{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T14:23:04Z","timestamp":1792333384009,"version":"4.4.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T00:00:00Z","timestamp":1416528000000},"content-version":"vor","delay-in-days":385,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.cell.2013.10.034","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T17:00:52Z","timestamp":1385053252000},"page":"1178-1187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":462,"title":["Temporal Response of the Human Virome to Immunosuppression and Antiviral Therapy"],"prefix":"10.1016","volume":"155","author":[{"given":"Iwijn","family":"De\u00a0Vlaminck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran\u00a0K.","family":"Khush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin","family":"Strehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bitika","family":"Kohli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Luikart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma\u00a0F.","family":"Neff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas\u00a0M.","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0N.","family":"Cornfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u00a0R.","family":"Nicolls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Weill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah\u00a0A.","family":"Valantine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen\u00a0R.","family":"Quake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2013.10.034_bib1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbmt.2003.11.001","article-title":"Incidence and outcome of adenovirus disease in transplant recipients after reduced-intensity conditioning with alemtuzumab","volume":"10","author":"Avivi","year":"2004","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.cell.2013.10.034_bib2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S1083-8791(03)00102-2","article-title":"Adenovirus infection in hematopoietic stem cell transplantation: effect of ganciclovir and impact on survival","volume":"9","author":"Bruno","year":"2003","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.cell.2013.10.034_bib3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/clpt.2011.111","article-title":"Biomarkers of over-immunosuppression","volume":"90","author":"Budde","year":"2011","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.cell.2013.10.034_bib4","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/infdis\/147.4.676","article-title":"Persistence of DNA sequences of BK virus and JC virus in normal human tissues and in diseased tissues","volume":"147","author":"Chesters","year":"1983","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.cell.2013.10.034_bib5","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.cell.2012.01.035","article-title":"The impact of the gut microbiota on human health: an integrative view","volume":"148","author":"Clemente","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cell.2013.10.034_bib6","doi-asserted-by":"crossref","first-page":"14691","DOI":"10.1073\/pnas.1005963107","article-title":"Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa","volume":"107","author":"De Filippo","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2013.10.034_bib7","doi-asserted-by":"crossref","first-page":"16266","DOI":"10.1073\/pnas.0808319105","article-title":"Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood","volume":"105","author":"Fan","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2013.10.034_bib8","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1056\/NEJMra064928","article-title":"Infection in solid-organ transplant recipients","volume":"357","author":"Fishman","year":"2007","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2013.10.034_bib9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1399-0012.2006.00618.x","article-title":"Cytomegalovirus in\u00a0transplantation - challenging the status quo","volume":"21","author":"Fishman","year":"2007","journal-title":"Clin. Transplant."},{"key":"10.1016\/j.cell.2013.10.034_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/rmv.524","article-title":"Torque teno virus (TTV): current status","volume":"17","author":"Hino","year":"2007","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.cell.2013.10.034_bib11","doi-asserted-by":"crossref","first-page":"e9836","DOI":"10.1371\/journal.pone.0009836","article-title":"Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome","volume":"5","author":"Jakobsson","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2013.10.034_bib12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0009-9236(95)90153-1","article-title":"Pharmacokinetics of tacrolimus in liver transplant patients","volume":"57","author":"Jusko","year":"1995","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.cell.2013.10.034_bib13","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2013.10.034_bib14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1310\/8C94-VYPQ-NG1H-4CNW","article-title":"TTV viral load as a marker for immune reconstitution after initiation of HAART in HIV-infected patients","volume":"3","author":"Madsen","year":"2002","journal-title":"HIV Clin. Trials"},{"issue":"Suppl","key":"10.1016\/j.cell.2013.10.034_bib15","doi-asserted-by":"crossref","first-page":"S219","DOI":"10.1016\/j.healun.2005.04.001","article-title":"Nodular endocardial infiltrates (Quilty lesions) cause significant variability in diagnosis of ISHLT Grade 2 and 3A rejection in cardiac allograft recipients","volume":"24","author":"Marboe","year":"2005","journal-title":"J.\u00a0Heart Lung Transplant."},{"key":"10.1016\/j.cell.2013.10.034_bib16","doi-asserted-by":"crossref","first-page":"e50937","DOI":"10.1371\/journal.pone.0050937","article-title":"Increased prevalence of anellovirus in pediatric patients with fever","volume":"7","author":"McElvania TeKippe","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2013.10.034_bib17","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1101\/gr.122705.111","article-title":"The human gut virome: inter-individual variation and dynamic response to diet","volume":"21","author":"Minot","year":"2011","journal-title":"Genome Res."},{"key":"10.1016\/j.cell.2013.10.034_bib18","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1126\/science.1198719","article-title":"Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans","volume":"332","author":"Muegge","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.cell.2013.10.034_bib19","unstructured":"Oksanen, J., Kindt, R., Legendre, P., O\u2019Hara, B., Stevens, M.H.H., Oksanen, M.J., and Suggests, M. (2007). The vegan package. Community ecology package. Version 2.0-7."},{"key":"10.1016\/j.cell.2013.10.034_bib20","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1128\/JCM.01362-06","article-title":"Frequent occult infection with Cytomegalovirus in cardiac transplant recipients despite antiviral prophylaxis","volume":"45","author":"Potena","year":"2007","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.cell.2013.10.034_bib21","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.4065\/mcp.2011.0309","article-title":"Antiviral drugs for viruses other than human immunodeficiency virus","volume":"86","author":"Razonable","year":"2011","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.cell.2013.10.034_bib22","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1086\/466532","article-title":"A longitudinal molecular surveillance study of human polyomavirus viremia in heart, kidney, liver, and pancreas transplant patients","volume":"192","author":"Razonable","year":"2005","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.cell.2013.10.034_bib23","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/nature09199","article-title":"Viruses in the faecal microbiota of monozygotic twins and their mothers","volume":"466","author":"Reyes","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.cell.2013.10.034_bib24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.healun.2008.10.001","article-title":"Assessment of the Cylex ImmuKnow cell function assay in pediatric heart transplant patients","volume":"28","author":"Rossano","year":"2009","journal-title":"J.\u00a0Heart Lung Transplant."},{"key":"10.1016\/j.cell.2013.10.034_bib25","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1016\/j.transproceed.2011.03.010","article-title":"Complications of endomyocardial biopsy in heart transplant patients: a retrospective study of 2117 consecutive procedures","volume":"43","author":"Saraiva","year":"2011","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.cell.2013.10.034_bib26","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.chom.2010.05.006","article-title":"Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin","volume":"7","author":"Schowalter","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2013.10.034_bib27","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1086\/315242","article-title":"Cytomegalovirus (CMV) DNA load predicts relapsing CMV infection after solid organ transplantation","volume":"181","author":"Sia","year":"2000","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.cell.2013.10.034_bib28","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1093\/bioinformatics\/bti623","article-title":"ROCR: visualizing classifier performance in R","volume":"21","author":"Sing","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2013.10.034_bib29","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.2165\/00003495-200464240-00004","article-title":"Viral prophylaxis in organ transplant patients","volume":"64","author":"Slifkin","year":"2004","journal-title":"Drugs"},{"key":"10.1016\/j.cell.2013.10.034_bib30","doi-asserted-by":"crossref","first-page":"6229","DOI":"10.1073\/pnas.1013924108","article-title":"Universal noninvasive detection of solid organ transplant rejection","volume":"108","author":"Snyder","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2013.10.034_bib31","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.healun.2005.03.019","article-title":"Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection","volume":"24","author":"Stewart","year":"2005","journal-title":"J.\u00a0Heart Lung Transplant."},{"key":"10.1016\/j.cell.2013.10.034_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jmv.20756","article-title":"Progression towards AIDS leads to increased Torque teno virus and Torque teno minivirus titers in tissues of HIV infected individuals","volume":"79","author":"Thom","year":"2007","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.cell.2013.10.034_bib33","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1386-6532(01)00157-3","article-title":"TT virus infection: prevalence of elevated viraemia and arguments for the immune control of viral load","volume":"21","author":"Touinssi","year":"2001","journal-title":"J.\u00a0Clin. Virol."},{"key":"10.1016\/j.cell.2013.10.034_bib34","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nature06244","article-title":"The human microbiome project","volume":"449","author":"Turnbaugh","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cell.2013.10.034_bib35","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2165\/00003088-199529060-00003","article-title":"Clinical pharmacokinetics of tacrolimus","volume":"29","author":"Venkataramanan","year":"1995","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.cell.2013.10.034_bib36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/ng818","article-title":"Identification of foreign gene sequences by transcript filtering against the human genome","volume":"30","author":"Weber","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2013.10.034_bib37","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/FTD.0b013e3181efb3d2","article-title":"Biomarkers as a tool for management of immunosuppression in transplant patients","volume":"32","author":"Wieland","year":"2010","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.cell.2013.10.034_bib38","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.trsl.2012.03.006","article-title":"Emerging view of the human virome","volume":"160","author":"Wylie","year":"2012","journal-title":"Transl. Res."},{"key":"10.1016\/j.cell.2013.10.034_bib39","doi-asserted-by":"crossref","first-page":"e27992","DOI":"10.1371\/journal.pone.0027992","article-title":"Accurate genome relative abundance estimation based on shotgun metagenomic reads","volume":"6","author":"Xia","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2013.10.034_bib40","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0888-7543(02)00043-5","article-title":"Pathogen discovery from human tissue by sequence-based computational subtraction","volume":"81","author":"Xu","year":"2003","journal-title":"Genomics"},{"key":"10.1016\/j.cell.2013.10.034_bib41","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2013.10.034_bib42","first-page":"109","article-title":"TT viruses: oncogenic or tumor-suppressive properties?","volume":"331","author":"zur Hausen","year":"2009","journal-title":"Curr. Top. Microbiol. Immunol."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867413013524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867413013524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,3]],"date-time":"2019-08-03T19:05:45Z","timestamp":1564859145000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867413013524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0092867413013524"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2013.10.034","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718185759.793487792","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Temporal Response of the Human Virome to Immunosuppression and Antiviral Therapy","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2013.10.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}