{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:12:38Z","timestamp":1792469558543,"version":"4.5.0"},"reference-count":108,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1234,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.cell.2010.02.043","type":"journal-article","created":{"date-parts":[[2010,3,22]],"date-time":"2010-03-22T02:02:58Z","timestamp":1269223378000},"page":"935-950","source":"Crossref","is-referenced-by-count":955,"title":["Anti-inflammatory Agents: Present and Future"],"prefix":"10.1016","volume":"140","author":[{"given":"Charles A.","family":"Dinarello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2010.02.043_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjcard.2009.12.059","article-title":"Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling following acute myocardial infarction","author":"Abbate","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.cell.2010.02.043_bib2","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1161\/CIRCULATIONAHA.107.740233","article-title":"Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction","volume":"117","author":"Abbate","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.cell.2010.02.043_bib3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/art.21521","article-title":"Statins as antiinflammatory and immunomodulatory agents: a future in rheumatologic therapy?","volume":"54","author":"Abeles","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cell.2010.02.043_bib4","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1056\/NEJMoa0807865","article-title":"An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist","volume":"360","author":"Aksentijevevich","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib5","doi-asserted-by":"crossref","first-page":"9745","DOI":"10.1073\/pnas.0308558101","article-title":"Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes","volume":"101","author":"Andrei","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2010.02.043_bib6","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1097\/QAD.0b013e3282fd6df4","article-title":"Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T\u00a0cells","volume":"22","author":"Archin","year":"2008","journal-title":"AIDS"},{"key":"10.1016\/j.cell.2010.02.043_bib7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/00062752-200103000-00010","article-title":"Pharmacologic induction of fetal hemoglobin: raising the therapeutic bar in sickle cell disease","volume":"8","author":"Atweh","year":"2001","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.cell.2010.02.043_bib8","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1074\/jbc.M109.046102","article-title":"Rab39a binds caspase-1 and Is required for caspase-1-dependent interleukin-1b secretion","volume":"284","author":"Becker","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2010.02.043_bib9","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1046\/j.1440-1711.2001.01031.x","article-title":"Expression and localization of IL-1beta mRNA is interrelated with cytoskeletal rearrangement in monocytes stimulated by adherence: a light microscopy in\u00a0situ hybridization study","volume":"79","author":"Bocker","year":"2001","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.cell.2010.02.043_bib10","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1242\/jcs.03377","article-title":"Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death","volume":"120","author":"Brough","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cell.2010.02.043_bib11","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.4049\/jimmunol.163.3.1521","article-title":"Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis","volume":"163","author":"Charles","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.cell.2010.02.043_bib12","doi-asserted-by":"crossref","first-page":"6261","DOI":"10.1073\/pnas.96.11.6261","article-title":"Converting enzyme-independent release of TNF\u03b1 and IL-1\u03b2 from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase-3","volume":"96","author":"Coeshott","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2010.02.043_bib13","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1210\/en.2008-1757","article-title":"Pioglitazone inhibits Toll-like receptor expression and activity in human monocytes and db\/db mice","volume":"150","author":"Dasu","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.cell.2010.02.043_bib14","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1182\/blood.V87.6.2095.bloodjournal8762095","article-title":"Biological basis for interleukin-1 in disease","volume":"87","author":"Dinarello","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.cell.2010.02.043_bib15","first-page":"40","article-title":"Differences between anti-tumor necrosis factor-alpha monoclonal antibodies and soluble TNF receptors in host defense impairment","volume":"74","author":"Dinarello","year":"2005","journal-title":"J. Rheumatol. Suppl."},{"key":"10.1016\/j.cell.2010.02.043_bib16","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cell.2010.02.043_bib17","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1056\/NEJMe0811014","article-title":"Interleukin-1beta and the autoinflammatory diseases","volume":"360","author":"Dinarello","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib18","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1084\/jem.163.6.1433","article-title":"Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1","volume":"163","author":"Dinarello","year":"1986","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib19","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.4049\/jimmunol.139.6.1902","article-title":"Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro","volume":"139","author":"Dinarello","year":"1987","journal-title":"J. Immunol."},{"key":"10.1016\/j.cell.2010.02.043_bib20","first-page":"A30","article-title":"XOMA 052, a potential disease modifying anti-1L-1beta antibody, shows sustained HbA1c reductions 3 months after a single injection with no increases in safety parameters in subjects with type 2 diabetes","volume":"58","author":"Donath","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.cell.2010.02.043_bib21","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/9696","article-title":"Mutations in the gene encoding mevalonate kinase cause hyper-IgD and periodic fever syndrome. International Hyper-IgD Study Group","volume":"22","author":"Drenth","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2010.02.043_bib22","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1164\/rccm.200204-302OC","article-title":"Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsis","volume":"166","author":"Eichacker","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cell.2010.02.043_bib23","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1136\/jnnp.2004.054882","article-title":"A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients","volume":"76","author":"Emsley","year":"2005","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.cell.2010.02.043_bib24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1056\/NEJM198902023200501","article-title":"The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells","volume":"320","author":"Endres","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1055\/s-2006-939554","article-title":"Inflammation and the activated protein C anticoagulant pathway","volume":"32","author":"Esmon","year":"2006","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.cell.2010.02.043_bib26","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1586\/14737140.8.6.865","article-title":"Lenalidomide and its role in the management of multiple myeloma","volume":"8","author":"Falco","year":"2008","journal-title":"Expert Rev. Anticancer Ther."},{"key":"10.1016\/j.cell.2010.02.043_bib27","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.4049\/jimmunol.158.4.1818","article-title":"Response to local inflammation of IL-1\u03b2 converting enzyme-deficient mice","volume":"158","author":"Fantuzzi","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.cell.2010.02.043_bib28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1172\/JCI117345","article-title":"Neutralization of endogenous IL-1 receptor antagonist exacerbates and prolongs inflammation in rabbit immune colitis","volume":"94","author":"Ferretti","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cell.2010.02.043_bib29","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/art.21061","article-title":"Rapid responses to anakinra in patients with refractory adult-onset Still's disease","volume":"52","author":"Fitzgerald","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cell.2010.02.043_bib30","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1084\/jem.170.5.1627","article-title":"Antibodies to cachectin\/tumor necrosis factor reduce interleukin 1\u03b2 and interleukin 6 appearance during lethal bacteremia","volume":"170","author":"Fong","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib31","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1182\/blood-2007-06-098061","article-title":"Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes","volume":"111","author":"Garcia-Manero","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.cell.2010.02.043_bib32","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1002\/art.22842","article-title":"Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations","volume":"56","author":"Gattorno","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cell.2010.02.043_bib33","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1517\/14656566.9.2.285","article-title":"Oral valproic acid for epilepsy\u2013long-term experience in therapy and side effects","volume":"9","author":"Gerstner","year":"2008","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.cell.2010.02.043_bib34","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1056\/NEJMoa055137","article-title":"Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition","volume":"355","author":"Goldbach-Mansky","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/tpj.2008.16","article-title":"Variations in the interleukin-1 receptor antagonist gene impact on survival of patients with advanced colorectal cancer","volume":"9","author":"Graziano","year":"2009","journal-title":"Pharmacogenomics J."},{"key":"10.1016\/j.cell.2010.02.043_bib36","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature07965","article-title":"Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence","volume":"459","author":"Gross","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.cell.2010.02.043_bib37","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/sj.leu.2405049","article-title":"The histone deacetylase inhibitor ITF2357 selectively targets cells bearing mutated JAK2(V617F)","volume":"22","author":"Guerini","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.cell.2010.02.043_bib38","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1002\/art.24959","article-title":"Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation","volume":"60","author":"Guma","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cell.2010.02.043_bib39","doi-asserted-by":"crossref","first-page":"397","DOI":"10.5414\/CPP41397","article-title":"Statins differ in their ability to block NF-kappaB activation in human blood monocytes","volume":"41","author":"Hilgendorff","year":"2003","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"10.1016\/j.cell.2010.02.043_bib40","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1073\/pnas.0437870100","article-title":"Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease","volume":"100","author":"Hockly","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2010.02.043_bib41","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/ng756","article-title":"Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome","volume":"29","author":"Hoffman","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2010.02.043_bib42","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/S0140-6736(04)17401-1","article-title":"Prevention of cold-associated acute inflammation in familail cold autoinflammatory syndrome by interleukin-1 receptor antagonist","volume":"364","author":"Hoffman","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2010.02.043_bib43","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1002\/art.23687","article-title":"Efficacy and safety of rilonacept (interleukin-1 trap) in patients with cryopyrin-associated periodic syndromes: Results from two sequential placebo-controlled studies","volume":"58","author":"Hoffman","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cell.2010.02.043_bib44","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1084\/jem.191.2.313","article-title":"Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice","volume":"191","author":"Horai","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib45","doi-asserted-by":"crossref","first-page":"8068","DOI":"10.4049\/jimmunol.181.11.8068","article-title":"A\u00a0novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia\/reperfusion injury","volume":"181","author":"Huang","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.cell.2010.02.043_bib46","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1167\/iovs.08-2462","article-title":"Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators","volume":"50","author":"Jin","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cell.2010.02.043_bib47","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1002\/art.25006","article-title":"Inflammatory arthritis in caspase 1 gene-deficient mice: Contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta","volume":"60","author":"Joosten","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cell.2010.02.043_bib48","doi-asserted-by":"crossref","first-page":"C1100","DOI":"10.1152\/ajpcell.00494.2003","article-title":"Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release","volume":"286","author":"Kahlenberg","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.cell.2010.02.043_bib49","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1042\/BJ20070779","article-title":"Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors","volume":"409","author":"Khan","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.cell.2010.02.043_bib50","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1002\/cmdc.200900045","article-title":"Searching for disease modifiers-PKC activation and HDAC inhibition - a dual drug approach to Alzheimer's disease that decreases Abeta production while blocking oxidative stress","volume":"4","author":"Kozikowski","year":"2009","journal-title":"ChemMedChem"},{"key":"10.1016\/j.cell.2010.02.043_bib51","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1158\/0008-5472.CAN-06-2956","article-title":"Interleukin-1beta-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors","volume":"67","author":"Krelin","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2010.02.043_bib52","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1073\/pnas.0907342107","article-title":"Resolvin D1 binds human phagocytes with evidence for proresolving receptors","volume":"107","author":"Krishnamoorthy","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2010.02.043_bib53","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1182\/blood-2008-03-144667","article-title":"HMG-CoA reductase inhibition induces IL-1beta release through Rac1\/PI3K\/PKB-dependent caspase-1 activation","volume":"112","author":"Kuijk","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.cell.2010.02.043_bib54","doi-asserted-by":"crossref","first-page":"29043","DOI":"10.1074\/jbc.270.49.29043","article-title":"Human mitogen-activated protein kinase CSBP1, but not CSBP2, complements a hog1 deletion in yeast","volume":"270","author":"Kumar","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2010.02.043_bib55","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1056\/NEJMoa0810787","article-title":"Use of canakinumab in the cryopyrin-associated periodic syndrome","volume":"360","author":"Lachmann","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib56","doi-asserted-by":"crossref","first-page":"36944","DOI":"10.1074\/jbc.274.52.36944","article-title":"ATP treatment of human monocytes promotes caspase-1 maturation and externalization","volume":"274","author":"Laliberte","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cell.2010.02.043_bib57","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1056\/NEJMoa065213","article-title":"Interleukin-1-receptor antagonist in type 2 diabetes mellitus","volume":"356","author":"Larsen","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib58","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s00125-006-0562-3","article-title":"Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells","volume":"50","author":"Larsen","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.cell.2010.02.043_bib59","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.2337\/dc09-0533","article-title":"Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes","volume":"32","author":"Larsen","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cell.2010.02.043_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2119\/2006-00005.Dinarello","article-title":"The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in\u00a0vitro and systemic inflammation in\u00a0vivo","volume":"11","author":"Leoni","year":"2005","journal-title":"Mol. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib61","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1073\/pnas.052702999","article-title":"The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines","volume":"99","author":"Leoni","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2010.02.043_bib62","doi-asserted-by":"crossref","first-page":"16236","DOI":"10.1073\/pnas.0807627105","article-title":"alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice","volume":"105","author":"Lewis","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2010.02.043_bib63","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2353\/ajpath.2009.081093","article-title":"The complement inhibitor FUT-175 suppresses T\u00a0cell autoreactivity in experimental autoimmune encephalomyelitis","volume":"175","author":"Li","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cell.2010.02.043_bib64","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJM199408183310701","article-title":"The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina","volume":"331","author":"Liuzzo","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib65","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S1074-7613(01)00229-1","article-title":"Rapid secretion of interleukin-1beta by microvesicle shedding","volume":"15","author":"MacKenzie","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2010.02.043_bib66","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1172\/JCI200215318","article-title":"Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets","volume":"110","author":"Maedler","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cell.2010.02.043_bib67","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev.med.080708.082655","article-title":"Progressive multifocal leukoencephalopathy in patients on immunomodulatory therapies","volume":"61","author":"Major","year":"2009","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib68","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF02427283","article-title":"Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans","volume":"29","author":"Mandrup-Poulsen","year":"1986","journal-title":"Diabetologia"},{"key":"10.1016\/j.cell.2010.02.043_bib69","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1182\/blood.V98.3.667","article-title":"The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment","volume":"98","author":"Marin","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.cell.2010.02.043_bib70","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/35106079","article-title":"Histone deacetylases and cancer: causes and therapies","volume":"1","author":"Marks","year":"2001","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2010.02.043_bib71","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.25.022106.141627","article-title":"Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (\u2217)","volume":"27","author":"Masters","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cell.2010.02.043_bib72","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cell.2007.02.042","article-title":"Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide","volume":"129","author":"Munch","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.cell.2010.02.043_bib73","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1182\/blood-2008-03-146720","article-title":"Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages","volume":"113","author":"Netea","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.cell.2010.02.043_bib74","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1084\/jem.191.2.303","article-title":"Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene","volume":"191","author":"Nicklin","year":"2000","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib75","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1160\/TH07-01-0052","article-title":"Activated protein C downregulates p38 mitogen-activated protein kinase and improves clinical parameters in an in-vivo model of septic shock","volume":"98","author":"Nold","year":"2007","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.cell.2010.02.043_bib76","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1200\/JCO.2005.01.9679","article-title":"Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies","volume":"24","author":"O'Connor","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.cell.2010.02.043_bib77","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.cyto.2009.07.506","article-title":"Decreased whole blood cytokine production during a phase I trial of the histone deacetylase inhibitor ITF2357","volume":"48","author":"Oldoni","year":"2009","journal-title":"Cytokine"},{"key":"10.1016\/j.cell.2010.02.043_bib78","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1172\/JCI28546.","article-title":"Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis","volume":"116","author":"Paniagua","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cell.2010.02.043_bib79","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1084\/jem.20050473","article-title":"Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade","volume":"201","author":"Pascual","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib80","doi-asserted-by":"crossref","first-page":"e1928","DOI":"10.1371\/journal.pone.0001928","article-title":"Oral high-dose atorvastatin treatment in relapsing-remitting multiple sclerosis","volume":"3","author":"Paul","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.cell.2010.02.043_bib81","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.4049\/jimmunol.165.8.4615","article-title":"ATP acts as an agonist to promote stimulus-induced secretion of IL-1 beta and IL-18 in human blood","volume":"165","author":"Perregaux","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.cell.2010.02.043_bib82","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1189\/jlb.0208145","article-title":"Alpha-1-antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood","volume":"85","author":"Pott","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cell.2010.02.043_bib83","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1517\/13543780903535867","article-title":"Anti-chemokine small molecule drugs: a promising future?","volume":"19","author":"Proudfoot","year":"2010","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.cell.2010.02.043_bib84","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.4049\/jimmunol.179.3.1913","article-title":"Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages","volume":"179","author":"Qu","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.cell.2010.02.043_bib85","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/sj.gene.6364393","article-title":"Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels","volume":"8","author":"Rafiq","year":"2007","journal-title":"Genes Immun."},{"key":"10.1016\/j.cell.2010.02.043_bib86","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1056\/NEJMoa0809568","article-title":"An autoinflammatory disease due to homozygous deletion of the IL1RN locus","volume":"360","author":"Reddy","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib87","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1111\/j.1471-4159.2004.02406.x","article-title":"Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction","volume":"89","author":"Ren","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cell.2010.02.043_bib88","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMoa0807646","article-title":"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein","volume":"359","author":"Ridker","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib89","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1084\/jem.173.3.699","article-title":"Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes","volume":"173","author":"Sampaio","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib90","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2174\/138920007780655397","article-title":"Histone deacetylase inhibitors: molecular and biological activity as a premise to clinical application","volume":"8","author":"Santini","year":"2007","journal-title":"Curr. Drug Metab."},{"issue":"Suppl 1","key":"10.1016\/j.cell.2010.02.043_bib91","doi-asserted-by":"crossref","first-page":"S200","DOI":"10.1038\/sj.bjp.0707489","article-title":"Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus","volume":"153","author":"Serhan","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cell.2010.02.043_bib92","doi-asserted-by":"crossref","first-page":"12230","DOI":"10.1073\/pnas.92.26.12230","article-title":"Osmotic regulation of cytokine synthesis in\u00a0vitro","volume":"92","author":"Shapiro","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2010.02.043_bib93","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1096\/fj.00-0311com","article-title":"Alpha-1-antitrypsin inhibits human immunodeficiency virus type 1","volume":"15","author":"Shapiro","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.cell.2010.02.043_bib94","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1096\/fj.09-134700","article-title":"Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery and induces glial apoptosis following experimental traumatic brain injury","volume":"23","author":"Shein","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.cell.2010.02.043_bib95","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.4049\/jimmunol.175.4.2630","article-title":"IL-converting enzyme\/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients","volume":"175","author":"Stack","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.cell.2010.02.043_bib96","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ijcard.2008.06.005","article-title":"The controversial effects of thiazolidinediones on cardiovascular morbidity and mortality","volume":"131","author":"Stafylas","year":"2009","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.cell.2010.02.043_bib97","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cyto.2009.07.567","article-title":"The inflammasome-mediated caspase-1 activation controls apipocyte differentiation and insulin sensitivity","volume":"48","author":"Stienstra","year":"2009","journal-title":"Cytokine"},{"key":"10.1016\/j.cell.2010.02.043_bib98","first-page":"5","article-title":"Regulatory roles for histone deacetylation in IL-1beta-induced nitric oxide release in pancreatic beta-cells","volume":"5","author":"Susick","year":"2007","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.cell.2010.02.043_bib99","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.jtcvs.2007.12.062","article-title":"Pexelizumab in ischemic heart disease: a systematic review and meta-analysis on 15,196 patients","volume":"136","author":"Testa","year":"2008","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.cell.2010.02.043_bib100","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0014-2999(02)02423-8","article-title":"Cytokine modulation and suppression of liver injury by a novel analogue of thalidomide","volume":"453","author":"Thiele","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cell.2010.02.043_bib101","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1086\/597274","article-title":"Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans","volume":"199","author":"van de Veerdonk","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.cell.2010.02.043_bib102","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cyto.2009.07.412","article-title":"The anti-CD20 antibody rituximab reduces the Th17 response","volume":"48","author":"van de Veerdonk","year":"2009","journal-title":"Cytokine"},{"key":"10.1016\/j.cell.2010.02.043_bib103","first-page":"S943","article-title":"Safety and efficacy of oral ITF 2357 in patients with active systemic onset juvenile idiopathic arthritis (SOJIA) Results of a phase II, open label, international, multicentre clinical trial","volume":"58","author":"Vojinovic","year":"2008","journal-title":"Arthritis Rheum. (Munch)"},{"key":"10.1016\/j.cell.2010.02.043_bib104","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1002\/art.23992","article-title":"Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trial","volume":"58","author":"Weinblatt","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cell.2010.02.043_bib105","doi-asserted-by":"crossref","first-page":"13622","DOI":"10.1073\/pnas.0501758102","article-title":"The kinase inhibitor imatinib mesylate inhibits TNF-{alpha} production in\u00a0vitro and prevents TNF-dependent acute hepatic inflammation","volume":"102","author":"Wolf","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2010.02.043_bib106","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.4049\/jimmunol.0804341","article-title":"The peroxisome proliferator-activated receptor gamma agonist pioglitazone improves cardiometabolic risk and renal inflammation in murine lupus","volume":"183","author":"Zhao","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.cell.2010.02.043_bib107","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2010.02.043_bib108","doi-asserted-by":"crossref","first-page":"702","DOI":"10.4049\/jimmunol.178.2.702","article-title":"Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T\u00a0cell stimulatory function of dendritic cells","volume":"178","author":"Zhou","year":"2007","journal-title":"J. Immunol."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867410002369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867410002369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T23:56:47Z","timestamp":1685491007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867410002369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":108,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0092867410002369"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2010.02.043","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}