{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:13:31Z","timestamp":1788614011083,"version":"build-2803163510"},"reference-count":10,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["11G8425N"],"award-info":[{"award-number":["11G8425N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["W0.014.22 N"],"award-info":[{"award-number":["W0.014.22 N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004497","name":"KU Leuven Research Council","doi-asserted-by":"publisher","award":["C3.24.033"],"award-info":[{"award-number":["C3.24.033"]}],"id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004497","name":"KU Leuven Research Council","doi-asserted-by":"publisher","award":["C14\/25\/131"],"award-info":[{"award-number":["C14\/25\/131"]}],"id":[{"id":"10.13039\/501100004497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ceca.2026.103169","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:46:08Z","timestamp":1783439168000},"page":"103169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dynamic control of NAADP signaling by kinases in T cells"],"prefix":"10.1016","volume":"137","author":[{"given":"Yi-Xuan","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5968-4828","authenticated-orcid":false,"given":"Geert","family":"Bultynck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6978-8620","authenticated-orcid":false,"given":"Femke","family":"Speelman-Rooms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"398","key":"10.1016\/j.ceca.2026.103169_bib0001","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aab0863","article-title":"Frontrunners of T cell activation: initial, localized Ca2+ signals mediated by NAADP and the type 1 ryanodine receptor","volume":"8","author":"Wolf","year":"2015","journal-title":"Sci. Signal."},{"issue":"9","key":"10.1016\/j.ceca.2026.103169_bib0002","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.1074\/jbc.M115.681833","article-title":"Nicotinic acid adenine dinucleotide phosphate plays a critical role in naive and effector murine t cells but not natural regulatory t cells","volume":"291","author":"Ali","year":"2016","journal-title":"J. Biologic. Chem."},{"issue":"709","key":"10.1016\/j.ceca.2026.103169_bib0003","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abe3800","article-title":"Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation","volume":"14","author":"Gu","year":"2021","journal-title":"Sci. Signal."},{"issue":"675","key":"10.1016\/j.ceca.2026.103169_bib0004","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abd5647","article-title":"HN1L\/JPT2: a signaling protein that connects NAADP generation to Ca2+ microdomain formation","volume":"14","author":"Roggenkamp","year":"2021","journal-title":"Sci. Signal."},{"issue":"25","key":"10.1016\/j.ceca.2026.103169_bib0005","doi-asserted-by":"crossref","first-page":"16906","DOI":"10.1074\/jbc.M601347200","article-title":"Second messenger function of nicotinic acid adenine dinucleotide phosphate revealed by an improved enzymatic cycling assay","volume":"281","author":"Gasser","year":"2006","journal-title":"J.Biologic. Chem."},{"issue":"561","key":"10.1016\/j.ceca.2026.103169_bib0006","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aat0358","article-title":"ORAI1, STIM1\/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation","volume":"11","author":"Diercks","year":"2018","journal-title":"Sci. Signal."},{"issue":"799","key":"10.1016\/j.ceca.2026.103169_bib0007","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.adg0661","article-title":"Convergent activation of Ca2+ permeability in two-pore channel 2 through distinct molecular routes","volume":"16","author":"Saito","year":"2023","journal-title":"Sci. Signal."},{"issue":"1","key":"10.1016\/j.ceca.2026.103169_bib0008","article-title":"Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"issue":"920","key":"10.1016\/j.ceca.2026.103169_bib0009","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.adp4326","article-title":"Multiple signaling events are required for NAADP synthesis by DUOX2 and formation of Ca2+ microdomains to initiate T cell activation","volume":"19","author":"Winterberg","year":"2026","journal-title":"Sci. Signal."},{"issue":"7","key":"10.1016\/j.ceca.2026.103169_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110290","article-title":"The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses","volume":"27","author":"Vardam-Kaur","year":"2024","journal-title":"iScience"}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014341602600062X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014341602600062X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T12:45:48Z","timestamp":1788612348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014341602600062X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":10,"alternative-id":["S014341602600062X"],"URL":"https:\/\/doi.org\/10.1016\/j.ceca.2026.103169","relation":{},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamic control of NAADP signaling by kinases in T cells","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceca.2026.103169","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103169"}}