{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:02:32Z","timestamp":1792724552152,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,16]],"date-time":"2016-07-16T00:00:00Z","timestamp":1468627200000},"content-version":"vor","delay-in-days":381,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.cell.2015.06.034","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T11:45:34Z","timestamp":1437047134000},"page":"375-390","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1103,"title":["FOXG1-Dependent Dysregulation of GABA\/Glutamate Neuron Differentiation in Autism Spectrum Disorders"],"prefix":"10.1016","volume":"162","author":[{"given":"Jessica","family":"Mariani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfilippo","family":"Coppola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexej","family":"Abyzov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Provini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Tomasini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Amenduni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Szekely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Palejev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Gerstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena L.","family":"Grigorenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Chawarska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A.","family":"Pelphrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Howe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora M.","family":"Vaccarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2015.06.034_bib1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/2040-2392-4-36","article-title":"SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs)","volume":"4","author":"Abrahams","year":"2013","journal-title":"Mol. autism"},{"key":"10.1016\/j.cell.2015.06.034_bib2","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1101\/gr.114876.110","article-title":"CNVnator: an approach to discover, genotype, and characterize typical and atypical CNVs from family and population genome sequencing","volume":"21","author":"Abyzov","year":"2011","journal-title":"Genome Res."},{"key":"10.1016\/j.cell.2015.06.034_bib3","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nature11629","article-title":"Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells","volume":"492","author":"Abyzov","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2015.06.034_bib4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ajhg.2008.05.015","article-title":"FOXG1 is responsible for the congenital variant of Rett syndrome","volume":"83","author":"Ariani","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cell.2015.06.034_bib5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10048-009-0220-2","article-title":"Revisiting the phenotype associated with FOXG1 mutations: two novel cases of congenital Rett variant","volume":"11","author":"Bahi-Buisson","year":"2010","journal-title":"Neurogenetics"},{"key":"10.1016\/j.cell.2015.06.034_bib6","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1212\/WNL.58.3.428","article-title":"Minicolumnar pathology in autism","volume":"58","author":"Casanova","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.cell.2015.06.034_bib7","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1177\/1073858403253552","article-title":"Disruption in the inhibitory architecture of the cell minicolumn: implications for autism","volume":"9","author":"Casanova","year":"2003","journal-title":"Neuroscientist"},{"key":"10.1016\/j.cell.2015.06.034_bib8","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1124\/pr.57.4.4","article-title":"International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels","volume":"57","author":"Catterall","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.cell.2015.06.034_bib9","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.biopsych.2013.04.018","article-title":"Adjusting head circumference for covariates in autism: clinical correlates of a highly heritable continuous trait","volume":"74","author":"Chaste","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.cell.2015.06.034_bib10","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1001\/archgenpsychiatry.2011.106","article-title":"Early generalized overgrowth in boys with autism","volume":"68","author":"Chawarska","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.cell.2015.06.034_bib11","doi-asserted-by":"crossref","first-page":"14646","DOI":"10.1073\/pnas.1211591109","article-title":"Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome","volume":"109","author":"Cheah","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2015.06.034_bib12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1212\/WNL.57.2.245","article-title":"Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study","volume":"57","author":"Courchesne","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.cell.2015.06.034_bib13","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.neuron.2007.10.016","article-title":"Mapping early brain development in autism","volume":"56","author":"Courchesne","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2015.06.034_bib14","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1001\/jama.2011.1638","article-title":"Neuron number and size in prefrontal cortex of children with autism","volume":"306","author":"Courchesne","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.cell.2015.06.034_bib15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: Database for Annotation, Visualization, and Integrated Discovery","volume":"4","author":"Dennis","year":"2003","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2015.06.034_bib16","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.neuron.2007.12.001","article-title":"Correction of fragile X syndrome in mice","volume":"56","author":"D\u00f6len","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2015.06.034_bib17","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.stem.2008.09.002","article-title":"Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals","volume":"3","author":"Eiraku","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cell.2015.06.034_bib18","doi-asserted-by":"crossref","first-page":"13764","DOI":"10.1073\/pnas.1111093108","article-title":"Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function","volume":"108","author":"Etherton","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2015.06.034_bib19","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1101\/gad.1743709","article-title":"Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain","volume":"23","author":"Fasano","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2015.06.034_bib20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/bioinformatics\/btq643","article-title":"RSEQtools: a modular framework to analyze RNA-Seq data using compact, anonymized data summaries","volume":"27","author":"Habegger","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2015.06.034_bib21","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nature11356","article-title":"Autistic-like behaviour in Scn1a+\/- mice and rescue by enhanced GABA-mediated neurotransmission","volume":"489","author":"Han","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2015.06.034_bib22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1126\/science.1090674","article-title":"Foxg1 suppresses early cortical cell fate","volume":"303","author":"Hanashima","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.cell.2015.06.034_bib23","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainres.2009.09.120","article-title":"Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders","volume":"1309","author":"Hutsler","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.cell.2015.06.034_bib24","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nature10523","article-title":"Spatio-temporal transcriptome of the human brain","volume":"478","author":"Kang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cell.2015.06.034_bib25","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/jmg.2010.087528","article-title":"The core FOXG1 syndrome phenotype consists of postnatal microcephaly, severe mental retardation, absent language, dyskinesia, and corpus callosum hypogenesis","volume":"48","author":"Kort\u00fcm","year":"2011","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.cell.2015.06.034_bib26","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1002\/ajmg.a.31465","article-title":"Head circumference and height in autism: a study by the Collaborative Program of Excellence in Autism","volume":"140","author":"Lainhart","year":"2006","journal-title":"Am. J. Med. Genet. A."},{"key":"10.1016\/j.cell.2015.06.034_bib27","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature12517","article-title":"Cerebral organoids model human brain development and microcephaly","volume":"501","author":"Lancaster","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cell.2015.06.034_bib28","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.cell.2015.06.034_bib29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1600-0404.2009.01234.x","article-title":"Parvalbumin-, calbindin-, and calretinin-immunoreactive hippocampal interneuron density in autism","volume":"121","author":"Lawrence","year":"2010","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.cell.2015.06.034_bib30","doi-asserted-by":"crossref","first-page":"12770","DOI":"10.1073\/pnas.1202944109","article-title":"Modeling human cortical development in\u00a0vitro using induced pluripotent stem cells","volume":"109","author":"Mariani","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2015.06.034_bib31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ydbio.2005.04.005","article-title":"Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis","volume":"283","author":"Martynoga","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cell.2015.06.034_bib32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1136\/jmg.2009.067884","article-title":"Novel FOXG1 mutations associated with the congenital variant of Rett syndrome","volume":"47","author":"Mencarelli","year":"2010","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.cell.2015.06.034_bib33","doi-asserted-by":"crossref","first-page":"5903","DOI":"10.1523\/JNEUROSCI.5270-06.2007","article-title":"Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation","volume":"27","author":"Ogiwara","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2015.06.034_bib34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nmeth.1591","article-title":"A more efficient method to generate integration-free human iPS cells","volume":"8","author":"Okita","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cell.2015.06.034_bib35","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.cell.2013.10.031","article-title":"Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism","volume":"155","author":"Parikshak","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.cell.2015.06.034_bib36","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/00004583-199604000-00020","article-title":"Regional brain enlargement in autism: a magnetic resonance imaging study","volume":"35","author":"Piven","year":"1996","journal-title":"J.\u00a0Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.cell.2015.06.034_bib37","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fncel.2013.00085","article-title":"Developmental regulation of GABAergic signalling in the hippocampus of neuroligin 3 R451C knock-in mice: an animal model of Autism","volume":"7","author":"Pizzarelli","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.cell.2015.06.034_bib38","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2015.06.034_bib39","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2015.06.034_bib40","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/WCO.0b013e328336eb13","article-title":"Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder","volume":"23","author":"Rubenstein","year":"2010","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.cell.2015.06.034_bib41","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/s00439-005-1310-3","article-title":"Haploinsufficiency of novel FOXG1B variants in a patient with severe mental retardation, brain malformations and microcephaly","volume":"117","author":"Shoichet","year":"2005","journal-title":"Hum. Genet."},{"key":"10.1016\/j.cell.2015.06.034_bib42","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2015.06.034_bib43","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/nature07456","article-title":"Neuroligins and neurexins link synaptic function to cognitive disease","volume":"455","author":"S\u00fcdhof","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cell.2015.06.034_bib44","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1126\/science.1146221","article-title":"A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice","volume":"318","author":"Tabuchi","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.cell.2015.06.034_bib45","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.neuron.2014.07.040","article-title":"Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits","volume":"83","author":"Tang","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2015.06.034_bib46","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cell.2015.06.034_bib47","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10803-008-0653-8","article-title":"Regulation of cerebral cortical size and neuron number by fibroblast growth factors: implications for autism","volume":"39","author":"Vaccarino","year":"2009","journal-title":"J.\u00a0Autism Dev. Disord."},{"key":"10.1016\/j.cell.2015.06.034_bib48","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1469-7610.2008.02010.x","article-title":"Autism and autism spectrum disorders: diagnostic issues for the coming decade","volume":"50","author":"Volkmar","year":"2009","journal-title":"J.\u00a0Child Psychol. Psychiatry"},{"key":"10.1016\/j.cell.2015.06.034_bib49","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.cell.2013.10.020","article-title":"Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism","volume":"155","author":"Willsey","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.cell.2015.06.034_bib50","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/0896-6273(95)90262-7","article-title":"Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres","volume":"14","author":"Xuan","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2015.06.034_bib51","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/nn1754","article-title":"Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy","volume":"9","author":"Yu","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2015.06.034_bib52","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1101\/cshperspect.a009886","article-title":"Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities","volume":"4","author":"Zoghbi","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286741500759X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286741500759X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T18:52:47Z","timestamp":1537469567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009286741500759X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S009286741500759X"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2015.06.034","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725649028.793508435","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FOXG1-Dependent Dysregulation of GABA\/Glutamate Neuron Differentiation in Autism Spectrum Disorders","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2015.06.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}