{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:15:13Z","timestamp":1778717713805,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["F31 NS111803"],"award-info":[{"award-number":["F31 NS111803"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009712","name":"Dravet Syndrome Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009712","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001068","name":"Dana Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.ceca.2021.102380","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T17:50:15Z","timestamp":1614016215000},"page":"102380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Two-photon calcium imaging of seizures in awake, head-fixed mice"],"prefix":"10.1016","volume":"96","author":[{"given":"Ala","family":"Somarowthu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin M.","family":"Goff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7404-735X","authenticated-orcid":false,"given":"Ethan M.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceca.2021.102380_bib0005","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neuron.2016.06.033","article-title":"GABAergic interneurons in the neocortex: from cellular properties to circuits","volume":"91","author":"Tremblay","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.ceca.2021.102380_bib0010","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.cell.2020.09.057","article-title":"Integrated morphoelectric and transcriptomic classification of cortical GABAergic cells","volume":"183","author":"Gouwens","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ceca.2021.102380_bib0015","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1038\/nn.3544","article-title":"A disinhibitory circuit mediates motor integration in the somatosensory cortex","volume":"16","author":"Lee","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ceca.2021.102380_bib0020","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nature12676","article-title":"Cortical interneurons that specialize in disinhibitory control","volume":"503","author":"Pi","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2021.102380_bib0025","doi-asserted-by":"crossref","first-page":"R18","DOI":"10.1016\/j.cub.2013.11.001","article-title":"Inhibitory neurons: vip cells hit the brake on inhibition","volume":"24","author":"Pfeffer","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ceca.2021.102380_bib0030","doi-asserted-by":"crossref","DOI":"10.3389\/fncir.2020.00032","article-title":"Common principles in functional organization of VIP\/Calretinin cell-driven disinhibitory circuits across cortical areas","volume":"14","author":"Guet-McCreight","year":"2020","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.ceca.2021.102380_bib0035","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrn2044","article-title":"Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks","volume":"8","author":"Bartos","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ceca.2021.102380_bib0040","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nature07991","article-title":"Parvalbumin neurons and gamma rhythms enhance cortical circuit performance","volume":"459","author":"Sohal","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2021.102380_bib0045","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nature08002","article-title":"Driving fast-spiking cells induces gamma rhythm and controls sensory responses","volume":"459","author":"Cardin","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2021.102380_bib0050","series-title":"Prog. Brain Res.","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/bs.pbr.2016.04.012","article-title":"Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy","author":"Jiang","year":"2016"},{"key":"10.1016\/j.ceca.2021.102380_bib0055","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0006-8993(80)90119-5","article-title":"Changes in excitatory and inhibitory synaptic potentials leading to epileptogenic activity","volume":"183","author":"Schwartzkroin","year":"1980","journal-title":"Brain Res."},{"key":"10.1016\/j.ceca.2021.102380_bib0060","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1002\/ana.410160710","article-title":"Mechanisms of epileptogenesis in cortical structures","volume":"16","author":"Prince","year":"1984","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ceca.2021.102380_bib0065","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1152\/jn.01378.2005","article-title":"Interneuron and pyramidal cell interplay during in vitro seizure-like events","volume":"95","author":"Ziburkus","year":"2006","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ceca.2021.102380_bib0070","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.pneurobio.2011.07.003","article-title":"GABAergic synchronization in the limbic system and its role in the generation of epileptiform activity","volume":"95","author":"Avoli","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ceca.2021.102380_bib0075","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/nm.2058","article-title":"Enhanced tonic GABA A inhibition in typical absence epilepsy","volume":"15","author":"Cope","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.ceca.2021.102380_bib0080","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1016\/j.celrep.2017.05.090","article-title":"Reliable and elastic propagation of cortical seizures in vivo","volume":"19","author":"Wenzel","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.ceca.2021.102380_bib0085","doi-asserted-by":"crossref","first-page":"8562","DOI":"10.1523\/JNEUROSCI.3176-18.2019","article-title":"Acute focal seizures start As local synchronizations of neuronal ensembles","volume":"39","author":"Wenzel","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2021.102380_bib0090","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/ana.25628","article-title":"Layer- and cell-specific recruitment dynamics during epileptic seizures in vivo","volume":"87","author":"Aeed","year":"2020","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ceca.2021.102380_bib0095","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1523\/JNEUROSCI.2370-19.2020","article-title":"Interneuron desynchronization precedes seizures in a mouse model of dravet syndrome","volume":"40","author":"Tran","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2021.102380_bib0100","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nrn3241","article-title":"The origin of extracellular fields and currents-EEG, ECoG, LFP and spikes","volume":"13","author":"Buzs\u00e1ki","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ceca.2021.102380_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms2056","article-title":"Evidence of an inhibitory restraint of seizure activity in humans","volume":"3","author":"Schevon","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ceca.2021.102380_bib0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms11098","article-title":"The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures","volume":"7","author":"Smith","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ceca.2021.102380_bib0115","article-title":"Two modes of inhibitory neuronal shutdown distinctly amplify seizures in humans","volume":"8","author":"Ahmed","year":"2020","journal-title":"MedRxiv"},{"key":"10.1016\/j.ceca.2021.102380_bib0120","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature24636","article-title":"Fully integrated silicon probes for high-density recording of neural activity","volume":"551","author":"Jun","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2021.102380_bib0125","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.conb.2018.01.009","article-title":"Challenges and opportunities for large-scale electrophysiology with Neuropixels probes","volume":"50","author":"Steinmetz","year":"2018","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ceca.2021.102380_bib0130","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2018.00082","article-title":"The enlightened brain: novel imaging methods focus on epileptic networks at multiple scales","volume":"12","author":"Rossi","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ceca.2021.102380_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-04349-8","article-title":"Asynchronous suppression of visual cortex during absence seizures in stargazer mice","volume":"9","author":"Meyer","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ceca.2021.102380_bib0140","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1093\/brain\/awv227","article-title":"GABAergic inhibition shapes interictal dynamics in awake epileptic mice","volume":"138","author":"Muldoon","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.ceca.2021.102380_bib0145","doi-asserted-by":"crossref","first-page":"131","DOI":"10.5698\/1535-7597.18.2.131","article-title":"Same pattern of neuron activation from seizure to seizure, only the timing changes","volume":"18","author":"Ewell","year":"2018","journal-title":"Epilepsy Curr."},{"key":"10.1016\/j.ceca.2021.102380_bib0150","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.neuron.2013.07.052","article-title":"Chronic cellular imaging of entire cortical columns in awake mice using microprisms","volume":"80","author":"Andermann","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.ceca.2021.102380_bib0155","doi-asserted-by":"crossref","first-page":"e1310","DOI":"10.1542\/peds.2015-1807","article-title":"Incidence of dravet syndrome in a US population","volume":"136","author":"Wu","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.ceca.2021.102380_bib0160","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.nbd.2012.08.003","article-title":"Mouse with Nav1.1 haploinsufficiency, a model for Dravet syndrome, exhibits lowered sociability and learning impairment","volume":"49","author":"Ito","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ceca.2021.102380_bib0165","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1411131111","article-title":"Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome","volume":"111","author":"Tai","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ceca.2021.102380_bib0170","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.13073","article-title":"A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients","volume":"5","author":"Sun","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.ceca.2021.102380_bib0175","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/nn1754","article-title":"Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy","volume":"9","author":"Yu","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ceca.2021.102380_bib0180","doi-asserted-by":"crossref","first-page":"5903","DOI":"10.1523\/JNEUROSCI.5270-06.2007","article-title":"Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation","volume":"27","author":"Ogiwara","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2021.102380_bib0185","doi-asserted-by":"crossref","first-page":"7912","DOI":"10.1523\/JNEUROSCI.0193-18.2018","article-title":"A transient developmental window of fast-spiking interneuron dysfunction in a mouse model of dravet syndrome","volume":"38","author":"Favero","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2021.102380_bib0190","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.46846","article-title":"Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of dravet syndrome","volume":"8","author":"Goff","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.ceca.2021.102380_bib0195","first-page":"061507","article-title":"Suite2p: beyond 10,000 neurons with standard two-photon microscopy","author":"Pachitariu","year":"2016","journal-title":"BioRxiv"},{"key":"10.1016\/j.ceca.2021.102380_bib0200","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/s41593-018-0209-y","article-title":"DeepLabCut: markerless pose estimation of user-defined body parts with deep learning","volume":"21","author":"Mathis","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ceca.2021.102380_bib0205","series-title":"Strain-and Age-dependent Hippocampal Neuron Sodium Currents Correlate With Epilepsy Severity in Dravet Syndrome Mice","author":"Mistry","year":"2014"},{"key":"10.1016\/j.ceca.2021.102380_bib0210","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1093\/cercor\/bhw002","article-title":"Unaltered network activity and interneuronal firing during spontaneous cortical dynamics in vivo in a mouse model of severe myoclonic epilepsy of infancy","volume":"26","author":"De Stasi","year":"2016","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.ceca.2021.102380_bib0215","first-page":"616094","article-title":"Population imaging of neural activity in awake behaving mice in multiple brain regions","author":"Piatkevich","year":"2019","journal-title":"BioRxiv"},{"key":"10.1016\/j.ceca.2021.102380_bib0220","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.14472","article-title":"A large field of view two-photon mesoscope with subcellular resolution for in vivo imaging","volume":"5","author":"Sofroniew","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.ceca.2021.102380_bib0225","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nbt.3594","article-title":"Wide field-of-view, multi-region, two-photon imaging of neuronal activity in the mammalian brain","volume":"34","author":"Stirman","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ceca.2021.102380_bib0230","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1016\/j.celrep.2016.12.004","article-title":"Long-term optical access to an estimated one million neurons in the live mouse cortex","volume":"17","author":"Kim","year":"2016","journal-title":"Cell Rep."}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416021000348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416021000348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:56:59Z","timestamp":1778716619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416021000348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":46,"alternative-id":["S0143416021000348"],"URL":"https:\/\/doi.org\/10.1016\/j.ceca.2021.102380","relation":{},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Two-photon calcium imaging of seizures in awake, head-fixed mice","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceca.2021.102380","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102380"}}