{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:27:47Z","timestamp":1791898067351,"version":"4.3.4"},"reference-count":92,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T00:00:00Z","timestamp":1422576000000},"content-version":"vor","delay-in-days":394,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.cell.2014.01.006","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T09:45:32Z","timestamp":1400492732000},"page":"456-468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":224,"title":["Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium"],"prefix":"10.1016","volume":"156","author":[{"given":"Marzena","family":"Schiwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Weisheit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Franken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Gutweiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akanksha","family":"Dixit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Meyer-Schwesinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith-Mira","family":"Pohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas\u00a0J.","family":"Maurice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Thiebes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Quast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Fuhrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Baumgarten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin\u00a0J.","family":"Lohse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghislain","family":"Opdenakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Bernhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Bucala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Panzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar","family":"Kolanus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann-Josef","family":"Gr\u00f6ne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalio","family":"Garbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Kastenm\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Percy\u00a0A.","family":"Knolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kurts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel\u00a0R.","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2014.01.006_bib1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev-immunol-020711-074942","article-title":"Neutrophil function: from mechanisms to disease","volume":"30","author":"Amulic","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1084550","article-title":"Intracellular bacterial biofilm-like pods in urinary tract infections","volume":"301","author":"Anderson","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.cell.2014.01.006_bib3","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1126\/science.1142883","article-title":"Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior","volume":"317","author":"Auffray","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.cell.2014.01.006_bib4","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.4049\/jimmunol.168.7.3536","article-title":"The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF","volume":"168","author":"Belge","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib5","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.4049\/jimmunol.181.6.3733","article-title":"Macrophage polarization in bacterial infections","volume":"181","author":"Benoit","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib6","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1128\/jb.152.3.1241-1247.1982","article-title":"Cloning of the chromosomal determinants encoding hemolysin production and mannose-resistant hemagglutination in Escherichia coli","volume":"152","author":"Berger","year":"1982","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.cell.2014.01.006_bib7","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nm1567","article-title":"MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment","volume":"13","author":"Bernhagen","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2014.01.006_bib8","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.immuni.2010.11.011","article-title":"Neutrophils, from marrow to microbes","volume":"33","author":"Borregaard","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2014.01.006_bib9","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.it.2011.04.009","article-title":"Neutrophil clearance: when the party is over, clean-up begins","volume":"32","author":"Bratton","year":"2011","journal-title":"Trends Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib10","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1126\/science.8036519","article-title":"Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog","volume":"265","author":"Cacalano","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.cell.2014.01.006_bib11","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/nature04651","article-title":"Chemokines enhance immunity by guiding naive CD8+ T\u00a0cells to sites of CD4+ T\u00a0cell-dendritic cell interaction","volume":"440","author":"Castellino","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cell.2014.01.006_bib12","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1189\/jlb.0804464","article-title":"CCL5-enhanced human immature dendritic cell migration through the basement membrane in\u00a0vitro depends on matrix metalloproteinase-9","volume":"79","author":"Chabot","year":"2006","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.cell.2014.01.006_bib13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1189\/jlb.1004612","article-title":"Regulation of matrix metalloproteinase-9 release from IL-8-stimulated human neutrophils","volume":"78","author":"Chakrabarti","year":"2005","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.cell.2014.01.006_bib14","doi-asserted-by":"crossref","first-page":"L702","DOI":"10.1152\/ajplung.00194.2013","article-title":"Heterogeneity of lung mononuclear phagocytes during pneumonia: contribution of chemokine receptors","volume":"305","author":"Chen","year":"2013","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.cell.2014.01.006_bib15","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1196\/annals.1326.018","article-title":"Neutrophil transepithelial migration and epithelial barrier function in IBD: potential targets for inhibiting neutrophil trafficking","volume":"1072","author":"Chin","year":"2006","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.cell.2014.01.006_bib16","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1182\/blood-2007-12-077917","article-title":"The phagocytes: neutrophils and monocytes","volume":"112","author":"Dale","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.cell.2014.01.006_bib17","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1002\/art.21978","article-title":"Rates of serious infection, including site-specific and bacterial intracellular infection, in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: results from the British Society for Rheumatology Biologics Register","volume":"54","author":"Dixon","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cell.2014.01.006_bib18","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1189\/jlb.0411193","article-title":"A novel p38-MAPK signaling axis modulates neutrophil biology in head and neck cancer","volume":"91","author":"Dumitru","year":"2012","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.cell.2014.01.006_bib19","doi-asserted-by":"crossref","first-page":"6100","DOI":"10.1128\/IAI.00881-06","article-title":"Tumor necrosis factor alpha- and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearance","volume":"74","author":"Engel","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2014.01.006_bib20","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.4049\/jimmunol.181.8.5579","article-title":"CCR2 mediates homeostatic and inflammatory release of Gr1(high) monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection","volume":"181","author":"Engel","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib21","doi-asserted-by":"crossref","first-page":"11658","DOI":"10.1074\/jbc.M607705200","article-title":"Murine CXCR1 is a functional receptor for GCP-2\/CXCL6 and interleukin-8\/CXCL8","volume":"282","author":"Fan","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2014.01.006_bib22","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/1074-7613(95)90001-2","article-title":"Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice","volume":"2","author":"Flynn","year":"1995","journal-title":"Immunity"},{"issue":"Suppl 1A","key":"10.1016\/j.cell.2014.01.006_bib23","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1016\/S0002-9343(02)01054-9","article-title":"Epidemiology of urinary tract infections: incidence, morbidity, and economic costs","volume":"113","author":"Foxman","year":"2002","journal-title":"Am. J. Med."},{"key":"10.1016\/j.cell.2014.01.006_bib24","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1084\/jem.192.6.881","article-title":"Interleukin 8 receptor deficiency confers susceptibility to acute experimental pyelonephritis and may have a human counterpart","volume":"192","author":"Frend\u00e9us","year":"2000","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2014.01.006_bib25","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1194637","article-title":"Fate mapping analysis reveals that adult microglia derive from primitive macrophages","volume":"330","author":"Ginhoux","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.cell.2014.01.006_bib26","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1128\/iai.65.8.3451-3456.1997","article-title":"Role of epithelial interleukin-8 (IL-8) and neutrophil IL-8 receptor A in\u00a0Escherichia coli-induced transuroepithelial neutrophil migration","volume":"65","author":"Godaly","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2014.01.006_bib27","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.4049\/jimmunol.162.5.3037","article-title":"Macrophage inflammatory protein-2 is required for neutrophil passage across the epithelial barrier of the infected urinary tract","volume":"162","author":"Hang","year":"1999","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib28","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1165\/rcmb.2003-0370OC","article-title":"Matrix metalloproteinase-9-deficient dendritic cells have impaired migration through tracheal epithelial tight junctions","volume":"30","author":"Ichiyasu","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cell.2014.01.006_bib29","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000136335","article-title":"The role of neutrophils and monocytes in innate immunity","volume":"15","author":"Kantari","year":"2008","journal-title":"Contrib. Microbiol."},{"key":"10.1016\/j.cell.2014.01.006_bib30","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJMoa011110","article-title":"Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent","volume":"345","author":"Keane","year":"2001","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2014.01.006_bib31","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1021\/cn200111m","article-title":"A simple method for quantifying functional selectivity and agonist bias","volume":"3","author":"Kenakin","year":"2012","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.cell.2014.01.006_bib32","doi-asserted-by":"crossref","first-page":"23214","DOI":"10.1074\/jbc.M402125200","article-title":"Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1\/2 activation by the two endogenous ligands for the CC chemokine receptor 7","volume":"279","author":"Kohout","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2014.01.006_bib33","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib34","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.4049\/jimmunol.163.3.1537","article-title":"Regulation of macrophage chemokine expression by lipopolysaccharide in\u00a0vitro and in\u00a0vivo","volume":"163","author":"Kopydlowski","year":"1999","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib35","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1053\/j.gastro.2005.07.047","article-title":"Anti-tumor necrosis factor therapy for ulcerative colitis","volume":"129","author":"Kountouras","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cell.2014.01.006_bib36","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nri3523","article-title":"The immune system and kidney disease: basic concepts and clinical implications","volume":"13","author":"Kurts","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib37","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature06887","article-title":"Rapid leukocyte migration by integrin-independent flowing and squeezing","volume":"453","author":"L\u00e4mmermann","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cell.2014.01.006_bib38","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.4049\/jimmunol.178.4.2000","article-title":"Distinct differentiation potential of blood monocyte subsets in the lung","volume":"178","author":"Landsman","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib39","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3181\/0703-MR-72","article-title":"Structure and function of basement membranes","volume":"232","author":"LeBleu","year":"2007","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.cell.2014.01.006_bib40","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nri2156","article-title":"Getting to the site of inflammation: the leukocyte adhesion cascade updated","volume":"7","author":"Ley","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib41","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1002\/art.21386","article-title":"Infections in patients with rheumatoid arthritis treated with biologic agents","volume":"52","author":"Listing","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cell.2014.01.006_bib42","first-page":"1105","article-title":"Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis","volume":"151","author":"Luca","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cell.2014.01.006_bib43","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib44","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1093\/emboj\/19.12.2803","article-title":"Type 1 pilus-mediated bacterial invasion of bladder epithelial cells","volume":"19","author":"Martinez","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2014.01.006_bib45","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nature06246","article-title":"Recognition of microorganisms and activation of the immune response","volume":"449","author":"Medzhitov","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cell.2014.01.006_bib46","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib47","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/rheumatology\/keh483","article-title":"Anti-TNF-alpha therapies: they are all the same (aren\u2019t they?)","volume":"44","author":"Mpofu","year":"2005","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.cell.2014.01.006_bib48","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1126\/science.282.5393.1494","article-title":"Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli","volume":"282","author":"Mulvey","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.cell.2014.01.006_bib49","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nature08511","article-title":"CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help","volume":"462","author":"Nakanishi","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.cell.2014.01.006_bib50","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nri1785","article-title":"Neutrophils and immunity: challenges and opportunities","volume":"6","author":"Nathan","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib51","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nrm2889","article-title":"Breaching multiple barriers: leukocyte motility through venular walls and the interstitium","volume":"11","author":"Nourshargh","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2014.01.006_bib52","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/aje\/kwh014","article-title":"History of urinary tract infection and risk of renal cell carcinoma","volume":"159","author":"Parker","year":"2004","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.cell.2014.01.006_bib53","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0092-8674(93)90134-C","article-title":"Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection","volume":"73","author":"Pfeffer","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.cell.2014.01.006_bib54","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.immuni.2012.10.016","article-title":"Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen","volume":"38","author":"Plantinga","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2014.01.006_bib55","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.imlet.2008.05.009","article-title":"Mucosal macrophages and the regulation of immune responses in the intestine","volume":"119","author":"Platt","year":"2008","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.cell.2014.01.006_bib56","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.pharmtox.010909.105800","article-title":"Molecular mechanism of \u03b2-arrestin-biased agonism at seven-transmembrane receptors","volume":"52","author":"Reiter","year":"2012","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.cell.2014.01.006_bib57","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1073\/pnas.1007811108","article-title":"Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology","volume":"108","author":"Roulis","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2014.01.006_bib58","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/art.30203","article-title":"Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice","volume":"63","author":"Santos","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cell.2014.01.006_bib59","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/j.1476-5381.2011.01648.x","article-title":"Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3","volume":"166","author":"Scholten","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cell.2014.01.006_bib60","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1126\/science.1219179","article-title":"A lineage of myeloid cells independent of Myb and hematopoietic stem cells","volume":"336","author":"Schulz","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.cell.2014.01.006_bib61","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/ni.1848","article-title":"Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs","volume":"11","author":"Semmling","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib62","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"Serbina","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib63","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1074-7613(03)00171-7","article-title":"TNF\/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection","volume":"19","author":"Serbina","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2014.01.006_bib64","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.immuni.2008.12.020","article-title":"Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin","volume":"30","author":"Shulman","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.cell.2014.01.006_bib65","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/ni1129","article-title":"Cognate CD4(+) T\u00a0cell licensing of dendritic cells in CD8(+) T\u00a0cell immunity","volume":"5","author":"Smith","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib66","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nri2779","article-title":"Phagocyte partnership during the onset and resolution of inflammation","volume":"10","author":"Soehnlein","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib67","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.berh.2006.08.010","article-title":"Infection and musculoskeletal conditions: Bacterial and opportunistic infections during anti-TNF therapy","volume":"20","author":"Strangfeld","year":"2006","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.cell.2014.01.006_bib68","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/ki.2011.257","article-title":"Acute pyelonephritis and renal scarring are caused by dysfunctional innate immunity in mCxcr2 heterozygous mice","volume":"80","author":"Svensson","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.cell.2014.01.006_bib69","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrurol.2011.44","article-title":"Matrix metalloproteinases and their clinical relevance in urinary bladder cancer","volume":"8","author":"Szarvas","year":"2011","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.cell.2014.01.006_bib70","doi-asserted-by":"crossref","first-page":"F1351","DOI":"10.1152\/ajprenal.00037.2012","article-title":"Matrix metalloproteinases in kidney homeostasis and diseases","volume":"302","author":"Tan","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.cell.2014.01.006_bib71","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1056\/NEJM199710093371502","article-title":"A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn\u2019s disease. Crohn\u2019s Disease cA2 Study Group","volume":"337","author":"Targan","year":"1997","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2014.01.006_bib72","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1182\/blood-2004-08-3346","article-title":"The transcriptional program of terminal granulocytic differentiation","volume":"105","author":"Theilgaard-M\u00f6nch","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.cell.2014.01.006_bib73","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1681\/ASN.2010101072","article-title":"Kidney dendritic cells induce innate immunity against bacterial pyelonephritis","volume":"22","author":"Tittel","year":"2011","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2014.01.006_bib74","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nmeth.1905","article-title":"Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice","volume":"9","author":"Tittel","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2014.01.006_bib75","doi-asserted-by":"crossref","unstructured":"Tittel, A.P., Heuser, C., and Kurts, C. (2013). Mouse Model for Pyelonephritis. Curr. Protoc. Immunol. edited by John E Coligan [et\u00a0al] Chapter 15, Unit 15 23 11\u201319.","DOI":"10.1002\/0471142735.im1523s101"},{"key":"10.1016\/j.cell.2014.01.006_bib76","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1182\/blood.V96.8.2673","article-title":"Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact","volume":"96","author":"Van den Steen","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.cell.2014.01.006_bib77","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/10409230290771546","article-title":"Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9)","volume":"37","author":"Van den Steen","year":"2002","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.cell.2014.01.006_bib78","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nmeth.2371","article-title":"Zymography methods for visualizing hydrolytic enzymes","volume":"10","author":"Vandooren","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2014.01.006_bib79","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2353\/ajpath.2010.090510","article-title":"Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation","volume":"176","author":"Voisin","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cell.2014.01.006_bib80","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1084\/jem.20051210","article-title":"Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils","volume":"203","author":"Wang","year":"2006","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2014.01.006_bib81","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.3201\/eid1510.090310","article-title":"Nontuberculous mycobacteria infections and anti-tumor necrosis factor-alpha therapy","volume":"15","author":"Winthrop","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.cell.2014.01.006_bib82","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1093\/rheumatology\/keq045","article-title":"Neutrophil function in inflammation and inflammatory diseases","volume":"49","author":"Wright","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.cell.2014.01.006_bib83","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nm0397-320","article-title":"Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome","volume":"3","author":"Donnelly","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2014.01.006_bib84","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1172\/JCI6886","article-title":"Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions","volume":"104","author":"Dubois","year":"1999","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2014.01.006_bib85","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/372560a0","article-title":"Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice","volume":"372","author":"Erickson","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.cell.2014.01.006_bib86","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1128\/MCB.20.11.4106-4114.2000","article-title":"Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion","volume":"20","author":"Jung","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cell.2014.01.006_bib87","doi-asserted-by":"crossref","first-page":"12053","DOI":"10.1073\/pnas.94.22.12053","article-title":"Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2","volume":"94","author":"Kuziel","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2014.01.006_bib88","doi-asserted-by":"crossref","first-page":"527","DOI":"10.4049\/jimmunol.1001767","article-title":"A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB\/NZW F1 and MRL\/lpr mice","volume":"186","author":"Leng","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2014.01.006_bib89","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1084\/jem.184.4.1397","article-title":"Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response","volume":"184","author":"Pasparakis","year":"1996","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2014.01.006_bib90","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/364798a0","article-title":"Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes","volume":"364","author":"Rothe","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.cell.2014.01.006_bib91","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF00217308","article-title":"Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate. An enzyme-histochemical study","volume":"238","author":"van Rooijen","year":"1984","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.cell.2014.01.006_bib92","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.immuni.2012.05.008","article-title":"The chemokine superfamily revisited","volume":"36","author":"Zlotnik","year":"2012","journal-title":"Immunity"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867414000166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867414000166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:23:04Z","timestamp":1758799384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867414000166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":92,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0092867414000166"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2014.01.006","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718262217.793492999","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2014.01.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}