{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:13:27Z","timestamp":1788614007528,"version":"build-2803163510"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["307998\/2022-3"],"award-info":[{"award-number":["307998\/2022-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["446384\/2024-0"],"award-info":[{"award-number":["446384\/2024-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["442098\/2023-5"],"award-info":[{"award-number":["442098\/2023-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"publisher","award":["RED00213-23"],"award-info":[{"award-number":["RED00213-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"publisher","award":["APQ-04926-26"],"award-info":[{"award-number":["APQ-04926-26"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"publisher","award":["APQ-02135-24"],"award-info":[{"award-number":["APQ-02135-24"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"publisher","award":["RED00059-23"],"award-info":[{"award-number":["RED00059-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"publisher","award":["APQ-03132-18"],"award-info":[{"award-number":["APQ-03132-18"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ceca.2026.103171","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T14:52:14Z","timestamp":1784645534000},"page":"103171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Disruption of compartmentalized calcium signaling via inositol 1,4,5-trisphosphate receptors (ITPRs) and gap junctions in primary liver cancer"],"prefix":"10.1016","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7714-991X","authenticated-orcid":false,"given":"Dawidson Assis","family":"Gomes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tales Leonardo","family":"de Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3935-7732","authenticated-orcid":false,"given":"\u00c9rica Emiliana da Silva","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2436-0201","authenticated-orcid":false,"given":"Vanessa Medeiros","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0233-7729","authenticated-orcid":false,"given":"Michele Angela","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ceca.2026.103171_bib0001","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/s41575-019-0217-8","article-title":"Metabolic rearrangements in primary liver cancers: cause and consequences","volume":"16","author":"Satriano","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ceca.2026.103171_bib0002","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13045-024-01527-8","article-title":"Metabolic reprogramming in the tumor microenvironment of liver cancer","volume":"17","author":"Lin","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.ceca.2026.103171_bib0003","doi-asserted-by":"crossref","DOI":"10.1038\/s44355-025-00030-2","article-title":"Pathophysiology, noninvasive diagnostics and emerging personalized treatments for metabolic associated liver diseases","volume":"2","author":"Tantu","year":"2025","journal-title":"Npj Gut Liver"},{"key":"10.1016\/j.ceca.2026.103171_bib0004","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.molmed.2018.02.006","article-title":"Genomic profiling and metabolic homeostasis in primary liver cancers","volume":"24","author":"Gingold","year":"2018","journal-title":"Trends. Mol. Med."},{"key":"10.1016\/j.ceca.2026.103171_bib0005","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1038\/s41388-019-0741-6","article-title":"Connexins in cancer: bridging the gap to the clinic","volume":"38","author":"Aasen","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.ceca.2026.103171_bib0006","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.trsl.2015.05.005","article-title":"Connexin and pannexin signaling in gastrointestinal and liver disease","volume":"166","author":"Maes","year":"2015","journal-title":"Transl. Res."},{"key":"10.1016\/j.ceca.2026.103171_bib0007","first-page":"101","article-title":"Type 3 IP3 receptors: the chameleon in cancer","author":"Rosa","year":"2020","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.ceca.2026.103171_bib0008","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.3390\/jcm9041096","article-title":"Inositol 1,4,5-trisphosphate receptors in Human disease: a comprehensive update","volume":"9","author":"Gambardella","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ceca.2026.103171_bib0009","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","article-title":"Calcium signalling: dynamics, homeostasis and remodelling","volume":"4","author":"Berridge","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ceca.2026.103171_bib0010","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.bbamcr.2008.10.005","article-title":"Inositol trisphosphate and calcium signalling mechanisms","volume":"1793","author":"Berridge","year":"2009","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"},{"key":"10.1016\/j.ceca.2026.103171_bib0011","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a035063","article-title":"Structure and function of IP 3 receptors","volume":"11","author":"Prole","year":"2019","journal-title":"Cold. Spring. Harb. Perspect. Biol."},{"key":"10.1016\/j.ceca.2026.103171_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2019.102132","article-title":"Type 3 inositol 1,4,5-trisphosphate receptor: a calcium channel for all seasons","volume":"85","author":"Mangla","year":"2020","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2026.103171_bib0013","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1054\/ceca.1999.0090","article-title":"Expression of inositol trisphosphate receptors","volume":"26","author":"Taylor","year":"1999","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2026.103171_bib0014","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.biolcel.2003.11.004","article-title":"Subcellular distribution of the inositol 1,4,5-trisphosphate receptors: functional relevance and molecular determinants","volume":"96","author":"Vermassen","year":"2004","journal-title":"Biol. Cell"},{"key":"10.1016\/j.ceca.2026.103171_bib0015","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.bbamcr.2018.06.004","article-title":"Pathophysiological consequences of isoform-specific IP3 receptor mutations","volume":"1865","author":"Kerkhofs","year":"2018","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Cell Res."},{"key":"10.1016\/j.ceca.2026.103171_bib0016","doi-asserted-by":"crossref","first-page":"14700","DOI":"10.1074\/jbc.270.24.14700","article-title":"Heterotetrameric complex formation of inositol 1,4,5-trisphosphate receptor subunits","volume":"270","author":"Monkawa","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2026.103171_bib0017","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1124\/mol.53.4.656","article-title":"Differences among type I, II, and III inositol-1,4,5-trisphosphate receptors in ligand-binding affinity influence the sensitivity of calcium stores to inositol-1,4,5-trisphosphate","volume":"53","author":"Wojcikiewicz","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ceca.2026.103171_bib0018","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/23954","article-title":"Type III InsP3 receptor channel stays open in the presence of increased calcium","volume":"396","author":"Hagar","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2026.103171_bib0019","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.bbamcr.2018.05.010","article-title":"Regulation of bile secretion by calcium signaling in health and disease","volume":"1865","author":"Trampert","year":"2018","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Cell Res."},{"key":"10.1016\/j.ceca.2026.103171_bib0020","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.3390\/ijms19123913","article-title":"Calcium signaling in cholangiocytes: methods, mechanisms, and effects","volume":"19","author":"Rodrigues","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ceca.2026.103171_bib0021","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1053\/gast.2002.32363","article-title":"The type II inositol 1,4,5, trisphosphate receptor can trigger Ca2+ waves in rat hepatocytes","volume":"122","author":"Hirata","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ceca.2026.103171_bib0022","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a002576","article-title":"Gap junctions","volume":"1","author":"Goodenough","year":"2009","journal-title":"Cold. Spring. Harb. Perspect. Biol."},{"key":"10.1016\/j.ceca.2026.103171_bib0023","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/15419060802357217","article-title":"Hemichannel-mediated inositol 1,4,5-trisphosphate (IP3) release in the cochlea: a novel mechanism of IP3 intercellular signaling","volume":"15","author":"Gossman","year":"2008","journal-title":"Cell Commun. Adhes."},{"key":"10.1016\/j.ceca.2026.103171_bib0024","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2403903121","article-title":"Large-pore connexin hemichannels function like molecule transporters independent of ion conduction","volume":"121","author":"Gaete","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ceca.2026.103171_bib0025","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1073\/pnas.86.8.2708","article-title":"Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions","volume":"86","author":"S\u00e1ez","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ceca.2026.103171_bib0026","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.bbamem.2017.05.016","article-title":"Gap junction gene and protein families: connexins, innexins, and pannexins","volume":"1860","author":"Beyer","year":"2018","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.ceca.2026.103171_bib0027","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.semcdb.2015.11.015","article-title":"Structural analysis of key gap junction domains\u2014Lessons from genome data and disease-linked mutants","volume":"50","author":"Bai","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ceca.2026.103171_bib0028","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.3390\/cancers16081533","article-title":"Understanding the role of connexins in hepatocellular carcinoma: molecular and prognostic implications","volume":"16","author":"Papadakos","year":"2024","journal-title":"Cancers. (Basel)"},{"key":"10.1016\/j.ceca.2026.103171_bib0029","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1478-811X-7-4","article-title":"Connexins: a myriad of functions extending beyond assembly of gap junction channels","volume":"7","author":"Dbouk","year":"2009","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.ceca.2026.103171_bib0030","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1038\/sj.jid.5700770","article-title":"Gap junctions: basic structure and function","volume":"127","author":"Me\u015fe","year":"2007","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.ceca.2026.103171_bib0031","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrc.2016.105","article-title":"Gap junctions and cancer: communicating for 50 years","volume":"16","author":"Aasen","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ceca.2026.103171_bib0032","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bbamem.2004.01.007","article-title":"Regulation of connexin biosynthesis, assembly, gap junction formation, and removal","volume":"1662","author":"Segretain","year":"2004","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"10.1016\/j.ceca.2026.103171_bib0033","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cellimm.2007.08.001","article-title":"Inflammatory conditions induce gap junctional communication between rat Kupffer cells both in vivo and in vitro","volume":"247","author":"Eugen\u00edn","year":"2007","journal-title":"Cell Immunol."},{"key":"10.1016\/j.ceca.2026.103171_bib0034","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2013.00405","article-title":"Connexin and pannexin (hemi)channels in the liver","volume":"4","author":"Maes","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ceca.2026.103171_bib0035","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ceca.2005.06.009","article-title":"Calcium signaling in liver","volume":"38","author":"Gaspers","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2026.103171_bib0036","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1042\/bj3040585","article-title":"Ca2+-mobilizing hormones induce sequentially ordered Ca2+ signals in multicellular systems of rat hepatocytes","volume":"304","author":"Combettes","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.ceca.2026.103171_bib0037","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1113\/JP277650","article-title":"Intercellular calcium waves integrate hormonal control of glucose output in the intact liver","volume":"597","author":"Gaspers","year":"2019","journal-title":"J. Physiol."},{"key":"10.1016\/j.ceca.2026.103171_bib0038","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ceca.2014.02.007","article-title":"Calcium-dependent regulation of glucose homeostasis in the liver","volume":"55","author":"Bartlett","year":"2014","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2026.103171_bib0039","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.jhep.2018.12.023","article-title":"Gap junctions in liver disease: implications for pathogenesis and therapy","volume":"70","author":"Hern\u00e1ndez-Guerra","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ceca.2026.103171_bib0040","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1091\/mbc.3.1.113","article-title":"Coordination of hormone-induced calcium signals in isolated rat hepatocyte couplets: demonstration with confocal microscopy","volume":"3","author":"Nathanson","year":"1992","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ceca.2026.103171_bib0041","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.1093\/emboj\/16.17.5398","article-title":"Coordinated intercellular calcium waves induced by noradrenaline in rat hepatocytes: dual control by gap junction permeability and agonist","volume":"16","author":"Tordjmann","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.ceca.2026.103171_bib0042","doi-asserted-by":"crossref","first-page":"8102","DOI":"10.1074\/jbc.270.14.8102","article-title":"Coordination of Ca2+ signaling by intercellular propagation of Ca2+ waves in the intact liver","volume":"270","author":"Robb-Gaspers","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2026.103171_bib0043","doi-asserted-by":"crossref","first-page":"R575","DOI":"10.1152\/ajpregu.1999.276.2.R575","article-title":"Effect of Ca2+ agonists in the perfused liver: determination via laser scanning confocal microscopy","volume":"276","author":"Motoyama","year":"1999","journal-title":"m. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.ceca.2026.103171_bib0044","doi-asserted-by":"crossref","first-page":"G167","DOI":"10.1152\/ajpgi.1995.269.1.G167","article-title":"Ca2+ waves are organized among hepatocytes in the intact organ","volume":"269","author":"Nathanson","year":"1995","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ceca.2026.103171_bib0045","doi-asserted-by":"crossref","first-page":"16313","DOI":"10.1074\/jbc.M109207200","article-title":"Molecular basis for pacemaker cells in epithelia","volume":"277","author":"Fatima Leite","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2026.103171_bib0046","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/S0016-5085(99)70021-1","article-title":"Communication via gap junctions modulates bile secretion in the isolated perfused rat liver","volume":"116","author":"Nathanson","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ceca.2026.103171_bib0047","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.bbrc.2004.07.192","article-title":"Endotoxin unmasks the role of gap junctions in the liver","volume":"322","author":"Correa","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ceca.2026.103171_bib0048","doi-asserted-by":"crossref","first-page":"C1186","DOI":"10.1152\/ajpcell.1995.268.5.C1186","article-title":"Altered expression and function of hepatocyte gap junctions after common bile duct ligation in the rat","volume":"268","author":"Fallon","year":"1995","journal-title":"Am. J. Physiol.: Cell Physiol."},{"key":"10.1016\/j.ceca.2026.103171_bib0049","doi-asserted-by":"crossref","first-page":"9948","DOI":"10.1073\/pnas.93.18.9948","article-title":"Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides","volume":"93","author":"Schlosser","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ceca.2026.103171_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3580001","article-title":"Stimulation of ATP secretion in the liver by therapeutic bile acids","volume":"358","author":"Nathanson","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.ceca.2026.103171_bib0051","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1053\/jhep.2002.34432","article-title":"Regulation of Ca2+ signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms","volume":"36","author":"Hirata","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.ceca.2026.103171_bib0052","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1053\/jhep.2002.35274","article-title":"Expression and regulation of gap junctions in rat cholangiocytes","volume":"36","author":"Bode","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.ceca.2026.103171_bib0053","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1006\/excr.1994.1170","article-title":"Modulation of connexins during differentiation of oval cells into hepatocytes","volume":"213","author":"Zhang","year":"1994","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ceca.2026.103171_bib0054","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.jhep.2013.01.023","article-title":"Importance of Connexin-43 based gap junction in cirrhosis and acute-on-chronic liver failure","volume":"58","author":"Balasubramaniyan","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ceca.2026.103171_bib0055","first-page":"58","article-title":"Cx43 phosphorylation on S279\/282 and intercellular communication are regulated by IP3\/IP3 receptor signaling","volume":"12","author":"Kang","year":"2014","journal-title":"Cell Commun. Signaling"},{"key":"10.1016\/j.ceca.2026.103171_bib0056","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1136\/gutjnl-2018-317811","article-title":"Expression of the type 3 InsP3 receptor is a final common event in the development of hepatocellular carcinoma","volume":"68","author":"Guerra","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.ceca.2026.103171_bib0057","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1002\/hep.24548","article-title":"Type 2 inositol 1,4,5-trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes","volume":"54","author":"Kruglov","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.ceca.2026.103171_bib0058","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/hep4.1012","article-title":"Hepatic inositol 1,4,5 trisphosphate receptor type 1 mediates fatty liver","volume":"1","author":"Feriod","year":"2017","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.ceca.2026.103171_bib0059","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1053\/j.gastro.2007.03.115","article-title":"Lipid rafts establish calcium waves in hepatocytes","volume":"133","author":"Nagata","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ceca.2026.103171_bib0060","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1002\/hep4.2042","article-title":"Molecular determinants of peri-apical targeting of inositol 1,4,5-trisphosphate receptor type 3 in cholangiocytes","volume":"6","author":"Rodrigues","year":"2022","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.ceca.2026.103171_bib0061","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112403","article-title":"Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) is overexpressed in cholangiocarcinoma and its expression correlates with S100 calcium-binding protein A4 (S100A4)","volume":"145","author":"Rodrigues","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ceca.2026.103171_bib0062","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0016-5085(03)01201-0","article-title":"Loss of inositol 1,4,5-trisphosphate receptors from bile duct epithelia is a common event in cholestasis","volume":"125","author":"Shibao","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ceca.2026.103171_bib0063","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1053\/j.gastro.2007.08.020","article-title":"Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile","volume":"133","author":"Minagawa","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ceca.2026.103171_bib0064","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/hep.30839","article-title":"Type 3 inositol 1,4,5-trisphosphate receptor is increased and enhances malignant properties in cholangiocarcinoma","volume":"71","author":"Ueasilamongkol","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.ceca.2026.103171_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2026.113104","article-title":"Regulation of chromatin dynamics by a calcium-dependent nucleoskeleton","volume":"302","author":"Gonz\u00e1lez","year":"2026","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ceca.2026.103171_bib0066","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ceca.2010.09.005","article-title":"The type III inositol 1,4,5-trisphosphate receptor is associated with aggressiveness of colorectal carcinoma","volume":"48","author":"Shibao","year":"2010","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ceca.2026.103171_bib0067","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/nature07119","article-title":"On the spontaneous emergence of cell polarity","volume":"454","author":"Altschuler","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ceca.2026.103171_bib0068","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/nrm2524","article-title":"Organelle positioning and cell polarity","volume":"9","author":"Bornens","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ceca.2026.103171_bib0069","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1111\/j.1440-1746.2007.05031.x","article-title":"Isolation and characterization of human gastric cell lines with stem cell phenotypes","volume":"22","author":"Yang","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ceca.2026.103171_bib0070","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrc3169","article-title":"Epithelial cell polarity, stem cells and cancer","volume":"12","author":"Martin-Belmonte","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ceca.2026.103171_bib0071","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/1097-4644(20001201)79:3<347::AID-JCB10>3.0.CO;2-2","article-title":"Growth inhibition in G1 and altered expression of cyclin D1 and p27kip-1after forced connexin expression in lung and liver carcinoma cells","volume":"79","author":"Koffler","year":"2000","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.ceca.2026.103171_bib0072","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cbi.2009.08.017","article-title":"Inhibition of proliferation of a hepatoma cell line by fucoxanthin in relation to cell cycle arrest and enhanced gap junctional intercellular communication","volume":"182","author":"Liu","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ceca.2026.103171_bib0073","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3390\/cancers11010117","article-title":"A barter economy in tumors: exchanging metabolites through gap junctions","volume":"11","author":"Swietach","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.ceca.2026.103171_bib0074","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/j.1582-4934.2011.01389.x","article-title":"Cx31.1 acts as a tumour suppressor in non-small cell lung cancer (NSCLC) cell lines through inhibition of cell proliferation and metastasis","volume":"16","author":"Zhang","year":"2012","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ceca.2026.103171_bib0075","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41580-020-0237-9","article-title":"Guidelines and definitions for research on epithelial\u2013mesenchymal transition","volume":"21","author":"Yang","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ceca.2026.103171_bib0076","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bbamem.2005.11.004","article-title":"Defective gap junctional intercellular communication in the carcinogenic process","volume":"1719","author":"Mesnil","year":"2005","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"10.1016\/j.ceca.2026.103171_bib0077","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1093\/carcin\/22.10.1593","article-title":"Reduction of malignant phenotype of HEPG2 cell is associated with the expression of connexin 26 but not connexin 32","volume":"22","author":"Yano","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ceca.2026.103171_bib0078","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0006-291X(03)01117-3","article-title":"A novel function of connexin 32: marked enhancement of liver function in a hepatoma cell line","volume":"307","author":"Yang","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ceca.2026.103171_bib0079","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1111\/j.1349-7006.2007.00564.x","article-title":"Disturbance of DNA methylation patterns in the early phase of hepatocarcinogenesis induced by a choline-deficient l-amino acid-defined diet in rats","volume":"98","author":"Shimizu","year":"2007","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ceca.2026.103171_bib0080","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/mc.20268","article-title":"CpG site hypermethylation of E-cadherin and connexin26 genes in hepatocellular carcinomas induced by a choline-deficient l-amino acid-defined diet in rats","volume":"46","author":"Tsujiuchi","year":"2007","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.ceca.2026.103171_bib0081","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/ijc.22696","article-title":"Cytoplasmic accumulation of connexin32 protein enhances motility and metastatic ability of human hepatoma cells in vitro and in vivo","volume":"121","author":"Li","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ceca.2026.103171_bib0082","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910712","article-title":"Connexin expression is altered in liver development of yotari (Dab1 -\/-) mice","volume":"22","author":"Pa\u0161tar","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ceca.2026.103171_bib0083","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00232-007-9051-y","article-title":"Control of intracellular localization and function of Cx43 by SEMA3F","volume":"217","author":"Kawasaki","year":"2007","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.ceca.2026.103171_bib0084","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/j.1349-7006.2012.02228.x","article-title":"Silencing of connexin 43 suppresses invasion, migration and lung metastasis of rat hepatocellular carcinoma cells","volume":"103","author":"Ogawa","year":"2012","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ceca.2026.103171_bib0085","article-title":"Connexin-43 can delay early recurrence and metastasis in patients with hepatitis B-related hepatocellular carcinoma and low serum alpha-fetoprotein after radical hepatectomy","volume":"13","author":"Sen Wang","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ceca.2026.103171_bib0086","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.tcb.2019.07.001","article-title":"Biological functions of Connexin43 beyond intercellular communication","volume":"29","author":"Martins-Marques","year":"2019","journal-title":"Trends. Cell Biol."},{"key":"10.1016\/j.ceca.2026.103171_bib0087","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.canlet.2006.12.024","article-title":"Connexin 43 expression promotes malignancy of HuH7 hepatocellular carcinoma cells via the inhibition of cell-cell communication","volume":"252","author":"Zhang","year":"2007","journal-title":"Cancer Lett."}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416026000643?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416026000643?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T12:45:04Z","timestamp":1788612304000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416026000643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":87,"alternative-id":["S0143416026000643"],"URL":"https:\/\/doi.org\/10.1016\/j.ceca.2026.103171","relation":{},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disruption of compartmentalized calcium signaling via inositol 1,4,5-trisphosphate receptors (ITPRs) and gap junctions in primary liver cancer","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ceca.2026.103171","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103171"}}