{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:34:42Z","timestamp":1778697282207,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81,700,332"],"award-info":[{"award-number":["81,700,332"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81,770,328"],"award-info":[{"award-number":["81,770,328"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81,900,324"],"award-info":[{"award-number":["81,900,324"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81,971,274"],"award-info":[{"award-number":["81,971,274"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,170,326"],"award-info":[{"award-number":["82,170,326"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ceca.2021.102483","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T14:15:42Z","timestamp":1633443342000},"page":"102483","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Activation of transient receptor potential vanilloid 4 exacerbates myocardial ischemia-reperfusion injury via JNK-CaMKII phosphorylation pathway in isolated mice hearts"],"prefix":"10.1016","volume":"100","author":[{"given":"Shaoshao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuaitao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiongfeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimei","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2018","key":"10.1016\/j.ceca.2021.102483_bib0001","first-page":"1736","article-title":"Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980\u20132017: a systematic analysis for the global burden of disease study","volume":"392","author":"Roth","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.ceca.2021.102483_bib0002","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.ceca.2021.102483_bib0003","doi-asserted-by":"crossref","first-page":"H1156","DOI":"10.1152\/ajpheart.00497.2020","article-title":"Transient receptor potential vanilloid 4 channel participates in mouse ventricular electrical activity","volume":"320","author":"Chaigne","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol"},{"key":"10.1016\/j.ceca.2021.102483_bib0004","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/cvr\/cvy156","article-title":"TRPV4 increases cardiomyocyte calcium cycling and contractility yet contributes to damage in the aged heart following hypoosmotic stress","volume":"115","author":"Jones","year":"2019","journal-title":"Cardiovasc. Res"},{"key":"10.1016\/j.ceca.2021.102483_bib0005","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.137528","article-title":"TRPV4 blockade suppresses atrial fibrillation in sterile pericarditis rats","volume":"5","author":"Liao","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.ceca.2021.102483_bib0006","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1152\/physrev.00016.2015","article-title":"TRPV4: molecular conductor of a diverse orchestra","volume":"96","author":"White","year":"2016","journal-title":"Physiol. Rev"},{"key":"10.1016\/j.ceca.2021.102483_bib0007","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/35036318","article-title":"OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity","volume":"2","author":"Strotmann","year":"2000","journal-title":"Nat. Cell Biol"},{"key":"10.1016\/j.ceca.2021.102483_bib0008","doi-asserted-by":"crossref","first-page":"e2828","DOI":"10.1038\/cddis.2017.227","article-title":"Activation of transient receptor potential vanilloid 4 involves in hypoxia\/reoxygenation injury in cardiomyocytes","volume":"8","author":"Wu","year":"2017","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ceca.2021.102483_bib0009","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7283683","article-title":"Blockade of transient receptor potential vanilloid 4 enhances antioxidation after myocardial ischemia\/reperfusion","volume":"2019","author":"Wu","year":"2019","journal-title":"Oxid. Med. Cell Longev"},{"key":"10.1016\/j.ceca.2021.102483_bib0010","doi-asserted-by":"crossref","first-page":"42678","DOI":"10.1038\/srep42678","article-title":"Blockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia\/reperfusion injury in mice","volume":"7","author":"Dong","year":"2017","journal-title":"Sci. Rep"},{"key":"10.1016\/j.ceca.2021.102483_bib0011","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s12035-014-8992-2","article-title":"Activation of transient receptor potential vanilloid 4 is involved in neuronal injury in middle cerebral artery occlusion in mice","volume":"53","author":"Jie","year":"2016","journal-title":"Mol. Neurobiol"},{"key":"10.1016\/j.ceca.2021.102483_bib0012","doi-asserted-by":"crossref","first-page":"e1775","DOI":"10.1038\/cddis.2015.146","article-title":"Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K\/Akt and upregulating p38 MAPK signaling pathways","volume":"6","author":"Jie","year":"2015","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ceca.2021.102483_bib0013","doi-asserted-by":"crossref","DOI":"10.1042\/CS20180815","article-title":"Pharmacological inhibition of TRPV4 channels protects against ischemia-reperfusion-induced renal insufficiency in neonatal pigs","author":"Soni","year":"2019","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.ceca.2021.102483_bib0014","doi-asserted-by":"crossref","first-page":"966","DOI":"10.3389\/fphys.2017.00966","article-title":"MiR-29a suppresses spermatogenic cell apoptosis in testicular ischemia-reperfusion injury by targeting TRPV4 channels","volume":"8","author":"Ning","year":"2017","journal-title":"Front. Physiol"},{"key":"10.1016\/j.ceca.2021.102483_bib0015","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.134464","article-title":"TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema","volume":"5","author":"Weber","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.ceca.2021.102483_bib0016","article-title":"Endothelial transient receptor potential v4 channels mediate lung ischemia-reperfusion injury","author":"Haywood","year":"2021","journal-title":"Ann. Thorac. Surg"},{"key":"10.1016\/j.ceca.2021.102483_bib0017","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.3389\/fphar.2019.01150","article-title":"Propofol induces cardioprotection against ischemia-reperfusion injury via suppression of transient receptor potential vanilloid 4 channel","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Pharmacol"},{"key":"10.1016\/j.ceca.2021.102483_bib0018","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/CS20070430","article-title":"MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets","volume":"115","author":"Muslin","year":"2008","journal-title":"Clin. Sci. (Lond)"},{"key":"10.1016\/j.ceca.2021.102483_bib0019","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.yjmcc.2016.12.007","article-title":"CaMKII is a nodal signal for multiple programmed cell death pathways in heart","volume":"103","author":"Feng","year":"2017","journal-title":"J. Mol. Cell Cardiol"},{"key":"10.1016\/j.ceca.2021.102483_bib0020","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1038\/s41467-020-16411-5","article-title":"TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+","volume":"11","author":"Woolums","year":"2020","journal-title":"Nat. Commun"},{"key":"10.1016\/j.ceca.2021.102483_bib0021","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.4049\/jimmunol.1901033","article-title":"TRPV4 protects the lung from bacterial pneumonia via MAPK molecular pathway switching","volume":"204","author":"Scheraga","year":"2020","journal-title":"J. Immunol"},{"key":"10.1016\/j.ceca.2021.102483_bib0022","doi-asserted-by":"crossref","first-page":"C96","DOI":"10.1152\/ajpcell.00559.2002","article-title":"Impaired osmotic sensation in mice lacking TRPV4","volume":"285","author":"Mizuno","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol"},{"key":"10.1016\/j.ceca.2021.102483_bib0023","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1161\/01.RES.0000249369.71709.5c","article-title":"Calmodulin kinase II inhibition shortens action potential duration by upregulation of K+ currents","volume":"99","author":"Li","year":"2006","journal-title":"Circ. Res"},{"key":"10.1016\/j.ceca.2021.102483_bib0024","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nm1215","article-title":"Calmodulin kinase II inhibition protects against structural heart disease","volume":"11","author":"Zhang","year":"2005","journal-title":"Nat. Med"},{"key":"10.1016\/j.ceca.2021.102483_bib0025","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1073\/pnas.95.6.2979","article-title":"HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte","volume":"95","author":"Claycomb","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.ceca.2021.102483_bib0026","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.1523\/JNEUROSCI.0359-11.2011","article-title":"The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells","volume":"31","author":"Ryskamp","year":"2011","journal-title":"J. Neurosci"},{"key":"10.1016\/j.ceca.2021.102483_bib0027","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/1089253211436350","article-title":"Myocardial ischemia reperfusion injury: from basic science to clinical bedside","volume":"16","author":"Frank","year":"2012","journal-title":"Semin Cardiothorac. Vasc. Anesth"},{"key":"10.1016\/j.ceca.2021.102483_bib0028","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/onc.2015.83","article-title":"Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy","volume":"35","author":"Adapala","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.ceca.2021.102483_bib0029","doi-asserted-by":"crossref","first-page":"e16713","DOI":"10.1371\/journal.pone.0016713","article-title":"Determinants of TRPV4 activity following selective activation by small molecule agonist GSK1016790A","volume":"6","author":"Jin","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ceca.2021.102483_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109697","article-title":"The effect of transient receptor potential vanilloid 4 on the intestinal epithelial barrier and human colonic cells was affected by tyrosine-phosphorylated claudin-7","volume":"122","author":"Huang","year":"2020","journal-title":"Biomed. Pharmacother"},{"key":"10.1016\/j.ceca.2021.102483_bib0031","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.cell.2012.08.034","article-title":"TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis","volume":"151","author":"Ye","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ceca.2021.102483_bib0032","doi-asserted-by":"crossref","first-page":"e12912","DOI":"10.1111\/cpr.12912","article-title":"Mechanical force modulates periodontal ligament stem cell characteristics during bone remodelling via TRPV4","author":"Jin","year":"2020","journal-title":"Cell Prolif"},{"key":"10.1016\/j.ceca.2021.102483_bib0033","doi-asserted-by":"crossref","first-page":"5768","DOI":"10.1007\/s12035-016-0113-y","article-title":"Activation of transient receptor potential vanilloid 4 promotes the proliferation of stem cells in the adult hippocampal dentate gyrus","volume":"54","author":"Tian","year":"2017","journal-title":"Mol. Neurobiol"},{"key":"10.1016\/j.ceca.2021.102483_bib0034","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/CIRCRESAHA.116.305348","article-title":"Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning","volume":"116","author":"Heusch","year":"2015","journal-title":"Circ. Res"},{"key":"10.1016\/j.ceca.2021.102483_bib0035","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aan5748","article-title":"Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes","volume":"10","author":"Lyons","year":"2017","journal-title":"Sci. Signal"},{"key":"10.1016\/j.ceca.2021.102483_bib0036","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nm.4017","article-title":"CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis","volume":"22","author":"Zhang","year":"2016","journal-title":"Nat. Med"},{"key":"10.1016\/j.ceca.2021.102483_bib0037","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/s41419-020-2605-y","article-title":"CaMKII\/calpain interaction mediates ischemia\/reperfusion injury in isolated rat hearts","volume":"11","author":"Lu","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ceca.2021.102483_bib0038","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(02)01036-X","article-title":"Bid, bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane","volume":"111","author":"Kuwana","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.ceca.2021.102483_bib0039","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1161\/01.RES.81.2.137","article-title":"Death by design. Programmed cell death in cardiovascular biology and disease","volume":"81","author":"MacLellan","year":"1997","journal-title":"Circ. Res"},{"key":"10.1016\/j.ceca.2021.102483_bib0040","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1161\/CIRCRESAHA.120.318409","article-title":"JNK2, a newly-identified SERCA2 enhancer, augments an arrhythmic [Ca(2+)](SR) leak-load relationship","volume":"128","author":"Yan","year":"2021","journal-title":"Circ. Res"},{"key":"10.1016\/j.ceca.2021.102483_bib0041","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.jacc.2018.01.060","article-title":"Role of stress kinase JNK in binge alcohol-evoked atrial arrhythmia","volume":"71","author":"Yan","year":"2018","journal-title":"J. Am. Coll. Cardiol"},{"key":"10.1016\/j.ceca.2021.102483_bib0042","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/cvr\/cvy011","article-title":"Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIIdelta expression in the aged atrium","volume":"114","author":"Gao","year":"2018","journal-title":"Cardiovasc. Res"},{"key":"10.1016\/j.ceca.2021.102483_bib0043","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/cbf.3587","article-title":"A review of myocardial ischaemia\/reperfusion injury: pathophysiology, experimental models, biomarkers, genetics and pharmacological treatment","volume":"39","author":"Gunata","year":"2021","journal-title":"Cell Biochem. Funct"}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416021001378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416021001378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T20:30:00Z","timestamp":1758918600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416021001378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":43,"alternative-id":["S0143416021001378"],"URL":"https:\/\/doi.org\/10.1016\/j.ceca.2021.102483","relation":{},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of transient receptor potential vanilloid 4 exacerbates myocardial ischemia-reperfusion injury via JNK-CaMKII phosphorylation pathway in isolated mice hearts","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceca.2021.102483","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102483"}}