{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:23:19Z","timestamp":1784197399177,"version":"3.55.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T00:00:00Z","timestamp":1428451200000},"content-version":"vor","delay-in-days":462,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.cell.2013.12.013","type":"journal-article","created":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T12:18:45Z","timestamp":1389874725000},"page":"291-303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"title":["An O2-Sensitive Glomus Cell-Stem Cell Synapse Induces Carotid Body Growth in Chronic Hypoxia"],"prefix":"10.1016","volume":"156","author":[{"given":"Aida","family":"Platero-Luengo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Gonz\u00e1lez-Granero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Dur\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"D\u00edaz-Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9\u00a0I.","family":"Piruat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9\u00a0Manuel","family":"Garc\u00eda-Verdugo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Pardal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"L\u00f3pez-Barneo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2013.12.013_bib1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0896-6273(04)00111-4","article-title":"For the long run: maintaining germinal niches in the adult brain","volume":"41","author":"\u00c1lvarez-Buylla","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2013.12.013_bib2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0046-8177(76)80052-4","article-title":"Chief cell hyperplasia in the human carotid body at high altitudes; physiologic and pathologic significance","volume":"7","author":"Arias-Stella","year":"1976","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.cell.2013.12.013_bib3","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1113\/jphysiol.2012.247254","article-title":"Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2","volume":"591","author":"Bishop","year":"2013","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.cell.2013.12.013_bib4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ydbio.2008.08.007","article-title":"A new role for the Endothelin-1\/Endothelin-A receptor signaling during early neural crest specification","volume":"323","author":"Bonano","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cell.2013.12.013_bib5","first-page":"H1327","article-title":"BQ123, an ETA-receptor antagonist, attenuates hypoxic pulmonary hypertension in rats","volume":"266","author":"Bonvallet","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.cell.2013.12.013_bib6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bbrc.2004.07.081","article-title":"Detection of hypoxia-evoked ATP release from chemoreceptor cells of the rat carotid body","volume":"322","author":"Buttigieg","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cell.2013.12.013_bib7","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.stem.2012.08.009","article-title":"Noisy neurons keep neural stem cells quiet","volume":"11","author":"Chell","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2013.12.013_bib8","doi-asserted-by":"crossref","first-page":"L1314","DOI":"10.1152\/ajplung.00454.2001","article-title":"Role of endothelin and endothelin A-type receptor in adaptation of the carotid body to chronic hypoxia","volume":"282","author":"Chen","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.cell.2013.12.013_bib9","doi-asserted-by":"crossref","first-page":"L1257","DOI":"10.1152\/ajplung.00419.2006","article-title":"Effect of the endothelin receptor antagonist bosentan on chronic hypoxia-induced morphological and physiological changes in rat carotid body","volume":"292","author":"Chen","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.cell.2013.12.013_bib10","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1242\/dev.125.5.813","article-title":"Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice","volume":"125","author":"Clouthier","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.cell.2013.12.013_bib11","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1111\/j.1471-4159.1992.tb11376.x","article-title":"Regulation of tyrosine hydroxylase gene expression in the rat carotid body by hypoxia","volume":"58","author":"Czyzyk-Krzeska","year":"1992","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.cell.2013.12.013_bib12","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0896-6273(04)00266-1","article-title":"Excitation-neurogenesis coupling in adult neural stem\/progenitor cells","volume":"42","author":"Deisseroth","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2013.12.013_bib13","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1128\/MCB.00128-12","article-title":"Differential impairment of catecholaminergic cell maturation and survival by genetic mitochondrial complex II dysfunction","volume":"32","author":"D\u00edaz-Castro","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cell.2013.12.013_bib14","first-page":"H828","article-title":"Protection from pulmonary hypertension with an orally active endothelin receptor antagonist in hypoxic rats","volume":"268","author":"Eddahibi","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.cell.2013.12.013_bib15","first-page":"R1260","article-title":"Normobaric hypoxia stimulates endothelin-1 gene expression in the rat","volume":"263","author":"Elton","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.cell.2013.12.013_bib16","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nature04404","article-title":"GABA regulates synaptic integration of newly generated neurons in the adult brain","volume":"439","author":"Ge","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cell.2013.12.013_bib17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/path.1711380203","article-title":"Hyperplasia of the carotid body","volume":"138","author":"Heath","year":"1982","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.cell.2013.12.013_bib18","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nn1265","article-title":"Dopamine depletion impairs precursor cell proliferation in Parkinson disease","volume":"7","author":"H\u00f6glinger","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2013.12.013_bib19","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/0092-8674(94)90017-5","article-title":"Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice","volume":"79","author":"Hosoda","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.cell.2013.12.013_bib20","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1007\/s00018-009-0143-y","article-title":"Breathing at high altitude","volume":"66","author":"Joseph","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cell.2013.12.013_bib21","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2013.12.013_bib22","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.cell.2007.10.006","article-title":"Taking neural crest stem cells to new heights","volume":"131","author":"Kokovay","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.cell.2013.12.013_bib23","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1254\/jphs.11R13CP","article-title":"Regulations of astrocytic functions by endothelins: roles in the pathophysiological responses of damaged brains","volume":"118","author":"Koyama","year":"2012","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.cell.2013.12.013_bib24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.neuro.051508.135600","article-title":"The glial nature of embryonic and adult neural stem cells","volume":"32","author":"Kriegstein","year":"2009","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.cell.2013.12.013_bib25","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/nn1522","article-title":"Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors","volume":"8","author":"Liu","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2013.12.013_bib26","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.physiol.63.1.259","article-title":"Cellular mechanism of oxygen sensing","volume":"63","author":"L\u00f3pez-Barneo","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cell.2013.12.013_bib27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0165-1838(94)00179-N","article-title":"Endothelins and rat carotid body: autoradiographic and functional pharmacological studies","volume":"53","author":"McQueen","year":"1995","journal-title":"J.\u00a0Auton. Nerv. Syst."},{"key":"10.1016\/j.cell.2013.12.013_bib28","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2013.12.013_bib29","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.stem.2010.07.007","article-title":"Oxygen in stem cell biology: a critical component of the stem cell niche","volume":"7","author":"Mohyeldin","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2013.12.013_bib30","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1523\/JNEUROSCI.20-19-07370.2000","article-title":"Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells","volume":"20","author":"Morrison","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2013.12.013_bib31","first-page":"L95","article-title":"Endothelin-A receptor antagonist prevents acute hypoxia-induced pulmonary hypertension in the rat","volume":"268","author":"Oparil","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.cell.2013.12.013_bib32","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.resp.2007.02.009","article-title":"Mechanisms of acute oxygen sensing by the carotid body: lessons from genetically modified animals","volume":"157","author":"Ortega-S\u00e1enz","year":"2007","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.cell.2013.12.013_bib33","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1085\/jgp.200910302","article-title":"Carotid body chemosensory responses in mice deficient of TASK channels","volume":"135","author":"Ortega-S\u00e1enz","year":"2010","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.cell.2013.12.013_bib34","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1097\/00001756-199912160-00003","article-title":"Role of ET-1 in hypoxia-induced mitosis of cultured rat carotid body chemoreceptors","volume":"10","author":"Paciga","year":"1999","journal-title":"Neuroreport"},{"key":"10.1016\/j.cell.2013.12.013_bib35","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/jcp.21812","article-title":"The role of oxygen in regulating neural stem cells in development and disease","volume":"220","author":"Panchision","year":"2009","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.cell.2013.12.013_bib36","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.cell.2007.07.043","article-title":"Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body","volume":"131","author":"Pardal","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.cell.2013.12.013_bib37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0034-5687(98)00026-7","article-title":"Time domains of the hypoxic ventilatory response","volume":"112","author":"Powell","year":"1998","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.cell.2013.12.013_bib38","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0031-6997(25)06809-7","article-title":"Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology","volume":"46","author":"Rubanyi","year":"1994","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.cell.2013.12.013_bib39","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1210\/mend.12.2.0064","article-title":"Endothelin-1 is a potent survival factor for c-Myc-dependent apoptosis","volume":"12","author":"Shichiri","year":"1998","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.cell.2013.12.013_bib40","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/990040","article-title":"The temporal requirement for endothelin receptor-B signalling during neural crest development","volume":"402","author":"Shin","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.cell.2013.12.013_bib41","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/nature11306","article-title":"Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision","volume":"489","author":"Song","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2013.12.013_bib42","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0895-3988(10)60066-9","article-title":"Gender differences in pulmonary inflammation following systemic cadmium administration in rats","volume":"23","author":"Stosic","year":"2010","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.cell.2013.12.013_bib43","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.stem.2011.09.010","article-title":"Metabolic regulation of hematopoietic stem cells in the hypoxic niche","volume":"9","author":"Suda","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2013.12.013_bib44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1113\/jphysiol.2003.052415","article-title":"Denervation of carotid baro- and chemoreceptors in humans","volume":"553","author":"Timmers","year":"2003","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.cell.2013.12.013_bib45","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.neuron.2005.08.023","article-title":"GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells","volume":"47","author":"Tozuka","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2013.12.013_bib46","doi-asserted-by":"crossref","first-page":"10208","DOI":"10.1073\/pnas.91.21.10208","article-title":"Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells","volume":"91","author":"Ure\u00f1a","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2013.12.013_bib47","doi-asserted-by":"crossref","first-page":"C1130","DOI":"10.1152\/ajpcell.1994.267.4.C1130","article-title":"Endothelins stimulate mitogen-activated protein kinase cascade through either ETA or ETB","volume":"267","author":"Wang","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.cell.2013.12.013_bib48","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and functional implications of adult neurogenesis","volume":"132","author":"Zhao","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.cell.2013.12.013_bib49","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nature02033","article-title":"A gene expression atlas of the central nervous system based on bacterial artificial chromosomes","volume":"425","author":"Gong","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.cell.2013.12.013_bib50","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1073\/pnas.030522297","article-title":"Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium","volume":"97","author":"Pardal","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2013.12.013_bib51","first-page":"4010","article-title":"Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth","volume":"60","author":"Ryan","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2013.12.013_bib52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/gene.10008","article-title":"hGFAP-cre transgenic mice for manipulation of glial and neuronal function in\u00a0vivo","volume":"31","author":"Zhuo","year":"2001","journal-title":"Genesis"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286741301547X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286741301547X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T11:40:03Z","timestamp":1746099603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009286741301547X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":52,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S009286741301547X"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2013.12.013","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718243239.793490185","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An O2-Sensitive Glomus Cell-Stem Cell Synapse Induces Carotid Body Growth in Chronic Hypoxia","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2013.12.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}