{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:46:09Z","timestamp":1793148369582,"version":"4.5.0"},"reference-count":230,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL169238"],"award-info":[{"award-number":["HL169238"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016220","name":"Georgia Clinical and Translational Science Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016220","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM136651"],"award-info":[{"award-number":["T32GM136651"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Biomaterials"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.celbio.2026.100372","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T15:34:00Z","timestamp":1770996840000},"page":"100372","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Nanoparticle-hydrogel composites for precision medicine"],"prefix":"10.1016","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4423-240X","authenticated-orcid":false,"given":"Sadiyah","family":"Parveen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suleyman B.","family":"Bozal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan S.","family":"Pober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Mark","family":"Saltzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celbio.2026.100372_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16030332","article-title":"Advancing Precision Medicine: A Review of Innovative In Silico Approaches for Drug Development, Clinical Pharmacology and Personalized Healthcare","volume":"16","author":"Marques","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.celbio.2026.100372_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107086","article-title":"Biologics, theranostics, and personalized medicine in drug delivery systems","volume":"201","author":"Puccetti","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.celbio.2026.100372_bib3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.mjafi.2021.06.021","article-title":"Precision medicine: Concept and tools","volume":"77","author":"Naithani","year":"2021","journal-title":"Med. J. Armed Forces India"},{"key":"10.1016\/j.celbio.2026.100372_bib4","article-title":"Smart nanoparticles for cancer therapy","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celbio.2026.100372_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e17488","article-title":"Advances in drug delivery systems, challenges and future directions","volume":"9","author":"Ezike","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.celbio.2026.100372_bib6","article-title":"Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions","volume":"9","author":"Lu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celbio.2026.100372_bib7","doi-asserted-by":"crossref","DOI":"10.1186\/s12645-024-00275-1","article-title":"pH-sensitive polymeric micelles enhance the co-delivery of doxorubicin and docetaxel: an emerging modality for treating breast cancer","volume":"15","author":"Farhoudi","year":"2024","journal-title":"Cancer Nano."},{"key":"10.1016\/j.celbio.2026.100372_bib8","article-title":"Microfluidics-enabled Serial Assembly of Lipid-siRNA-sorafenib Nanoparticles for Synergetic Hepatocellular Carcinoma Therapy","volume":"35","author":"Chen","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib9","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jid.2024.07.019","article-title":"Enhanced Intratumoral Delivery of Immunomodulator Monophosphoryl Lipid A through Hyperbranched Polyglycerol\u2013Coated Biodegradable Nanoparticles","volume":"145","author":"Chang","year":"2025","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.celbio.2026.100372_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adi1617","article-title":"Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma","volume":"15","author":"Khang","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celbio.2026.100372_bib11","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1080\/02726351.2025.2463114","article-title":"Surface-functionalized pullulan-based polymeric nanoparticles containing resveratrol: a green approach for lung cancer targeted delivery","volume":"43","author":"Pawara","year":"2025","journal-title":"Part. Sci. Technol."},{"key":"10.1016\/j.celbio.2026.100372_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41427-024-00560-w","article-title":"A multifunctional mesoporous silica drug delivery nanosystem that ameliorates tumor hypoxia and increases radiotherapy efficacy","volume":"16","author":"Chu","year":"2024","journal-title":"NPG Asia Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib13","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1021\/acs.molpharmaceut.4c00595","article-title":"Hydrogels as a Potential Biomaterial for Multimodal Therapeutic Applications","volume":"21","author":"Kaur","year":"2024","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.celbio.2026.100372_bib14","article-title":"Smart\/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications","volume":"13","author":"El-Husseiny","year":"2022","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.celbio.2026.100372_bib15","article-title":"Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity","volume":"6","author":"Cao","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.celbio.2026.100372_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1174075","article-title":"Stimuli-responsive hydrogels: smart state of-the-art platforms for cardiac tissue engineering","volume":"11","author":"El-Husseiny","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.celbio.2026.100372_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/pat.70132","article-title":"Bioactive Hydrogels (Bio- HyGs): Emerging Trends in Drug Delivery and Wound Healing Applications","volume":"36","author":"Thirumalaivasan","year":"2025","journal-title":"Polymers for Advanced Techs."},{"key":"10.1016\/j.celbio.2026.100372_bib18","doi-asserted-by":"crossref","first-page":"7692","DOI":"10.1039\/D4TB00397G","article-title":"Nanocellulose-based hydrogels as versatile materials with interesting functional properties for tissue engineering applications","volume":"12","author":"Tamo","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.celbio.2026.100372_bib19","series-title":"Materials Science and Engineering: an Introduction","author":"Callister","year":"2018"},{"key":"10.1016\/j.celbio.2026.100372_bib20","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1021\/mp800051m","article-title":"Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles","volume":"5","author":"Alexis","year":"2008","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.celbio.2026.100372_bib21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.nantod.2014.04.008","article-title":"Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects","volume":"9","author":"Barua","year":"2014","journal-title":"Nano Today"},{"key":"10.1016\/j.celbio.2026.100372_bib22","series-title":"Pharmaceutical Sciences Encyclopedia","first-page":"1","article-title":"Clearance of Nanoparticles During Circulation","author":"Lee","year":"2013"},{"key":"10.1016\/j.celbio.2026.100372_bib23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijpharm.2005.10.010","article-title":"Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles","volume":"307","author":"Owens","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.celbio.2026.100372_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.critrevonc.2018.06.008","article-title":"Pharmacokinetics variability: Why nanoparticles are not just magic-bullets in oncology","volume":"129","author":"Rodallec","year":"2018","journal-title":"Crit. Rev. Oncol.\/Hematol."},{"key":"10.1016\/j.celbio.2026.100372_bib25","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.polymer.2008.01.027","article-title":"Hydrogels in drug delivery: Progress and challenges","volume":"49","author":"Hoare","year":"2008","journal-title":"Polymer"},{"key":"10.1016\/j.celbio.2026.100372_bib26","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.mattod.2023.03.006","article-title":"Hydrogel-enabled, local administration and combinatorial delivery of immunotherapies for cancer treatment","volume":"65","author":"Erfani","year":"2023","journal-title":"Mater. Today"},{"key":"10.1016\/j.celbio.2026.100372_bib27","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1039\/D4BM00155A","article-title":"Multifunctional antibacterial hydrogels for chronic wound management","volume":"12","author":"Hu","year":"2024","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.celbio.2026.100372_bib28","doi-asserted-by":"crossref","DOI":"10.1208\/s12249-024-02786-x","article-title":"A Comprehensive Review of Hydrogel-Based Drug Delivery Systems: Classification, Properties, Recent Trends, and Applications","volume":"25","author":"Hameed","year":"2024","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.celbio.2026.100372_bib29","first-page":"86","article-title":"In situ forming oxygen\/ROS-responsive niche-like hydrogel enabling gelation-triggered chemotherapy and inhibition of metastasis","volume":"21","author":"Chen","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib30","first-page":"550","article-title":"A reactive oxygen species-responsive hydrogel encapsulated with bone marrow derived stem cells promotes repair and regeneration of spinal cord injury","volume":"19","author":"Li","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib31","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.jconrel.2024.11.065","article-title":"A ROS-responsive hydrogel that targets inflamed mucosa to relieve ulcerative colitis by reversing intestinal mucosal barrier loss","volume":"377","author":"Wang","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.celbio.2026.100372_bib32","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbad110","article-title":"ROS-responsive hydrogels with spatiotemporally sequential delivery of antibacterial and anti-inflammatory drugs for the repair of MRSA-infected wounds","volume":"11","author":"Qiao","year":"2024","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.celbio.2026.100372_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122887","article-title":"ROS-responsive injectable hydrogels loaded with exosomes carrying miR-4500 reverse liver fibrosis","volume":"314","author":"Yang","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.celbio.2026.100372_bib34","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1039\/C6TB02407F","article-title":"Development of ionic strength\/pH\/enzyme triple-responsive zwitterionic hydrogel of the mixed l -glutamic acid and l -lysine polypeptide for site-specific drug delivery","volume":"5","author":"Ma","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.celbio.2026.100372_bib35","article-title":"Ultrafast enzyme-responsive hydrogel for real-time assessment and treatment optimization in infected wounds","volume":"23","author":"Zhao","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.celbio.2026.100372_bib36","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1007\/s10118-022-2726-0","article-title":"Intestine Enzyme-responsive Polysaccharide-based Hydrogel to Open Epithelial Tight Junctions for Oral Delivery of Imatinib against Colon Cancer","volume":"40","author":"Wang","year":"2022","journal-title":"Chin. J. Polym. Sci."},{"key":"10.1016\/j.celbio.2026.100372_bib37","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1002\/adfm.201002662","article-title":"Polymeric Multilayers that contain Silver Nanoparticles can be Stamped onto Biological Tissues to Provide Antibacterial Activity","volume":"21","author":"Agarwal","year":"2011","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib38","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/adhm.201300537","article-title":"Reduction in wound bioburden using a silver-loaded dissolvable microfilm construct","volume":"3","author":"Herron","year":"2014","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib39","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S0196-6553(99)70055-6","article-title":"Efficacy of topical silver against fungal burn wound pathogens","volume":"27","author":"Wright","year":"1999","journal-title":"Am. J. Infect. Control"},{"key":"10.1016\/j.celbio.2026.100372_bib40","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.burns.2003.09.030","article-title":"In vitro cytotoxity of silver: implication for clinical wound care","volume":"30","author":"Poon","year":"2004","journal-title":"Burns"},{"key":"10.1016\/j.celbio.2026.100372_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14030574","article-title":"Drug Delivery Strategies and Biomedical Significance of Hydrogels: Translational Considerations","volume":"14","author":"Raina","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.celbio.2026.100372_bib42","doi-asserted-by":"crossref","first-page":"13620","DOI":"10.1021\/acsnano.9b08659","article-title":"Nanomedicines Lost in Translation","volume":"13","author":"Guidolin","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.celbio.2026.100372_bib43","doi-asserted-by":"crossref","first-page":"14255","DOI":"10.1073\/pnas.1618156113","article-title":"Scalable manufacturing of biomimetic moldable hydrogels for industrial applications","volume":"113","author":"Yu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celbio.2026.100372_bib44","doi-asserted-by":"crossref","first-page":"11385","DOI":"10.1021\/acs.chemrev.0c01177","article-title":"Translational Applications of Hydrogels","volume":"121","author":"Correa","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.celbio.2026.100372_bib45","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1002\/jbm.b.34048","article-title":"Sterilization of hydrogels for biomedical applications: A review","volume":"106","author":"Galante","year":"2018","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.celbio.2026.100372_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/srep21154","article-title":"A simple method for the production of large volume 3D macroporous hydrogels for advanced biotechnological, medical and environmental applications","volume":"6","author":"Savina","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celbio.2026.100372_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/gels11070520","article-title":"Dual-Drug Delivery Systems Using Hydrogel-Nanoparticle Composites: Recent Advances and Key Applications","volume":"11","author":"Yoon","year":"2025","journal-title":"Gels"},{"key":"10.1016\/j.celbio.2026.100372_bib48","doi-asserted-by":"crossref","first-page":"22780","DOI":"10.1021\/acsnano.4c06888","article-title":"Hybrid Nanoparticle\u2013Hydrogel Systems for Drug Delivery Depots and Other Biomedical Applications","volume":"18","author":"Choi","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.celbio.2026.100372_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.150403","article-title":"Engineering multifunctional dynamic hydrogel for biomedical and tissue regenerative applications","volume":"487","author":"Yin","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.celbio.2026.100372_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-5173(96)04486-9","article-title":"Steric stabilization of nanoparticles: Size and surface properties","volume":"138","author":"Lourenco","year":"1996","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.celbio.2026.100372_bib51","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s13404-011-0015-8","article-title":"Polyethylene glycol functionalized gold nanoparticles: the influence of capping density on stability in various media","volume":"44","author":"Manson","year":"2011","journal-title":"Gold Bull."},{"key":"10.1016\/j.celbio.2026.100372_bib52","doi-asserted-by":"crossref","first-page":"10871","DOI":"10.1021\/acs.langmuir.5b02797","article-title":"Lipid-PEG conjugates sterically stabilize and reduce the toxicity of phytantriol-based lyotropic liquid crystalline nanoparticles","volume":"31","author":"Zhai","year":"2015","journal-title":"Langmuir"},{"key":"10.1016\/j.celbio.2026.100372_bib53","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jconrel.2016.11.033","article-title":"Unique size and shape-dependent uptake behaviors of non-spherical nanoparticles by endothelial cells due to a shearing flow","volume":"245","author":"Jurney","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.celbio.2026.100372_bib54","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/j.bbamem.2009.06.022","article-title":"Nanoparticles evading the reticuloendothelial system: role of the supported bilayer","volume":"1788","author":"Li","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celbio.2026.100372_bib55","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ijpharm.2017.09.028","article-title":"The effect of particle shape on cellular interaction and drug delivery applications of micro- and nanoparticles","volume":"532","author":"Jindal","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.celbio.2026.100372_bib56","doi-asserted-by":"crossref","first-page":"8089","DOI":"10.1039\/C8RA00033F","article-title":"The shape effect on polymer nanoparticle transport in a blood vessel","volume":"8","author":"Uhl","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.celbio.2026.100372_bib57","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1073\/pnas.1216893110","article-title":"Particle shape enhances specificity of antibody-displaying nanoparticles","volume":"110","author":"Barua","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celbio.2026.100372_bib58","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1080\/21691401.2017.1415212","article-title":"Chitosan nanoparticles loaded hydrogels promote skin wound healing through the modulation of reactive oxygen species","volume":"46","author":"Wang","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.celbio.2026.100372_bib59","doi-asserted-by":"crossref","first-page":"53804","DOI":"10.1039\/C6RA08404D","article-title":"Synthesis and characterization of PLGA nanoparticle\/4-arm-PEG hybrid hydrogels with controlled porous structures","volume":"6","author":"Zhuang","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.celbio.2026.100372_bib60","first-page":"14","article-title":"Injectable polymeric nanoparticle hydrogel system for long-term anti-inflammatory effect to treat osteoarthritis","volume":"7","author":"Seo","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/ph11040118","article-title":"Lipid Nanoparticles and Their Hydrogel Composites for Drug Delivery: A Review","volume":"11","author":"Desfran\u00e7ois","year":"2018","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.celbio.2026.100372_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/gels9070576","article-title":"Solid Lipid Nanoparticles Embedded Hydrogels as a Promising Carrier for Retarding Irritation of Leflunomide","volume":"9","author":"Alhelal","year":"2023","journal-title":"Gels"},{"key":"10.1016\/j.celbio.2026.100372_bib63","article-title":"An mRNA lipid nanoparticle-incorporated nanofiber-hydrogel composite for cancer immunotherapy","volume":"16","author":"Zhu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celbio.2026.100372_bib64","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adr2631","article-title":"Generation of an inflammatory niche in a hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines","volume":"11","author":"Meany","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celbio.2026.100372_bib65","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ijpharm.2019.04.079","article-title":"Gold nanoparticles loaded into polymeric hydrogel for wound healing in rats: Effect of nanoparticles\u2019 shape and surface modification","volume":"565","author":"Mahmoud","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.celbio.2026.100372_bib66","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/jbcr\/iraa205","article-title":"Incorporation of Silver Nanoparticles in Hydrogel Matrices for Controlling Wound Infection","volume":"42","author":"Pangli","year":"2021","journal-title":"J. Burn Care Res."},{"key":"10.1016\/j.celbio.2026.100372_bib67","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1021\/acsapm.2c00359","article-title":"Multifunctional Magnetic Hydrogels Fabricated by Iron Oxide Nanoparticles Mediated Radical Polymerization","volume":"4","author":"Ibeaho","year":"2022","journal-title":"ACS Appl. Polym. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib68","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s11427-017-9287-8","article-title":"Effect of nanoheat stimulation mediated by magnetic nanocomposite hydrogel on the osteogenic differentiation of mesenchymal stem cells","volume":"61","author":"Cao","year":"2018","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.celbio.2026.100372_bib69","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1039\/C6LC00474A","article-title":"Portable visual quantitative detection of aflatoxin B1 using a target-responsive hydrogel and a distance-readout microfluidic chip","volume":"16","author":"Ma","year":"2016","journal-title":"Lab Chip"},{"key":"10.1016\/j.celbio.2026.100372_bib70","doi-asserted-by":"crossref","first-page":"10801","DOI":"10.1002\/adma.201603632","article-title":"Assembly-Induced Thermogenesis of Gold Nanoparticles in the Presence of Alternating Magnetic Field for Controllable Drug Release of Hydrogel","volume":"28","author":"Wang","year":"2016","journal-title":"Adv. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib71","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1130523","article-title":"Magnetic iron oxide nanoparticle-loaded hydrogels for photothermal therapy of cancer cells","volume":"11","author":"Ji","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.celbio.2026.100372_bib72","doi-asserted-by":"crossref","first-page":"424","DOI":"10.7150\/ntno.86467","article-title":"Magnetic Resonance Imaging and Iron-oxide Nanoparticles in the era of Personalized Medicine","volume":"7","author":"Rahman","year":"2023","journal-title":"Nanotheranostics"},{"key":"10.1016\/j.celbio.2026.100372_bib73","doi-asserted-by":"crossref","DOI":"10.3390\/polym16233318","article-title":"Carbon Based Polymeric Nanocomposite Hydrogel Bioink: A Review","volume":"16","author":"Madhusudhan","year":"2024","journal-title":"Polymers"},{"key":"10.1016\/j.celbio.2026.100372_bib74","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jconrel.2018.12.014","article-title":"Applications of \u03c0-\u03c0 stacking interactions in the design of drug-delivery systems","volume":"294","author":"Zhuang","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.celbio.2026.100372_bib75","doi-asserted-by":"crossref","first-page":"15833","DOI":"10.1021\/acsomega.3c07724","article-title":"Photothermal Hydrogel Composites Featuring G4-Carbon Nanomaterial Networks for Staphylococcus aureus Inhibition","volume":"9","author":"Sardaru","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.celbio.2026.100372_bib76","doi-asserted-by":"crossref","first-page":"6137","DOI":"10.2147\/IJN.S429626","article-title":"Temperature-Sensitive Nanocarbon Hydrogel for Photothermal Therapy of Tumors","volume":"18","author":"Tan","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.celbio.2026.100372_bib77","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-80222-7","article-title":"Fluorescent antimicrobial hydrogel based on fluorophore N-doped carbon dots originated from cellulose nanocrystals","volume":"14","author":"Ahmed","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celbio.2026.100372_bib78","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1021\/acscentsci.0c01306","article-title":"Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications","volume":"6","author":"Liu","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.celbio.2026.100372_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.ntm.2025.100083","article-title":"Nanoparticles for drug delivery: Insight into in vitro and in vivo drug release from nanomedicines","volume":"4","author":"Ewii","year":"2025","journal-title":"Nano TransMed"},{"key":"10.1016\/j.celbio.2026.100372_bib80","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/s41563-023-01472-w","article-title":"Hydrogels for RNA delivery","volume":"22","author":"Zhong","year":"2023","journal-title":"Nat. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib81","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1021\/acsanm.1c03904","article-title":"Hydrogel\u2013Metal\u2013Organic-Framework Nanoparticle Composites for Immobilization of Active Biomacromolecules","volume":"5","author":"Wang","year":"2022","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib82","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1021\/acsbiomaterials.6b00286","article-title":"Protein\u2013Nanoparticle Hydrogels That Self-assemble in Response to Peptide-Based Molecular Recognition","volume":"3","author":"Parisi-Amon","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.celbio.2026.100372_bib83","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celbio.2026.100372_bib84","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa2035389","article-title":"Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine","volume":"384","author":"Baden","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celbio.2026.100372_bib85","doi-asserted-by":"crossref","DOI":"10.3390\/polym11020275","article-title":"Nanoparticle-Hydrogel Composites: From Molecular Interactions to Macroscopic Behavior","volume":"11","author":"Dannert","year":"2019","journal-title":"Polymers"},{"key":"10.1016\/j.celbio.2026.100372_bib86","doi-asserted-by":"crossref","DOI":"10.3390\/ma13010188","article-title":"Hydrogels as Potential Nano-, Micro- and Macro-Scale Systems for Controlled Drug Delivery","volume":"13","author":"Chyzy","year":"2020","journal-title":"Materials"},{"key":"10.1016\/j.celbio.2026.100372_bib87","doi-asserted-by":"crossref","DOI":"10.3390\/ma17194792","article-title":"Cutting-Edge Hydrogel Technologies in Tissue Engineering and Biosensing: An Updated Review","volume":"17","author":"Parvin","year":"2024","journal-title":"Materials"},{"key":"10.1016\/j.celbio.2026.100372_bib88","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3606765","article-title":"Advancements in the Use of Hydrogels for Regenerative Medicine: Properties and Biomedical Applications","volume":"2022","author":"Revete","year":"2022","journal-title":"Int. J. Biomater."},{"key":"10.1016\/j.celbio.2026.100372_bib89","article-title":"Biopolymer hydrogels in biomedicine: Bridging chemistry, biology, and clinical translation","volume":"318","author":"Li","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.celbio.2026.100372_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122718","article-title":"Biomedical applications of functional hydrogels: Innovative developments, relevant clinical trials and advanced products","volume":"312","author":"Z\u00f6ller","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.celbio.2026.100372_bib91","first-page":"39","article-title":"Hydrogel as a bioactive material to regulate stem cell fate","volume":"1","author":"Tsou","year":"2016","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib92","doi-asserted-by":"crossref","DOI":"10.1007\/s10856-019-6318-7","article-title":"Overview of natural hydrogels for regenerative medicine applications","volume":"30","author":"Catoira","year":"2019","journal-title":"J. Mater. Sci., Mater. Med."},{"key":"10.1016\/j.celbio.2026.100372_bib93","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1016\/j.biomaterials.2010.02.044","article-title":"Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering","volume":"31","author":"Zhu","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.celbio.2026.100372_bib94","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/jbm.b.34371","article-title":"Surface modification of polyvinyl alcohol (PVA)\/polyacrylamide (PAAm) hydrogels with polydopamine and REDV for improved applicability","volume":"108","author":"Wu","year":"2020","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.celbio.2026.100372_bib95","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.coche.2019.02.010","article-title":"Hybrid hydrogels for biomedical applications","volume":"24","author":"Palmese","year":"2019","journal-title":"Curr. Opin. Chem. Eng."},{"key":"10.1016\/j.celbio.2026.100372_bib96","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.630943","article-title":"Design and Development of Hybrid Hydrogels for Biomedical Applications: Recent Trends in Anticancer Drug Delivery and Tissue Engineering","volume":"9","author":"Cai","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.celbio.2026.100372_bib97","doi-asserted-by":"crossref","DOI":"10.1002\/adem.202400944","article-title":"Strategy and Advancement in Hybrid Hydrogel and Their Applications: Recent Progress and Trends","volume":"26","author":"Choudhary","year":"2024","journal-title":"Adv. Eng. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib98","doi-asserted-by":"crossref","DOI":"10.3390\/gels8030167","article-title":"Versatility of Hydrogels: From Synthetic Strategies, Classification, and Properties to Biomedical Applications","volume":"8","author":"Ahmad","year":"2022","journal-title":"Gels"},{"key":"10.1016\/j.celbio.2026.100372_bib99","series-title":"Multicomponent Hydrogels","first-page":"1","article-title":"Hydrogels: Definition, History, Classifications, Formation, Constitutive Characteristics, and Applications","author":"Dodda","year":"2023"},{"key":"10.1016\/j.celbio.2026.100372_bib100","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27092902","article-title":"Hydrogels: Properties and Applications in Biomedicine","volume":"27","author":"Ho","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.celbio.2026.100372_bib101","doi-asserted-by":"crossref","DOI":"10.3390\/gels9070523","article-title":"Polymer-Based Hydrogels Applied in Drug Delivery: An Overview","volume":"9","author":"Thang","year":"2023","journal-title":"Gels"},{"key":"10.1016\/j.celbio.2026.100372_bib102","doi-asserted-by":"crossref","DOI":"10.3390\/gels8050301","article-title":"Current Understanding of Hydrogel for Drug Release and Tissue Engineering","volume":"8","author":"Lei","year":"2022","journal-title":"Gels"},{"key":"10.1016\/j.celbio.2026.100372_bib103","doi-asserted-by":"crossref","DOI":"10.3390\/gels8090577","article-title":"Dynamic Covalent Hydrogels: Strong yet Dynamic","volume":"8","author":"Han","year":"2022","journal-title":"Gels"},{"key":"10.1016\/j.celbio.2026.100372_bib104","doi-asserted-by":"crossref","first-page":"6674","DOI":"10.1021\/acs.chemmater.4c00507","article-title":"Boronate Ester Hydrogels for Biomedical Applications: Challenges and Opportunities","volume":"36","author":"Terriac","year":"2024","journal-title":"Chem. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib105","doi-asserted-by":"crossref","DOI":"10.3390\/gels4010021","article-title":"Hydrogels Based on Dynamic Covalent and Non Covalent Bonds: A Chemistry Perspective","volume":"4","author":"Picchioni","year":"2018","journal-title":"Gels"},{"key":"10.1016\/j.celbio.2026.100372_bib106","article-title":"Nano-crosslinked dynamic hydrogels for biomedical applications","volume":"20","author":"Wang","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.celbio.2026.100372_bib107","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.actbio.2024.05.052","article-title":"Near-infrared light-responsive hydrogels for on-demand dual delivery of proangiogenic growth factors","volume":"183","author":"Nazemidashtarjandi","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.celbio.2026.100372_bib108","doi-asserted-by":"crossref","first-page":"17168","DOI":"10.1039\/D1NR04625J","article-title":"Near-infrared light-responsive hybrid hydrogels for the synergistic chemo-photothermal therapy of oral cancer","volume":"13","author":"Wu","year":"2021","journal-title":"Nanoscale"},{"key":"10.1016\/j.celbio.2026.100372_bib109","doi-asserted-by":"crossref","DOI":"10.1038\/s41528-022-00193-5","article-title":"A temperature responsive adhesive hydrogel for fabrication of flexible electronic sensors","volume":"6","author":"Liu","year":"2022","journal-title":"npj Flex. Electron."},{"key":"10.1016\/j.celbio.2026.100372_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2021.110104","article-title":"pH-responsive hydrogel loaded with insulin as a bioactive dressing for enhancing diabetic wound healing","volume":"210","author":"Li","year":"2021","journal-title":"Mater. Des."},{"key":"10.1016\/j.celbio.2026.100372_bib111","doi-asserted-by":"crossref","DOI":"10.1007\/s40820-020-00585-0","article-title":"Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing","volume":"13","author":"He","year":"2021","journal-title":"Nano-Micro Lett."},{"key":"10.1016\/j.celbio.2026.100372_bib112","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics10010049","article-title":"pH-Responsive \u201cSmart\u201d Hydrogel for Controlled Delivery of Silver Nanoparticles to Infected Wounds","volume":"10","author":"Haidari","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.celbio.2026.100372_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2023.110726","article-title":"Microenvironment responsive hypoxia-mimetic DFO composite hydrogel for on-demand neovascularization to promote tendon-to-bone healing","volume":"259","author":"Xu","year":"2023","journal-title":"Compos. B Eng."},{"key":"10.1016\/j.celbio.2026.100372_bib114","article-title":"Preparation and application of enzyme-based hydrogels","volume":"23","author":"Wen","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.celbio.2026.100372_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.102064","article-title":"Hypoxia-responsive calixarene-grafted self-assembled peptide hydrogel for inflammation suppression in ischemic stroke","volume":"54","author":"Zheng","year":"2024","journal-title":"Nano Today"},{"key":"10.1016\/j.celbio.2026.100372_bib116","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201400010","article-title":"Nanoparticle\u2013Hydrogel Composites: Concept, Design, and Applications of These Promising, Multi-Functional Materials","volume":"2","author":"Thoniyot","year":"2015","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celbio.2026.100372_bib117","doi-asserted-by":"crossref","first-page":"35251","DOI":"10.1039\/D3RA07391B","article-title":"Revolutionizing biomedicine: Advancements, applications, and prospects of nanocomposite macromolecular carbohydrate-based hydrogel biomaterials: A review","volume":"13","author":"Alshangiti","year":"2023","journal-title":"RSC Adv."},{"key":"10.1016\/j.celbio.2026.100372_bib118","doi-asserted-by":"crossref","DOI":"10.3390\/polym9120636","article-title":"Recent Advances in Antimicrobial Hydrogels Containing Metal Ions and Metals\/Metal Oxide Nanoparticles","volume":"9","author":"Wahid","year":"2017","journal-title":"Polymers"},{"key":"10.1016\/j.celbio.2026.100372_bib119","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202005941","article-title":"Stimuli-Responsive Nanocomposite Hydrogels for Biomedical Applications","volume":"31","author":"Lavrador","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib120","article-title":"Nanoparticles-hydrogel composites: A promising innovative system for local antimicrobial applications","volume":"89","author":"Pham","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.celbio.2026.100372_bib121","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1002\/pol.20210652","article-title":"Gelation and yielding behavior of polymer\u2013nanoparticle hydrogels","volume":"59","author":"Grosskopf","year":"2021","journal-title":"J. Polym. Sci."},{"key":"10.1016\/j.celbio.2026.100372_bib122","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jcat.2021.12.026","article-title":"Dynamics of diffusion-limited photocatalytic degradation of dye by polymeric hydrogel with embedded TiO2 nanoparticles","volume":"406","author":"Mansurov","year":"2022","journal-title":"J. Catal."},{"key":"10.1016\/j.celbio.2026.100372_bib123","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1021\/acsbiomaterials.1c01399","article-title":"A Three-Dimensional Printable Hydrogel Formulation for the Local Delivery of Therapeutic Nanoparticles to Cervical Cancer","volume":"8","author":"Kiseleva","year":"2022","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.celbio.2026.100372_bib124","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1021\/acsbiomaterials.2c00284","article-title":"Injectable Hydrogel Containing Cowpea Mosaic Virus Nanoparticles Prevents Colon Cancer Growth","volume":"8","author":"Nkanga","year":"2022","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.celbio.2026.100372_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2023.122170","article-title":"Dox-loaded TPU-PLGA nanoparticles embedded chitosan hydrogel formulation as an effective anti-cancer therapy","volume":"383","author":"Manhas","year":"2023","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.celbio.2026.100372_bib126","doi-asserted-by":"crossref","DOI":"10.3390\/gels10050307","article-title":"Rheological and Injectability Evaluation of Sterilized Poloxamer-407-Based Hydrogels Containing Docetaxel-Loaded Lipid Nanoparticles","volume":"10","author":"Marques","year":"2024","journal-title":"Gels"},{"key":"10.1016\/j.celbio.2026.100372_bib127","article-title":"Gold-Enhanced Brachytherapy by a Nanoparticle-Releasing Hydrogel and 3D-Printed Subcutaneous Radioactive Implant Approach","volume":"12","author":"Kiseleva","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.129228","article-title":"ROS scavenging activity of polydopamine nanoparticle-loaded supramolecular gelatin-based hydrogel promoted cardiomyocyte proliferation","volume":"259","author":"Zarkesh","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.celbio.2026.100372_bib129","doi-asserted-by":"crossref","first-page":"6724","DOI":"10.1002\/anie.202015340","article-title":"Embedment of Quantum Dots and Biomolecules in a Dipeptide Hydrogel Formed In Situ Using Microfluidics","volume":"60","author":"Li","year":"2021","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.celbio.2026.100372_bib130","article-title":"Polymeric nanocomposite hydrogel scaffold for jawbone regeneration: The role of rosuvastatin calcium-loaded silica nanoparticles","volume":"6","author":"Adel","year":"2023","journal-title":"Int. J. Pharm.: X"},{"key":"10.1016\/j.celbio.2026.100372_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2023.213677","article-title":"Preparation and characterization of 3D bioprinted gelatin methacrylate hydrogel incorporated with curcumin loaded chitosan nanoparticles for in vivo wound healing application","volume":"156","author":"Khoshmaram","year":"2024","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.celbio.2026.100372_bib132","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijpharm.2019.01.019","article-title":"Silver nanoparticle impregnated chitosan-PEG hydrogel enhances wound healing in diabetes induced rabbits","volume":"559","author":"Masood","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.celbio.2026.100372_bib133","doi-asserted-by":"crossref","first-page":"18604","DOI":"10.1021\/acsnano.4c04766","article-title":"Multifunctional Nanoparticle-Loaded Injectable Alginate Hydrogels with Deep Tumor Penetration for Enhanced Chemo-Immunotherapy of Cancer","volume":"18","author":"Yang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.celbio.2026.100372_bib134","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ijbiomac.2018.07.060","article-title":"Novel chitosan hydrogels reinforced by silver nanoparticles with ultrahigh mechanical and high antibacterial properties for accelerating wound healing","volume":"119","author":"Xie","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.celbio.2026.100372_bib135","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1021\/acs.jpcb.2c00771","article-title":"Relationship between Gel Mesh and Particle Size in Determining Nanoparticle Diffusion in Hydrogel Nanocomposites","volume":"126","author":"Moncure","year":"2022","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.celbio.2026.100372_bib136","doi-asserted-by":"crossref","DOI":"10.1063\/1.4978054","article-title":"Network confinement and heterogeneity slows nanoparticle diffusion in polymer gels","volume":"146","author":"Parrish","year":"2017","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.celbio.2026.100372_bib137","doi-asserted-by":"crossref","first-page":"9366","DOI":"10.1021\/acs.jpcb.3c03249","article-title":"Role of Ligand Shell Density in the Diffusive Behavior of Nanoparticles in Hydrogels","volume":"127","author":"Moncure","year":"2023","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.celbio.2026.100372_bib138","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1039\/D1TB02850B","article-title":"A chitosan-based multifunctional hydrogel containing in situ rapidly bioreduced silver nanoparticles for accelerating infected wound healing","volume":"10","author":"Zhao","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.celbio.2026.100372_bib139","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1021\/acsbiomaterials.1c01560","article-title":"Shaping and Patterning Supramolecular Materials-Stem Cell-Compatible Dual-Network Hybrid Gels Loaded with Silver Nanoparticles","volume":"8","author":"Piras","year":"2022","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.celbio.2026.100372_bib140","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1021\/acsabm.8b00471","article-title":"In Situ Synthesis of Silver Nanoparticles within Hydrogel-Conjugated Membrane for Enhanced Antibacterial Properties","volume":"2","author":"Somayajula","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib141","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.1066617","article-title":"Photothermal nanohybrid hydrogels for biomedical applications","volume":"10","author":"Ding","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.celbio.2026.100372_bib142","doi-asserted-by":"crossref","first-page":"18963","DOI":"10.1021\/acsnano.4c02312","article-title":"Injectable Nanocomposite Hydrogels Improve Intraperitoneal Co-delivery of Chemotherapeutics and Immune Checkpoint Inhibitors for Enhanced Peritoneal Metastasis Therapy","volume":"18","author":"Liang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.celbio.2026.100372_bib143","doi-asserted-by":"crossref","first-page":"6951","DOI":"10.1039\/D2BM01113A","article-title":"Sustained release of drug-loaded nanoparticles from injectable hydrogels enables long-term control of macrophage phenotype","volume":"10","author":"Soni","year":"2022","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.celbio.2026.100372_bib144","doi-asserted-by":"crossref","first-page":"6433","DOI":"10.1021\/acsami.3c17580","article-title":"Construction of a Soft Antifouling PAA\/PSBMA Hydrogel Coating with High Toughness and Low Swelling through the Dynamic Coordination Bonding Provided by Al(OH)3 Nanoparticles","volume":"16","author":"Hu","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.celbio.2026.100372_bib145","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1080\/20550324.2022.2076025","article-title":"Progress and prospects of nanocomposite hydrogels in bone tissue engineering","volume":"8","author":"Du","year":"2022","journal-title":"Nanocomposites"},{"key":"10.1016\/j.celbio.2026.100372_bib146","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.biomaterials.2017.12.024","article-title":"Clay nanoparticles for regenerative medicine and biomaterial design: A review of clay bioactivity","volume":"159","author":"Mousa","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.celbio.2026.100372_bib147","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-024-02555-9","article-title":"Dynamic hydrogel\u2013metal\u2013organic framework system promotes bone regeneration in periodontitis through controlled drug delivery","volume":"22","author":"Luo","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.celbio.2026.100372_bib148","doi-asserted-by":"crossref","first-page":"34924","DOI":"10.1021\/acsami.8b11436","article-title":"Combinatorial Screening of Nanoclay-Reinforced Hydrogels: A Glimpse of the \u201cHoly Grail\u201d","volume":"10","author":"Hasany","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.celbio.2026.100372_bib149","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2021.214352","article-title":"Cyclodextrin-based host\u2013guest supramolecular hydrogels for local drug delivery","volume":"454","author":"Fang","year":"2022","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.celbio.2026.100372_bib150","doi-asserted-by":"crossref","DOI":"10.3390\/polym13213782","article-title":"Self-Healing Hydrogels: Preparation, Mechanism and Advancement in Biomedical Applications","volume":"13","author":"Devi V K","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.celbio.2026.100372_bib151","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.1040492","article-title":"Magnetic hydrogels with ordered structure for biomedical applications","volume":"10","author":"Xue","year":"2022","journal-title":"Front. Chem."},{"key":"10.1016\/j.celbio.2026.100372_bib152","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics12010104","article-title":"Advanced Hydrogels Combined with Silver and Gold Nanoparticles against Antimicrobial Resistance","volume":"12","author":"Moreno Ruiz","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.celbio.2026.100372_bib153","article-title":"3D printing of hydrogel composite systems: Recent advances in technology for tissue engineering","volume":"4","author":"Jang","year":"2018","journal-title":"Int. J. Bioprint."},{"key":"10.1016\/j.celbio.2026.100372_bib154","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1021\/acsabm.4c00379","article-title":"Gold-Hydrogel Nanocomposites for High-Resolution Laser-Based 3D Printing of Scaffolds with SERS-Sensing Properties","volume":"7","author":"Ventisette","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib155","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14122596","article-title":"3D Bioprinting Using Hydrogels: Cell Inks and Tissue Engineering Applications","volume":"14","author":"Dell","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.celbio.2026.100372_bib156","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s44222-024-00251-9","article-title":"Lithography-based 3D printing of hydrogels","volume":"3","author":"Dhand","year":"2025","journal-title":"Nat. Rev. Bioeng."},{"key":"10.1016\/j.celbio.2026.100372_bib157","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202202408","article-title":"Collagen Hydrogel Containing Polyethylenimine-Gold Nanoparticles for Drug Release and Enhanced Beating Properties of Engineered Cardiac Tissues","volume":"12","author":"Roshanbinfar","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib158","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-15206-y","article-title":"Exploiting the role of nanoparticle shape in enhancing hydrogel adhesive and mechanical properties","volume":"11","author":"Arno","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celbio.2026.100372_bib159","article-title":"Precise Tuning of Polymeric Fiber Dimensions to Enhance the Mechanical Properties of Alginate Hydrogel Matrices","volume":"13","author":"Li","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.celbio.2026.100372_bib160","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.actbio.2022.05.042","article-title":"An Injectable Nanocomposite Hydrogel Improves Tumor Penetration and Cancer Treatment Efficacy","volume":"147","author":"Luo","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.celbio.2026.100372_bib161","doi-asserted-by":"crossref","first-page":"5253","DOI":"10.1021\/acsnano.7b08499","article-title":"Silencing of Intestinal Glycoprotein CD98 by Orally Targeted Nanoparticles Enhances Chemosensitization of Colon Cancer","volume":"12","author":"Xiao","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.celbio.2026.100372_bib162","doi-asserted-by":"crossref","first-page":"23838","DOI":"10.1039\/D0NR05053A","article-title":"Intratumoral injection of hydrogel-embedded nanoparticles enhances retention in glioblastoma","volume":"12","author":"Brachi","year":"2020","journal-title":"Nanoscale"},{"key":"10.1016\/j.celbio.2026.100372_bib163","article-title":"Correction to: Sustained release of valproic acid loaded on chitosan nanoparticles within hybrid of alginate\/chitosan hydrogel with\/without stem cells in regeneration of spinal cord injury","volume":"12","author":"Jafarimanesh","year":"2023","journal-title":"Prog. Biomater."},{"key":"10.1016\/j.celbio.2026.100372_bib164","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1021\/acsabm.4c01659","article-title":"Nanoparticle-Reinforced Hydrogel with a Well-Defined Pore Structure for Sustainable Drug Release and Effective Wound Healing","volume":"8","author":"Zhang","year":"2025","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib165","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17010127","article-title":"Nanoparticle-in-hydrogel delivery system for the sequential release of two drugs","volume":"17","author":"Van Straten","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.celbio.2026.100372_bib166","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jconrel.2016.12.015","article-title":"Controlled nanoparticle release from a hydrogel by DNA-mediated particle disaggregation","volume":"246","author":"Nowald","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.celbio.2026.100372_bib167","doi-asserted-by":"crossref","DOI":"10.3390\/gels8050298","article-title":"Smart Methylcellulose Hydrogels for pH-Triggered Delivery of Silver Nanoparticles","volume":"8","author":"Bonetti","year":"2022","journal-title":"Gels"},{"key":"10.1016\/j.celbio.2026.100372_bib168","doi-asserted-by":"crossref","DOI":"10.1186\/s40824-022-00281-7","article-title":"Construction of antibacterial nano-silver embedded bioactive hydrogel to repair infectious skin defects","volume":"26","author":"Dong","year":"2022","journal-title":"Biomater. Res."},{"key":"10.1016\/j.celbio.2026.100372_bib169","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/s10439-020-02471-7","article-title":"An Injectable Nanocomposite Hydrogel for Potential Application of Vascularization and Tissue Repair","volume":"48","author":"Ding","year":"2020","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.celbio.2026.100372_bib170","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1002\/jbm.a.36723","article-title":"An injectable scaffold based on temperature-responsive hydrogel and factor-loaded nanoparticles for application in vascularization in tissue engineering","volume":"107","author":"He","year":"2019","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.celbio.2026.100372_bib171","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.2147\/IJN.S180859","article-title":"Nanoparticle-modified chitosan-agarose-gelatin scaffold for sustained release of SDF-1 and BMP-2","volume":"13","author":"Wang","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.celbio.2026.100372_bib172","article-title":"Sequential delivery of IL-10 and icariin using nanoparticle\/hydrogel hybrid system for prompting bone defect repair","volume":"29","author":"Li","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.celbio.2026.100372_bib173","article-title":"A ROS-responsive hydrogel encapsulated with matrix metalloproteinase-13 siRNA nanocarriers to attenuate osteoarthritis progression","volume":"23","author":"Wang","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.celbio.2026.100372_bib174","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.addr.2019.08.010","article-title":"Domesticating the foreign body response: Recent advances and applications","volume":"144","author":"Veiseh","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.celbio.2026.100372_bib175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030636","article-title":"Biomaterials: Foreign Bodies or Tuners for the Immune Response?","volume":"20","author":"Mariani","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celbio.2026.100372_bib176","doi-asserted-by":"crossref","DOI":"10.1002\/jbm.a.37983","article-title":"Implantable Medical Devices, Biomaterials, and the Foreign Body Response: A Surgical Perspective","volume":"113","author":"Kalashnikov","year":"2025","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.celbio.2026.100372_bib177","doi-asserted-by":"crossref","DOI":"10.1063\/5.0228692","article-title":"Immunomodulatory hydrogels for tissue repair and regeneration","volume":"12","author":"Liu","year":"2024","journal-title":"APL Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib178","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.3390\/ma8095269","article-title":"Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials","volume":"8","author":"Sheikh","year":"2015","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.celbio.2026.100372_bib179","article-title":"Dynamic and living devices for overcoming fibrosis of implanted biomaterials","author":"Jackson","year":"2025","journal-title":"Bioeng. Transla. Med."},{"key":"10.1016\/j.celbio.2026.100372_bib180","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10300","article-title":"Advanced strategies to thwart foreign body response to implantable devices","volume":"7","author":"Capuani","year":"2022","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.celbio.2026.100372_bib181","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12070613","article-title":"Dual Network Hydrogels Incorporated with Bone Morphogenic Protein-7-Loaded Hyaluronic Acid Complex Nanoparticles for Inducing Chondrogenic Differentiation of Synovium-Derived Mesenchymal Stem Cells","volume":"12","author":"Min","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.celbio.2026.100372_bib182","doi-asserted-by":"crossref","first-page":"7592","DOI":"10.1021\/acsami.1c21260","article-title":"Magnesium Oxide Nanoparticle Coordinated Phosphate-Functionalized Chitosan Injectable Hydrogel for Osteogenesis and Angiogenesis in Bone Regeneration","volume":"14","author":"Chen","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.celbio.2026.100372_bib183","doi-asserted-by":"crossref","DOI":"10.3390\/gels9080645","article-title":"Comparative Study of In Situ Gel Formulation Based on the Physico-Chemical Aspect: Systematic Review","volume":"9","author":"Kurniawansyah","year":"2023","journal-title":"Gels"},{"key":"10.1016\/j.celbio.2026.100372_bib184","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejpb.2007.02.025","article-title":"Thermoresponsive hydrogels in biomedical applications","volume":"68","author":"Klouda","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.celbio.2026.100372_bib185","article-title":"Recent advances on thermosensitive hydrogels-mediated precision therapy","volume":"19","author":"Chen","year":"2024","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.celbio.2026.100372_bib186","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124872","article-title":"Hyaluronic acid-based injectable nanocomposite hydrogels with photo-thermal antibacterial properties for infected chronic diabetic wound healing","volume":"242","author":"Yang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.celbio.2026.100372_bib187","doi-asserted-by":"crossref","first-page":"9017","DOI":"10.1021\/acs.nanolett.4c02113","article-title":"Programming of in Situ Tumor Vaccines via Supramolecular Nanodrug\/Hydrogel Composite and Deformable Nanoadjuvant for Cancer Immunotherapy","volume":"24","author":"Shao","year":"2024","journal-title":"Nano Lett."},{"key":"10.1016\/j.celbio.2026.100372_bib188","article-title":"A Bioactive Injectable Hydrogel Regulates Tumor Metastasis and Wound Healing for Melanoma via NIR-Light Triggered Hyperthermia","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celbio.2026.100372_bib189","article-title":"A Physiologically Responsive Nanocomposite Hydrogel for Treatment of Head and Neck Squamous Cell Carcinoma via Proteolysis-Targeting Chimeras Enhanced Immunotherapy","volume":"35","author":"Wu","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib190","article-title":"Ferritin-Based Nanocomposite Hydrogel Promotes Tumor Penetration and Enhances Cancer Chemoimmunotherapy","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celbio.2026.100372_bib191","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122675","article-title":"In situ hydrogel based on Cu\u2013Fe3O4 nanoclusters exploits oxidative stress and the ferroptosis\/cuproptosis pathway for chemodynamic therapy","volume":"311","author":"Zhang","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.celbio.2026.100372_bib192","article-title":"Hydrogel Crosslinked with Nanoparticles for Prevention of Surgical Hemorrhage and Recurrence of Hepatocellular Carcinoma","volume":"11","author":"Zhu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celbio.2026.100372_bib193","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2024.213925","article-title":"Dual electro-\/pH-responsive nanoparticle\/hydrogel system for controlled delivery of anticancer peptide","volume":"162","author":"Resina","year":"2024","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.celbio.2026.100372_bib194","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126221","article-title":"Intratumoral thermo-chemotherapeutic alginate hydrogel containing doxorubicin loaded PLGA nanoparticle and heating agent","volume":"251","author":"Tsai","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.celbio.2026.100372_bib195","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122959","article-title":"Injectable and adhesive MgO2-potentiated hydrogel with sequential tumor synergistic therapy and osteogenesis for challenging postsurgical osteosarcoma treatment","volume":"315","author":"Zhang","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.celbio.2026.100372_bib196","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16080981","article-title":"Local, Sustained, and Targeted Co-Delivery of MEK Inhibitor and Doxorubicin Inhibits Tumor Progression in E-Cadherin-Positive Breast Cancer","volume":"16","author":"Kuhn","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.celbio.2026.100372_bib197","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-32257-5","article-title":"Nanocomposite formulation for a sustained release of free drug and drug-loaded responsive nanoparticles: an approach for a local therapy of glioblastoma multiforme","volume":"13","author":"Erthal","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celbio.2026.100372_bib198","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15092358","article-title":"Thermo-Responsive Hydrogels Encapsulating Targeted Core\u2013Shell Nanoparticles as Injectable Drug Delivery Systems","volume":"15","author":"Ertugral-Samgar","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.celbio.2026.100372_bib199","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202203337","article-title":"Alleviate Periodontitis and Its Comorbidity Hypertension using a Nanoparticle-Embedded Functional Hydrogel System","volume":"12","author":"Xu","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib200","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12050993","article-title":"In-Situ Thermoresponsive Hydrogel Containing Resveratrol-Loaded Nanoparticles as a Localized Drug Delivery Platform for Dry Eye Disease","volume":"12","author":"De Luca","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.celbio.2026.100372_bib201","doi-asserted-by":"crossref","DOI":"10.3390\/jfb14020082","article-title":"Hyaluronic Acid Hydrogel Containing Resveratrol-Loaded Chitosan Nanoparticles as an Adjuvant in Atopic Dermatitis Treatment","volume":"14","author":"Conte","year":"2023","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.celbio.2026.100372_bib202","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-025-03275-4","article-title":"Injectable hydrogels with ROS-triggered drug release enable the co-delivery of antibacterial agent and anti-inflammatory nanoparticle for periodontitis treatment","volume":"23","author":"Zhu","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.celbio.2026.100372_bib203","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.01.081","article-title":"Engineering biocompatible carbon dots nano-enzymes hydrogel for efficient antioxidative and anti-inflammatory treatment of dry eye disease","volume":"381","author":"Yu","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.celbio.2026.100372_bib204","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1007\/s13346-023-01332-9","article-title":"The development of a solid lipid nanoparticle (SLN)-based lacticin 3147 hydrogel for the treatment of wound infections","volume":"13","author":"Ryan","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.celbio.2026.100372_bib205","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1039\/D4BM01315H","article-title":"A thiol\u2013ene click-based strategy to customize injectable polymer\u2013nanoparticle hydrogel properties for therapeutic delivery","volume":"13","author":"Bailey","year":"2025","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.celbio.2026.100372_bib206","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.actbio.2025.05.072","article-title":"Improving tendon repair through spatiotemporal modulation of TGF-\u03b21 expression using an ultrasound-responsive hydrogel carrying siRNA-loaded nanoparticles","volume":"201","author":"Liu","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.celbio.2026.100372_bib207","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-024-02965-9","article-title":"Targeted lipid nanoparticles distributed in hydrogel treat osteoarthritis by modulating cholesterol metabolism and promoting endogenous cartilage regeneration","volume":"22","author":"Zhao","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.celbio.2026.100372_bib208","first-page":"95","article-title":"Hydrogel forming microneedles loaded with VEGF and Ritlecitinib\/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment","volume":"38","author":"Ding","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib209","doi-asserted-by":"crossref","first-page":"39784","DOI":"10.1021\/acsami.4c05425","article-title":"Transforming Cell\u2013Drug Interaction through Granular Hydrogel-Mediated Delivery of Polyplex Nanoparticles for Enhanced Safety and Extended Efficacy in Gene Therapy","volume":"16","author":"Zhang","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.celbio.2026.100372_bib210","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbad046","article-title":"A multifunctional nanocomposite hydrogel with controllable release behavior enhances bone regeneration","volume":"10","author":"Mao","year":"2023","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.celbio.2026.100372_bib211","article-title":"Directing cellular responses in a nanocomposite 3D matrix for tissue regeneration with nanoparticle-mediated drug delivery","volume":"23","author":"\u00d6zliseli","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.celbio.2026.100372_bib212","article-title":"Magnesium Nanocomposite Hydrogel Reverses the Pathologies to Enhance Mandible Regeneration","volume":"37","author":"Guo","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib213","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113893","article-title":"Multifunctional nanocomposite hydrogel with dual-factor controlled release for stem cell recruitment, immunomodulation and bone remodeling","volume":"384","author":"Jiao","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.celbio.2026.100372_bib214","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jconrel.2023.09.026","article-title":"Controlled extracellular vesicles release from aminoguanidine nanoparticle-loaded polylysine hydrogel for synergistic treatment of spinal cord injury","volume":"363","author":"Wang","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.celbio.2026.100372_bib215","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-025-03289-y","article-title":"Stem cells derived exosome laden oxygen generating hydrogel composites with good electrical conductivity for the tissue-repairing process of post-myocardial infarction","volume":"23","author":"Xu","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.celbio.2026.100372_bib216","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.144490","article-title":"Synergistic effects of modified zinc oxide nanoparticle in a hybrid chitosan-gelatin hydrogel for bone regeneration","volume":"315","author":"Hia","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.celbio.2026.100372_bib217","article-title":"Exosome-coated oxygen nanobubble-laden hydrogel augments intracellular delivery of exosomes for enhanced wound healing","volume":"15","author":"Han","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celbio.2026.100372_bib218","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202412240","article-title":"An Immunomodulatory Hydrogel Featuring Antibacterial and Reactive Oxygen Species Scavenging Properties for Treating Periodontitis in Diabetes","volume":"37","author":"Ge","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib219","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00449-022-02843-4","article-title":"Carbon nanoparticles-based hydrogel nanocomposite induces bone repair in vivo","volume":"46","author":"Zhou","year":"2023","journal-title":"Bioprocess Biosyst. Eng."},{"key":"10.1016\/j.celbio.2026.100372_bib220","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202404702","article-title":"Carbon Dots Crosslinked Egg White Hydrogel for Tissue Engineering","volume":"11","author":"Wu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.celbio.2026.100372_bib221","doi-asserted-by":"crossref","first-page":"15962","DOI":"10.1021\/acsnano.3c04134","article-title":"Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing","volume":"17","author":"Shang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.celbio.2026.100372_bib222","doi-asserted-by":"crossref","DOI":"10.3390\/jfb14020086","article-title":"Silk\u2013Inorganic Nanoparticle Hybrid Hydrogel as an Injectable Bone Repairing Biomaterial","volume":"14","author":"Sun","year":"2023","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.celbio.2026.100372_bib223","doi-asserted-by":"crossref","DOI":"10.1080\/10717544.2025.2476144","article-title":"Development of a single-dose Q fever vaccine with an injectable nanoparticle-loaded hydrogel: effect of sustained co-delivery of antigen and adjuvant","volume":"32","author":"Wang","year":"2025","journal-title":"Drug Deliv."},{"key":"10.1016\/j.celbio.2026.100372_bib224","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202301495","article-title":"Broad and Durable Humoral Responses Following Single Hydrogel Immunization of SARS-CoV-2 Subunit Vaccine","volume":"12","author":"Ou","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.celbio.2026.100372_bib225","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2020.102019","article-title":"Review of precision cancer medicine: Evolution of the treatment paradigm","volume":"86","author":"Tsimberidou","year":"2020","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.celbio.2026.100372_bib226","article-title":"Non-invasive epidermal proteomics and machine learning permits molecular subclassification of psoriasis and eczematous dermatitis","author":"Wang","year":"2025","journal-title":"medRxiv"},{"key":"10.1016\/j.celbio.2026.100372_bib227","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrg3849","article-title":"Cystic fibrosis genetics: from molecular understanding to clinical application","volume":"16","author":"Cutting","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.celbio.2026.100372_bib228","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.cell.2020.10.043","article-title":"Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2","volume":"183","author":"Walls","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celbio.2026.100372_bib229","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10680","article-title":"Hydrogels in the clinic: An update","volume":"9","author":"Clegg","year":"2024","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.celbio.2026.100372_bib230","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10246","article-title":"Nanoparticles in the clinic: An update post COVID-19 vaccines","volume":"6","author":"Anselmo","year":"2021","journal-title":"Bioeng. Transl. Med."}],"container-title":["Cell Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050562326000280?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050562326000280?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:30:12Z","timestamp":1789489812000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S3050562326000280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":230,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S3050562326000280"],"URL":"https:\/\/doi.org\/10.1016\/j.celbio.2026.100372","relation":{},"ISSN":["3050-5623"],"issn-type":[{"value":"3050-5623","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanoparticle-hydrogel composites for precision medicine","name":"articletitle","label":"Article Title"},{"value":"Cell Biomaterials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celbio.2026.100372","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100372"}}