{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T19:00:30Z","timestamp":1781463630630,"version":"3.54.1"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR- 152"],"award-info":[{"award-number":["TRR- 152"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FKZ 464424253"],"award-info":[{"award-number":["FKZ 464424253"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FKZ 239283807"],"award-info":[{"award-number":["FKZ 239283807"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research Bonn Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["233024"],"award-info":[{"award-number":["233024"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ceca.2025.103101","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:30:12Z","timestamp":1764894612000},"page":"103101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Nuclear Ca2+-Calmodulin signaling in cardiac myocytes reduces catecholamine-evoked protein translation and prevents hypertrophy"],"prefix":"10.1016","volume":"133","author":[{"given":"Anja","family":"Riedel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekka","family":"Medert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Monaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enio","family":"Gjerga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenia","family":"Tolksdorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christin","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Malz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Schrader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Kuryshev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Jungmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"L\u00f6wenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koenraad","family":"Philippaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Wirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Ottenheijm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Benes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Most","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Dieterich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"V\u00f6lkers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilmar","family":"Bading","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1387-2636","authenticated-orcid":false,"given":"Marc","family":"Freichel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceca.2025.103101_bib0001","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ceca.2025.103101_bib0002","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1016\/j.bbadis.2013.07.023","article-title":"Regulation of fetal gene expression in heart failure","volume":"1832","author":"Dirkx","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ceca.2025.103101_bib0003","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1161\/CIRCULATIONAHA.115.013894","article-title":"Inhibition of hypertrophy is a good therapeutic strategy in ventricular pressure overload","volume":"131","author":"Schiattarella","year":"2015","journal-title":"Circulation"},{"issue":"Suppl 7","key":"10.1016\/j.ceca.2025.103101_bib0004","doi-asserted-by":"crossref","first-page":"S182","DOI":"10.1097\/00005344-199100177-00052","article-title":"Endothelin-1 stimulates hypertrophy and contractility of neonatal rat cardiac myocytes in a serum-free medium. II","volume":"17","author":"Suzuki","year":"1991","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.ceca.2025.103101_bib0005","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1157\/13087900","article-title":"Cardiac hypertrophy: molecular and cellular events]","volume":"59","author":"Carreno","year":"2006","journal-title":"Rev Esp Cardiol"},{"key":"10.1016\/j.ceca.2025.103101_bib0006","doi-asserted-by":"crossref","first-page":"14466","DOI":"10.1074\/jbc.275.19.14466","article-title":"The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes","volume":"275","author":"Morisco","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceca.2025.103101_bib0007","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1161\/CIRCRESAHA.117.310355","article-title":"Calcium signaling and transcriptional regulation in cardiomyocytes","volume":"121","author":"Dewenter","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.ceca.2025.103101_bib0008","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1038\/sj.emboj.7601417","article-title":"TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy","volume":"25","author":"Onohara","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.ceca.2025.103101_bib0009","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1093\/eurheartj\/ehv250","article-title":"A background Ca2+ entry pathway mediated by TRPC1\/TRPC4 is critical for development of pathological cardiac remodelling","volume":"36","author":"Camacho Londono","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ceca.2025.103101_bib0010","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.yjmcc.2010.01.020","article-title":"Most, Orai1 and Stim1 regulate normal and hypertrophic growth in cardiomyocytes","volume":"48","author":"Voelkers","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ceca.2025.103101_bib0011","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1161\/CIRCRESAHA.110.220038","article-title":"The IP3 receptor regulates cardiac hypertrophy in response to select stimuli","volume":"107","author":"Nakayama","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.ceca.2025.103101_bib0012","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0092-8674(00)80847-8","article-title":"PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts","volume":"101","author":"Marx","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.ceca.2025.103101_bib0013","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1161\/CIRCULATIONAHA.114.008927","article-title":"Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure","volume":"130","author":"Ljubojevic","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.ceca.2025.103101_bib0014","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","article-title":"Calcium signaling","volume":"131","author":"Clapham","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.ceca.2025.103101_bib0015","doi-asserted-by":"crossref","first-page":"7166","DOI":"10.1093\/emboj\/16.23.7166","article-title":"Nuclear calcium signalling by individual cytoplasmic calcium puffs","volume":"16","author":"Lipp","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/j.ceca.2025.103101_bib0016","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1471-2202-8-57","article-title":"Calcium signals can freely cross the nuclear envelope in hippocampal neurons: somatic calcium increases generate nuclear calcium transients","volume":"8","author":"Eder","year":"2007","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.ceca.2025.103101_bib0017","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/978-3-7091-0932-8_17","article-title":"Nuclear calcium signaling","volume":"970","author":"Bengtson","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.ceca.2025.103101_bib0018","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrn3531","article-title":"Nuclear calcium signalling in the regulation of brain function","volume":"14","author":"Bading","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.ceca.2025.103101_bib0019","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1242\/jcs.021386","article-title":"Endothelin-1 enhances nuclear Ca2+ transients in atrial myocytes through ins(1,4,5)P3-dependent Ca2+ release from perinuclear Ca2+ stores","volume":"121","author":"Kockskamper","year":"2008","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ceca.2025.103101_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s004240050098","article-title":"Calcium transport pathways in the nucleus","volume":"432","author":"Gerasimenko","year":"1996","journal-title":"Pflug. Arch"},{"key":"10.1016\/j.ceca.2025.103101_bib0021","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.molcel.2009.02.005","article-title":"Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes","volume":"33","author":"Higazi","year":"2009","journal-title":"Mol Cell"},{"key":"10.1016\/j.ceca.2025.103101_bib0022","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/81321","article-title":"Decoding calcium signals involved in cardiac growth and function","volume":"6","author":"Frey","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.ceca.2025.103101_bib0023","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1172\/JCI27374","article-title":"Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling","volume":"116","author":"Wu","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ceca.2025.103101_bib0024","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0960-9822(00)80027-5","article-title":"MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium","volume":"9","author":"Kolodziejczyk","year":"1999","journal-title":"Curr Biol"},{"key":"10.1016\/j.ceca.2025.103101_bib0025","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1073\/pnas.0813013106","article-title":"The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload","volume":"106","author":"Backs","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceca.2025.103101_bib0026","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1172\/JCI38022","article-title":"Requirement for Ca2+\/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice","volume":"119","author":"Ling","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ceca.2025.103101_bib0027","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/297504a0","article-title":"Calcium-binding protein parvalbumin is associated with fast contracting muscle fibres","volume":"297","author":"Celio","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2025.103101_bib0028","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125050","article-title":"Stimulus-dependent regulation of nuclear Ca2+ signaling in cardiomyocytes: a role of neuronal calcium sensor-1","volume":"10","author":"Nakao","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ceca.2025.103101_bib0029","doi-asserted-by":"crossref","first-page":"23039","DOI":"10.1074\/jbc.M115.654962","article-title":"Nuclear calcium buffering capacity shapes neuronal architecture","volume":"290","author":"Mauceri","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceca.2025.103101_bib0030","doi-asserted-by":"crossref","first-page":"27517","DOI":"10.1074\/jbc.M203002200","article-title":"Epidermal growth factor-mediated activation of the ETS domain transcription factor elk-1 requires nuclear calcium","volume":"277","author":"Pusl","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceca.2025.103101_bib0031","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1006\/jmcc.2000.1185","article-title":"Phosphorylation of elk-1 by MEK\/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy","volume":"32","author":"Babu","year":"2000","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ceca.2025.103101_bib0032","doi-asserted-by":"crossref","first-page":"30245","DOI":"10.1074\/jbc.270.51.30245","article-title":"Functional elimination of calmodulin within the nucleus by targeted expression of an inhibitor peptide","volume":"270","author":"Wang","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceca.2025.103101_bib0033","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000604","article-title":"Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity","volume":"5","author":"Zhang","year":"2009","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ceca.2025.103101_bib0034","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neuron.2011.04.022","article-title":"Nuclear calcium-VEGFD signaling controls maintenance of dendrite arborization necessary for memory formation","volume":"71","author":"Mauceri","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.ceca.2025.103101_bib0035","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuron.2012.10.037","article-title":"Nuclear calcium signaling in spinal neurons drives a genomic program required for persistent inflammatory pain","volume":"77","author":"Simonetti","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.ceca.2025.103101_bib0036","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1083\/jcb.201602001","article-title":"Nuclear calcium is required for human T cell activation","volume":"215","author":"Monaco","year":"2016","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ceca.2025.103101_bib0037","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/cvr\/cvu174","article-title":"Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase","volume":"104","author":"Werfel","year":"2014","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ceca.2025.103101_bib0038","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/nprot.2006.207","article-title":"Production and characterization of adeno-associated viral vectors","volume":"1","author":"Grieger","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1016\/j.ceca.2025.103101_bib0039","unstructured":"A. S, FastQC: a quality control tool for high throughput sequence data, 2010."},{"key":"10.1016\/j.ceca.2025.103101_bib0040","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ceca.2025.103101_bib0041","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ceca.2025.103101_bib0042","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.ceca.2025.103101_bib0043","doi-asserted-by":"crossref","first-page":"W199","DOI":"10.1093\/nar\/gkz401","article-title":"WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs","volume":"47","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ceca.2025.103101_bib0044","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ng.3593","article-title":"Functional characterization of somatic mutations in cancer using network-based inference of protein activity","volume":"48","author":"Alvarez","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.ceca.2025.103101_bib0045","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1101\/gr.240663.118","article-title":"Benchmark and integration of resources for the estimation of human transcription factor activities","volume":"29","author":"Garcia-Alonso","year":"2019","journal-title":"Genome Res"},{"key":"10.1016\/j.ceca.2025.103101_bib0046","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1186\/s12859-016-1402-1","article-title":"Efficient randomization of biological networks while preserving functional characterization of individual nodes","volume":"17","author":"Iorio","year":"2016","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.ceca.2025.103101_bib0047","doi-asserted-by":"crossref","first-page":"8074","DOI":"10.1074\/jbc.M112.432773","article-title":"Nuclear calcium signaling regulates nuclear export of a subset of class IIa histone deacetylases following synaptic activity","volume":"288","author":"Schlumm","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceca.2025.103101_bib0048","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1101\/gad.1338705","article-title":"Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2","volume":"19","author":"Nakagawa","year":"2005","journal-title":"Genes Dev"},{"key":"10.1016\/j.ceca.2025.103101_bib0049","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1161\/CIRCRESAHA.109.209007","article-title":"Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2","volume":"106","author":"McCalmon","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.ceca.2025.103101_bib0050","first-page":"2709","article-title":"Upregulation of SPI1 during myocardial infarction aggravates cardiac tissue injury and disease progression through activation of the TLR4\/NFkappaB axis","volume":"14","author":"Liu","year":"2022","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.ceca.2025.103101_bib0051","doi-asserted-by":"crossref","first-page":"7867","DOI":"10.1111\/jcmm.16704","article-title":"Runt-related transcription factor 1 (Runx1) aggravates pathological cardiac hypertrophy by promoting p53 expression","volume":"25","author":"Zhang","year":"2021","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.ceca.2025.103101_bib0052","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1161\/01.RES.82.2.244","article-title":"Biphasic activation of the JAK\/STAT pathway by angiotensin II in rat cardiomyocytes","volume":"82","author":"Kodama","year":"1998","journal-title":"Circ Res"},{"key":"10.1016\/j.ceca.2025.103101_bib0053","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1172\/JCI27643.","article-title":"Transcription factor MITF regulates cardiac growth and hypertrophy","volume":"116","author":"Tshori","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ceca.2025.103101_bib0054","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.yjmcc.2015.09.010","article-title":"MITF interacts with the SWI\/SNF subunit, BRG1, to promote GATA4 expression in cardiac hypertrophy","volume":"88","author":"Mehta","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ceca.2025.103101_bib0055","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1177\/1087057113500812","article-title":"Phenotypic screening with human iPS cell-derived cardiomyocytes: hTS-compatible assays for interrogating cardiac hypertrophy","volume":"18","author":"Carlson","year":"2013","journal-title":"J Biomol Screen"},{"key":"10.1016\/j.ceca.2025.103101_bib0056","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.ajpath.2011.11.007","article-title":"The NF-kappaB subunit c-rel stimulates cardiac hypertrophy and fibrosis","volume":"180","author":"Gaspar-Pereira","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ceca.2025.103101_bib0057","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1128\/MCB.00229-15","article-title":"Orphan nuclear receptor Nur77 inhibits cardiac hypertrophic response to beta-adrenergic stimulation","volume":"35","author":"Yan","year":"2015","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ceca.2025.103101_bib0058","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1093\/cvr\/cvy125","article-title":"Nur77 protects against adverse cardiac remodelling by limiting neuropeptide Y signalling in the sympathoadrenal-cardiac axis","volume":"114","author":"Medzikovic","year":"2018","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ceca.2025.103101_bib0059","doi-asserted-by":"crossref","DOI":"10.1172\/JCI150595","article-title":"YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload","volume":"132","author":"Kashihara","year":"2022","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ceca.2025.103101_bib0060","doi-asserted-by":"crossref","first-page":"13252","DOI":"10.1002\/jcp.27997","article-title":"miR-29a attenuates cardiac hypertrophy through inhibition of PPARdelta expression","volume":"234","author":"Zhang","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ceca.2025.103101_bib0061","doi-asserted-by":"crossref","first-page":"7697","DOI":"10.12659\/MSM.912984","article-title":"Identification of potential gene interactions in heart failure caused by idiopathic dilated cardiomyopathy","volume":"24","author":"Huang","year":"2018","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.ceca.2025.103101_bib0062","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.cell.2010.11.036","article-title":"C\/EBPbeta controls exercise-induced cardiac growth and protects against pathological cardiac remodeling","volume":"143","author":"Bostrom","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ceca.2025.103101_bib0063","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026744","article-title":"Activating transcription factor 3 deficiency promotes cardiac hypertrophy, dysfunction, and fibrosis induced by pressure overload","volume":"6","author":"Zhou","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ceca.2025.103101_bib0064","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.yjmcc.2012.09.004","article-title":"Anti-apoptotic function of the E2F transcription factor 4 (E2F4)\/p130, a member of retinoblastoma gene family in cardiac myocytes","volume":"53","author":"Dingar","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ceca.2025.103101_bib0065","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1038\/ncomms4303","article-title":"IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling","volume":"5","author":"Jiang","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.ceca.2025.103101_bib0066","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s00395-012-0326-9","article-title":"Interferon regulatory factor 3 is a negative regulator of pathological cardiac hypertrophy","volume":"108","author":"Lu","year":"2013","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.ceca.2025.103101_bib0067","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.yjmcc.2010.04.008","article-title":"Kruppel-like factor 4 regulates pressure-induced cardiac hypertrophy","volume":"49","author":"Liao","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ceca.2025.103101_bib0068","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.bbamcr.2012.10.023","article-title":"Stress-induced nuclear import of apoptosis signal-regulating kinase 1 is mediated by karyopherin alpha2\/beta1 heterodimer","volume":"1833","author":"Sturchler","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ceca.2025.103101_bib0069","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1158\/1535-7163.MCT-15-0052","article-title":"Targeting the nuclear import receptor Kpnbeta1 as an anticancer therapeutic","volume":"15","author":"van der Watt","year":"2016","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.ceca.2025.103101_bib0070","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1093\/emboj\/17.15.4491","article-title":"Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells","volume":"17","author":"Jakel","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.ceca.2025.103101_bib0071","doi-asserted-by":"crossref","first-page":"22549","DOI":"10.1074\/jbc.M109.019935","article-title":"Importin-beta is a GDP-to-GTP exchange factor of Ran: implications for the mechanism of nuclear import","volume":"284","author":"Lonhienne","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceca.2025.103101_bib0072","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrm2410","article-title":"Spatial and temporal coordination of mitosis by Ran GTPase","volume":"9","author":"Clarke","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ceca.2025.103101_bib0073","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1128\/MCB.06130-11","article-title":"Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators","volume":"32","author":"Michelle","year":"2012","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ceca.2025.103101_bib0074","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2018.08.030","article-title":"Exon junction complexes suppress spurious splice sites to safeguard transcriptome integrity","volume":"72","author":"Boehm","year":"2018","journal-title":"Mol Cell"},{"key":"10.1016\/j.ceca.2025.103101_bib0075","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11626-010-9368-1","article-title":"The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro","volume":"47","author":"Watkins","year":"2011","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"10.1016\/j.ceca.2025.103101_bib0076","doi-asserted-by":"crossref","first-page":"10551","DOI":"10.1016\/S0021-9258(19)50052-7","article-title":"Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy","volume":"267","author":"Sadoshima","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceca.2025.103101_bib0077","doi-asserted-by":"crossref","first-page":"32562","DOI":"10.1074\/jbc.M801904200","article-title":"Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMP-activated protein kinase","volume":"283","author":"Stuck","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ceca.2025.103101_bib0078","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nm.4452","article-title":"A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway","volume":"24","author":"Lehmann","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.ceca.2025.103101_bib0079","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1093\/emboj\/18.16.4560","article-title":"Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing","volume":"18","author":"Mayeda","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.ceca.2025.103101_bib0080","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbrc.2019.11.185","article-title":"RNPS1 inhibition aggravates ischemic brain injury and promotes neuronal death","volume":"523","author":"Zhang","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ceca.2025.103101_bib0081","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ebiom.2017.09.022","article-title":"Antihypertrophic effects of small molecules that maintain mitochondrial ATP levels under hypoxia","volume":"24","author":"Nagai","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ceca.2025.103101_bib0082","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.abb0993","article-title":"A phosphorylation-regulated eIF3d translation switch mediates cellular adaptation to metabolic stress","volume":"370","author":"Lamper","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ceca.2025.103101_bib0083","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1357-2725(98)00128-9","article-title":"Eukaryotic initiation factor eIF2","volume":"31","author":"Kimball","year":"1999","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.ceca.2025.103101_bib0084","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S1097-2765(00)00108-8","article-title":"Regulated translation initiation controls stress-induced gene expression in mammalian cells","volume":"6","author":"Harding","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/j.ceca.2025.103101_bib0085","article-title":"Why is start codon selection so precise in eukaryotes?","volume":"2","author":"Asano","year":"2014","journal-title":"Transl. (Austin)"},{"key":"10.1016\/j.ceca.2025.103101_bib0086","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nature09003","article-title":"eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation","volume":"465","author":"Jennings","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2025.103101_bib0087","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1101\/gad.11.18.2396","article-title":"GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation in Saccharomyces cerevisiae","volume":"11","author":"Huang","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/j.ceca.2025.103101_bib0088","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1172\/JCI73787","article-title":"Protein kinetic signatures of the remodeling heart following isoproterenol stimulation","volume":"124","author":"Lam","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ceca.2025.103101_bib0089","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/01.RES.73.3.413","article-title":"Molecular characterization of angiotensin II\u2013induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype","volume":"73","author":"Sadoshima","year":"1993","journal-title":"Circ Res"},{"key":"10.1016\/j.ceca.2025.103101_bib0090","doi-asserted-by":"crossref","first-page":"E4079","DOI":"10.1073\/pnas.1315587110","article-title":"Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy","volume":"110","author":"Putinski","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ceca.2025.103101_bib0091","article-title":"Translating translation to mechanisms of cardiac hypertrophy","volume":"7","author":"Zeitz","year":"2020","journal-title":"J Cardiovasc Dev Dis"},{"key":"10.1016\/j.ceca.2025.103101_bib0092","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.yjmcc.2020.03.004","article-title":"Saraf-dependent activation of mTORC1 regulates cardiac growth","volume":"141","author":"Sanlialp","year":"2020","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ceca.2025.103101_bib0093","doi-asserted-by":"crossref","first-page":"H1119","DOI":"10.1152\/ajpheart.00284.2017","article-title":"Temporal dynamics of cardiac hypertrophic growth in response to pressure overload","volume":"313","author":"Wang","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ceca.2025.103101_bib0094","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201810018","article-title":"TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation","volume":"11","author":"Grund","year":"2019","journal-title":"EMBO Mol Med"}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416025001095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416025001095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T18:37:08Z","timestamp":1781462228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416025001095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":94,"alternative-id":["S0143416025001095"],"URL":"https:\/\/doi.org\/10.1016\/j.ceca.2025.103101","relation":{"is-supplemented-by":[{"id-type":"uri","id":"https:\/\/www.ebi.ac.uk\/biostudies\/studies\/S-BSST1959","asserted-by":"subject"}]},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nuclear Ca2+-Calmodulin signaling in cardiac myocytes reduces catecholamine-evoked protein translation and prevents hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceca.2025.103101","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103101"}}