{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:51:23Z","timestamp":1791399083840,"version":"4.3.3"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1173,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.cell.2010.03.055","type":"journal-article","created":{"date-parts":[[2010,5,28]],"date-time":"2010-05-28T01:56:14Z","timestamp":1275011774000},"page":"775-785","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":396,"title":["Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice"],"prefix":"10.1016","volume":"141","author":[{"given":"Shau-Kwaun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Tvrdik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Peden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Spangrude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario R.","family":"Capecchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2010.03.055_bib1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1467-9280.1993.tb00587.x","article-title":"Neuronal coding of serial order: syntax of grooming in the neostriatum","volume":"4","author":"Aldridge","year":"1993","journal-title":"Psychol. Sci."},{"key":"10.1016\/j.cell.2010.03.055_bib2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0165-3806(99)00113-3","article-title":"Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain","volume":"117","author":"Alliot","year":"1999","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.cell.2010.03.055_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.1205707","article-title":"The immune response in autism: a new frontier for autism research","volume":"80","author":"Ashwood","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cell.2010.03.055_bib4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0166-4328(89)80119-6","article-title":"Progressive degradation of serial grooming chains by descending decerebration","volume":"33","author":"Berridge","year":"1989","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.cell.2010.03.055_bib5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF00227239","article-title":"Cortex, striatum and cerebellum: control of serial order in a grooming sequence","volume":"90","author":"Berridge","year":"1992","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.cell.2010.03.055_bib6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0166-4328(87)90242-7","article-title":"Natural syntax rules control action sequence of rats","volume":"23","author":"Berridge","year":"1987","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.cell.2010.03.055_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jneumeth.2004.08.001","article-title":"A repetitive movement detector used for automatic monitoring and quantification of scratching in mice","volume":"142","author":"Brash","year":"2005","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.cell.2010.03.055_bib8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1101\/SQB.1997.062.01.034","article-title":"Hox genes and mammalian development","volume":"62","author":"Capecchi","year":"1997","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.cell.2010.03.055_bib9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/gene.1030","article-title":"Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse line","volume":"30","author":"Constien","year":"2001","journal-title":"Genesis"},{"key":"10.1016\/j.cell.2010.03.055_bib10","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.pnpbp.2007.12.026","article-title":"Obsessive-compulsive disorder and immunology: a review","volume":"32","author":"da Rocha","year":"2008","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.cell.2010.03.055_bib11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0896-6273(00)80432-8","article-title":"Microglia-derived nerve growth factor causes cell death in the developing retina","volume":"20","author":"Frade","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2010.03.055_bib12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0896-6273(00)00113-6","article-title":"Toward a neurobiology of obsessive-compulsive disorder","volume":"28","author":"Graybiel","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2010.03.055_bib13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0896-6273(01)00564-5","article-title":"Hoxb8 is required for normal grooming behavior in mice","volume":"33","author":"Greer","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2010.03.055_bib14","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.1073\/pnas.0802176105","article-title":"Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice","volume":"105","author":"Holstege","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2010.03.055_bib15","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0193-953X(05)70176-3","article-title":"The epidemiology and cross-national presentation of obsessive-compulsive disorder","volume":"23","author":"Horwath","year":"2000","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.cell.2010.03.055_bib16","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neulet.2008.07.022","article-title":"TNF-alpha polymorphisms are associated with obsessive-compulsive disorder","volume":"442","author":"Hounie","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cell.2010.03.055_bib17","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1176\/jnp.2008.20.4.390","article-title":"A psychological and neuroanatomical model of obsessive-compulsive disorder","volume":"20","author":"Huey","year":"2008","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.cell.2010.03.055_bib18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0014-5793(95)01162-8","article-title":"A rapid and non-invasive selection of transgenic embryos before implantation using green fluorescent protein (GFP)","volume":"375","author":"Ikawa","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cell.2010.03.055_bib19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jemt.1114","article-title":"Origin of microglia","volume":"54","author":"Kaur","year":"2001","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.cell.2010.03.055_bib20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/nass\/48.1.211","article-title":"MicroRNA-196 inhibits HOXB8 expression in myeloid differentiation of HL60 cells","volume":"48","author":"Kawasaki","year":"2004","journal-title":"Nucleic Acids Symp. Ser. (Oxf)"},{"key":"10.1016\/j.cell.2010.03.055_bib21","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/nar\/17.5.1881","article-title":"Expression of Hox-2.4 homeobox gene directed by proviral insertion in a myeloid leukemia","volume":"17","author":"Kongsuwan","year":"1989","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2010.03.055_bib22","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1182\/blood.V90.5.1840","article-title":"Lineage-specific regulation of hematopoiesis by HOX-B8 (HOX-2.4): inhibition of granulocytic differentiation and potentiation of monocytic differentiation","volume":"90","author":"Krishnaraju","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.cell.2010.03.055_bib23","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1176\/appi.ajp.157.5.683","article-title":"Cytokines and the brain: implications for clinical psychiatry","volume":"157","author":"Kronfol","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.cell.2010.03.055_bib24","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1159\/000110430","article-title":"Molecular mechanisms of schizophrenia","volume":"20","author":"Lang","year":"2007","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.cell.2010.03.055_bib25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/hup.1011","article-title":"The psychoneuroimmunology of depression","volume":"24","author":"Leonard","year":"2009","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.cell.2010.03.055_bib26","doi-asserted-by":"crossref","first-page":"e356","DOI":"10.1371\/journal.pone.0000356","article-title":"Extensive polycistronism and antisense transcription in the Mammalian Hox clusters","volume":"2","author":"Mainguy","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2010.03.055_bib27","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0896-6273(04)00069-8","article-title":"Microglia promote the death of developing Purkinje cells","volume":"41","author":"Marin-Teva","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2010.03.055_bib28","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1002\/j.1460-2075.1993.tb06062.x","article-title":"Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene","volume":"12","author":"Perkins","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2010.03.055_bib29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1182\/blood.V80.1.185.185","article-title":"Expression of selected human HOX-2 genes in B\/T acute lymphoid leukemia and interleukin-2\/interleukin-1 beta-stimulated natural killer lymphocytes","volume":"80","author":"Petrini","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.cell.2010.03.055_bib30","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nature08185","article-title":"Common polygenic variation contributes to risk of schizophrenia and bipolar disorder","volume":"460","author":"Purcell","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.cell.2010.03.055_bib31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.immunol.021908.132528","article-title":"Microglial physiology: unique stimuli, specialized responses","volume":"27","author":"Ransohoff","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cell.2010.03.055_bib32","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nature08192","article-title":"Common variants on chromosome 6p22.1 are associated with schizophrenia","volume":"460","author":"Shi","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.cell.2010.03.055_bib33","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2010.03.055_bib34","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1634\/stemcells.2006-0013","article-title":"Mouse models of hematopoietic engraftment: limitations of transgenic green fluorescent protein strains and a high-performance liquid chromatography approach to analysis of erythroid chimerism","volume":"24","author":"Spangrude","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.cell.2010.03.055_bib35","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/nature08186","article-title":"Common variants conferring risk of schizophrenia","volume":"460","author":"Stefansson","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.cell.2010.03.055_bib36","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jaut.2006.07.006","article-title":"Schizophrenia, autoimmunity and immune system dysregulation: a comprehensive model updated and revisited","volume":"27","author":"Strous","year":"2006","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.cell.2010.03.055_bib37","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainres.2010.01.052","article-title":"Dopamine receptor modulation of repetitive grooming actions in the rat: potential relevance for Tourette syndrome","volume":"1322","author":"Taylor","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.cell.2010.03.055_bib38","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1523\/JNEUROSCI.4363-08.2009","article-title":"Resting microglia directly monitor the functional state of synapses in\u00a0vivo and determine the fate of ischemic terminals","volume":"29","author":"Wake","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cell.2010.03.055_bib39","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/j.exphem.2006.08.001","article-title":"Distinct roles of IL-7 and stem cell factor in the OP9-DL1 T-cell differentiation culture system","volume":"34","author":"Wang","year":"2006","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.cell.2010.03.055_bib40","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature06104","article-title":"Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice","volume":"448","author":"Welch","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cell.2010.03.055_bib41","doi-asserted-by":"crossref","unstructured":"Constien, R., Forde, A., Liliensiek, B., Grone, H.J., Nawroth, P., Hammerling, G., and Arnold, B. (2001). Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse line. Genesis 30, 36\u201344.","DOI":"10.1002\/gene.1030"},{"key":"10.1016\/j.cell.2010.03.055_bib42","doi-asserted-by":"crossref","unstructured":"Greer, J.M., and Capecchi, M.R. (2002). Hoxb8 is required for normal grooming behavior in mice. Neuron 33, 23\u201334.","DOI":"10.1016\/S0896-6273(01)00564-5"},{"key":"10.1016\/j.cell.2010.03.055_bib43","doi-asserted-by":"crossref","unstructured":"Holstege, J.C., de Graaff, W., Hossaini, M., Cano, S.C., Jaarsma, D., van den Akker, E., and Deschamps, J. (2008). Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice. Proc. Natl. Acad. Sci. USA 105, 6338\u20136343.","DOI":"10.1073\/pnas.0802176105"},{"key":"10.1016\/j.cell.2010.03.055_bib44","doi-asserted-by":"crossref","unstructured":"Ikawa, M., Kominami, K., Yoshimura, Y., Tanaka, K., Nishimune, Y., and Okabe, M. (1995). A rapid and non-invasive selection of transgenic embryos before implantation using green fluorescent protein (GFP). FEBS Lett. 375, 125\u2013128.","DOI":"10.1016\/0014-5793(95)01162-8"},{"key":"10.1016\/j.cell.2010.03.055_bib45","doi-asserted-by":"crossref","unstructured":"Soriano, P. (1999). Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21, 70\u201371.","DOI":"10.1038\/5007"},{"key":"10.1016\/j.cell.2010.03.055_bib46","doi-asserted-by":"crossref","unstructured":"Srinivas, S., Watanabe, T., Lin, C.S., William, C.M., Tanabe, Y., Jessell, T.M., and Costantini, F. (2001). Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1, 4.","DOI":"10.1186\/1471-213X-1-4"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867410003740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867410003740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:09:38Z","timestamp":1758798578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867410003740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0092867410003740"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2010.03.055","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.5103956.5039057","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2010.03.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}