{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:54:50Z","timestamp":1791420890951,"version":"4.3.3"},"reference-count":63,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":2274,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.cell.2007.03.054","type":"journal-article","created":{"date-parts":[[2007,7,31]],"date-time":"2007-07-31T15:11:58Z","timestamp":1185894718000},"page":"1215-1225","source":"Crossref","is-referenced-by-count":220,"title":["Engulfment Is Required for Cell Competition"],"prefix":"10.1016","volume":"129","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas E.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2007.03.054_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1242\/dev.117.1.29","article-title":"Programmed cell death during Drosophila embryogenesis","volume":"117","author":"Abrams","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.cell.2007.03.054_bib2","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.neuron.2006.04.027","article-title":"Essential role of the apoptotic cell engulfment genes draper and ced-6 in programmed axon pruning during Drosophila metamorphosis","volume":"50","author":"Awasaki","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2007.03.054_bib3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.ge.17.120183.002021","article-title":"Sex determination and dosage compensation in Drosophila melanogaster","volume":"17","author":"Baker","year":"1983","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.cell.2007.03.054_bib4","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1242\/dev.00663","article-title":"Kette regulates actin dynamincs and genetically interacts with Wave and Wasp","volume":"130","author":"Bogdan","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.cell.2007.03.054_bib5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0012-1606(89)90231-5","article-title":"Experimental phenocopy of a Minute maternal-effect mutation alters blastoderm determination in embryos of Drosophila melanogaster","volume":"132","author":"Boring","year":"1989","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cell.2007.03.054_bib6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2121-5-26","article-title":"The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity","volume":"5","author":"Cikala","year":"2004","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.cell.2007.03.054_bib7","series-title":"The Development of Drosophila melanogaster","first-page":"747","article-title":"Imaginal disc development","author":"Cohen","year":"1993"},{"key":"10.1016\/j.cell.2007.03.054_bib8","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.yexcr.2003.09.023","article-title":"Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals","volume":"293","author":"Cui","year":"2004","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.cell.2007.03.054_bib9","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/381421a0","article-title":"A gene complex acting downstream of dpp in Drosophila wing morphogenesis","volume":"381","author":"de Celis","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.cell.2007.03.054_bib10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0092-8674(04)00214-4","article-title":"Drosophila Myc regulates organ size by inducing cell competition","volume":"117","author":"de la Cova","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.cell.2007.03.054_bib11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2006.01.005","article-title":"From cell structure to transcription: Hippo forges a new path","volume":"124","author":"Edgar","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.cell.2007.03.054_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1023\/A:1009650917818","article-title":"Cell surface exposure of phosphatidylserine during apoptosis is phylogenetically conserved","volume":"3","author":"van den Eijnde","year":"1998","journal-title":"Apoptosis"},{"key":"10.1016\/j.cell.2007.03.054_bib13","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.4049\/jimmunol.148.7.2207","article-title":"Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages","volume":"148","author":"Fadok","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.cell.2007.03.054_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/35011084","article-title":"A receptor for phosphatidylserine-specific clearance of apoptotic cells","volume":"405","author":"Fadok","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cell.2007.03.054_bib15","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0076-6879(05)07056-4","article-title":"Analyses of RAS regulation of eye development in Drosophila melanogaster","volume":"407","author":"Firth","year":"2006","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cell.2007.03.054_bib16","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1126\/science.284.5422.1991","article-title":"Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila","volume":"284","author":"Franc","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.cell.2007.03.054_bib17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0952-7915(99)80009-0","article-title":"Phagocytosis and development: back to the future","volume":"11","author":"Franc","year":"1999","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.cell.2007.03.054_bib18","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0896-6273(03)00289-7","article-title":"Unwrapping glial biology: Gcm target genes regulating glial development, diversification, and function","volume":"38","author":"Freeman","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2007.03.054_bib19","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/BF00383486","article-title":"Cellular degeneration in the production of some mutant phenotypes in Drosophila melanogaster","volume":"103","author":"Fristrom","year":"1969","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/j.cell.2007.03.054_bib20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/newbio245251a0","article-title":"Developmental compartmentalisation of the wing disk of Drosophila","volume":"245","author":"Garcia-Bellido","year":"1973","journal-title":"Nat. New Biol."},{"key":"10.1016\/j.cell.2007.03.054_bib21","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1126\/science.1104751","article-title":"Extrusion and death of DPP\/BMP-compromised epithelial cells in the developing Drosophila wing","volume":"307","author":"Gibson","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.cell.2007.03.054_bib22","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1242\/dev.120.8.2121","article-title":"Expression of baculovirus P35 prevents cell death in Drosophila","volume":"120","author":"Hay","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.cell.2007.03.054_bib23","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/35084103","article-title":"Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans","volume":"412","author":"Hoeppner","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cell.2007.03.054_bib24","doi-asserted-by":"crossref","first-page":"5417","DOI":"10.1242\/dev.01409","article-title":"Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish","volume":"131","author":"Hong","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.cell.2007.03.054_bib25","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.cub.2004.06.015","article-title":"Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role","volume":"14","author":"Huh","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2007.03.054_bib26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature03263","article-title":"Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans","volume":"434","author":"Kinchen","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.cell.2007.03.054_bib27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0065-2660(08)60142-X","article-title":"The Minute genes in Drosophila and their molecular functions","volume":"38","author":"Lambertsson","year":"1998","journal-title":"Adv. Genet."},{"key":"10.1016\/j.cell.2007.03.054_bib28","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0896-6273(00)80701-1","article-title":"Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis","volume":"22","author":"Lee","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2007.03.054_bib29","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1126\/science.1087621","article-title":"Phosphatidylserine receptor is required for clearance of apoptotic cells","volume":"302","author":"Li","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.cell.2007.03.054_bib30","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1182\/blood.V95.9.2943.009k17_2943_2946","article-title":"Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis","volume":"95","author":"Lorenzi","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.cell.2007.03.054_bib31","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.neuron.2006.04.028","article-title":"The Drosophila cell corpse engulfment receptor draper mediates glial clearance of severed axons","volume":"50","author":"MacDonald","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2007.03.054_bib32","doi-asserted-by":"crossref","first-page":"48466","DOI":"10.1074\/jbc.M408597200","article-title":"Draper-mediated and phosphatidylserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes\/macrophages","volume":"279","author":"Manaka","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2007.03.054_bib33","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1084\/jem.182.5.1545","article-title":"Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl","volume":"182","author":"Martin","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cell.2007.03.054_bib34","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1074\/jbc.M509775200","article-title":"The presumptive phosphatidylserine receptor is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cells","volume":"281","author":"Mitchell","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2007.03.054_bib35","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0012-1606(75)90330-9","article-title":"Minutes: Mutants of Drosophila autonomously affecting cell division rate","volume":"42","author":"Morata","year":"1975","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cell.2007.03.054_bib36","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0092-8674(04)00262-4","article-title":"dMyc transforms cells into super-competitors","volume":"117","author":"Moreno","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.cell.2007.03.054_bib37","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/416755a","article-title":"Cells compete for Decapentaplegic survival factor to prevent apoptosis in Drosophila wing development","volume":"416","author":"Moreno","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.cell.2007.03.054_bib38","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1038\/sj.onc.1202746","article-title":"MYC oncogenes and human neoplastic disease","volume":"18","author":"Nesbit","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.cell.2007.03.054_bib39","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S0092-8674(00)81462-2","article-title":"Coordination of growth and cell division in the Drosophila wing","volume":"93","author":"Neufeld","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.cell.2007.03.054_bib40","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1242\/dev.127.4.851","article-title":"Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics","volume":"127","author":"Newsome","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.cell.2007.03.054_bib41","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1101\/gad.12.21.3337","article-title":"Myoblast city, the Drosophila homolog of DOCK180\/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes","volume":"12","author":"Nolan","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.cell.2007.03.054_bib42","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1053\/j.gastro.2005.10.049","article-title":"Cell competition leads to a high level of normal liver reconstitution by transplanted fetal liver stem\/progenitor cells","volume":"130","author":"Oertel","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cell.2007.03.054_bib43","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1242\/dev.01268","article-title":"Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute","volume":"131","author":"Oliver","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.cell.2007.03.054_bib44","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S1286-4579(03)00157-6","article-title":"Identification of cytoskeletal regulatory proteins required for efficient phagocytosis in Drosophila","volume":"5","author":"Pearson","year":"2003","journal-title":"Microbes Infect."},{"key":"10.1016\/j.cell.2007.03.054_bib45","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1242\/dev.01432","article-title":"Caspase inhibition during apoptosis causes abnormal signalling and developmental abnormalities in Drosophila","volume":"131","author":"Perez-Garijo","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.cell.2007.03.054_bib46","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/35004000","article-title":"CED-2\/CrkII and CED-10\/Rac control phagocytosis and cell migration in Caenorhabditis elegans","volume":"2","author":"Reddien","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2007.03.054_bib47","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev.cellbio.20.022003.114619","article-title":"The engulfment process of programmed cell death in Caenorhabditis elegans","volume":"20","author":"Reddien","year":"2004","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.cell.2007.03.054_bib48","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/35084096","article-title":"Phagocytosis promotes programmed cell death in C. elegans","volume":"412","author":"Reddien","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cell.2007.03.054_bib49","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/S0960-9822(01)00587-5","article-title":"An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism","volume":"11","author":"Rosenblatt","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2007.03.054_bib50","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.devcel.2004.08.019","article-title":"Apoptotic cells can induce compensatory proliferation through the JNK and the Wingless signaling pathways","volume":"7","author":"Ryoo","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cell.2007.03.054_bib51","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1126\/science.1104784","article-title":"Extrusion of cells with inappropriate Dpp signaling from Drosophila wing disc epithelia","volume":"307","author":"Shen","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.cell.2007.03.054_bib52","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0012-1606(79)90284-7","article-title":"Parameters of cell competition in the compartments of the wing disc of Drosophila","volume":"69","author":"Simpson","year":"1979","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cell.2007.03.054_bib53","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0012-1606(81)90261-X","article-title":"Differential mitotic rates and patterns of growth in compartments in the Drosophila wing","volume":"85","author":"Simpson","year":"1981","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cell.2007.03.054_bib54","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1097-2765(00)80403-7","article-title":"Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs","volume":"5","author":"Tanimoto","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2007.03.054_bib55","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1242\/dev.120.7.1829","article-title":"Embryonic origin of hemocytes and their relationship to cell death in Drosophila","volume":"120","author":"Tepass","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.cell.2007.03.054_bib56","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1534\/genetics.106.061929","article-title":"Genes affecting cell competition in Drosophila","volume":"175","author":"Tyler","year":"2007","journal-title":"Genetics"},{"key":"10.1016\/j.cell.2007.03.054_bib57","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1084\/jem.182.5.1597","article-title":"Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes","volume":"182","author":"Verhoven","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cell.2007.03.054_bib58","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.devcel.2005.11.007","article-title":"Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis","volume":"10","author":"Vidal","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cell.2007.03.054_bib59","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1126\/science.1087641","article-title":"Cell corpse engulfment mediated by C. elegans Phosphatidylserine Receptor through CED-5 and CED-12","volume":"302","author":"Wang","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.cell.2007.03.054_bib60","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/32195","article-title":"C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180","volume":"392","author":"Wu","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.cell.2007.03.054_bib61","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1242\/dev.117.4.1223","article-title":"Analysis of genetic mosaics in developing and adult Drosophila tissues","volume":"117","author":"Xu","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.cell.2007.03.054_bib62","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1084\/jem.190.9.1329","article-title":"Antigen receptor-induced activation and cytoskeletal rearrangement are Impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes","volume":"190","author":"Zhang","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cell.2007.03.054_bib63","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(01)00190-8","article-title":"CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans","volume":"104","author":"Zhou","year":"2001","journal-title":"Cell"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867407005351?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867407005351?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T12:42:21Z","timestamp":1683981741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867407005351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0092867407005351"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2007.03.054","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1087303.540321","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1087303.541224","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}