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Ar, Exercise for osteoarthritis of the knee (Review), (2015). 10.1002\/14651858.CD004376.pub3."},{"key":"10.1016\/j.ceca.2021.102467_bib0069","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/acr.23791","article-title":"Moderate physical activity and prevention of cartilage loss in people with knee osteoarthritis: data from the osteoarthritis initiative","volume":"71","author":"Bricca","year":"2019","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.ceca.2021.102467_bib0070","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.joca.2018.07.010","article-title":"The impact of physical activity level on the short- and long-term pain relief from supervised exercise therapy and education: a study of 12,796 Danish patients with knee osteoarthritis","volume":"26","author":"Skou","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.ceca.2021.102467_bib0071","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1111\/jcmm.15204","article-title":"Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis","volume":"24","author":"Zhao","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ceca.2021.102467_bib0072","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/978-94-007-2888-2_46","article-title":"Mechanosensory calcium signaling","volume":"740","author":"Jones","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ceca.2021.102467_bib0073","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/19336950.2021.1903184","article-title":"Mechanosensory and mechanotransductive processes mediated by ion channels in articular chondrocytes: potential therapeutic targets for osteoarthritis","volume":"15","author":"Zhang","year":"2021","journal-title":"Channels"},{"key":"10.1016\/j.ceca.2021.102467_bib0074","unstructured":"B.-.Y. Xu, Y. Jin, X.-.H. Ma, C.-.Y. Wang, Y. Guo, D. 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