{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:45:10Z","timestamp":1792547110914,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":2547,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.cell.2006.06.055","type":"journal-article","created":{"date-parts":[[2006,9,8]],"date-time":"2006-09-08T15:25:10Z","timestamp":1157729110000},"page":"955-968","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1232,"title":["TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth"],"prefix":"10.1016","volume":"126","author":[{"given":"Ken","family":"Inoki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjiao","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotta","family":"Lindvall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kryn","family":"Stankunas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cun-yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ormond A.","family":"MacDougald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart O.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Liang","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2006.06.055_bib1","doi-asserted-by":"crossref","first-page":"51372","DOI":"10.1074\/jbc.M303956200","article-title":"Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1\/cyclin B","volume":"278","author":"Astrinidis","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2006.06.055_bib2","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/35083081","article-title":"Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6\/Arrow","volume":"3","author":"Bafico","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2006.06.055_bib3","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/1521-1878(200011)22:11<961::AID-BIES1>3.0.CO;2-T","article-title":"Catenins, Wnt signaling and cancer","volume":"22","author":"Barker","year":"2000","journal-title":"Bioessays"},{"key":"10.1016\/j.cell.2006.06.055_bib4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0014-5793(03)01015-9","article-title":"Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function?","volume":"553","author":"Barry","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cell.2006.06.055_bib5","doi-asserted-by":"crossref","first-page":"23977","DOI":"10.1074\/jbc.C200171200","article-title":"AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling","volume":"277","author":"Bolster","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2006.06.055_bib6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ccr.2004.06.020","article-title":"Dysregulation of HIF and\u00a0VEGF is a unifying feature of the familial hamartoma syndromes","volume":"6","author":"Brugarolas","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2006.06.055_bib7","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/385829a0","article-title":"pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila","volume":"385","author":"Brunner","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.cell.2006.06.055_bib8","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1002\/j.1460-2075.1996.tb00830.x","article-title":"Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C","volume":"15","author":"Cook","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2006.06.055_bib9","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1101\/gad.1199104","article-title":"Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome","volume":"18","author":"Corradetti","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2006.06.055_bib10","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1432-1033.1995.tb20498.x","article-title":"5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?","volume":"229","author":"Corton","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.cell.2006.06.055_bib11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1006\/dbio.2001.0317","article-title":"Missing links in GSK3 regulation","volume":"235","author":"Dominguez","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cell.2006.06.055_bib12","first-page":"3145","article-title":"Beta-catenin regulates vascular endothelial growth factor expression in colon cancer","volume":"63","author":"Easwaran","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2006.06.055_bib13","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1038\/sj.onc.1207542","article-title":"Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression","volume":"23","author":"Fingar","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.cell.2006.06.055_bib14","doi-asserted-by":"crossref","first-page":"14042","DOI":"10.1016\/S0021-9258(18)47901-X","article-title":"Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3","volume":"262","author":"Fiol","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2006.06.055_bib15","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ncb847","article-title":"Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling","volume":"4","author":"Gao","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2006.06.055_bib16","doi-asserted-by":"crossref","first-page":"14424","DOI":"10.1074\/jbc.273.23.14424","article-title":"Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability","volume":"273","author":"Hashemolhosseini","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2006.06.055_bib17","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.1212704","article-title":"Upstream and downstream of mTOR","volume":"18","author":"Hay","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2006.06.055_bib18","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35017574","article-title":"Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation","volume":"406","author":"Hoeflich","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cell.2006.06.055_bib19","doi-asserted-by":"crossref","first-page":"21162","DOI":"10.1074\/jbc.M501900200","article-title":"Essential role of beta-catenin in postnatal bone acquisition","volume":"280","author":"Holmen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2006.06.055_bib20","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0960-9822(02)01077-1","article-title":"Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis","volume":"12","author":"Horman","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2006.06.055_bib21","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0092-8674(03)00929-2","article-title":"TSC2 mediates cellular energy response to control cell growth and survival","volume":"115","author":"Inoki","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.cell.2006.06.055_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2004.12.003","article-title":"AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism","volume":"1","author":"Kahn","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2006.06.055_bib23","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1101\/gad.14.11.1319","article-title":"Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin","volume":"14","author":"Kolligs","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2006.06.055_bib24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1469-1809.2003.00012.x","article-title":"Tuberous sclerosis: from tubers to mTOR","volume":"67","author":"Kwiatkowski","year":"2003","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.cell.2006.06.055_bib25","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/sj.onc.1203273","article-title":"Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer","volume":"19","author":"Li","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.cell.2006.06.055_bib26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S1097-2765(02)00636-6","article-title":"Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control","volume":"10","author":"Loewith","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2006.06.055_bib27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cell.2005.02.031","article-title":"Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis","volume":"121","author":"Ma","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.cell.2006.06.055_bib28","doi-asserted-by":"crossref","first-page":"5947","DOI":"10.1074\/jbc.C200473200","article-title":"The tuberin-hamartin complex negatively regulates Beta-catenin signaling activity","volume":"278","author":"Mak","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2006.06.055_bib29","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0002-9440(10)62958-6","article-title":"Aberrant beta-catenin signaling in tuberous sclerosis","volume":"167","author":"Mak","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cell.2006.06.055_bib30","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.tibs.2003.09.003","article-title":"Rheb fills a GAP between TSC and TOR","volume":"28","author":"Manning","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.cell.2006.06.055_bib31","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/35077108","article-title":"LDL-receptor-related protein 6 is a receptor for Dickkopf proteins","volume":"411","author":"Mao","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cell.2006.06.055_bib32","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0092-8674(00)80112-9","article-title":"XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos","volume":"86","author":"Molenaar","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.cell.2006.06.055_bib33","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrg1427","article-title":"WNT and beta-catenin signalling: diseases and therapies","volume":"5","author":"Moon","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.cell.2006.06.055_bib34","doi-asserted-by":"crossref","first-page":"29864","DOI":"10.1074\/jbc.273.45.29864","article-title":"Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase\/Akt-dependent pathway","volume":"273","author":"Muise-Helmericks","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2006.06.055_bib35","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1210\/endo.141.12.7819","article-title":"Parathyroid hormone-related protein down-regulates bone sialoprotein gene expression in cementoblasts: role of the protein kinase A pathway","volume":"141","author":"Ouyang","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.cell.2006.06.055_bib36","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/35035124","article-title":"An LDL-receptor-related protein mediates Wnt signalling in mice","volume":"407","author":"Pinson","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cell.2006.06.055_bib37","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1101\/gad.14.15.1837","article-title":"Wnt signaling and cancer","volume":"14","author":"Polakis","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2006.06.055_bib38","doi-asserted-by":"crossref","first-page":"13489","DOI":"10.1073\/pnas.0405659101","article-title":"Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase","volume":"101","author":"Roux","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2006.06.055_bib39","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1126\/science.272.5264.1023","article-title":"Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly","volume":"272","author":"Rubinfeld","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.cell.2006.06.055_bib40","doi-asserted-by":"crossref","first-page":"28463","DOI":"10.1074\/jbc.M500191200","article-title":"Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine","volume":"280","author":"Sansom","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2006.06.055_bib41","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1126\/science.1106148","article-title":"Phosphorylation and regulation of Akt\/PKB by the rictor-mTOR complex","volume":"307","author":"Sarbassov","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.cell.2006.06.055_bib42","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/ncb996","article-title":"Rheb promotes cell growth as a component of the insulin\/TOR signalling network","volume":"5","author":"Saucedo","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2006.06.055_bib43","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/ncb995","article-title":"Rheb is an essential regulator of S6K in controlling cell growth in Drosophila","volume":"5","author":"Stocker","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2006.06.055_bib44","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/35035117","article-title":"LDL-receptor-related proteins in Wnt signal transduction","volume":"407","author":"Tamai","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cell.2006.06.055_bib45","doi-asserted-by":"crossref","first-page":"37297","DOI":"10.1074\/jbc.M303389200","article-title":"A role for NF-kappaB essential modifier\/IkappaB kinase-gamma (NEMO\/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha","volume":"278","author":"Tang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2006.06.055_bib46","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/18884","article-title":"Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells","volume":"398","author":"Tetsu","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.cell.2006.06.055_bib47","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0092-8674(02)01014-0","article-title":"The beta-catenin\/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells","volume":"111","author":"van de Wetering","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.cell.2006.06.055_bib48","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature01611","article-title":"Wnt proteins are lipid-modified and can act as stem cell growth factors","volume":"423","author":"Willert","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.cell.2006.06.055_bib49","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1146\/annurev.cellbio.14.1.59","article-title":"Mechanisms of Wnt signaling in development","volume":"14","author":"Wodarz","year":"1998","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.cell.2006.06.055_bib50","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2006.01.016","article-title":"TOR signaling in growth and metabolism","volume":"124","author":"Wullschleger","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.cell.2006.06.055_bib51","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0092-8674(00)80324-4","article-title":"The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling\u00a0pathway that regulates embryonic axis formation","volume":"90","author":"Zeng","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.cell.2006.06.055_bib52","first-page":"6050","article-title":"Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia","volume":"61","author":"Zhang","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2006.06.055_bib53","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI13505","article-title":"Role of AMP-activated protein kinase in mechanism of metformin action","volume":"108","author":"Zhou","year":"2001","journal-title":"J. Clin. Invest."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867406010166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867406010166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:55:39Z","timestamp":1758797739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867406010166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S0092867406010166"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2006.06.055","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2006.06.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}