{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:18:54Z","timestamp":1778631534560,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["582491"],"award-info":[{"award-number":["582491"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["IN200415"],"award-info":[{"award-number":["IN200415"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.ceca.2020.102246","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T11:33:09Z","timestamp":1592479989000},"page":"102246","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Oxytocin prevents neuronal network pain-related changes on spinal cord dorsal horn in vitro"],"prefix":"10.1016","volume":"90","author":[{"given":"Irma A.","family":"Tello-Garc\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8502-1692","authenticated-orcid":false,"given":"Jes\u00fas","family":"P\u00e9rez-Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guadalupe","family":"Mart\u00ednez-Lorenzana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6472-1419","authenticated-orcid":false,"given":"Abimael","family":"Gonz\u00e1lez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1651-8931","authenticated-orcid":false,"given":"Miguel","family":"Cond\u00e9s-Lara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceca.2020.102246_bib0005","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.pain.2006.01.029","article-title":"Oxytocin and electrical stimulation of the paraventricular hypothalamic nucleus produce antinociceptive effects that are reversed by an oxytocin antagonist","volume":"122","author":"Miranda-Cardenas","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.ceca.2020.102246_bib0010","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1113\/jphysiol.2001.013492","article-title":"Oxytocin mediates stress-induced analgesia in adult mice","volume":"540","author":"a Robinson","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2020.102246_bib0015","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.pain.2013.05.003","article-title":"Neurohormonal effects of oxytocin and vasopressin receptor agonists on spinal pain processing in male rats","volume":"154","author":"Juif","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.ceca.2020.102246_bib0020","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1007\/s00221-019-05651-7","article-title":"Recurrent antinociception induced by intrathecal or peripheral oxytocin in a neuropathic pain rat model","volume":"237","author":"Gonz\u00e1lez-Hern\u00e1ndez","year":"2019","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.ceca.2020.102246_bib0025","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neuropharm.2017.11.031","article-title":"Oxytocin inhibits the rat medullary dorsal horn Sp5c\/C1 nociceptive transmission through OT but not V1A receptors","volume":"129","author":"Garc\u00eda-Boll","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ceca.2020.102246_bib0030","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1097\/j.pain.0000000000001024","article-title":"Peripheral oxytocin receptors inhibit the nociceptive input signal to spinal dorsal horn wide-dynamic-range neurons","volume":"158","author":"Gonz\u00e1lez-Hern\u00e1ndez","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.ceca.2020.102246_bib0035","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1002\/ejp.1427","article-title":"Effect of local infiltration with oxytocin on hemodynamic response to surgical incision and postoperative pain in patients having open laparoscopic surgery under general anesthesia","volume":"23","author":"Zayas\u2010Gonz\u00e1lez","year":"2019","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.ceca.2020.102246_bib0040","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/cns.12551","article-title":"Successful pain management with epidural oxytocin","volume":"22","author":"Cond\u00e9s-Lara","year":"2016","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.ceca.2020.102246_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/425818","article-title":"Calcium imaging of living astrocytes in the mouse spinal cord following sensory stimulation","volume":"2012","author":"Cirillo","year":"2012","journal-title":"Neural Plast."},{"key":"10.1016\/j.ceca.2020.102246_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneumeth.2007.11.011","article-title":"Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy","volume":"169","author":"Davalos","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ceca.2020.102246_bib0055","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1600990","article-title":"In vivo characterization of distinct modality-specific subsets of somatosensory neurons using GCaMP","volume":"2","author":"Emery","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ceca.2020.102246_bib0060","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nmeth.1856","article-title":"Chronic in vivo imaging in the mouse spinal cord using an implanted chamber","volume":"9","author":"Farrar","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ceca.2020.102246_bib0065","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1113\/jphysiol.2012.230532","article-title":"Long-term in vivo imaging of normal and pathological mouse spinal cord with subcellular resolution using implanted glass windows","volume":"590","author":"Fenrich","year":"2012","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2020.102246_bib0070","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.expneurol.2012.07.014","article-title":"Two-photon imaging of spinal cord cellular networks","volume":"242","author":"Johannssen","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ceca.2020.102246_bib0075","doi-asserted-by":"crossref","first-page":"11450","DOI":"10.1038\/ncomms11450","article-title":"Imaging large-scale cellular activity in spinal cord of freely behaving mice","volume":"7","author":"Sekiguchi","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ceca.2020.102246_bib0080","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nature11810","article-title":"Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo","volume":"493","author":"Vrontou","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2020.102246_bib0085","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.pain.2008.09.008","article-title":"Activity-dependent potentiation of calcium signals in spinal sensory networks in inflammatory pain states","volume":"140","author":"Luo","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.ceca.2020.102246_bib0090","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1111\/j.1460-9568.2005.04393.x","article-title":"Long-range oscillatory Ca2+ waves in rat spinal dorsal horn","volume":"22","author":"Ruscheweyh","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ceca.2020.102246_bib0095","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.288.5472.1765","article-title":"Neuronal plasticity: increasing the gain in pain","volume":"288","author":"Woolf","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.ceca.2020.102246_bib0100","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"},{"key":"10.1016\/j.ceca.2020.102246_bib0105","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12868-018-0441-0","article-title":"Calcium currents in striatal fast-spiking interneurons: dopaminergic modulation of Ca V 1 channels","volume":"19","author":"Rend\u00f3n-Ochoa","year":"2018","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.ceca.2020.102246_bib0110","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/ejn.13806","article-title":"Cortical stimulation relieves parkinsonian pathological activity in vitro","volume":"49","author":"Aparicio\u2010Ju\u00e1rez","year":"2019","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ceca.2020.102246_bib0115","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.nbd.2016.02.023","article-title":"Pathophysiological signatures of functional connectomics in parkinsonian and dyskinetic striatal microcircuits","volume":"91","author":"P\u00e9rez-Ortega","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ceca.2020.102246_bib0120","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1152\/jn.01131.2007","article-title":"Encoding network states by striatal cell assemblies","volume":"99","author":"Carrillo-Reid","year":"2008","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ceca.2020.102246_bib0125","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fnsys.2013.00078","article-title":"Global actions of nicotine on the striatal microcircuit","volume":"7","author":"Plata","year":"2013","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.ceca.2020.102246_bib0130","doi-asserted-by":"crossref","first-page":"11326","DOI":"10.1523\/JNEUROSCI.1380-10.2010","article-title":"Dynamics of the Parkinsonian striatal microcircuit: entrainment into a dominant network state","volume":"30","author":"J\u00e1idar","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2020.102246_bib0135","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejphar.2017.01.018","article-title":"Formalin injection produces long-lasting hypersensitivity with characteristics of neuropathic pain","volume":"797","author":"Salinas-Abarca","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ceca.2020.102246_bib0140","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jpain.2006.06.006","article-title":"Peripheral formalin injection induces long-lasting increases in cyclooxygenase 1 expression by microglia in the spinal cord","volume":"8","author":"Zhang","year":"2007","journal-title":"J. Pain"},{"key":"10.1016\/j.ceca.2020.102246_bib0145","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1054\/jpai.2001.9804","article-title":"Long-lasting inflammation and long-term hyperalgesia after subcutaneous formalin injection into the rat hindpaw","volume":"2","author":"Fu","year":"2001","journal-title":"J. Pain"},{"key":"10.1016\/j.ceca.2020.102246_bib0150","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1152\/jn.2001.86.6.3030","article-title":"NMDA receptor-dependent periodic oscillations in cultured spinal cord networks","volume":"86","author":"Keefer","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ceca.2020.102246_bib0155","doi-asserted-by":"crossref","first-page":"19364","DOI":"10.1074\/jbc.M116.732347","article-title":"Presynaptic N-methyl-D-aspartate (NMDA) receptor activity is increased through protein kinase C in paclitaxel-induced neuropathic pain","volume":"291","author":"Xie","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2020.102246_bib0160","first-page":"591","article-title":"Acute nerve injury induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn of intact rat","volume":"56","author":"Hong-mei","year":"2004","journal-title":"Sheng Li Xue Bao: [Acta Physiol. Sin.]"},{"key":"10.1016\/j.ceca.2020.102246_bib0165","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1126\/science.1127233","article-title":"Synaptic amplifier of inflammatory pain in the spinal dorsal horn","volume":"312","author":"Ikeda","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.ceca.2020.102246_bib0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2019.112974","article-title":"Imaging spinal cord activity in behaving animals","volume":"320","author":"Nelson","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ceca.2020.102246_bib0175","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.brainres.2005.03.020","article-title":"Oxytocin actions on afferent evoked spinal cord neuronal activities in neuropathic but not in normal rats","volume":"1045","author":"Cond\u00e9s-Lara","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.ceca.2020.102246_bib0180","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1523\/JNEUROSCI.18-07-02377.1998","article-title":"Oxytocin modulates glutamatergic synaptic transmission between cultured neonatal spinal cord dorsal horn neurons","volume":"18","author":"Jo","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2020.102246_bib0185","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/BF03348959","article-title":"Oxytocin reduces the activity of N-methyl \u2014 D \u2014 aspartate receptors in cultured neurons","volume":"16","author":"Caruso","year":"1993","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.ceca.2020.102246_bib0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fncel.2011.00003","article-title":"Newborn analgesia mediated by oxytocin during delivery","volume":"5","author":"Mazzuca","year":"2011","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ceca.2020.102246_bib0195","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1152\/jn.00609.2013","article-title":"Synaptic modulation and inward current produced by oxytocin in substantia gelatinosa neurons of adult rat spinal cord slices","volume":"111","author":"Jiang","year":"2014","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ceca.2020.102246_bib0200","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.brainres.2006.12.045","article-title":"GABA-mediated oxytocinergic inhibition in dorsal horn neurons by hypothalamic paraventricular nucleus stimulation","volume":"1137","author":"Rojas-Piloni","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.ceca.2020.102246_bib0205","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.tips.2014.09.004","article-title":"Oxytocin and analgesia: Future trends","volume":"35","author":"Gonz\u00e1lez-Hern\u00e1ndez","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ceca.2020.102246_bib0210","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1369-1600.2012.00439.x","article-title":"Oxytocin regulates changes of extracellular glutamate and GABA levels induced by methamphetamine in the mouse brain","volume":"17","author":"Qi","year":"2012","journal-title":"Addict. Biol."},{"key":"10.1016\/j.ceca.2020.102246_bib0215","doi-asserted-by":"crossref","DOI":"10.1186\/1744-8069-4-19","article-title":"Oxytocin-induced antinociception in the spinal cord is mediated by a subpopulation of glutamatergic neurons in lamina I-II which amplify GABAergic inhibition","volume":"4","author":"Breton","year":"2008","journal-title":"Mol. Pain"},{"key":"10.1016\/j.ceca.2020.102246_bib0220","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fnmol.2018.00248","article-title":"Oxytocin relieves neuropathic pain through GABA release and presynaptic TRPV1 inhibition in spinal cord","volume":"11","author":"Sun","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ceca.2020.102246_bib0225","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.celrep.2017.10.063","article-title":"Oxytocin modulates nociception as an agonist of pain-sensing TRPV1","volume":"21","author":"Nersesyan","year":"2017","journal-title":"Cell Rep."}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416020300889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416020300889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:47:10Z","timestamp":1778629630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416020300889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":45,"alternative-id":["S0143416020300889"],"URL":"https:\/\/doi.org\/10.1016\/j.ceca.2020.102246","relation":{},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxytocin prevents neuronal network pain-related changes on spinal cord dorsal horn in vitro","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceca.2020.102246","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102246"}}