{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:13:27Z","timestamp":1788614007969,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007844","name":"National Sun Yat-sen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["109-2320-B-020-002-MY3"],"award-info":[{"award-number":["109-2320-B-020-002-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ceca.2026.103170","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:54:31Z","timestamp":1784044471000},"page":"103170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Activation of human bitter taste receptor (TAS2R) subtypes and TAS2R14 genotypes by Bacillus amyloliquefaciens exopolysaccharides"],"prefix":"10.1016","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3841-2559","authenticated-orcid":false,"given":"Wei-Wen","family":"Sung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tse-Hsuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Hsin","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9989-884X","authenticated-orcid":false,"given":"Hsueh-Ling","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceca.2026.103170_bib0001","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)80706-0","article-title":"T2Rs function as bitter taste receptors","volume":"100","author":"Chandrashekar","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.ceca.2026.103170_bib0002","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202200775","article-title":"Activation profile of TAS2R2, the 26th human bitter taste receptor","volume":"67","author":"Lang","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ceca.2026.103170_bib0003","doi-asserted-by":"crossref","first-page":"8484","DOI":"10.1074\/jbc.M116.771949","article-title":"Flavones modulate respiratory epithelial innate immunity: anti-inflammatory effects and activation of the T2R14 receptor","volume":"292","author":"Hariri","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2026.103170_bib0004","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1096\/fj.13-242594","article-title":"The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14","volume":"28","author":"Levit","year":"2014","journal-title":"Faseb J."},{"key":"10.1016\/j.ceca.2026.103170_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2025.109872","article-title":"TAS2R5 and TAS2R38 are bitter taste receptors whose colonic expressions could play important roles in age-associated processes","volume":"140","author":"Jal\u0161evac","year":"2025","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ceca.2026.103170_bib0006","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202400452R","article-title":"Molecular mechanism of bitter taste receptor agonist-mediated relaxation of airway smooth muscle","volume":"38","author":"Conaway","year":"2024","journal-title":"Faseb J."},{"key":"10.1016\/j.ceca.2026.103170_bib0007","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1748-1716.2011.02308.x","article-title":"Taste receptor signalling - from tongues to lungs","volume":"204","author":"Kinnamon","year":"2012","journal-title":"Acta Physiol. (Oxf)"},{"key":"10.1016\/j.ceca.2026.103170_bib0008","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/s41598-017-01562-1","article-title":"Participants with normal weight or with obesity show different relationships of 6-n-Propylthiouracil (PROP) taster status with BMI and plasma endocannabinoids","volume":"7","author":"Carta","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ceca.2026.103170_bib0009","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-54604-1","article-title":"TAS2R38 bitter taste receptor and attainment of exceptional longevity","volume":"9","author":"Melis","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ceca.2026.103170_bib0010","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.cub.2005.01.047","article-title":"The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception","volume":"15","author":"Bufe","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ceca.2026.103170_bib0011","doi-asserted-by":"crossref","first-page":"43","DOI":"10.37796\/2211-8039.1175","article-title":"The influence of TAS2R38 bitter taste gene polymorphisms on obesity risk in three racially diverse groups","volume":"11","author":"Chupeerach","year":"2021","journal-title":"Biomedicine (Taipei)"},{"key":"10.1016\/j.ceca.2026.103170_bib0012","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.biochi.2018.06.013","article-title":"A cross-talk between fat and bitter taste modalities","volume":"159","author":"Khan","year":"2019","journal-title":"Biochimie"},{"key":"10.1016\/j.ceca.2026.103170_bib0013","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1007\/s40520-020-01745-3","article-title":"Taste receptor polymorphisms and longevity: a systematic review and meta-analysis","volume":"33","author":"Di Bona","year":"2021","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.ceca.2026.103170_bib0014","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000499875","article-title":"Single nucleotide polymorphisms in chemosensory pathway genes GNB3, TAS2R19, and TAS2R38 are associated with chronic rhinosinusitis","volume":"180","author":"Purnell","year":"2019","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.ceca.2026.103170_bib0015","doi-asserted-by":"crossref","first-page":"7376","DOI":"10.1523\/JNEUROSCI.23-19-07376.2003","article-title":"Functional interaction between T2R taste receptors and G-protein alpha subunits expressed in taste receptor cells","volume":"23","author":"Ueda","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ceca.2026.103170_bib0016","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1076\/apab.110.1.137.908","article-title":"Presence of a plasma membrane targeting sequence in the amino-terminal region of the rat somatostatin receptor 3","volume":"110","author":"Ammon","year":"2002","journal-title":"Arch Physiol. Biochem."},{"key":"10.1016\/j.ceca.2026.103170_bib0017","doi-asserted-by":"crossref","first-page":"17616","DOI":"10.1074\/jbc.M116.722736","article-title":"\u03b22-adrenergic receptors chaperone trapped bitter taste receptor 14 to the cell surface as a heterodimer and exert unidirectional desensitization of taste receptor function","volume":"291","author":"Kim","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2026.103170_bib0018","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.ijbiomac.2021.06.187","article-title":"Bacillus amyloliquefaciens exopolysaccharide preparation induces glucagon-like peptide 1 secretion through the activation of bitter taste receptors","volume":"185","author":"Sung","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ceca.2026.103170_bib0019","first-page":"3449","article-title":"Scientific Opinion on the maintenance of the list of QPS biological agents intentionally added to food and feed (2013 update)","volume":"11","author":"Hazards","year":"2013","journal-title":"EFSA J."},{"key":"10.1016\/j.ceca.2026.103170_bib0020","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/693253","article-title":"Synthesis, production, and biotechnological applications of exopolysaccharides and polyhydroxyalkanoates by archaea","volume":"2011","author":"Poli","year":"2011","journal-title":"Archaea"},{"key":"10.1016\/j.ceca.2026.103170_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2023.109850","article-title":"Antipathogenic potentials of exopolysaccharides produced by lactic acid bacteria and their food and health applications","volume":"152","author":"Kavitake","year":"2023","journal-title":"Food Control"},{"key":"10.1016\/j.ceca.2026.103170_bib0022","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jbiosc.2018.05.028","article-title":"Production, characterization and antibacterial activity of exopolysaccharide from a newly isolated Weissella cibaria under sucrose effect","volume":"126","author":"Yu","year":"2018","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.ceca.2026.103170_bib0023","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11626-015-9970-3","article-title":"In vitro evaluation of anticancer properties of exopolysaccharides from Lactobacillus acidophilus in colon cancer cell lines","volume":"52","author":"Deepak","year":"2016","journal-title":"In Vitro Cell. Dev. Biol.-Anim."},{"key":"10.1016\/j.ceca.2026.103170_bib0024","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ijbiomac.2019.12.217","article-title":"Exopolysaccharides of Bacillus amyloliquefaciens modulate glycemic level in mice and promote glucose uptake of cells through the activation of Akt","volume":"146","author":"Chen","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ceca.2026.103170_bib0025","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810237","article-title":"Exopolysaccharides of Bacillus amyloliquefaciens Amy-1 mitigate inflammation by inhibiting ERK1\/2 and NF-\u03baB pathways and activating p38\/Nrf2 pathway","volume":"23","author":"Sung","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ceca.2026.103170_bib0026","doi-asserted-by":"crossref","first-page":"884","DOI":"10.3389\/fphys.2019.00884","article-title":"Bitter taste receptors for asthma therapeutics","volume":"10","author":"Nayak","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ceca.2026.103170_bib0027","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.3390\/md12074260","article-title":"Recognition of LPS by TLR4: potential for anti-inflammatory therapies","volume":"12","author":"Nijland","year":"2014","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ceca.2026.103170_bib0028","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00018-014-1736-7","article-title":"Taste receptors in innate immunity","volume":"72","author":"Lee","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ceca.2026.103170_bib0029","doi-asserted-by":"crossref","first-page":"5806","DOI":"10.1038\/s41598-020-62747-9","article-title":"TAS2R38 is a novel modifier gene in patients with cystic fibrosis","volume":"10","author":"Castaldo","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ceca.2026.103170_bib0030","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1159\/000508938","article-title":"Primary ciliary dyskinesia: the impact of taste receptor (TAS2R38) gene polymorphisms on disease outcome and severity","volume":"181","author":"Piatti","year":"2020","journal-title":"Int. Arch Allergy Immunol."},{"key":"10.1016\/j.ceca.2026.103170_bib0031","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.11410","article-title":"Association between bitter taste receptor phenotype and clinical outcomes among patients with COVID-19","volume":"4","author":"Barham","year":"2021","journal-title":"JAMA Netw. Open."},{"key":"10.1016\/j.ceca.2026.103170_bib0032","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0300061","article-title":"Association of the bitter taste genes TAS2R38 and CA6 and breast cancer risk; a case-control study of Polish women in Poland and Polish immigrants in USA","volume":"19","author":"\u0141ukasiewicz-\u015amieta\u0144ska","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.ceca.2026.103170_bib0033","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/alr.23077","article-title":"Genetics of denatonium-responsive bitter receptors in aspirin-exacerbated respiratory disease","volume":"13","author":"Douglas","year":"2023","journal-title":"Int. Forum Allergy Rhinol."},{"key":"10.1016\/j.ceca.2026.103170_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113437","article-title":"Lidocaine induces apoptosis in head and neck squamous cell carcinoma through activation of bitter taste receptor T2R14","volume":"42","author":"Miller","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.ceca.2026.103170_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2021.102499","article-title":"The bitter end: T2R bitter receptor agonists elevate nuclear calcium and induce apoptosis in non-ciliated airway epithelial cells","volume":"101","author":"McMahon","year":"2022","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2026.103170_bib0036","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000443796","article-title":"Association between polymorphisms in bitter taste receptor genes and clinical features in Korean asthmatics","volume":"91","author":"Yoon","year":"2016","journal-title":"Respiration"},{"key":"10.1016\/j.ceca.2026.103170_bib0037","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1093\/humrep\/dex305","article-title":"Taste receptor polymorphisms and male infertility","volume":"32","author":"Gentiluomo","year":"2017","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ceca.2026.103170_bib0038","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1471-2350-11-88","article-title":"A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer","volume":"11","author":"Campa","year":"2010","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.ceca.2026.103170_bib0039","series-title":"Paper Presented at the Seminars in Cell & Developmental Biology","article-title":"Bitter taste receptor research comes of age: from characterization to modulation of TAS2Rs","author":"Behrens","year":"2013"},{"key":"10.1016\/j.ceca.2026.103170_bib0040","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/s41422-024-00995-4","article-title":"Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist","volume":"34","author":"Tao","year":"2024","journal-title":"Cell Res."},{"key":"10.1016\/j.ceca.2026.103170_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106422","article-title":"Predicted structure and cell signaling of TAS2R14 reveal receptor hyper-flexibility for detecting diverse bitter tastes","volume":"26","author":"Tokmakova","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.ceca.2026.103170_bib0042","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.biocel.2016.03.005","article-title":"Bitter taste receptors: novel insights into the biochemistry and pharmacology","volume":"77","author":"Jaggupilli","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ceca.2026.103170_bib0043","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.3390\/ijms25137325","article-title":"Bitter taste receptor 46 (hTAS2R46) protects monocytes\/macrophages from oxidative stress","volume":"25","author":"Talmon","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ceca.2026.103170_bib0044","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.3389\/fimmu.2018.02949","article-title":"Human T2R38 bitter taste receptor expression in resting and activated lymphocytes","volume":"9","author":"Tran","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ceca.2026.103170_bib0045","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.70232","article-title":"Bitter taste receptors in bacterial infections and innate immunity","volume":"13","author":"Rudolph","year":"2025","journal-title":"Immun. Inflamm. Dis."}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416026000631?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416026000631?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T12:45:11Z","timestamp":1788612311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416026000631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":45,"alternative-id":["S0143416026000631"],"URL":"https:\/\/doi.org\/10.1016\/j.ceca.2026.103170","relation":{},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of human bitter taste receptor (TAS2R) subtypes and TAS2R14 genotypes by Bacillus amyloliquefaciens exopolysaccharides","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceca.2026.103170","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103170"}}