{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:28:53Z","timestamp":1790299733934,"version":"4.1.0"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.ceca.2019.102132","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T01:51:58Z","timestamp":1574646718000},"page":"102132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Type 3 inositol 1,4,5-trisphosphate receptor: A calcium channel for all seasons"],"prefix":"10.1016","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9037-5129","authenticated-orcid":false,"given":"Anjali","family":"Mangla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8187-2753","authenticated-orcid":false,"given":"Mateus T.","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Nathanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceca.2019.102132_bib0005","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1152\/physrev.00035.2006","article-title":"Inositol trisphosphate receptor Ca2+ release channels","volume":"87","author":"Foskett","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ceca.2019.102132_bib0010","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a035063","article-title":"Structure and function of IP3 receptors","volume":"11","author":"Prole","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ceca.2019.102132_bib0015","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.1074\/jbc.M115.705301","article-title":"Unique regulatory properties of heterotetrameric inositol 1,4,5-trisphosphate receptors revealed by studying concatenated receptor constructs","volume":"291","author":"Chandrasekhar","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2019.102132_bib0020","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","article-title":"Calcium signalling: dynamics, homeostasis and remodelling","volume":"4","author":"Berridge","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ceca.2019.102132_bib0025","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.1074\/jbc.M706550200","article-title":"c-Met must translocate to the nucleus to initiate calcium signals","volume":"283","author":"Gomes","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"45","key":"10.1016\/j.ceca.2019.102132_bib0030","doi-asserted-by":"crossref","first-page":"16650","DOI":"10.1074\/jbc.RA118.006961","article-title":"Epidermal growth factor (EGF) triggers nuclear calcium signaling through the intranuclear phospholipase C delta-4 (PLCdelta4)","volume":"294","author":"de Miranda","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2019.102132_bib0035","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature15249","article-title":"Gating machinery of InsP3R channels revealed by electron cryomicroscopy","volume":"527","author":"Fan","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2019.102132_bib0040","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/s41594-018-0089-6","article-title":"Structural basis for the regulation of inositol trisphosphate receptors by Ca(2+) and IP3","volume":"25","author":"Paknejad","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ceca.2019.102132_bib0045","doi-asserted-by":"crossref","first-page":"8106","DOI":"10.1074\/jbc.M108337200","article-title":"A novel recombinant hyperaffinity inositol 1,4,5-trisphosphate (IP(3)) absorbent traps IP(3), resulting in specific inhibition of IP(3)-mediated calcium signaling","volume":"277","author":"Uchiyama","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2019.102132_bib0050","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1113\/jphysiol.2008.152314","article-title":"Regulation of single inositol 1,4,5-trisphosphate receptor channel activity by protein kinase A phosphorylation","volume":"586","author":"Wagner","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2019.102132_bib0055","doi-asserted-by":"crossref","first-page":"21579","DOI":"10.1074\/jbc.M801680200","article-title":"ATP modulation of Ca2+ release by type-2 and type-3 inositol (1, 4, 5)-triphosphate receptors. Differing ATP sensitivities and molecular determinants of action","volume":"283","author":"Betzenhauser","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2019.102132_bib0060","doi-asserted-by":"crossref","first-page":"15688","DOI":"10.1074\/jbc.M110.206482","article-title":"Isoform-specific regulation of the inositol 1,4,5-trisphosphate receptor by O-linked glycosylation","volume":"286","author":"Bimboese","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2019.102132_bib0065","doi-asserted-by":"crossref","first-page":"8170","DOI":"10.1074\/jbc.M113.504159","article-title":"Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species","volume":"289","author":"Bansaghi","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2019.102132_bib0070","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/23954","article-title":"Type III InsP3 receptor channel stays open in the presence of increased calcium","volume":"396","author":"Hagar","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2019.102132_bib0075","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/351751a0","article-title":"Bell-shaped calcium-response curves of Ins(1,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum","volume":"351","author":"Bezprozvanny","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2019.102132_bib0080","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/emboj\/18.5.1303","article-title":"Encoding of Ca2+ signals by differential expression of IP3 receptor subtypes","volume":"18","author":"Miyakawa","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.ceca.2019.102132_bib0085","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0006-3495(01)75685-8","article-title":"Single-channel recordings of recombinant inositol trisphosphate receptors in mammalian nuclear envelope","volume":"81","author":"Boehning","year":"2001","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2019.102132_bib0090","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1529\/biophysj.104.049593","article-title":"Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms","volume":"88","author":"Tu","year":"2005","journal-title":"Biophys. J."},{"key":"10.1016\/j.ceca.2019.102132_bib0095","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0896-6273(01)80037-4","article-title":"Calmodulin mediates calcium-dependent inactivation of the cerebellar type 1 inositol 1,4,5-trisphosphate receptor","volume":"23","author":"Michikawa","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.ceca.2019.102132_bib0100","doi-asserted-by":"crossref","first-page":"12755","DOI":"10.1074\/jbc.M609833200","article-title":"Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors","volume":"282","author":"Iwai","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2019.102132_bib0105","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1042\/bj3550059","article-title":"Selective recognition of inositol phosphates by subtypes of the inositol trisphosphate receptor","volume":"355","author":"Nerou","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.ceca.2019.102132_bib0110","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1053\/gast.2002.32363","article-title":"The type II inositol 1,4,5-trisphosphate receptor can trigger Ca2+ waves in rat hepatocytes","volume":"122","author":"Hirata","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ceca.2019.102132_bib0115","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0006-291X(05)81219-7","article-title":"Inositol 1,4,5-trisphosphate receptor is phosphorylated by cyclic AMP-dependent protein kinase at serines 1755 and 1589","volume":"175","author":"Ferris","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ceca.2019.102132_bib0120","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1074\/jbc.273.10.5670","article-title":"Phosphorylation of inositol 1,4,5-trisphosphate receptors by cAMP-dependent protein kinase. Type I, II, and III receptors are differentially susceptible to phosphorylation and are phosphorylated in intact cells","volume":"273","author":"Wojcikiewicz","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2019.102132_bib0125","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ceca.2006.12.002","article-title":"Calcium mobilization via type III inositol 1,4,5-trisphosphate receptors is not altered by PKA-mediated phosphorylation of serines 916, 934, and 1832","volume":"42","author":"Soulsby","year":"2007","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2019.102132_bib0130","doi-asserted-by":"crossref","first-page":"25116","DOI":"10.1074\/jbc.M109.010132","article-title":"Protein kinase A increases type-2 inositol 1,4,5-trisphosphate receptor activity by phosphorylation of serine 937","volume":"284","author":"Betzenhauser","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2019.102132_bib0135","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ceca.2016.10.005","article-title":"Regulation of IP3 receptors by cyclic AMP","volume":"63","author":"Taylor","year":"2017","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2019.102132_bib0140","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1083\/jcb.200803172","article-title":"Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP","volume":"183","author":"Tovey","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ceca.2019.102132_bib0145","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1073\/pnas.88.6.2232","article-title":"Inositol trisphosphate receptor: phosphorylation by protein kinase C and calcium calmodulin-dependent protein kinases in reconstituted lipid vesicles","volume":"88","author":"Ferris","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ceca.2019.102132_bib0150","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0014-5793(03)01487-X","article-title":"The contribution of serine residues 1588 and 1755 to phosphorylation of the type I inositol 1,4,5-trisphosphate receptor by PKA and PKG","volume":"557","author":"Soulsby","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ceca.2019.102132_bib0155","doi-asserted-by":"crossref","first-page":"13813","DOI":"10.1523\/JNEUROSCI.2069-07.2007","article-title":"Regulation of the inositol 1,4,5-trisphosphate receptor type I by O-GlcNAc glycosylation","volume":"27","author":"Rengifo","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2019.102132_bib0160","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cell.2004.11.048","article-title":"Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44","volume":"120","author":"Higo","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.ceca.2019.102132_bib0165","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/hep.23625","article-title":"Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver","volume":"52","author":"Cruz","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.ceca.2019.102132_bib0170","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1002\/hep.24548","article-title":"Type 2 inositol 1,4,5-trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes","volume":"54","author":"Kruglov","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.ceca.2019.102132_bib0175","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/hep4.1012","article-title":"Hepatic inositol 1,4,5 trisphosphate receptor type 1 mediates fatty liver","volume":"1","author":"Feriod","year":"2017","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.ceca.2019.102132_bib0180","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1085\/jgp.116.4.547","article-title":"Calcium wave propagation in pancreatic acinar cells: functional interaction of inositol 1,4,5-trisphosphate receptors, ryanodine receptors, and mitochondria","volume":"116","author":"Straub","year":"2000","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ceca.2019.102132_bib0185","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1126\/science.1114110","article-title":"IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism","volume":"309","author":"Futatsugi","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ceca.2019.102132_bib0190","doi-asserted-by":"crossref","first-page":"13953","DOI":"10.1038\/srep13953","article-title":"IP3R deficit underlies loss of salivary fluid secretion in Sjogren\u2019s Syndrome","volume":"5","author":"Teos","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ceca.2019.102132_bib0195","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/ncb980","article-title":"Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum","volume":"5","author":"Echevarria","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ceca.2019.102132_bib0200","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1073\/pnas.0536590100","article-title":"Nuclear and cytosolic calcium are regulated independently","volume":"100","author":"Leite","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ceca.2019.102132_bib0205","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/31960","article-title":"Calcium oscillations increase the efficiency and specificity of gene expression","volume":"392","author":"Dolmetsch","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2019.102132_bib0210","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrn3531","article-title":"Nuclear calcium signalling in the regulation of brain function","volume":"14","author":"Bading","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ceca.2019.102132_bib0215","doi-asserted-by":"crossref","first-page":"27517","DOI":"10.1074\/jbc.M203002200","article-title":"Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium","volume":"277","author":"Pusl","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2019.102132_bib0220","doi-asserted-by":"crossref","first-page":"17061","DOI":"10.1074\/jbc.M700490200","article-title":"Nucleoplasmic calcium is required for cell proliferation","volume":"282","author":"Rodrigues","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2019.102132_bib0225","doi-asserted-by":"crossref","DOI":"10.1146\/annurev-biochem-060614-034216","article-title":"Enjoy the trip: calcium in mitochondria back and forth","author":"De Stefani","year":"2016","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ceca.2019.102132_bib0230","doi-asserted-by":"crossref","first-page":"40892","DOI":"10.1074\/jbc.M506623200","article-title":"The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria","volume":"280","author":"Mendes","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2019.102132_bib0235","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1083\/jcb.200608073","article-title":"Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels","volume":"175","author":"Szabadkai","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ceca.2019.102132_bib0240","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1038\/s41467-019-11646-3","article-title":"IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer","volume":"10","author":"Bartok","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ceca.2019.102132_bib0245","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aat7397","article-title":"Polycystin 2 regulates mitochondrial Ca(2+) signaling, bioenergetics, and dynamics through mitofusin 2","volume":"12","author":"Kuo","year":"2019","journal-title":"Sci. Signal."},{"key":"10.1016\/j.ceca.2019.102132_bib0250","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jprot.2012.12.018","article-title":"In-depth proteomic analysis of mammalian mitochondria-associated membranes (MAM)","volume":"79","author":"Poston","year":"2013","journal-title":"J. Proteomics"},{"key":"10.1016\/j.ceca.2019.102132_bib0255","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.neuron.2008.04.015","article-title":"Mechanism of Ca2+ disruption in Alzheimer\u2019s disease by presenilin regulation of InsP3 receptor channel gating","volume":"58","author":"Cheung","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.ceca.2019.102132_bib0260","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1113\/jphysiol.2013.261784","article-title":"The role of Ca2+ in the pathophysiology of pancreatitis","volume":"592","author":"Gerasimenko","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2019.102132_bib0265","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.bbamcr.2018.05.015","article-title":"Calcium signaling and the therapeutic targeting of cancer cells","volume":"1865","author":"Bong","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.ceca.2019.102132_bib0270","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.bbamcr.2018.06.004","article-title":"Pathophysiological consequences of isoform-specific IP3 receptor mutations","volume":"1865","author":"Kerkhofs","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.ceca.2019.102132_bib0275","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.bbamcr.2018.05.009","article-title":"Ca(2+) signaling and spinocerebellar ataxia","volume":"1865","author":"Hisatsune","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.ceca.2019.102132_bib0280","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1172\/JCI70720","article-title":"Abolished InsP3R2 function inhibits sweat secretion in both humans and mice","volume":"124","author":"Klar","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ceca.2019.102132_bib0285","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1172\/JCI86862","article-title":"Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma","volume":"126","author":"Hedberg","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ceca.2019.102132_bib0290","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10038-007-0233-3","article-title":"A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population","volume":"53","author":"Oishi","year":"2008","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.ceca.2019.102132_bib0295","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1053\/gast.2001.26280","article-title":"Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver","volume":"121","author":"Hirata","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ceca.2019.102132_bib0300","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.bbamcr.2018.05.010","article-title":"Regulation of bile secretion by calcium signaling in health and disease","volume":"1865","author":"Trampert","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.ceca.2019.102132_bib0305","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1053\/j.gastro.2007.08.020","article-title":"Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile","volume":"133","author":"Minagawa","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ceca.2019.102132_bib0310","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1053\/j.gastro.2007.08.071","article-title":"Ursodeoxycholic acid stimulates cholangiocyte fluid secretion in mice via CFTR-dependent ATP secretion","volume":"133","author":"Fiorotto","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ceca.2019.102132_bib0315","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0016-5085(03)01201-0","article-title":"Loss of inositol 1,4,5-trisphosphate receptors from bile duct epithelia is a common event in cholestasis","volume":"125","author":"Shibao","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ceca.2019.102132_bib0320","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2015.03.014","article-title":"Nuclear factor, erythroid 2-like 2 regulates expression of type 3 inositol 1,4,5-trisphosphate receptor and calcium signaling in cholangiocytes","volume":"149","author":"Weerachayaphorn","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ceca.2019.102132_bib0325","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1074\/jbc.M114.587030","article-title":"Post-translational regulation of the type III inositol 1,4,5-trisphosphate receptor by miRNA-506","volume":"290","author":"Ananthanarayanan","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2019.102132_bib0330","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/MAJ.0b013e3182955457","article-title":"Sepsis-associated cholestasis in adult patients: a prospective study","volume":"346","author":"Fan","year":"2013","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.ceca.2019.102132_bib0335","doi-asserted-by":"crossref","first-page":"614081","DOI":"10.1155\/2013\/614081","article-title":"Alkaline phosphatase: the next independent predictor of the poor 90-day outcome in alcoholic hepatitis","volume":"2013","author":"Kasztelan-Szczerbinska","year":"2013","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.ceca.2019.102132_bib0340","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/hep.30228","article-title":"Effects of endotoxin on type 3 inositol 1,4,5-Trisphosphate receptor in human cholangiocytes","volume":"69","author":"Franca","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.ceca.2019.102132_bib0345","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/S0016-5085(99)70023-5","article-title":"Secretagogues cause ubiquitination and down-regulation of inositol 1,4,5-Trisphosphate receptors in rat pancreatic acinar cells","volume":"116","author":"Wojcikiewicz","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ceca.2019.102132_bib0350","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/bs.pmbts.2016.02.004","article-title":"Chapter 4 - inositol 1,4,5-trisphosphate receptor ubiquitination","volume":"141","author":"Wright","year":"2016","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.ceca.2019.102132_bib0355","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1126\/science.273.5274.503","article-title":"Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor","volume":"273","author":"Khan","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ceca.2019.102132_bib0360","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nature22965","article-title":"PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth","volume":"546","author":"Kuchay","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2019.102132_bib0365","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature22798","article-title":"BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation","volume":"546","author":"Bononi","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2019.102132_bib0370","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1158\/0008-5472.CAN-09-2886","article-title":"Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival","volume":"70","author":"Kang","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.ceca.2019.102132_bib0375","doi-asserted-by":"crossref","first-page":"72324","DOI":"10.18632\/oncotarget.20327","article-title":"Downregulation of type 3 inositol (1,4,5)-trisphosphate receptor decreases breast cancer cell migration through an oscillatory Ca(2+) signal","volume":"8","author":"Mound","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ceca.2019.102132_bib0380","first-page":"3691","article-title":"Possible involvement of inositol 1,4,5-trisphosphate receptor type 3 (IP3R3) in the peritoneal dissemination of gastric cancers","volume":"23","author":"Sakakura","year":"2003","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ceca.2019.102132_bib0385","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ceca.2010.09.005","article-title":"The type III inositol 1,4,5-trisphosphate receptor is associated with aggressiveness of colorectal carcinoma","volume":"48","author":"Shibao","year":"2010","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2019.102132_bib0390","article-title":"Type 3 inositol 1,4,5-Trisphosphate receptor is increased and enhances malignant properties in cholangiocarcinoma","author":"Ueasilamongkol","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.ceca.2019.102132_bib0395","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1053\/jhep.2002.34432","article-title":"Regulation of Ca(2+) signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms","volume":"36","author":"Hirata","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.ceca.2019.102132_bib0400","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1016\/j.celrep.2016.02.030","article-title":"Selective vulnerability of cancer cells by inhibition of Ca(2+) transfer from endoplasmic reticulum to mitochondria","volume":"14","author":"Cardenas","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.ceca.2019.102132_bib0405","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1136\/gutjnl-2018-317811","article-title":"Expression of the type 3 InsP3 receptor is a final common event in the development of hepatocellular carcinoma","volume":"68","author":"Guerra","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.ceca.2019.102132_bib0410","doi-asserted-by":"crossref","first-page":"11678","DOI":"10.1074\/jbc.270.19.11678","article-title":"Type I, II, and III inositol 1,4,5-trisphosphate receptors are unequally susceptible to down-regulation and are expressed in markedly different proportions in different cell types","volume":"270","author":"Wojcikiewicz","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2019.102132_bib0415","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1053\/j.gastro.2007.03.115","article-title":"Lipid rafts establish calcium waves in hepatocytes","volume":"133","author":"Nagata","year":"2007","journal-title":"Gastroenterology"}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416019302015?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416019302015?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T20:27:05Z","timestamp":1758918425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416019302015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":83,"alternative-id":["S0143416019302015"],"URL":"https:\/\/doi.org\/10.1016\/j.ceca.2019.102132","relation":{},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Type 3 inositol 1,4,5-trisphosphate receptor: A calcium channel for all seasons","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceca.2019.102132","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102132"}}