabetic HIP rats","volume":"53","author":"Verma","year":"2016","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.ceca.2017.11.006_bib0015","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.2337\/db16-0044","article-title":"Hyperamylinemia increases IL-1\u03b2 synthesis in the heart via peroxidative sarcolemmal injury","volume":"65","author":"Liu","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.ceca.2017.11.006_bib0020","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.bpj.2012.06.045","article-title":"Two-step mechanism of membrane disruption by A\u03b2 through membrane fragmentation and pore formation","volume":"103","author":"Sciacca","year":"2012","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2017.11.006_bib0025","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1074\/jbc.271.4.1988","article-title":"Pore formation by the cytotoxic islet amyloid peptide amylin","volume":"271","author":"Mirzabekov","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2017.11.006_bib0030","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/CIRCRESAHA.111.258285","article-title":"Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats","volume":"110","author":"Despa","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.ceca.2017.11.006_bib0035","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1073\/pnas.84.23.8628","article-title":"Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients","volume":"84","author":"Cooper","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ceca.2017.11.006_bib0040","first-page":"E446","article-title":"Amylin\u2013insulin relationships in insulin resistance with and without diabetic hyperglycemia","volume":"265","author":"Pieber","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0045","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1210\/er.2007-0037","article-title":"Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis","volume":"29","author":"Haataja","year":"2008","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ceca.2017.11.006_bib0050","doi-asserted-by":"crossref","first-page":"e001015","DOI":"10.1161\/JAHA.114.001015","article-title":"Cardioprotection by controlling hyperamylinemia in a \u201chumanized\u201d diabetic rat model","volume":"3","author":"Despa","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ceca.2017.11.006_bib0055","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s00125-014-3171-6","article-title":"Molecular mechanisms of diabetic cardiomyopathy","volume":"57","author":"Bugger","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.ceca.2017.11.006_bib0060","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1021\/bi901444w","article-title":"Simultaneous single-molecule fluorescence and conductivity studies reveal distinct classes of A\u03b2 species on lipid bilayers","volume":"49","author":"Schauerte","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.ceca.2017.11.006_bib0065","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1042\/BST0350957","article-title":"Calcium in the heart: when it's good it's very very good, but when it's bad, it's horrid","volume":"35","author":"Roderick","year":"2007","journal-title":"Biochem. Soc. Trans."},{"volume":"vol. 1","year":"2001","author":"Bers","key":"10.1016\/j.ceca.2017.11.006_bib0070"},{"key":"10.1016\/j.ceca.2017.11.006_bib0075","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0006-3495(98)77520-4","article-title":"Na\u2013Ca exchange and the trigger for sarcoplasmic reticulum Ca release: studies in adult rabbit ventricular myocytes","volume":"75","author":"Litwin","year":"1998","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2017.11.006_bib0080","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.yjmcc.2016.10.015","article-title":"I love it when a plan comes together: insight gained through convergence of competing mathematical models","volume":"102","author":"Gong","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0085","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.sbi.2014.01.006","article-title":"Computational modeling of subcellular transport and signaling","volume":"25","author":"Hake","year":"2014","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0090","doi-asserted-by":"crossref","first-page":"158rv11","DOI":"10.1126\/scitranslmed.3003528","article-title":"Computational medicine: translating models to clinical care","volume":"4","author":"Winslow","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ceca.2017.11.006_bib0095","doi-asserted-by":"crossref","first-page":"H1045","DOI":"10.1152\/ajpheart.00219.2010","article-title":"A mathematical model of the murine ventricular myocyte: a data-driven biophysically based approach applied to mice overexpressing the canine NCX isoform","volume":"299","author":"Li","year":"2010","journal-title":"AJP Heart Circ. Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0100","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.bpj.2011.07.021","article-title":"Dynamics of calcium sparks and calcium leak in the heart","volume":"101","author":"Williams","year":"2011","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2017.11.006_bib0105","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1016\/j.bpj.2014.11.003","article-title":"Superresolution modeling of calcium release in the heart","volume":"107","author":"Walker","year":"2014","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2017.11.006_bib0110","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3389\/fphys.2012.00351","article-title":"Modeling effects of L-type Ca(2+) current and Na(+)\u2013Ca(2+) exchanger on Ca(2+) trigger flux in rabbit myocytes with realistic T-tubule geometries","volume":"3","author":"Kekenes-Huskey","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0115","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1529\/biophysj.104.047449","article-title":"A mathematical treatment of integrated Ca dynamics within the ventricular myocyte","volume":"87","author":"Shannon","year":"2004","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2017.11.006_bib0120","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1161\/01.CIR.0000016701.85760.97","article-title":"Intracellular Na(+) concentration is elevated in heart failure but Na\/K pump function is unchanged","volume":"105","author":"Despa","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ceca.2017.11.006_bib0125","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1113\/JP272011","article-title":"The calcium-frequency response in the rat ventricular myocyte: an experimental and modelling study","volume":"594","author":"Gattoni","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0130","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.yjmcc.2015.07.016","article-title":"There and back again: iterating between population-based modeling and experiments reveals surprising regulation of calcium transients in rat cardiac myocytes","volume":"96","author":"Devenyi","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0135","first-page":"H1335","article-title":"Cardiac myocyte calcium transport in phospholamban knockout mouse: relaxation and endogenous CaMKII effects","volume":"274","author":"Li","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0140","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1113\/jphysiol.1994.sp020130","article-title":"Relaxation in rabbit and rat cardiac cells: species-dependent differences in cellular mechanisms","volume":"476","author":"Bassani","year":"1994","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0145","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1113\/jphysiol.2013.266676","article-title":"A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII","volume":"592","author":"Morotti","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0150","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1469-7793.2000.00121.x","article-title":"Effects of amylin and other peptide hormones on Na+\u2013K+ transport and contractility in rat skeletal muscle","volume":"527","author":"Clausen","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0155","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1137\/0904010","article-title":"Automatic selection of methods for solving stiff and nonstiff systems of ordinary differential equations","volume":"4","author":"Petzold","year":"1983","journal-title":"SIAM J. Sci. Stat. Comput."},{"key":"10.1016\/j.ceca.2017.11.006_bib0160","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1109\/2.294849","article-title":"Genetic algorithms: a survey","volume":"27","author":"Srinivas","year":"1994","journal-title":"Computer"},{"key":"10.1016\/j.ceca.2017.11.006_bib0165","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1016\/S0006-3495(01)75943-7","article-title":"A mathematical model of action potential heterogeneity in adult rat left ventricular myocytes","volume":"81","author":"Pandit","year":"2001","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2017.11.006_bib0170","doi-asserted-by":"crossref","first-page":"C146","DOI":"10.1152\/ajpcell.00017.2008","article-title":"Poloxamer 188 reduces the contraction-induced force decline in lumbrical muscles from MDX mice","volume":"295","author":"Ng","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0175","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.bbamem.2007.01.012","article-title":"Structural and functional recovery of electropermeabilized skeletal muscle in-vivo after treatment with surfactant poloxamer 188","volume":"1768","author":"Collins","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ceca.2017.11.006_bib0180","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1161\/01.HYP.34.6.1242","article-title":"Epoxyeicosatrienoic acids increase intracellular calcium concentration in vascular smooth muscle cells","volume":"34","author":"Fang","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.ceca.2017.11.006_bib0185","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0026-895X(24)12026-3","article-title":"Inhibition of cardiac L-type calcium channels by epoxyeicosatrienoic acids","volume":"55","author":"Chen","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0190","doi-asserted-by":"crossref","first-page":"608","DOI":"10.2337\/diabetes.55.03.06.db05-1284","article-title":"Mechanisms of [Ca2+](i) transient decrease in cardiomyopathy of db\/db type 2 diabetic mice","volume":"55","author":"Pereira","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.ceca.2017.11.006_bib0195","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1006\/jmcc.2002.2034","article-title":"Frequency-dependent acceleration of relaxation in the heart depends on CaMKII, but not phospholamban","volume":"34","author":"DeSantiago","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0200","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/j.bpj.2012.03.045","article-title":"Sodium accumulation in SERCA knockout-induced heart failure","volume":"102","author":"Li","year":"2012","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2017.11.006_bib0205","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.1113\/jphysiol.2011.211052","article-title":"Changes of SERCA activity have only modest effects on sarcoplasmic reticulum Ca2+ content in rat ventricular myocytes","volume":"589","author":"Bode","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0210","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.bpj.2010.04.071","article-title":"Sodium-calcium exchange is essential for effective triggering of calcium release in mouse heart","volume":"99","author":"Neco","year":"2010","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2017.11.006_bib0215","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1083\/jcb.200710107","article-title":"Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathway","volume":"180","author":"Lowe","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0220","first-page":"1","article-title":"The role of dyadic organization in regulation of sarcoplasmic reticulum Ca2+ handling during rest in rabbit ventricular myocytes","author":"Bovo","year":"2014","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2017.11.006_bib0225","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1085\/jgp.113.3.469","article-title":"Local control models of cardiac excitation\u2013contraction coupling. A possible role for allosteric interactions between ryanodine receptors","volume":"113","author":"Stern","year":"1999","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0230","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1085\/jgp.110.4.415","article-title":"Local control model of excitation contraction coupling in skeletal muscle","volume":"110","author":"Stern","year":"1997","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0235","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/415198a","article-title":"Cardiac excitation\u2013contraction coupling","volume":"415","author":"Bers","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2017.11.006_bib0240","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.bbrc.2004.07.121","article-title":"Calcium calcineurin signaling in the regulation of cardiac hypertrophy","volume":"322","author":"Wilkins","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ceca.2017.11.006_bib0245","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuropharm.2016.07.008","article-title":"Multiple target of hAmylin on rat primary hippocampal neurons","volume":"113","author":"Zhang","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ceca.2017.11.006_bib0250","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1096\/fj.05-4749com","article-title":"Extracellular ATP-stimulated current in wild-type and P2X4 receptor transgenic mouse ventricular myocytes: implications for a cardiac physiologic role of P2X4 receptors","volume":"20","author":"Shen","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.ceca.2017.11.006_bib0255","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1113\/jphysiol.2002.025619","article-title":"Mechanisms underlying the frequency dependence of contraction and [Ca(2+)](i) transients in mouse ventricular myocytes","volume":"543","author":"Antoons","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0260","first-page":"H703","article-title":"CaMKII is responsible for activity-dependent acceleration of relaxation in rat ventricular myocytes","volume":"268","author":"Bassani","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0265","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1161\/01.RES.0000236790.08267.74","article-title":"Life, sudden death, and intracellular calcium","volume":"99","author":"Eisner","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.ceca.2017.11.006_bib0270","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/cvr\/cvv149","article-title":"Stochastic spontaneous calcium release events trigger premature ventricular complexes by overcoming electrotonic load","volume":"107","author":"Campos","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ceca.2017.11.006_bib0275","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1161\/hh0202.103230","article-title":"Ca2+ signaling in cardiac myocytes overexpressing the \u03b11 subunit of L-type Ca2+ channel","volume":"90","author":"Song","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.ceca.2017.11.006_bib0280","doi-asserted-by":"crossref","DOI":"10.1161\/01.RES.0000200739.90811.9f","article-title":"Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes","volume":"98","author":"Kohlhaas","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.ceca.2017.11.006_bib0285","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/j.bpj.2012.04.015","article-title":"CaMKII\u03b4C slows [Ca]i decline in cardiac myocytes by promoting Ca sparks","volume":"102","author":"Guo","year":"2012","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2017.11.006_bib0290","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.yjmcc.2014.10.018","article-title":"T-tubule disruption promotes calcium alternans in failing ventricular myocytes: mechanistic insights from computational modeling","volume":"79","author":"Nivala","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0295","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1152\/physrev.2000.80.2.853","article-title":"Regulation of contraction in striated muscle","volume":"80","author":"Gordon","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ceca.2017.11.006_bib0300","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1006\/jmcc.2002.2038","article-title":"Calcium, calmodulin, and calcium-calmodulin kinase II: heartbeat to heartbeat and beyond","volume":"34","author":"Maier","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0305","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.yjmcc.2011.10.018","article-title":"Cardiomyocyte calcineurin signaling in subcellular domains: from the sarcolemma to the nucleus and beyond","volume":"52","author":"Heineke","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0310","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.physiol.70.113006.100455","article-title":"Calcium cycling and signaling in cardiac myocytes","volume":"70","author":"Bers","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0315","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/j.bpj.2008.11.064","article-title":"Sensitivity of NFAT cycling to cytosolic calcium concentration: implications for hypertrophic signals in cardiac myocytes","volume":"96","author":"Cooling","year":"2009","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2017.11.006_bib0320","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1113\/jphysiol.2009.183517","article-title":"Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout","volume":"588","author":"Louch","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0325","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2170\/jjphysiol.54.523","article-title":"Computational modeling of cardiac ventricular action potentials in rat and mouse: review","volume":"54","author":"Demir","year":"2004","journal-title":"Jpn. J. Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0330","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1095-6433(02)00177-0","article-title":"Comparison of cardiac excitation\u2013contraction coupling in isolated ventricular myocytes between rat and mouse","volume":"133","author":"Hintz","year":"2002","journal-title":"Comp. Biochem. Physiol. A: Mol. Integr. Physiol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/503906","article-title":"There goes the neighborhood: pathological alterations in T-tubule morphology and consequences for cardiomyocyte Ca2+ handling","volume":"2010","author":"Louch","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.ceca.2017.11.006_bib0340","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.2337\/db05-1216","article-title":"Imaging of insulin signaling in skeletal muscle of living mice shows major role of T-tubules","volume":"55","author":"Lauritzen","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.ceca.2017.11.006_bib0345","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1529\/biophysj.107.107888","article-title":"Insulin transport within skeletal muscle transverse tubule networks","volume":"93","author":"Shorten","year":"2007","journal-title":"Biophys. J."}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416017301537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416017301537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T20:23:22Z","timestamp":1758918202000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416017301537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":69,"alternative-id":["S0143416017301537"],"URL":"https:\/\/doi.org\/10.1016\/j.ceca.2017.11.006","relation":{},"ISSN":["0143-4160"],"issn-type":[{"type":"print","value":"0143-4160"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Computational modeling of amylin-induced calcium dysregulation in rat ventricular cardiomyocytes","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceca.2017.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}