{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:29:08Z","timestamp":1791221348155,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2907,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1016\/j.cell.2005.06.042","type":"journal-article","created":{"date-parts":[[2005,8,12]],"date-time":"2005-08-12T07:38:16Z","timestamp":1123832296000},"page":"449-459","source":"Crossref","is-referenced-by-count":340,"title":["Rpe65 Is the Retinoid Isomerase in Bovine Retinal Pigment Epithelium"],"prefix":"10.1016","volume":"122","author":[{"given":"Minghao","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid N.","family":"Moghrabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel H.","family":"Travis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2005.06.042_bib1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.physiol.64.082701.102229","article-title":"G proteins and phototransduction","volume":"64","author":"Arshavsky","year":"2002","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cell.2005.06.042_bib2","doi-asserted-by":"crossref","first-page":"14978","DOI":"10.1016\/S0021-9258(18)98574-1","article-title":"Identification and partial characterization of a retinal pigment epithelial membrane receptor for plasma retinol-binding protein","volume":"266","author":"Bavik","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2005.06.042_bib3","doi-asserted-by":"crossref","first-page":"23035","DOI":"10.1016\/S0021-9258(18)50052-1","article-title":"Characterization of a plasma retinol-binding protein membrane receptor expressed in the retinal pigment epithelium","volume":"267","author":"Bavik","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2005.06.042_bib4","doi-asserted-by":"crossref","first-page":"6090","DOI":"10.1021\/bi0342416","article-title":"Purification and characterization of a transmembrane domain-deleted form of lecithin retinol acyltransferase","volume":"42","author":"Bok","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.cell.2005.06.042_bib5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1085\/jgp.20018495","article-title":"HEK293S cells have functional retinoid processing machinery","volume":"119","author":"Brueggemann","year":"2002","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.cell.2005.06.042_bib6","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1016\/j.visres.2003.08.001","article-title":"Visual cycle retinoid processing proteins are present in HEK293S cells","volume":"43","author":"Chen","year":"2003","journal-title":"Vision Res."},{"key":"10.1016\/j.cell.2005.06.042_bib7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0014-5793(98)01459-8","article-title":"Lack of effect of RPE65 removal on the enzymatic processing of all-trans-retinol into 11-cis-retinol in vitro","volume":"440","author":"Choo","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cell.2005.06.042_bib8","doi-asserted-by":"crossref","first-page":"16674","DOI":"10.1016\/S0021-9258(18)55354-0","article-title":"Topological and epitope mapping of the cellular retinaldehyde-binding protein from retina","volume":"266","author":"Crabb","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2005.06.042_bib9","doi-asserted-by":"crossref","first-page":"5809","DOI":"10.1021\/bi0341004","article-title":"All-trans-retinyl esters are the substrates for isomerization in the vertebrate visual cycle","volume":"42","author":"Gollapalli","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.cell.2005.06.042_bib10","doi-asserted-by":"crossref","first-page":"11824","DOI":"10.1021\/bi035227w","article-title":"RPE65 operates in the vertebrate visual cycle by stereospecifically binding all-trans-retinyl esters","volume":"42","author":"Gollapalli","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.cell.2005.06.042_bib11","doi-asserted-by":"crossref","first-page":"15751","DOI":"10.1016\/S0021-9258(18)82319-5","article-title":"Molecular cloning and expression of RPE65, a novel retinal pigment epithelium-specific microsomal protein that is post-transcriptionally regulated in vitro","volume":"268","author":"Hamel","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2005.06.042_bib12","series-title":"Vision of Invertebrates (Handbook of Sensory Physiology, VII 6 A)","first-page":"45","article-title":"The physiology of invertebrate visual pigments","author":"Hamsdorf","year":"1979"},{"key":"10.1016\/j.cell.2005.06.042_bib13","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/humu.20010","article-title":"Leber congenital amaurosis: comprehensive survey of the genetic heterogeneity, refinement of the clinical definition, and genotype-phenotype correlations as a strategy for molecular diagnosis","volume":"23","author":"Hanein","year":"2004","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.cell.2005.06.042_bib14","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1085\/jgp.41.3.501","article-title":"The rhodopsin system of the squid","volume":"41","author":"Hubbard","year":"1958","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.cell.2005.06.042_bib15","doi-asserted-by":"crossref","first-page":"25411","DOI":"10.1016\/S0021-9258(18)47265-1","article-title":"Molecular cloning and structural analysis of the human gene encoding cellular retinaldehyde-binding protein","volume":"269","author":"Intres","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2005.06.042_bib16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1126\/science.1108965","article-title":"The structure of a retinal-forming carotenoid oxygenase","volume":"308","author":"Kloer","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.cell.2005.06.042_bib17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0014-5793(99)00606-7","article-title":"Identification of RPE65 in transformed kidney cells","volume":"452","author":"Ma","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cell.2005.06.042_bib18","first-page":"1429","article-title":"Expression, purification, and MALDI analysis of RPE65","volume":"42","author":"Ma","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cell.2005.06.042_bib19","doi-asserted-by":"crossref","first-page":"12478","DOI":"10.1016\/S0021-9258(18)37779-2","article-title":"Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine","volume":"263","author":"MacDonald","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2005.06.042_bib20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0896-6273(02)00912-1","article-title":"Isomerization and oxidation of vitamin a in cone-dominant retinas: A novel pathway for visual-pigment regeneration in daylight","volume":"36","author":"Mata","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2005.06.042_bib21","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1074\/jbc.M310042200","article-title":"Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells","volume":"279","author":"Mata","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2005.06.042_bib22","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1021\/bi026911y","article-title":"Retinyl esters are the substrate for isomerohydrolase","volume":"42","author":"Moiseyev","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.cell.2005.06.042_bib23","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/3813","article-title":"Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle","volume":"20","author":"Redmond","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2005.06.042_bib24","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1074\/jbc.274.6.3834","article-title":"Molecular and biochemical characterization of lecithin retinol acyltransferase","volume":"274","author":"Ruiz","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2005.06.042_bib25","doi-asserted-by":"crossref","first-page":"7618","DOI":"10.1016\/S0021-9258(18)47610-7","article-title":"Photochemistry and stereoselectivity of cellular retinaldehyde-binding protein from bovine retina","volume":"262","author":"Saari","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2005.06.042_bib26","doi-asserted-by":"crossref","first-page":"8084","DOI":"10.1016\/S0021-9258(18)68445-5","article-title":"CoA- and non-CoA-dependent retinol esterification in retinal pigment epithelium","volume":"263","author":"Saari","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2005.06.042_bib27","doi-asserted-by":"crossref","first-page":"8636","DOI":"10.1016\/S0021-9258(18)81839-7","article-title":"Lecithin:retinol acyltransferase in retinal pigment epithelial microsomes","volume":"264","author":"Saari","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2005.06.042_bib28","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1042\/bj2910697","article-title":"Retinol esterification in bovine retinal pigment epithelium: reversibility of lecithin:retinol acyltransferase","volume":"291","author":"Saari","year":"1993","journal-title":"Biochem. J."},{"key":"10.1016\/j.cell.2005.06.042_bib29","series-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook","year":"1989"},{"key":"10.1016\/j.cell.2005.06.042_bib30","series-title":"The Molecular Mechanism of Photoreception","first-page":"303","article-title":"Turnover of photoreceptor membrane and pigment in invertebrates","author":"Schwemer","year":"1985"},{"key":"10.1016\/j.cell.2005.06.042_bib31","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1021\/bi00056a009","article-title":"Kinetic mechanism of lecithin retinol acyl transferase","volume":"32","author":"Shi","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.cell.2005.06.042_bib32","first-page":"4293","article-title":"Genetics and phenotypes of RPE65 mutations in inherited retinal degeneration","volume":"41","author":"Thompson","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cell.2005.06.042_bib33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/abbi.1997.0276","article-title":"RPE65, the major retinal pigment epithelium microsomal membrane protein, associates with phospholipid liposomes","volume":"346","author":"Tsilou","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cell.2005.06.042_bib34","doi-asserted-by":"crossref","first-page":"8623","DOI":"10.1073\/pnas.150236297","article-title":"Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness","volume":"97","author":"Van Hooser","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2005.06.042_bib35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1523\/JNEUROSCI.21-01-00053.2001","article-title":"The Rpe65 Leu450Met variation increases retinal resistance against light-induced degeneration by slowing rhodopsin regeneration","volume":"21","author":"Wenzel","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cell.2005.06.042_bib36","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1021\/bi971908d","article-title":"Regulation of isomerohydrolase activity in the visual cycle","volume":"37","author":"Winston","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.cell.2005.06.042_bib37","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.cell.2004.05.016","article-title":"A palmitoylation switch mechanism in the regulation of the visual cycle","volume":"117","author":"Xue","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.cell.2005.06.042_bib38","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1136\/jmg.40.9.709","article-title":"A Tyr368His RPE65 founder mutation is associated with variable expression and progression of early onset retinal dystrophy in 10 families of a genetically isolated population","volume":"40","author":"Yzer","year":"2003","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.cell.2005.06.042_bib39","first-page":"1604","article-title":"Identification of the RPE65 protein in mammalian cone photoreceptors","volume":"43","author":"Znoiko","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867405006963?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867405006963?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T08:31:23Z","timestamp":1626337883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867405006963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S0092867405006963"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2005.06.042","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1027409.329541","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}