{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:32:43Z","timestamp":1792571563953,"version":"4.5.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3180,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.cell.2004.10.027","type":"journal-article","created":{"date-parts":[[2004,11,12]],"date-time":"2004-11-12T12:23:03Z","timestamp":1100262183000},"page":"457-468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":348,"title":["TROSPA, an Ixodes scapularis Receptor for Borrelia burgdorferi"],"prefix":"10.1016","volume":"119","author":[{"given":"Utpal","family":"Pal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth R.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandhini","family":"Ramamoorthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravinda M.","family":"deSilva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukai","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pypaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred S.","family":"Kantor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Telford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Fikrig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2004.10.027_BIB1","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1086\/323351","article-title":"Salp25D, an Ixodes scapularis antioxidant, is 1 of 14 immunodominant antigens in engorged tick salivary glands","volume":"184","author":"Das","year":"2001","journal-title":"J. Infect. Dis"},{"key":"10.1016\/j.cell.2004.10.027_BIB2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4269\/ajtmh.1995.53.397","article-title":"Growth and migration of Borrelia burgdorferi in Ixodes ticks during blood feeding","volume":"53","author":"de Silva","year":"1995","journal-title":"Am. J. Trop. Med. Hyg"},{"key":"10.1016\/j.cell.2004.10.027_BIB3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1084\/jem.183.1.271","article-title":"Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine","volume":"183","author":"de Silva","year":"1996","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.cell.2004.10.027_BIB4","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1126\/science.276.5313.718","article-title":"Exploitation of mammalian host cell functions by bacterial pathogens","volume":"276","author":"Finlay","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.cell.2004.10.027_BIB5","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1083\/jcb.152.3.595","article-title":"Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells","volume":"152","author":"Folsch","year":"2001","journal-title":"J. Cell Biol"},{"key":"10.1016\/j.cell.2004.10.027_BIB6","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1073\/pnas.0306845101","article-title":"Outer-surface protein C of the Lyme disease spirochete","volume":"101","author":"Grimm","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2004.10.027_BIB7","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1046\/j.1365-2958.1998.01103.x","article-title":"Decorin-binding adhesins from Borrelia burgdorferi","volume":"30","author":"Guo","year":"1998","journal-title":"Mol. Microbiol"},{"key":"10.1016\/j.cell.2004.10.027_BIB8","doi-asserted-by":"crossref","first-page":"8125","DOI":"10.1093\/nar\/15.20.8125","article-title":"An analysis of 5\u2032-noncoding sequences from 699 vertebrate messenger RNAs","volume":"15","author":"Kozak","year":"1987","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.cell.2004.10.027_BIB9","series-title":"Arthritis and Allied Conditions","first-page":"2321","article-title":"Lyme disease","author":"Malawista","year":"2000"},{"key":"10.1016\/j.cell.2004.10.027_BIB10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev.en.40.010195.001253","article-title":"Cellular and molecular interrelationships between ticks and prokaryotic tick-borne pathogens","volume":"40","author":"Munderloh","year":"1995","journal-title":"Annu. Rev. Entomol"},{"key":"10.1016\/j.cell.2004.10.027_BIB11","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0140-6736(98)01146-5","article-title":"Lyme borreliosis","volume":"352","author":"Nadelman","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2004.10.027_BIB12","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1073\/pnas.0307669100","article-title":"Disruption of Ixodes scapularis anticoagulation by using RNA interference","volume":"101","author":"Narasimhan","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2004.10.027_BIB13","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1073\/pnas.98.2.670","article-title":"Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks","volume":"98","author":"Ohnishi","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2004.10.027_BIB14","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI9427","article-title":"Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A","volume":"106","author":"Pal","year":"2000","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.cell.2004.10.027_BIB15","doi-asserted-by":"crossref","first-page":"7398","DOI":"10.4049\/jimmunol.166.12.7398","article-title":"Inhibition of Borrelia burgdorferi-tick interactions in vivo by outer surface protein A antibody","volume":"166","author":"Pal","year":"2001","journal-title":"J. Immunol"},{"key":"10.1016\/j.cell.2004.10.027_BIB16","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1172\/JCI200419894","article-title":"OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands","volume":"113","author":"Pal","year":"2004","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.cell.2004.10.027_BIB17","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1046\/j.1365-2958.1998.01127.x","article-title":"Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31","volume":"30","author":"Probert","year":"1998","journal-title":"Mol. Microbiol"},{"key":"10.1016\/j.cell.2004.10.027_BIB18","unstructured":"Sauer, J.R., and Hair, A.J. (1986). Morphology, Physiology and Biology of Ticks, Volume 1 (New York: Ellis Horwood Limited and John Wiley and Sons)."},{"key":"10.1016\/j.cell.2004.10.027_BIB19","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1128\/JCM.38.1.382-388.2000","article-title":"Temporal changes in outer surface proteins A and C of the Lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice","volume":"38","author":"Schwan","year":"2000","journal-title":"J. Clin. Microbiol"},{"key":"10.1016\/j.cell.2004.10.027_BIB20","unstructured":"Sonenshine, D.E. (1993). Biology of Ticks, Volume 1 (New York: Oxford University Press)."},{"key":"10.1016\/j.cell.2004.10.027_BIB21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM200107123450207","article-title":"Lyme disease","volume":"345","author":"Steere","year":"2001","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.cell.2004.10.027_BIB22","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1172\/JCI21681","article-title":"The emergence of Lyme disease","volume":"113","author":"Steere","year":"2004","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.cell.2004.10.027_BIB23","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1084\/jem.20031960","article-title":"Essential role for OspA\/B in the life cycle of the Lyme disease spirochete","volume":"199","author":"Yang","year":"2004","journal-title":"J. Exp. Med"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867404010414?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867404010414?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:51:55Z","timestamp":1758797515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867404010414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0092867404010414"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2004.10.027","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1022875.264650","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TROSPA, an Ixodes scapularis Receptor for Borrelia burgdorferi","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2004.10.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Cell Press. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}