{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:52:16Z","timestamp":1777438336379,"version":"3.51.4"},"reference-count":102,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"\u201cRicerca Scientifica di Ateneo\u201d","award":["2010\u20132018"],"award-info":[{"award-number":["2010\u20132018"]}]},{"name":"FFABR","award":["2017"],"award-info":[{"award-number":["2017"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.ceca.2020.102160","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T11:29:08Z","timestamp":1578914948000},"page":"102160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["NCX and EAAT transporters in ischemia: At the crossroad between glutamate metabolism and cell survival"],"prefix":"10.1016","volume":"86","author":[{"given":"Silvia","family":"Piccirillo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Magi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0530-2262","authenticated-orcid":false,"given":"Pasqualina","family":"Castaldo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Preziuso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1518-1495","authenticated-orcid":false,"given":"Vincenzo","family":"Lariccia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Amoroso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceca.2020.102160_bib0005","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/s41580-018-0052-8","article-title":"The machineries, regulation and cellular functions of mitochondrial calcium","volume":"19","author":"Giorgi","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ceca.2020.102160_bib0010","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004242","article-title":"Calcium signaling in cardiac myocytes","volume":"3","author":"Fearnley","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ceca.2020.102160_bib0015","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1161\/01.RES.86.5.596","article-title":"Sarcoplasmic reticulum Ca2+\/Calmodulin-dependent protein kinase is altered in heart failure","volume":"86","author":"Netticadan","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.ceca.2020.102160_bib0020","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1750-1326-4-20","article-title":"Calcium signaling in neurodegeneration","volume":"4","author":"Marambaud","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ceca.2020.102160_bib0025","doi-asserted-by":"crossref","first-page":"H1723","DOI":"10.1152\/ajpheart.00553.2011","article-title":"Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures","volume":"301","author":"Sanada","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0030","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion--from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.ceca.2020.102160_bib0035","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1007\/s00018-018-3002-x","article-title":"The dual face of glutamate: from a neurotoxin to a potential survival factor-metabolic implications in health and disease","volume":"76","author":"Magi","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ceca.2020.102160_bib0040","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","article-title":"Cell biology of ischemia\/reperfusion injury","volume":"298","author":"Kalogeris","year":"2012","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.ceca.2020.102160_bib0045","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.pneurobio.2013.12.008","article-title":"Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke?","volume":"115","author":"Leng","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0050","doi-asserted-by":"crossref","first-page":"44951","DOI":"10.1038\/srep44951","article-title":"Multiple H+ sensors mediate the extracellular acidification-induced [Ca2+]i elevation in cultured rat ventricular cardiomyocytes","volume":"7","author":"Hu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ceca.2020.102160_bib0055","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.bbrc.2015.10.027","article-title":"A pathophysiological role of TRPV1 in ischemic injury after transient focal cerebral ischemia in mice","volume":"467","author":"Miyanohara","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ceca.2020.102160_bib0060","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/brain\/awl325","article-title":"Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia","volume":"130","author":"Pignataro","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.ceca.2020.102160_bib0065","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0166-2236(03)00210-8","article-title":"The ASICs: signaling molecules? Modulators?","volume":"26","author":"Krishtal","year":"2003","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ceca.2020.102160_bib0070","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.bbabio.2009.01.005","article-title":"Regulation of mitochondrial dehydrogenases by calcium ions","volume":"1787","author":"Denton","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ceca.2020.102160_bib0075","first-page":"262","article-title":"The role of calcium in the ischemic myocardium","volume":"102","author":"Nayler","year":"1981","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ceca.2020.102160_bib0080","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bbadis.2009.09.003","article-title":"Mitochondria, oxidative metabolism and cell death in stroke","volume":"1802","author":"Sims","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ceca.2020.102160_bib0085","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ceca.2010.01.003","article-title":"Calcium, ischemia and excitotoxicity","volume":"47","author":"Szydlowska","year":"2010","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2020.102160_bib0090","first-page":"372","article-title":"Neuroexcitation, excitotoxicity and human neurological disease","volume":"68","author":"Whetsell","year":"1993","journal-title":"Lab. Invest."},{"key":"10.1016\/j.ceca.2020.102160_bib0095","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.neuroscience.2016.11.007","article-title":"Glutamate dehydrogenase as a neuroprotective target against brain ischemia and reperfusion","volume":"340","author":"Kim","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.ceca.2020.102160_bib0100","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1096\/fj.201601033R","article-title":"Glutamate oxaloacetate transaminase enables anaplerotic refilling of TCA cycle intermediates in stroke-affected brain","volume":"31","author":"Rink","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.ceca.2020.102160_bib0105","doi-asserted-by":"crossref","first-page":"13073","DOI":"10.1038\/s41598-017-13478-x","article-title":"Essential role of the Na+-Ca2+ exchanger (NCX) in glutamate-enhanced cell survival in cardiac cells exposed to hypoxia\/reoxygenation","volume":"7","author":"Maiolino","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ceca.2020.102160_bib0110","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41419-018-0784-6","article-title":"Glutamate as a potential \"survival factor\" in an in vitro model of neuronal hypoxia\/reoxygenation injury: leading role of the Na+\/Ca2+ exchanger","volume":"9","author":"Piccirillo","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ceca.2020.102160_bib0115","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.phrs.2007.10.005","article-title":"Mitochondrial localization of Na+-Ca2+ exchangers NCX1-3 in neurons and astrocytes of adult rat brain in situ","volume":"56","author":"Gobbi","year":"2007","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ceca.2020.102160_bib0120","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ceca.2006.06.004","article-title":"Cellular and subcellular localization of Na+-Ca2+ exchanger protein isoforms, NCX1, NCX2, and NCX3 in cerebral cortex and hippocampus of adult rat","volume":"41","author":"Minelli","year":"2007","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2020.102160_bib0125","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1152\/physrev.1999.79.3.763","article-title":"Sodium\/calcium exchange: its physiological implications","volume":"79","author":"Blaustein","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ceca.2020.102160_bib0130","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev.physiol.62.1.111","article-title":"Sodium-calcium exchange: a molecular perspective","volume":"62","author":"Philipson","year":"2000","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0135","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1042\/BJ20070619","article-title":"Na+\/Ca2+ exchangers: three mammalian gene families control Ca2+ transport","volume":"406","author":"Lytton","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.ceca.2020.102160_bib0140","doi-asserted-by":"crossref","first-page":"C1250","DOI":"10.1152\/ajpcell.1997.272.4.C1250","article-title":"Tissue specificity and alternative splicing of the Na+\/Ca2+ exchanger isoforms NCX1, NCX2, and NCX3 in rat","volume":"272","author":"Quednau","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0145","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/cvr\/cvp264","article-title":"Targeting calcium transport in ischaemic heart disease","volume":"84","author":"Talukder","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ceca.2020.102160_bib0150","doi-asserted-by":"crossref","first-page":"RA161","DOI":"10.12659\/MSM.883533","article-title":"The Na+\/Ca2+ exchanger in cardiac ischemia\/reperfusion injury","volume":"18","author":"Chen","year":"2012","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.ceca.2020.102160_bib0155","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.phrs.2014.08.004","article-title":"Novel therapeutic strategies for ischemic heart disease","volume":"89","author":"Perricone","year":"2014","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ceca.2020.102160_bib0160","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.coph.2007.09.001","article-title":"Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases","volume":"8","author":"Xiong","year":"2008","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.ceca.2020.102160_bib0165","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.physiol.70.113006.100455","article-title":"Calcium cycling and signaling in cardiac myocytes","volume":"70","author":"Bers","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0170","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ejphar.2006.06.012","article-title":"Reduction by SEA0400 of myocardial ischemia-induced cytoplasmic and mitochondrial Ca2+ overload","volume":"543","author":"Namekata","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ceca.2020.102160_bib0175","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00726-011-0863-9","article-title":"Toward a new role for plasma membrane sodium-dependent glutamate transporters of astrocytes: maintenance of antioxidant defenses beyond extracellular glutamate clearance","volume":"42","author":"Had-Aissouni","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/j.ceca.2020.102160_bib0180","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.bbrc.2015.03.129","article-title":"Na+-Ca2+ exchanger targeting miR-132 prevents apoptosis of cardiomyocytes under hypoxic condition by suppressing Ca2+ overload","volume":"460","author":"Hong","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ceca.2020.102160_bib0185","first-page":"1369","article-title":"Na+\/Ca2+ exchanger 1 (NCX-1) mediates the anti-apoptotic effect of Akt1 in neonatal rat cardiomyocytes during ischemia\/reperfusion","volume":"8","author":"Huang","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.ceca.2020.102160_bib0190","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ejphar.2016.11.045","article-title":"Na+\/Ca2+ exchanger 1 inhibition abolishes ischemic tolerance induced by ischemic preconditioning in different cardiac models","volume":"794","author":"Castaldo","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ceca.2020.102160_bib0195","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"key":"10.1016\/j.ceca.2020.102160_bib0200","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0022-5223(96)70065-X","article-title":"Cardiac preconditioning with calcium: clinically accessible myocardial protection","volume":"112","author":"Meldrum","year":"1996","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.ceca.2020.102160_bib0205","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1161\/01.RES.80.6.790","article-title":"Ca2+ as a mediator of ischemic preconditioning","volume":"80","author":"Miyawaki","year":"1997","journal-title":"Circ. Res."},{"issue":"3\u20134","key":"10.1016\/j.ceca.2020.102160_bib0210","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbrc.2012.10.114","article-title":"Preferential involvement of Na(+)\/Ca(2)(+) exchanger type-1 in the brain damage caused by transient focal cerebral ischemia in mice","volume":"429","author":"Morimoto","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ceca.2020.102160_bib0215","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1161\/01.STR.0000143730.29964.93","article-title":"Two sodium\/calcium exchanger gene products, NCX1 and NCX3, play a major role in the development of permanent focal cerebral ischemia","volume":"35","author":"Pignataro","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.ceca.2020.102160_bib0220","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.ceca.2007.08.003","article-title":"Na+\/Ca2+ exchanger 2 is neuroprotective by exporting Ca2+ during a transient focal cerebral ischemia in the mouse","volume":"43","author":"Jeon","year":"2008","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2020.102160_bib0225","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1177\/0271678X15611913","article-title":"Neuronal NCX1 overexpression induces stroke resistance while knockout induces vulnerability via Akt","volume":"36","author":"Molinaro","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.ceca.2020.102160_bib0230","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.expneurol.2007.10.013","article-title":"NCX3 knockout mice exhibit increased hippocampal CA1 and CA2 neuronal damage compared to wild-type mice following global cerebral ischemia","volume":"210","author":"Jeffs","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ceca.2020.102160_bib0235","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.neulet.2006.06.003","article-title":"Selective alteration of expression of Na+\/Ca2+ exchanger isoforms after transient focal cerebral ischemia in rats","volume":"404","author":"Li","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ceca.2020.102160_bib0240","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/sj.jcbfm.9600207","article-title":"Permanent focal brain ischemia induces isoform-dependent changes in the pattern of Na+\/Ca2+ exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions","volume":"26","author":"Boscia","year":"2006","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.ceca.2020.102160_bib0245","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ceca.2018.04.007","article-title":"Calcium- and ATP-dependent regulation of Na+\/Ca2+ exchange function in BHK cells: comparison of NCX1 and NCX3 exchangers","volume":"73","author":"Lariccia","year":"2018","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2020.102160_bib0250","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1085\/jgp.114.5.701","article-title":"Ionic regulatory properties of brain and kidney splice variants of the NCX1 Na+-Ca2+ exchanger","volume":"114","author":"Dyck","year":"1999","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0255","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-3-319-55858-5_3","article-title":"Structure-dynamic coupling through Ca2+-Binding regulatory domains of mammalian NCX Isoform\/Splice variants","volume":"981","author":"Khananshvili","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ceca.2020.102160_bib0260","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1042\/bst0220991","article-title":"Energy metabolism, ion homeostasis, and cell damage in the brain","volume":"22","author":"Katsura","year":"1994","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ceca.2020.102160_bib0265","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1161\/CIRCRESAHA.113.302095","article-title":"Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes","volume":"113","author":"Kolwicz","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.ceca.2020.102160_bib0270","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1053\/euhj.2001.2979","article-title":"Molecular and genetic aspects of cardiac fatty acid homeostasis in health and disease","volume":"23","author":"de Windt","year":"2002","journal-title":"Eur. Heart J."},{"issue":"1\u20132","key":"10.1016\/j.ceca.2020.102160_bib0275","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11010-009-0101-x","article-title":"The importance of myocardial amino acids during ischemia and reperfusion in dilated left ventricle of patients with degenerative mitral valve disease","volume":"330","author":"Venturini","year":"2009","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.ceca.2020.102160_bib0280","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1258\/ebm.2012.012025","article-title":"Amino acids as metabolic substrates during cardiac ischemia","volume":"237","author":"Drake","year":"2012","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.ceca.2020.102160_bib0285","first-page":"838","article-title":"Metabolic modulators in heart disease: past, present, and future","volume":"33","author":"Lopaschuk","year":"2017","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0290","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s00424-006-0096-z","article-title":"Expression and activity of the glutamate transporter EAAT2 in cardiac hypertrophy: implications for ischaemia reperfusion injury","volume":"452","author":"King","year":"2006","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.ceca.2020.102160_bib0295","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1113\/expphysiol.2009.049452","article-title":"Amino acid transamination is crucial for ischaemic cardioprotection in normal and preconditioned isolated rat hearts--focus on L-glutamate","volume":"95","author":"Lofgren","year":"2010","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0300","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/j.1440-1681.2006.04497.x","article-title":"L-glutamate and glutamine improve haemodynamic function and restore myocardial glycogen content during postischaemic reperfusion: a radioactive tracer study in the rat isolated heart","volume":"33","author":"Stottrup","year":"2006","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0305","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/j.1440-1681.2008.04914.x","article-title":"Cardioprotection by L-glutamate during postischaemic reperfusion: reduced infarct size and enhanced glycogen resynthesis in a rat insulin-free heart model","volume":"35","author":"Kristiansen","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0310","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1093\/ejcts\/ezx368","article-title":"A dose-response study of glutamate supplementation in isolated, perfused rat hearts undergoing ischaemia and cold cardioplegia","volume":"53","author":"Kimose","year":"2018","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"3","key":"10.1016\/j.ceca.2020.102160_bib0315","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/cvr\/cvr051","article-title":"Metabolic fingerprint of ischaemic cardioprotection: importance of the malate-aspartate shuttle","volume":"91","author":"Nielsen","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ceca.2020.102160_bib0320","first-page":"H281","article-title":"Tricarboxylic acid cycle metabolites during ischemia in isolated perfused rat heart","volume":"244","author":"Peuhkurinen","year":"1983","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0325","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1042\/cs0700007","article-title":"Cardiac metabolism and performance during L-glutamic acid infusion in postoperative cardiac failure","volume":"70","author":"Pisarenko","year":"1986","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.ceca.2020.102160_bib0330","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0022-2828(03)00182-2","article-title":"Glutamate loading protects freshly isolated and perfused adult cardiomyocytes against intracellular ROS generation","volume":"35","author":"King","year":"2003","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0335","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0301-0082(99)00060-X","article-title":"Metabolism and functions of glutathione in brain","volume":"62","author":"Dringen","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0340","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1161\/01.STR.29.5.1048","article-title":"Glutamate, glutamine, and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats","volume":"29","author":"Pascual","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.ceca.2020.102160_bib0345","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s12975-015-0395-9","article-title":"The role of Na+\/Ca2+ exchanger subtypes in neuronal ischemic injury","volume":"6","author":"Shenoda","year":"2015","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.ceca.2020.102160_bib0350","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1749-6632.1997.tb48431.x","article-title":"Toward the development of strategies to prevent ischemic neuronal injury. In vitro studies","volume":"825","author":"Marini","year":"1997","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"Suppl 1","key":"10.1016\/j.ceca.2020.102160_bib0355","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000052066","article-title":"A review of therapeutic potentials in ischemic stroke","volume":"39","author":"Qin","year":"1998","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.ceca.2020.102160_bib0360","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1474-4422(02)00164-3","article-title":"Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?","volume":"1","author":"Ikonomidou","year":"2002","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ceca.2020.102160_bib0365","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1089\/ars.2014.6106","article-title":"Inducible glutamate oxaloacetate transaminase as a therapeutic target against ischemic stroke","volume":"22","author":"Khanna","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ceca.2020.102160_bib0370","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1172\/JCI71886","article-title":"Extrasynaptic glutamate release through cystine\/glutamate antiporter contributes to ischemic damage","volume":"124","author":"Soria","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ceca.2020.102160_bib0375","doi-asserted-by":"crossref","first-page":"4978","DOI":"10.1523\/JNEUROSCI.2672-10.2011","article-title":"A signaling cascade of nuclear calcium-CREB-ATF3 activated by synaptic NMDA receptors defines a gene repression module that protects against extrasynaptic NMDA receptor-induced neuronal cell death and ischemic brain damage","volume":"31","author":"Zhang","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2020.102160_bib0380","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.neuron.2007.01.025","article-title":"Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death","volume":"53","author":"Zhang","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.ceca.2020.102160_bib0385","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.cell.2012.06.029","article-title":"Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists","volume":"150","author":"Papouin","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ceca.2020.102160_bib0390","doi-asserted-by":"crossref","first-page":"6732","DOI":"10.1523\/JNEUROSCI.6371-11.2012","article-title":"Synaptic NMDA receptors mediate hypoxic excitotoxic death","volume":"32","author":"Wroge","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2020.102160_bib0395","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1089\/ars.2011.3930","article-title":"Oxygen-inducible glutamate oxaloacetate transaminase as protective switch transforming neurotoxic glutamate to metabolic fuel during acute ischemic stroke","volume":"14","author":"Rink","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ceca.2020.102160_bib0400","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/dmcn.12851","article-title":"Potential protective role of endogenous glutamate-oxaloacetate transaminase against glutamate excitotoxicity in fetal hypoxic-ischaemic asphyxia","volume":"58","author":"Perez-Mato","year":"2016","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.ceca.2020.102160_bib0405","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4062\/biomolther.2015.078","article-title":"Alpha-ketoglutarate: physiological functions and applications","volume":"24","author":"Wu","year":"2016","journal-title":"Biomol. Ther. (Seoul)"},{"key":"10.1016\/j.ceca.2020.102160_bib0410","doi-asserted-by":"crossref","first-page":"823","DOI":"10.2217\/fnl.11.55","article-title":"A new look at glutamate and ischemia: NMDA agonist improves long-term functional outcome in a rat model of stroke","volume":"6","author":"Dhawan","year":"2011","journal-title":"Future Neurol."},{"key":"10.1016\/j.ceca.2020.102160_bib0415","doi-asserted-by":"crossref","first-page":"19289","DOI":"10.1074\/jbc.M201572200","article-title":"Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms","volume":"277","author":"Fiermonte","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2020.102160_bib0420","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1093\/emboj\/20.18.5060","article-title":"Citrin and aralar1 are Ca2+-stimulated aspartate\/glutamate transporters in mitochondria","volume":"20","author":"Palmieri","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.ceca.2020.102160_bib0425","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","article-title":"Glutamate uptake","volume":"65","author":"Danbolt","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0430","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1124\/mol.113.087775","article-title":"Glutamate-induced ATP synthesis: relationship between plasma membrane Na+\/Ca2+ exchanger and excitatory amino acid transporters in brain and heart cell models","volume":"84","author":"Magi","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ceca.2020.102160_bib0435","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034015","article-title":"Physical and functional interaction of NCX1 and EAAC1 transporters leading to glutamate-enhanced ATP production in brain mitochondria","volume":"7","author":"Magi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ceca.2020.102160_bib0440","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.yjmcc.2004.04.008","article-title":"Localization and function of the brain excitatory amino acid transporter type 1 in cardiac mitochondria","volume":"37","author":"Ralphe","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0445","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1021\/bi00480a025","article-title":"Purification and reconstitution of the sodium- and potassium-coupled glutamate transport glycoprotein from rat brain","volume":"29","author":"Danbolt","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/j.ceca.2020.102160_bib0450","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1002\/jcp.22609","article-title":"Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics","volume":"226","author":"Kim","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0455","first-page":"20","article-title":"Excitatory amino acid transporters (EAATs): glutamate transport and beyond","author":"Magi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ceca.2020.102160_bib0460","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physrev.00042.2016","article-title":"Physiology of Astroglia","volume":"98","author":"Verkhratsky","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ceca.2020.102160_bib0465","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-3-319-08894-5_2","article-title":"Glutamate metabolism in the brain focusing on astrocytes","volume":"11","author":"Schousboe","year":"2014","journal-title":"Adv. Neurobiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0470","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3389\/fendo.2013.00102","article-title":"Astrocytic control of biosynthesis and turnover of the neurotransmitters glutamate and GABA","volume":"4","author":"Schousboe","year":"2013","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.ceca.2020.102160_bib0475","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1002\/glia.22964","article-title":"Principles of sodium homeostasis and sodium signalling in astroglia","volume":"64","author":"Rose","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.ceca.2020.102160_bib0480","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1471-4159.1987.tb05641.x","article-title":"Influence of Na+, K+, and Ca2+ on glutamine synthesis and distribution in rat brain cortex slices: a possible linkage of glutamine synthetase with cerebral transport processes and energetics in the astrocytes","volume":"48","author":"Benjamin","year":"1987","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ceca.2020.102160_bib0485","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1046\/j.1471-4159.2003.01981.x","article-title":"Glutamine efflux from astrocytes is mediated by multiple pathways","volume":"87","author":"Deitmer","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ceca.2020.102160_bib0490","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1023\/A:1022397704922","article-title":"Role of astrocytes in the maintenance and modulation of glutamatergic and GABAergic neurotransmission","volume":"28","author":"Schousboe","year":"2003","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ceca.2020.102160_bib0495","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/jcbfm.2011.149","article-title":"Sweet sixteen for ANLS","volume":"32","author":"Pellerin","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.ceca.2020.102160_bib0500","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/cvr\/cvx024","article-title":"Cardiac mGluR1 metabotropic receptors in cardioprotection","volume":"113","author":"Vincent","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ceca.2020.102160_bib0505","first-page":"H1825","article-title":"Transport and metabolism of L-glutamate during oxygenation, anoxia, and reoxygenation of rat cardiac myocytes","volume":"270","author":"Dinkelborg","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ceca.2020.102160_bib0510","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1006\/jmcc.2000.1474","article-title":"Glutamate-loading stimulates metabolic flux and improves cell recovery following chemical hypoxia in isolated cardiomyocytes","volume":"33","author":"Williams","year":"2001","journal-title":"J. Mol. Cell. Cardiol."}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416020300026?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416020300026?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T20:29:39Z","timestamp":1758918579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416020300026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":102,"alternative-id":["S0143416020300026"],"URL":"https:\/\/doi.org\/10.1016\/j.ceca.2020.102160","relation":{},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NCX and EAAT transporters in ischemia: At the crossroad between glutamate metabolism and cell survival","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceca.2020.102160","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102160"}}