{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:13:03Z","timestamp":1790507583043,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,27]],"date-time":"2016-08-27T00:00:00Z","timestamp":1472256000000},"content-version":"vor","delay-in-days":392,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.cell.2015.07.058","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T15:52:05Z","timestamp":1440690725000},"page":"987-1002","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"title":["Viral and Cellular Genomes Activate Distinct DNA Damage Responses"],"prefix":"10.1016","volume":"162","author":[{"given":"Govind\u00a0A.","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clodagh\u00a0C.","family":"O\u2019Shea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2015.07.058_bib1","doi-asserted-by":"crossref","first-page":"9169","DOI":"10.1073\/pnas.1403565111","article-title":"DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin","volume":"111","author":"Ayrapetov","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2015.07.058_bib2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature01368","article-title":"DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation","volume":"421","author":"Bakkenist","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.cell.2015.07.058_bib3","doi-asserted-by":"crossref","first-page":"8173","DOI":"10.1073\/pnas.122228699","article-title":"Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX","volume":"99","author":"Bassing","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2015.07.058_bib4","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.1073\/pnas.90.12.5613","article-title":"Lethality induced by a single site-specific double-strand break in a dispensable yeast plasmid","volume":"90","author":"Bennett","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2015.07.058_bib5","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.1128\/JVI.00170-08","article-title":"A role for E1B-AP5 in ATR signaling pathways during adenovirus infection","volume":"82","author":"Blackford","year":"2008","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2015.07.058_bib6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1084\/jem.105.3.195","article-title":"Cytological and cytochemical studies of HeLa cells infected with adeno-viruses","volume":"105","author":"Boyer","year":"1957","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2015.07.058_bib7","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.4049\/jimmunol.1100040","article-title":"The DNA damage response induces IFN","volume":"187","author":"Brzostek-Racine","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2015.07.058_bib8","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.celrep.2014.10.060","article-title":"Activation of DNA damage response signaling by condensed chromatin","volume":"9","author":"Burgess","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2015.07.058_bib9","doi-asserted-by":"crossref","first-page":"6610","DOI":"10.1093\/emboj\/cdg630","article-title":"The Mre11 complex is required for ATM activation and the G2\/M checkpoint","volume":"22","author":"Carson","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2015.07.058_bib10","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/emboj.2009.15","article-title":"Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection","volume":"28","author":"Carson","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2015.07.058_bib11","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1126\/science.1069398","article-title":"Genomic instability in mice lacking histone H2AX","volume":"296","author":"Celeste","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.cell.2015.07.058_bib12","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1073\/pnas.76.2.655","article-title":"Adenovirus DNA replication in\u00a0vitro","volume":"76","author":"Challberg","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2015.07.058_bib13","doi-asserted-by":"crossref","first-page":"6232","DOI":"10.1128\/JVI.00384-13","article-title":"Role of E1B55K in E4orf6\/E1B55K E3 ligase complexes formed by different human adenovirus serotypes","volume":"87","author":"Cheng","year":"2013","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2015.07.058_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.molcel.2010.09.019","article-title":"The DNA damage response: making it safe to play with knives","volume":"40","author":"Ciccia","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2015.07.058_bib15","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1111\/j.1751-1097.2011.00995.x","article-title":"\u03b3H2Ax: biomarker of damage or functional participant in DNA repair \u201call that glitters is not gold!\u201d","volume":"87","author":"Cleaver","year":"2011","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.cell.2015.07.058_bib16","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nrc3399","article-title":"DNA repair dysregulation from cancer driver to therapeutic target","volume":"12","author":"Curtin","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cell.2015.07.058_bib17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nchembio.63","article-title":"A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex","volume":"4","author":"Dupr\u00e9","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cell.2015.07.058_bib18","doi-asserted-by":"crossref","first-page":"426","DOI":"10.4161\/cc.2.5.509","article-title":"Focusing on foci: H2AX and the recruitment of DNA-damage response factors","volume":"2","author":"Fernandez-Capetillo","year":"2003","journal-title":"Cell Cycle"},{"key":"10.1016\/j.cell.2015.07.058_bib19","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.dnarep.2004.03.024","article-title":"H2AX: the histone guardian of the genome","volume":"3","author":"Fernandez-Capetillo","year":"2004","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.cell.2015.07.058_bib20","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1021\/jm301859s","article-title":"Discovery of 4-4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in\u00a0vivo antitumor activity","volume":"56","author":"Foote","year":"2013","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.cell.2015.07.058_bib21","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1128\/JVI.01748-10","article-title":"Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection","volume":"85","author":"Forrester","year":"2011","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2015.07.058_bib22","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1158\/0008-5472.CAN-05-4603","article-title":"The DNA damage response arouses the immune system","volume":"66","author":"Gasser","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2015.07.058_bib23","doi-asserted-by":"crossref","first-page":"8687","DOI":"10.1128\/JVI.00376-13","article-title":"The kinase activity of ataxia-telangiectasia mutated interferes with adenovirus E4 mutant DNA replication","volume":"87","author":"Gautam","year":"2013","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2015.07.058_bib24","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1126\/science.1140735","article-title":"An oncogene-induced DNA damage model for cancer development","volume":"319","author":"Halazonetis","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.cell.2015.07.058_bib25","doi-asserted-by":"crossref","first-page":"R914","DOI":"10.1016\/S0960-9822(00)80103-7","article-title":"Evolution: the long evolutionary reach of viruses","volume":"9","author":"Hendrix","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cell.2015.07.058_bib26","doi-asserted-by":"crossref","first-page":"9152","DOI":"10.1158\/0008-5472.CAN-04-2727","article-title":"Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM","volume":"64","author":"Hickson","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2015.07.058_bib27","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/01.mph.0000153958.95486.6f","article-title":"Fatal adenovirus hepatitis during standard chemotherapy for childhood acute lymphoblastic leukemia","volume":"27","author":"Hough","year":"2005","journal-title":"J.\u00a0Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.cell.2015.07.058_bib28","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.cell.2015.07.058_bib29","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1535-6108(02)00060-0","article-title":"Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents","volume":"1","author":"Johnson","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2015.07.058_bib30","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.celrep.2014.07.024","article-title":"A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance","volume":"8","author":"Khurana","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2015.07.058_bib31","doi-asserted-by":"crossref","first-page":"37538","DOI":"10.1074\/jbc.274.53.37538","article-title":"Substrate specificities and identification of putative substrates of ATM kinase family members","volume":"274","author":"Kim","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2015.07.058_bib32","series-title":"Fields virology","author":"Knipe","year":"2013"},{"key":"10.1016\/j.cell.2015.07.058_bib33","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.1128\/JVI.00380-12","article-title":"Replication-uncoupled histone deposition during adenovirus DNA replication","volume":"86","author":"Komatsu","year":"2012","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2015.07.058_bib34","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.1091496","article-title":"Direct activation of the ATM protein kinase by the Mre11\/Rad50\/Nbs1 complex","volume":"304","author":"Lee","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.cell.2015.07.058_bib35","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1126\/science.1108297","article-title":"ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex","volume":"308","author":"Lee","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.cell.2015.07.058_bib36","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1128\/JCM.01893-13","article-title":"Disseminated adenovirus infection in cancer patients presenting with focal pulmonary consolidation","volume":"52","author":"Lee","year":"2014","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.cell.2015.07.058_bib37","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.cell.2004.08.015","article-title":"Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins","volume":"118","author":"Lisby","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.cell.2015.07.058_bib38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.molcel.2005.11.025","article-title":"MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals","volume":"21","author":"Lou","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2015.07.058_bib39","doi-asserted-by":"crossref","first-page":"7376","DOI":"10.1073\/pnas.96.13.7376","article-title":"Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation","volume":"96","author":"Luo","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2015.07.058_bib40","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.virol.2007.03.049","article-title":"The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication","volume":"365","author":"Mathew","year":"2007","journal-title":"Virology"},{"key":"10.1016\/j.cell.2015.07.058_bib41","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.virol.2007.12.034","article-title":"Nbs1-dependent binding of Mre11 to adenovirus E4 mutant viral DNA is important for inhibiting DNA replication","volume":"374","author":"Mathew","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.cell.2015.07.058_bib42","doi-asserted-by":"crossref","first-page":"6899","DOI":"10.1128\/JVI.07119-11","article-title":"Coordinate regulation of DNA damage and type I interferon responses imposes an antiviral state that attenuates mouse gammaherpesvirus type 68 replication in primary macrophages","volume":"86","author":"Mboko","year":"2012","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2015.07.058_bib43","doi-asserted-by":"crossref","first-page":"5987","DOI":"10.1128\/JVI.00091-09","article-title":"Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication","volume":"83","author":"Nichols","year":"2009","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2015.07.058_bib44","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.1038\/sj.onc.1209047","article-title":"Viruses - seeking and destroying the tumor program","volume":"24","author":"O\u2019Shea","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.cell.2015.07.058_bib45","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ccr.2004.11.012","article-title":"Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity","volume":"6","author":"O\u2019Shea","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2015.07.058_bib46","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.cell.2012.08.035","article-title":"A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors","volume":"151","author":"Ou","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cell.2015.07.058_bib47","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1101\/gad.2021311","article-title":"Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications","volume":"25","author":"Polo","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2015.07.058_bib48","doi-asserted-by":"crossref","first-page":"5075","DOI":"10.1002\/j.1460-2075.1994.tb06837.x","article-title":"Adenovirus replication and transcription sites are spatially separated in the nucleus of infected cells","volume":"13","author":"Pombo","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2015.07.058_bib49","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0027-5107(96)00023-1","article-title":"DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes","volume":"355","author":"Povirk","year":"1996","journal-title":"Mutat. Res."},{"key":"10.1016\/j.cell.2015.07.058_bib50","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1101\/gad.926401","article-title":"Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex","volume":"15","author":"Querido","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2015.07.058_bib51","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0092-8674(77)90045-9","article-title":"Identification of a protein linked to the ends of adenovirus DNA","volume":"11","author":"Rekosh","year":"1977","journal-title":"Cell"},{"key":"10.1016\/j.cell.2015.07.058_bib52","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1083\/jcb.146.5.905","article-title":"Megabase chromatin domains involved in DNA double-strand breaks in\u00a0vivo","volume":"146","author":"Rogakou","year":"1999","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cell.2015.07.058_bib53","doi-asserted-by":"crossref","first-page":"8767","DOI":"10.1128\/JVI.00879-13","article-title":"Adenovirus E1A oncogene induces rereplication of cellular DNA and alters DNA replication dynamics","volume":"87","author":"Singhal","year":"2013","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2015.07.058_bib54","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1083\/jcb.200906064","article-title":"Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites","volume":"187","author":"So","year":"2009","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cell.2015.07.058_bib55","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/nature09307","article-title":"Heterochromatin silencing of p53 target genes by a small viral protein","volume":"466","author":"Soria","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.cell.2015.07.058_bib56","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1126\/science.1159051","article-title":"Activation of the cellular DNA damage response in the absence of DNA lesions","volume":"320","author":"Soutoglou","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.cell.2015.07.058_bib57","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/ncb1591","article-title":"Positional stability of single double-strand breaks in mammalian cells","volume":"9","author":"Soutoglou","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2015.07.058_bib58","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/pbc.21120","article-title":"Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia","volume":"50","author":"Steiner","year":"2008","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.cell.2015.07.058_bib59","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrm3047","article-title":"The MRE11 complex: starting from the ends","volume":"12","author":"Stracker","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2015.07.058_bib60","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nature00863","article-title":"Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex","volume":"418","author":"Stracker","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.cell.2015.07.058_bib61","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/acel.12246","article-title":"The replicometer is broken: telomeres activate cellular senescence in response to genotoxic stresses","volume":"13","author":"Suram","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/j.cell.2015.07.058_bib62","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0092-8674(80)90362-1","article-title":"DNA replication and the early to late transition in adenovirus infection","volume":"22","author":"Thomas","year":"1980","journal-title":"Cell"},{"key":"10.1016\/j.cell.2015.07.058_bib63","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.1093\/emboj\/cdg541","article-title":"Requirement of the MRN complex for ATM activation by DNA damage","volume":"22","author":"Uziel","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2015.07.058_bib64","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.micro.112408.134016","article-title":"Genomes in conflict: maintaining genome integrity during virus infection","volume":"64","author":"Weitzman","year":"2010","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.cell.2015.07.058_bib65","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1093\/nar\/25.15.2985","article-title":"Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells","volume":"25","author":"Xiao","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2015.07.058_bib66","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0960-9822(01)00019-7","article-title":"Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice","volume":"11","author":"Zhu","year":"2001","journal-title":"Curr. Biol."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867415009745?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867415009745?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T22:26:05Z","timestamp":1567117565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867415009745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0092867415009745"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2015.07.058","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Viral and Cellular Genomes Activate Distinct DNA Damage Responses","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2015.07.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}