{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:27:02Z","timestamp":1790404022231,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Agency for Innovation by Science and Technology"},{"name":"Belgian Federal Government","award":["IUAP P7\/13"],"award-info":[{"award-number":["IUAP P7\/13"]}]},{"name":"FWO","award":["G.0702.12"],"award-info":[{"award-number":["G.0702.12"]}]},{"name":"Research Council of the KU Leuven","award":["GOA\/14\/011"],"award-info":[{"award-number":["GOA\/14\/011"]}]},{"name":"Research Council of the KU Leuven","award":["PF-TRPLe"],"award-info":[{"award-number":["PF-TRPLe"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.ceca.2018.04.004","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T11:45:11Z","timestamp":1523706311000},"page":"72-81","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":88,"special_numbering":"C","title":["Differential effects of lipopolysaccharide on mouse sensory TRP channels"],"prefix":"10.1016","volume":"73","author":[{"given":"Brett","family":"Boonen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeranddy A.","family":"Alpizar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"L\u00f3pez-Requena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Voets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Talavera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceca.2018.04.004_bib0005","doi-asserted-by":"crossref","first-page":"9577","DOI":"10.1073\/pnas.0502272102","article-title":"The evolution of vertebrate toll-like receptors","volume":"102","author":"Roach","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ceca.2018.04.004_bib0010","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev.immunol.24.021605.090552","article-title":"Genetic analysis of host resistance: toll-like receptor signaling and immunity at large","volume":"24","author":"Beutler","year":"2006","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ceca.2018.04.004_bib0015","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.ceca.2018.04.004_bib0020","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ceca.2018.04.004_bib0025","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1476-5381.1992.tb14503.x","article-title":"The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia","volume":"107","author":"Cunha","year":"1992","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ceca.2018.04.004_bib0030","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/35093019","article-title":"Molecular mechanisms of nociception","volume":"413","author":"Julius","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2018.04.004_bib0035","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature12479","article-title":"Bacteria activate sensory neurons that modulate pain and inflammation","volume":"501","author":"Chiu","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2018.04.004_bib0040","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1177\/0022034511400225","article-title":"LPS sensitizes TRPV1 via activation of TLR4 in trigeminal sensory neurons","volume":"90","author":"Diogenes","year":"2011","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.ceca.2018.04.004_bib0045","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.joen.2007.07.001","article-title":"Lipopolysaccharide from Porphyromonas gingivalis sensitizes capsaicin-sensitive nociceptors","volume":"37","author":"Ferraz","year":"2011","journal-title":"J. Endod."},{"key":"10.1016\/j.ceca.2018.04.004_bib0050","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1038\/ncomms4125","article-title":"TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins","volume":"5","author":"Meseguer","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ceca.2018.04.004_bib0055","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.13133","article-title":"Gustatory-mediated avoidance of bacterial lipopolysaccharides via TRPA1 activation in Drosophila","volume":"5","author":"Soldano","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.ceca.2018.04.004_bib0060","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s00424-012-1204-x","article-title":"Bimodal effects of cinnamaldehyde and camphor on mouse TRPA1","volume":"465","author":"Alpizar","year":"2013","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.ceca.2018.04.004_bib0065","doi-asserted-by":"crossref","first-page":"9874","DOI":"10.1523\/JNEUROSCI.2221-07.2007","article-title":"Bimodal action of menthol on the transient receptor potential channel TRPA1","volume":"27","author":"Karashima","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2018.04.004_bib0070","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.cub.2005.04.018","article-title":"The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin","volume":"15","author":"Macpherson","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ceca.2018.04.004_bib0075","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.mcn.2006.05.005","article-title":"More than cool: promiscuous relationships of menthol and other sensory compounds","volume":"32","author":"Macpherson","year":"2006","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.ceca.2018.04.004_bib0080","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nn1692","article-title":"Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels","volume":"9","author":"Xu","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ceca.2018.04.004_bib0085","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.cub.2011.01.031","article-title":"The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil","volume":"21","author":"Everaerts","year":"2011","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ceca.2018.04.004_bib0090","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/s41467-017-01201-3","article-title":"TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells","volume":"8","author":"Alpizar","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ceca.2018.04.004_bib0095","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1073\/pnas.0808487106","article-title":"TRPA1 acts as a cold sensor in vitro and in vivo","volume":"106","author":"Karashima","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ceca.2018.04.004_bib0100","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/emmm.201100134","article-title":"Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors","volume":"3","author":"Descoeur","year":"2011","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ceca.2018.04.004_bib0105","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2018.04.004_bib0110","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1113\/jphysiol.1993.sp019813","article-title":"Mobile and immobile calcium buffers in bovine adrenal chromaffin cells","volume":"469","author":"Zhou","year":"1993","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2018.04.004_bib0115","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.chemphyslip.2010.12.008","article-title":"Spontaneous insertion of lipopolysaccharide into lipid membranes from aqueous solution","volume":"164","author":"Alam","year":"2011","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.ceca.2018.04.004_bib0120","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/cbf.290050107","article-title":"Effect of Escherichia coli lipopolysaccharide on the microviscosity of liver plasma membranes and hepatocyte suspensions and monolayers","volume":"5","author":"Portol\u00e9s","year":"1987","journal-title":"Cell. Biochem. Funct."},{"key":"10.1016\/j.ceca.2018.04.004_bib0125","doi-asserted-by":"crossref","first-page":"35508","DOI":"10.1038\/srep35508","article-title":"Lipopolysaccharide-induced hemolysis: evidence for direct membrane interactions","volume":"6","author":"Brauckmann","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ceca.2018.04.004_bib0130","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nn2056","article-title":"A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic","volume":"11","author":"Salazar","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ceca.2018.04.004_bib0135","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0028-3908(03)00305-8","article-title":"Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1\/TRPV1) antagonist","volume":"46","author":"Gunthorpe","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ceca.2018.04.004_bib0140","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0092-8674(02)00637-2","article-title":"Molecular basis for species-specific sensitivity to \"hot\" chili peppers","volume":"108","author":"Jordt","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.ceca.2018.04.004_bib0145","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1038\/ncb1801","article-title":"Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells","volume":"10","author":"Wagner","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ceca.2018.04.004_bib0150","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nature02732","article-title":"The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels","volume":"430","author":"Voets","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2018.04.004_bib0155","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0092-8674(02)00652-9","article-title":"A TRP channel that senses cold stimuli and menthol","volume":"108","author":"Peier","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.ceca.2018.04.004_bib0160","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S1471-4906(02)02316-5","article-title":"Formyl-peptide receptors revisited","volume":"23","author":"Le","year":"2002","journal-title":"Trends Immunol."},{"key":"10.1016\/j.ceca.2018.04.004_bib0165","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1462-5822.2005.00610.x","article-title":"Neutrophil chemotaxis by pathogen-associated molecular patterns--formylated peptides are crucial but not the sole neutrophil attractants produced by Staphylococcus aureus","volume":"8","author":"Durr","year":"2006","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.ceca.2018.04.004_bib0170","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1128\/CMR.13.1.16","article-title":"Exotoxins of Staphylococcus aureus","volume":"13","author":"Dinges","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ceca.2018.04.004_bib0175","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/154405910608500108","article-title":"Trigeminal nociceptors express TLR-4 and CD14: a mechanism for pain due to infection","volume":"85","author":"Wadachi","year":"2006","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.ceca.2018.04.004_bib0180","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1128\/CMR.8.2.268","article-title":"Endotoxemia: methods of detection and clinical correlates","volume":"8","author":"Hurley","year":"1995","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ceca.2018.04.004_bib0185","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1099\/jmm.0.45976-0","article-title":"Quantification of endotoxins in necrotic root canals from symptomatic and asymptomatic teeth","volume":"54","author":"Jacinto","year":"2005","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.ceca.2018.04.004_bib0190","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1084\/jem.20111355","article-title":"TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation","volume":"209","author":"Tauseef","year":"2012","journal-title":"J. Exp. Med."},{"issue":"Pt. 1","key":"10.1016\/j.ceca.2018.04.004_bib0195","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1042\/bj3250223","article-title":"Involvement of diacylglycerol production in activation of nuclear factor kappaB by a CD14-mediated lipopolysaccharide stimulus","volume":"325","author":"Yamamoto","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.ceca.2018.04.004_bib0200","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2202-14-21","article-title":"Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse","volume":"14","author":"Vandewauw","year":"2013","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.ceca.2018.04.004_bib0205","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1744-8069-4-42","article-title":"Direct activation of transient receptor potential vanilloid 1 (TRPV1) by diacylglycerol (DAG)","volume":"4","author":"Woo","year":"2008","journal-title":"Mol. Pain"},{"key":"10.1016\/j.ceca.2018.04.004_bib0210","doi-asserted-by":"crossref","first-page":"24079","DOI":"10.1074\/jbc.M114.572503","article-title":"Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogs","volume":"289","author":"Morales-Lazaro","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2018.04.004_bib0215","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nchembio.712","article-title":"Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site","volume":"8","author":"Nieto-Posadas","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ceca.2018.04.004_bib0220","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.neuron.2011.02.051","article-title":"TRPM3 is a nociceptor channel involved in the detection of noxious heat","volume":"70","author":"Vriens","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.ceca.2018.04.004_bib0225","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.neuron.2004.08.038","article-title":"The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel","volume":"43","author":"Chuang","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.ceca.2018.04.004_bib0230","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature719","article-title":"Identification of a cold receptor reveals a general role for TRP channels in thermosensation","volume":"416","author":"McKemy","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2018.04.004_bib0235","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.1038\/ncomms8150","article-title":"TRPM8 is a neuronal osmosensor that regulates eye blinking in mice","volume":"6","author":"Quallo","year":"2015","journal-title":"Nat. Commun."}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416018300022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416018300022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T20:24:40Z","timestamp":1758918280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416018300022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":47,"alternative-id":["S0143416018300022"],"URL":"https:\/\/doi.org\/10.1016\/j.ceca.2018.04.004","relation":{},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential effects of lipopolysaccharide on mouse sensory TRP channels","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceca.2018.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}