{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:11:35Z","timestamp":1778670695167,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["19-15-00184"],"award-info":[{"award-number":["19-15-00184"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS056224"],"award-info":[{"award-number":["R01NS056224"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["M\\u041A-1299.2019.4"],"award-info":[{"award-number":["M\\u041A-1299.2019.4"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.ceca.2020.102319","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T11:21:38Z","timestamp":1605525698000},"page":"102319","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["In vivo analysis of the spontaneous firing of cerebellar Purkinje cells in awake transgenic mice that model spinocerebellar ataxia type 2"],"prefix":"10.1016","volume":"93","author":[{"given":"Polina A.","family":"Egorova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra V.","family":"Gavrilova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilya B.","family":"Bezprozvanny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ceca.2020.102319_bib0005","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41582-018-0051-6","article-title":"Spinocerebellar ataxias: prospects and challenges for therapy development","volume":"14","author":"Ashizawa","year":"2018","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.ceca.2020.102319_bib0010","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s12035-012-8348-8","article-title":"Spinocerebellar ataxia type 2: clinical presentation, molecular mechanisms, and therapeutic perspectives","volume":"47","author":"Magana","year":"2013","journal-title":"Mol. Neurobiol."},{"issue":"10","key":"10.1016\/j.ceca.2020.102319_bib0015","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nrn.2017.92","article-title":"Polyglutamine spinocerebellar ataxias - from genes to potential treatments","volume":"18","author":"Paulson","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ceca.2020.102319_bib0020","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-3-319-71779-1_8","article-title":"Spinocerebellar Ataxia type 2","volume":"1049","author":"Scoles","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ceca.2020.102319_bib0025","doi-asserted-by":"crossref","DOI":"10.1007\/s13311-018-00696-y","article-title":"Genetics, mechanisms, and therapeutic progress in polyglutamine spinocerebellar ataxias","author":"Buijsen","year":"2019","journal-title":"Neurotherapeutics"},{"issue":"4","key":"10.1016\/j.ceca.2020.102319_bib0030","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1007\/s13311-019-00777-6","article-title":"Molecular mechanisms and therapeutics for spinocerebellar Ataxia type 2","volume":"16","author":"Egorova","year":"2019","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ceca.2020.102319_bib0035","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1113\/jphysiol.1980.sp013358","article-title":"Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices","volume":"305","author":"Llinas","year":"1980","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2020.102319_bib0040","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1113\/jphysiol.1980.sp013357","article-title":"Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices","volume":"305","author":"Llinas","year":"1980","journal-title":"J. Physiol."},{"issue":"12","key":"10.1016\/j.ceca.2020.102319_bib0045","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1523\/JNEUROSCI.17-12-04517.1997","article-title":"Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons","volume":"17","author":"Raman","year":"1997","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.ceca.2020.102319_bib0050","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1523\/JNEUROSCI.19-05-01663.1999","article-title":"Ionic currents underlying spontaneous action potentials in isolated cerebellar Purkinje neurons","volume":"19","author":"Raman","year":"1999","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.ceca.2020.102319_bib0055","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/(SICI)1097-4695(199707)33:1<18::AID-NEU3>3.0.CO;2-G","article-title":"Analysis of spontaneous electrical activity in cerebellar Purkinje cells acutely isolated from postnatal rats","volume":"33","author":"Nam","year":"1997","journal-title":"J. Neurobiol."},{"issue":"24","key":"10.1016\/j.ceca.2020.102319_bib0060","doi-asserted-by":"crossref","first-page":"10603","DOI":"10.1523\/JNEUROSCI.22-24-10603.2002","article-title":"Active contribution of dendrites to the tonic and trimodal patterns of activity in cerebellar Purkinje neurons","volume":"22","author":"Womack","year":"2002","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.ceca.2020.102319_bib0065","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1523\/JNEUROSCI.23-02-00367.2003","article-title":"Persistent changes in spontaneous firing of Purkinje neurons triggered by the nitric oxide signaling cascade","volume":"23","author":"Smith","year":"2003","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.ceca.2020.102319_bib0070","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrn3011","article-title":"Spatiotemporal firing patterns in the cerebellum","volume":"12","author":"De Zeeuw","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"issue":"10","key":"10.1016\/j.ceca.2020.102319_bib0075","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.chembiol.2012.07.013","article-title":"Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2","volume":"19","author":"Kasumu","year":"2012","journal-title":"Chem. Biol."},{"issue":"6","key":"10.1016\/j.ceca.2020.102319_bib0080","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.neuron.2005.02.012","article-title":"Increased noise level of purkinje cell activities minimizes impact of their modulation during sensorimotor control","volume":"45","author":"Hoebeek","year":"2005","journal-title":"Neuron"},{"issue":"32","key":"10.1016\/j.ceca.2020.102319_bib0085","doi-asserted-by":"crossref","first-page":"11292","DOI":"10.1523\/JNEUROSCI.1357-15.2015","article-title":"Neuronal atrophy early in degenerative Ataxia Is a compensatory mechanism to regulate membrane excitability","volume":"35","author":"Dell\u2019Orco","year":"2015","journal-title":"J. Neurosci."},{"issue":"37","key":"10.1016\/j.ceca.2020.102319_bib0090","doi-asserted-by":"crossref","first-page":"12786","DOI":"10.1523\/JNEUROSCI.1643-12.2012","article-title":"Chronic suppression of inositol 1,4,5-triphosphate receptor-mediated calcium signaling in cerebellar purkinje cells alleviates pathological phenotype in spinocerebellar ataxia 2 mice","volume":"32","author":"Kasumu","year":"2012","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.ceca.2020.102319_bib0095","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/hmg\/dds427","article-title":"Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2","volume":"22","author":"Hansen","year":"2013","journal-title":"Hum. Mol. Genet."},{"issue":"36","key":"10.1016\/j.ceca.2020.102319_bib0100","doi-asserted-by":"crossref","first-page":"13002","DOI":"10.1523\/JNEUROSCI.2789-11.2011","article-title":"Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3","volume":"31","author":"Shakkottai","year":"2011","journal-title":"J. Neurosci."},{"issue":"23","key":"10.1016\/j.ceca.2020.102319_bib0105","doi-asserted-by":"crossref","first-page":"8882","DOI":"10.1523\/JNEUROSCI.0891-15.2015","article-title":"Spinocerebellar ataxia type 6 protein aggregates cause deficits in motor learning and cerebellar plasticity","volume":"35","author":"Mark","year":"2015","journal-title":"J. Neurosci."},{"issue":"21","key":"10.1016\/j.ceca.2020.102319_bib0110","doi-asserted-by":"crossref","first-page":"7258","DOI":"10.1523\/JNEUROSCI.3582-09.2010","article-title":"The therapeutic mode of action of 4-aminopyridine in cerebellar ataxia","volume":"30","author":"Alvina","year":"2010","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.ceca.2020.102319_bib0115","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nn1648","article-title":"Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia","volume":"9","author":"Walter","year":"2006","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.ceca.2020.102319_bib0120","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.expneurol.2012.04.015","article-title":"Disruption of Purkinje cell function prior to huntingtin accumulation and cell loss in an animal model of Huntington disease","volume":"236","author":"Dougherty","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ceca.2020.102319_bib0125","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.expneurol.2012.11.015","article-title":"Purkinje cell dysfunction and loss in a knock-in mouse model of Huntington disease","volume":"240","author":"Dougherty","year":"2013","journal-title":"Exp. Neurol."},{"issue":"6","key":"10.1016\/j.ceca.2020.102319_bib0130","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1152\/jn.00913.2015","article-title":"In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model","volume":"115","author":"Egorova","year":"2016","journal-title":"J. Neurophysiol."},{"issue":"5","key":"10.1016\/j.ceca.2020.102319_bib0135","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/s12311-018-0951-4","article-title":"In vivo analysis of the climbing fiber-purkinje cell circuit in SCA2-58Q transgenic mouse model","volume":"17","author":"Egorova","year":"2018","journal-title":"Cerebellum"},{"key":"10.1016\/j.ceca.2020.102319_bib0140","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3389\/fnins.2020.00279","article-title":"Ataxic symptoms in Huntington\u2019s disease transgenic mouse model are alleviated by chlorzoxazone","volume":"14","author":"Egorova","year":"2020","journal-title":"Front. Neurosci."},{"issue":"44","key":"10.1016\/j.ceca.2020.102319_bib0145","doi-asserted-by":"crossref","first-page":"15533","DOI":"10.1523\/JNEUROSCI.2454-12.2012","article-title":"Cerebellar ataxia by enhanced Ca(V)2.1 currents is alleviated by Ca2+-dependent K+-channel activators in Cacna1a(S218L) mutant mice","volume":"32","author":"Gao","year":"2012","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.ceca.2020.102319_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006763","article-title":"Hypothermia-induced dystonia and abnormal cerebellar activity in a mouse model with a single disease-mutation in the sodium-potassium pump","volume":"13","author":"Isaksen","year":"2017","journal-title":"PLoS Genet."},{"issue":"2","key":"10.1016\/j.ceca.2020.102319_bib0155","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.040840","article-title":"In vivo cerebellar circuit function is disrupted in an mdx mouse model of Duchenne muscular dystrophy","volume":"13","author":"Stay","year":"2019","journal-title":"Dis. Model. Mech."},{"issue":"7","key":"10.1016\/j.ceca.2020.102319_bib0160","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1523\/JNEUROSCI.23-07-02600.2003","article-title":"Somatic and dendritic small-conductance calcium-activated potassium channels regulate the output of cerebellar Purkinje neurons","volume":"23","author":"Womack","year":"2003","journal-title":"J. Neurosci."},{"issue":"21","key":"10.1016\/j.ceca.2020.102319_bib0165","doi-asserted-by":"crossref","first-page":"7249","DOI":"10.1523\/JNEUROSCI.6341-09.2010","article-title":"KCa channels as therapeutic targets in episodic ataxia type-2","volume":"30","author":"Alvina","year":"2010","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.ceca.2020.102319_bib0170","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/acn3.527","article-title":"Targeting potassium channels to treat cerebellar ataxia","volume":"5","author":"Bushart","year":"2018","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"10","key":"10.1016\/j.ceca.2020.102319_bib0175","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S1474-4422(15)00201-X","article-title":"Riluzole in patients with hereditary cerebellar ataxia: a randomised, double-blind, placebo-controlled trial","volume":"14","author":"Romano","year":"2015","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.ceca.2020.102319_bib0180","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/79162","article-title":"Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human","volume":"26","author":"Huynh","year":"2000","journal-title":"Nat. Genet."},{"issue":"88","key":"10.1016\/j.ceca.2020.102319_bib0185","first-page":"e51869","article-title":"Flat-floored air-lifted platform: a new method for combining behavior with microscopy or electrophysiology on awake freely moving rodents","author":"Kislin","year":"2014","journal-title":"J. Vis. Exp."},{"issue":"81","key":"10.1016\/j.ceca.2020.102319_bib0190","article-title":"Dantrolene is neuroprotective in Huntington\u2019s disease transgenic mouse model","volume":"6","author":"Chen","year":"2011","journal-title":"Mol. Neurodegener."},{"issue":"29","key":"10.1016\/j.ceca.2020.102319_bib0195","doi-asserted-by":"crossref","first-page":"9148","DOI":"10.1523\/JNEUROSCI.0660-09.2009","article-title":"Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2","volume":"29","author":"Liu","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2020.102319_bib0200","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1749-6632.2002.tb07574.x","article-title":"Historical review of the significance of the cerebellum and the role of Purkinje cells in motor learning","volume":"978","author":"Ito","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"18","key":"10.1016\/j.ceca.2020.102319_bib0205","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1523\/JNEUROSCI.5486-07.2008","article-title":"Purkinje-cell-restricted restoration of Kv3.3 function restores complex spikes and rescues motor coordination in Kcnc3 mutants","volume":"28","author":"Hurlock","year":"2008","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.ceca.2020.102319_bib0210","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2170\/jjphysiol.34.781","article-title":"The modifiable neuronal network of the cerebellum","volume":"34","author":"Ito","year":"1984","journal-title":"Jpn. J. Physiol."},{"issue":"30","key":"10.1016\/j.ceca.2020.102319_bib0215","doi-asserted-by":"crossref","first-page":"7599","DOI":"10.1523\/JNEUROSCI.0559-08.2008","article-title":"The origin of the complex spike in cerebellar Purkinje cells","volume":"28","author":"Davie","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2020.102319_bib0220","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0079-6123(05)51009-4","article-title":"Inferior olive and oculomotor system","volume":"151","author":"Barmack","year":"2006","journal-title":"Prog. Brain Res."},{"issue":"27","key":"10.1016\/j.ceca.2020.102319_bib0225","doi-asserted-by":"crossref","first-page":"12323","DOI":"10.1073\/pnas.1001745107","article-title":"Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels","volume":"107","author":"Chen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"36","key":"10.1016\/j.ceca.2020.102319_bib0230","doi-asserted-by":"crossref","first-page":"12778","DOI":"10.1523\/JNEUROSCI.2579-11.2011","article-title":"Abnormalities in the climbing fiber-Purkinje cell circuitry contribute to neuronal dysfunction in ATXN1[82Q] mice","volume":"31","author":"Barnes","year":"2011","journal-title":"J. Neurosci."},{"issue":"16","key":"10.1016\/j.ceca.2020.102319_bib0235","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1113\/JP271897","article-title":"Cellular and circuit mechanisms underlying spinocerebellar ataxias","volume":"594","author":"Meera","year":"2016","journal-title":"J. Physiol."},{"issue":"9","key":"10.1016\/j.ceca.2020.102319_bib0240","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.034181","article-title":"Aberrant cerebellar Purkinje cell activity as the cause of motor attacks in a mouse model of episodic ataxia type 2","volume":"11","author":"Tara","year":"2018","journal-title":"Dis. Model. Mech."},{"issue":"4","key":"10.1016\/j.ceca.2020.102319_bib0245","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.str.2018.02.017","article-title":"An intracellular allosteric modulator binding pocket in SK2 ion channels is shared by multiple chemotypes","volume":"26","author":"Cho","year":"2018","journal-title":"Structure"},{"issue":"2","key":"10.1016\/j.ceca.2020.102319_bib0250","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1365-2125.2004.02132.x","article-title":"Robustness of chlorzoxazone as an in vivo measure of cytochrome P450 2E1 activity","volume":"58","author":"Ernstgard","year":"2004","journal-title":"Br. J. Clin. Pharmacol."}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416020301615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416020301615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:25:44Z","timestamp":1778667944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416020301615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":50,"alternative-id":["S0143416020301615"],"URL":"https:\/\/doi.org\/10.1016\/j.ceca.2020.102319","relation":{},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo analysis of the spontaneous firing of cerebellar Purkinje cells in awake transgenic mice that model spinocerebellar ataxia type 2","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceca.2020.102319","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102319"}}