{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:31:56Z","timestamp":1791405116094,"version":"4.3.3"},"reference-count":20,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2450,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.cell.2006.10.023","type":"journal-article","created":{"date-parts":[[2006,11,3]],"date-time":"2006-11-03T07:53:54Z","timestamp":1162540434000},"page":"465-468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":123,"title":["PGC-1\u03b1, a New Therapeutic Target in Huntington's Disease?"],"prefix":"10.1016","volume":"127","author":[{"given":"Jetta K.","family":"McGill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Flint","family":"Beal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2006.10.023_bib1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1023\/B:NERE.0000014824.04728.dd","volume":"29","author":"Browne","year":"2004","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.cell.2006.10.023_bib2","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/hmg\/ddh162","volume":"13","author":"Choo","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2006.10.023_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2006.09.015","volume":"127","author":"Cui","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.cell.2006.10.023_bib4","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/hmg\/ddg046","volume":"12","author":"Gines","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cell.2006.10.023_bib5","doi-asserted-by":"crossref","first-page":"7111","DOI":"10.1073\/pnas.1232352100","volume":"100","author":"Handschin","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2006.10.023_bib6","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/35093131","volume":"413","author":"Herzig","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cell.2006.10.023_bib7","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1101\/gad.1177604","volume":"18","author":"Kelly","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2006.10.023_bib8","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1371\/journal.pbio.0030101","volume":"3","author":"Leone","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cell.2006.10.023_bib9","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cell.2006.10.023_bib10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2004.09.013","volume":"119","author":"Lin","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.cell.2006.10.023_bib11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cmet.2005.05.004","volume":"1","author":"Lin","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.cell.2006.10.023_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/cne.10776","volume":"465","author":"Menalled","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.cell.2006.10.023_bib13","doi-asserted-by":"crossref","first-page":"30773","DOI":"10.1074\/jbc.M504749200","volume":"280","author":"Milakovic","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2006.10.023_bib14","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nn884","volume":"5","author":"Panov","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2006.10.023_bib15","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0092-8674(00)81410-5","volume":"92","author":"Puigserver","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.cell.2006.10.023_bib16","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1210\/er.2002-0012","volume":"24","author":"Puigserver","year":"2003","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.cell.2006.10.023_bib17","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.mad.2005.09.010","volume":"127","author":"Squitieri","year":"2006","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.cell.2006.10.023_bib18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0168-9525(03)00074-X","volume":"19","author":"Sugars","year":"2003","journal-title":"Trends Genet."},{"key":"10.1016\/j.cell.2006.10.023_bib19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.cell.2006.09.024","volume":"127","author":"St-Pierre","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.cell.2006.10.023_bib20","author":"Weydt","year":"2006","journal-title":"Cell Metab"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867406013535?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867406013535?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:57:11Z","timestamp":1758797831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867406013535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0092867406013535"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2006.10.023","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PGC-1\u03b1, a New Therapeutic Target in Huntington's Disease?","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2006.10.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}