{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:32:05Z","timestamp":1792089125534,"version":"4.4.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2116,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.cell.2007.07.043","type":"journal-article","created":{"date-parts":[[2007,10,26]],"date-time":"2007-10-26T05:58:26Z","timestamp":1193378306000},"page":"364-377","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":303,"title":["Glia-like Stem Cells Sustain Physiologic Neurogenesis in the Adult Mammalian Carotid Body"],"prefix":"10.1016","volume":"131","author":[{"given":"Ricardo","family":"Pardal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Ortega-S\u00e1enz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Dur\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"L\u00f3pez-Barneo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2007.07.043_bib1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1365-2559.1991.tb00877.x","article-title":"Immunocytochemistry of paragangliomas\u2014value of staining for S-100 protein and glial fibrillary acid protein in diagnosis and prognosis","volume":"18","author":"Achilles","year":"1991","journal-title":"Histopathology"},{"key":"10.1016\/j.cell.2007.07.043_bib2","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1126\/science.135.3509.1127","article-title":"Are new neurons formed in the brains of adult mammals?","volume":"135","author":"Altman","year":"1962","journal-title":"Science"},{"key":"10.1016\/j.cell.2007.07.043_bib3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/cne.901370404","article-title":"Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb","volume":"137","author":"Altman","year":"1969","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.cell.2007.07.043_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/35067582","article-title":"A unified hypothesis on the lineage of neural stem cells","volume":"2","author":"Alvarez-Buylla","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cell.2007.07.043_bib5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0046-8177(76)80052-4","article-title":"Chief cell hyperplasia in the human carotid body at high altitudes; physiologic and pathologic significance","volume":"7","author":"Arias-Stella","year":"1976","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.cell.2007.07.043_bib6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1227\/01.NEU.0000073315.88827.72","article-title":"Autotransplantation of human carotid body cell aggregates for treatment of Parkinson's disease","volume":"53","author":"Arjona","year":"2003","journal-title":"Neurosurgery"},{"key":"10.1016\/j.cell.2007.07.043_bib7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00439-003-0969-6","article-title":"Altitude is a phenotypic modifier in hereditary paraganglioma type 1: evidence for an oxygen-sensing defect","volume":"113","author":"Astrom","year":"2003","journal-title":"Hum. Genet."},{"key":"10.1016\/j.cell.2007.07.043_bib8","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0896-6273(02)00825-5","article-title":"Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity","volume":"35","author":"Bixby","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2007.07.043_bib9","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/ng1395","article-title":"VEGF links hippocampal activity with neurogenesis, learning and memory","volume":"36","author":"Cao","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2007.07.043_bib10","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/(SICI)1097-4695(199808)36:2<190::AID-NEU7>3.0.CO;2-X","article-title":"The neuronal stem cell of the olfactory epithelium","volume":"36","author":"Calof","year":"1998","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.cell.2007.07.043_bib11","series-title":"Oxygen Sensing, Responses and Adaptation to Hypoxia","first-page":"439","article-title":"Mechanisms of morphological and functional plasticity in the chronically hypoxic carotid body","author":"Dinger","year":"2003"},{"key":"10.1016\/j.cell.2007.07.043_bib12","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/nn1144","article-title":"The glial identity of neural stem cells","volume":"6","author":"Doetsch","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2007.07.043_bib13","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)80783-7","article-title":"Subventricular zone astrocytes are neural stem cells in the adult mammalian brain","volume":"97","author":"Doetsch","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.cell.2007.07.043_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.1711040102","article-title":"The carotid body in emphysema and left ventricular hypertrophy","volume":"104","author":"Edwards","year":"1971","journal-title":"J. Pathol."},{"key":"10.1016\/j.cell.2007.07.043_bib15","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/3305","article-title":"Neurogenesis in the adult human hippocampus","volume":"4","author":"Eriksson","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2007.07.043_bib16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0896-6273(00)80449-3","article-title":"Cellular and functional recovery of Parkinsonian rats after intrastriatal transplantation of carotid body cell aggregates","volume":"20","author":"Espejo","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2007.07.043_bib17","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/nn1340","article-title":"GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain","volume":"7","author":"Garcia","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2007.07.043_bib18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/path.1711380203","article-title":"Hyperplasia of the carotid body","volume":"138","author":"Heath","year":"1982","journal-title":"J. Pathol."},{"key":"10.1016\/j.cell.2007.07.043_bib19","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1242\/dev.127.8.1607","article-title":"Fate of the mammalian cardiac neural crest","volume":"127","author":"Jiang","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.cell.2007.07.043_bib20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.devcel.2005.07.001","article-title":"Toward an understanding of the physiological function of mammalian stem cells","volume":"9","author":"Joseph","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cell.2007.07.043_bib21","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ydbio.2005.04.004","article-title":"Mash1 is required for glomus cell formation in the mouse carotid body","volume":"283","author":"Kameda","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cell.2007.07.043_bib22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nn1175","article-title":"Localized striatal delivery of GDNF as a treatment for Parkinson disease","volume":"7","author":"Kirik","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2007.07.043_bib23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0046-8177(89)90199-8","article-title":"Paragangliomas: assessment of prognosis by histologic, immunohistochemical, and ultrastructural techniques","volume":"20","author":"Kliewer","year":"1989","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.cell.2007.07.043_bib24","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0896-6273(02)00827-9","article-title":"Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness","volume":"35","author":"Kruger","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2007.07.043_bib25","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1126\/science.3952494","article-title":"Cell line segregation during peripheral nervous system ontogeny","volume":"231","author":"Le Douarin","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.cell.2007.07.043_bib26","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0092-8674(90)90662-X","article-title":"CNS stem cells express a new class of intermediate filament protein","volume":"60","author":"Lendahl","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.cell.2007.07.043_bib27","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1126\/science.2456613","article-title":"Chemotransduction in the carotid body: K+ current modulated by PO2 in type I chemoreceptor cells","volume":"241","author":"L\u00f3pez-Barneo","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.cell.2007.07.043_bib28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.physiol.63.1.259","article-title":"Cellular mechanism of oxygen sensing","volume":"63","author":"L\u00f3pez-Barneo","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cell.2007.07.043_bib29","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0896-6273(00)80733-3","article-title":"Recovery of chronic parkinsonian monkeys by autotransplants of carotid body cell aggregates into putamen","volume":"22","author":"Luquin","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2007.07.043_bib30","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0896-6273(03)00116-8","article-title":"Neuronal or glial progeny: regional differences in radial glia fate","volume":"37","author":"Malatesta","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2007.07.043_bib31","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1152\/jappl.1984.57.5.1430","article-title":"A morphometric study of the carotid body in chronically hypoxic rats","volume":"57","author":"McGregor","year":"1984","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.cell.2007.07.043_bib32","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1523\/JNEUROSCI.0122-06.2006","article-title":"Neuroprotection by transgenic expression of glucose-6-phosphate dehydrogenase in dopaminergic nigrostriatal neurons of mice","volume":"26","author":"Mejias","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cell.2007.07.043_bib33","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/nature02060","article-title":"Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation","volume":"425","author":"Molofsky","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.cell.2007.07.043_bib34","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(00)80583-8","article-title":"Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells","volume":"96","author":"Morrison","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.cell.2007.07.043_bib35","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1523\/JNEUROSCI.20-19-07370.2000","article-title":"Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells","volume":"20","author":"Morrison","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cell.2007.07.043_bib36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/dbio.1997.8539","article-title":"Role of basic FGF and oxygen in control of proliferation, survival, and neuronal differentiation in carotid body chromaffin cells","volume":"184","author":"Nurse","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cell.2007.07.043_bib37","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1097\/00001756-200110290-00028","article-title":"Basic FGF localization in rat carotid body: paracrine role in O2-chemoreceptor survival","volume":"12","author":"Paciga","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.cell.2007.07.043_bib38","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1097\/00001756-199912160-00003","article-title":"Role of ET-1 in hypoxia-induced mitosis of cultured rat carotid body chemoreceptors","volume":"10","author":"Paciga","year":"1999","journal-title":"Neuroreport"},{"key":"10.1016\/j.cell.2007.07.043_bib39","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/1096-9861(20001002)425:4<479::AID-CNE2>3.0.CO;2-3","article-title":"Vascular niche for adult hippocampal neurogenesis","volume":"425","author":"Palmer","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.cell.2007.07.043_bib40","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nn812","article-title":"Low glucose-sensing cells in the carotid body","volume":"5","author":"Pardal","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2007.07.043_bib41","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1073\/pnas.030522297","article-title":"Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium","volume":"97","author":"Pardal","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2007.07.043_bib42","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1002\/1097-0142(19801215)46:12<2623::AID-CNCR2820461215>3.0.CO;2-U","article-title":"Malignant carotid body paraganglioma: light and electron microscopic study of the tumor and its metastases","volume":"46","author":"Robertson","year":"1980","journal-title":"Cancer"},{"key":"10.1016\/j.cell.2007.07.043_bib43","doi-asserted-by":"crossref","first-page":"7153","DOI":"10.1523\/JNEUROSCI.21-18-07153.2001","article-title":"Astrocytes give rise to new neurons in the adult mammalian hippocampus","volume":"21","author":"Seri","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cell.2007.07.043_bib44","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nmeth926","article-title":"Defining the actual sensitivity and specificity of the neurosphere assay in stem cell biology","volume":"3","author":"Singec","year":"2006","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2007.07.043_bib45","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/0092-8674(92)90393-Q","article-title":"Isolation of a stem cell for neurons and glia from the mammalian neural crest","volume":"71","author":"Stemple","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.cell.2007.07.043_bib46","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1523\/JNEUROSCI.23-01-00141.2003","article-title":"Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted parkinsonian rats","volume":"23","author":"Toledo-Aral","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cell.2007.07.043_bib47","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1083\/jcb.200504061","article-title":"Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart","volume":"170","author":"Tomita","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cell.2007.07.043_bib48","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1523\/JNEUROSCI.4312-04.2005","article-title":"Selective glial cell line-derived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after intrastriatal transplantation","volume":"25","author":"Villadiego","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cell.2007.07.043_bib49","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/jemt.10191","article-title":"Chronic hypoxia-induced morphological and neurochemical changes in the carotid body","volume":"59","author":"Wang","year":"2002","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.cell.2007.07.043_bib50","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/dbio.1998.8987","article-title":"A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture","volume":"202","author":"Young","year":"1998","journal-title":"Dev. Biol."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867407010239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867407010239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:00:43Z","timestamp":1758798043000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867407010239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0092867407010239"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2007.07.043","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1097032.546016","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1097032.554751","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1097032.556132","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1097032.553000","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glia-like Stem Cells Sustain Physiologic Neurogenesis in the Adult Mammalian Carotid Body","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2007.07.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}