{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:08:25Z","timestamp":1792022905600,"version":"4.4.0"},"reference-count":98,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T00:00:00Z","timestamp":1508457600000},"content-version":"vor","delay-in-days":384,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.cell.2016.07.055","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T12:33:03Z","timestamp":1476966783000},"page":"610-624","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":848,"title":["Malaria: Biology and Disease"],"prefix":"10.1016","volume":"167","author":[{"given":"Alan F.","family":"Cowman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Healer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danushka","family":"Marapana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2016.07.055_bib1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/voxs.12115","article-title":"Plasmodium knowlesi - an emerging pathogen","volume":"10 1","author":"Ahmed","year":"2015","journal-title":"ISBT Sci. Ser."},{"key":"10.1016\/j.cell.2016.07.055_bib2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature12876","article-title":"A molecular marker of artemisinin-resistant Plasmodium falciparum malaria","volume":"505","author":"Ariey","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.07.055_bib3","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1186\/1475-2875-13-418","article-title":"Primaquine: the risks and the benefits","volume":"13","author":"Ashley","year":"2014","journal-title":"Malar. J."},{"key":"10.1016\/j.cell.2016.07.055_bib4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pt.2013.12.007","article-title":"Malaria, primigravidae, and antibodies: knowledge gained and future perspectives","volume":"30","author":"Ata\u00edde","year":"2014","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.cell.2016.07.055_bib5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1128\/CMR.00074-12","article-title":"Evidence and implications of mortality associated with acute Plasmodium vivax malaria","volume":"26","author":"Baird","year":"2013","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.cell.2016.07.055_bib6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nature14451","article-title":"A novel multiple-stage antimalarial agent that inhibits protein synthesis","volume":"522","author":"Baraga\u00f1a","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.07.055_bib7","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1462-5822.2011.01597.x","article-title":"The moving junction of apicomplexan parasites: a key structure for invasion","volume":"13","author":"Besteiro","year":"2011","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.cell.2016.07.055_bib8","doi-asserted-by":"crossref","first-page":"6752","DOI":"10.1074\/jbc.M411465200","article-title":"A surface phospholipase is involved in the migration of plasmodium sporozoites through cells","volume":"280","author":"Bhanot","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2016.07.055_bib9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev-micro-092412-155730","article-title":"Plasmodium nesting: remaking the erythrocyte from the inside out","volume":"67","author":"Boddey","year":"2013","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.cell.2016.07.055_bib10","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nm0398-358","article-title":"Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria","volume":"4","author":"Bull","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2016.07.055_bib11","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1172\/JCI62182","article-title":"Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity","volume":"122","author":"Chan","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2016.07.055_bib12","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1007\/s00018-014-1614-3","article-title":"Surface antigens of Plasmodium falciparum-infected erythrocytes as immune targets and malaria vaccine candidates","volume":"71","author":"Chan","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cell.2016.07.055_bib13","doi-asserted-by":"crossref","first-page":"e1002199","DOI":"10.1371\/journal.ppat.1002199","article-title":"An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparum","volume":"7","author":"Chen","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cell.2016.07.055_bib14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1741-7015-12-31","article-title":"Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: a systematic review","volume":"12","author":"Church","year":"2014","journal-title":"BMC Med."},{"key":"10.1016\/j.cell.2016.07.055_bib15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.4161\/hv.6.1.9677","article-title":"From the circumsporozoite protein to the RTS, S\/AS candidate vaccine","volume":"6","author":"Cohen","year":"2010","journal-title":"Hum. Vaccin."},{"key":"10.1016\/j.cell.2016.07.055_bib16","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/192733a0","article-title":"Gamma-globulin and acquired immunity to human malaria","volume":"192","author":"Cohen","year":"1961","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.07.055_bib17","doi-asserted-by":"crossref","first-page":"e1003344","DOI":"10.1371\/journal.ppat.1003344","article-title":"Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress","volume":"9","author":"Collins","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cell.2016.07.055_bib18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4269\/tropmed.1999.61-04","article-title":"A retrospective examination of sporozoite- and trophozoite-induced infections with Plasmodium falciparum: development of parasitologic and clinical immunity during primary infection","volume":"61","author":"Collins","year":"1999","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.cell.2016.07.055_bib19","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.chom.2007.10.002","article-title":"Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells","volume":"2","author":"Coppi","year":"2007","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2016.07.055_bib20","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nature10606","article-title":"Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum","volume":"480","author":"Crosnier","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.07.055_bib21","doi-asserted-by":"crossref","first-page":"211ps218","DOI":"10.1126\/scitranslmed.3007432","article-title":"Piecing together the puzzle of severe malaria","volume":"5","author":"Cunnington","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2016.07.055_bib22","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.chom.2015.09.007","article-title":"Processing of Plasmodium falciparum merozoite surface protein MSP1 activates a spectrin-binding function enabling parasite egress from RBCs","volume":"18","author":"Das","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2016.07.055_bib23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1086\/523762","article-title":"Direct in\u00a0vivo assessment of microcirculatory dysfunction in severe falciparum malaria","volume":"197","author":"Dondorp","year":"2008","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.cell.2016.07.055_bib24","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","article-title":"Artemisinin resistance in Plasmodium falciparum malaria","volume":"361","author":"Dondorp","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2016.07.055_bib25","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.chom.2014.11.017","article-title":"A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys","volume":"17","author":"Douglas","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2016.07.055_bib26","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1126\/science.1188191","article-title":"A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes","volume":"328","author":"Dvorin","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.cell.2016.07.055_bib27","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1038\/srep03549","article-title":"Pre-erythrocytic antibody profiles induced by controlled human malaria infections in healthy volunteers under chloroquine prophylaxis","volume":"3","author":"Felgner","year":"2013","journal-title":"Sci Rep"},{"key":"10.1016\/j.cell.2016.07.055_bib28","doi-asserted-by":"crossref","first-page":"e1000218","DOI":"10.1371\/journal.pmed.1000218","article-title":"The relationship between anti-merozoite antibodies and incidence of Plasmodium falciparum malaria: A systematic review and meta-analysis","volume":"7","author":"Fowkes","year":"2010","journal-title":"PLoS Med."},{"key":"10.1016\/j.cell.2016.07.055_bib29","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nature09107","article-title":"Thousands of chemical starting points for antimalarial lead identification","volume":"465","author":"Gamo","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.07.055_bib30","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1038\/ncomms3862","article-title":"Triggers of key calcium signals during erythrocyte invasion by Plasmodium falciparum","volume":"4","author":"Gao","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2016.07.055_bib31","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/1475-2875-13-335","article-title":"Plasmodium falciparum malaria and invasive bacterial co-infection in young African children: the dysfunctional spleen hypothesis","volume":"13","author":"G\u00f3mez-P\u00e9rez","year":"2014","journal-title":"Malar. J."},{"key":"10.1016\/j.cell.2016.07.055_bib32","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0140-6736(15)00807-7","article-title":"Implementation of the malaria candidate vaccine RTS,S\/AS01","volume":"387","author":"Greenwood","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2016.07.055_bib33","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.chom.2012.09.010","article-title":"Uncovering common principles in protein export of malaria parasites","volume":"12","author":"Gr\u00fcring","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2016.07.055_bib34","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12916-015-0365-9","article-title":"Microvascular obstruction and endothelial activation are independently associated with the clinical manifestations of severe falciparum malaria in adults: an observational study","volume":"13","author":"Hanson","year":"2015","journal-title":"BMC Med."},{"key":"10.1016\/j.cell.2016.07.055_bib35","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/infdis\/jis675","article-title":"Defining falciparum-malaria-attributable severe febrile illness in moderate-to-high transmission settings on the basis of plasma PfHRP2 concentration","volume":"207","author":"Hendriksen","year":"2013","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.cell.2016.07.055_bib36","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1128\/IAI.02676-14","article-title":"Reversible conformational change in the Plasmodium falciparum circumsporozoite protein masks its adhesion domains","volume":"83","author":"Herrera","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.cell.2016.07.055_bib37","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1017\/S0031182000075673","article-title":"Proteins on the surface of the malaria parasite and cell invasion","volume":"108","author":"Holder","year":"1994","journal-title":"Parasitology"},{"key":"10.1016\/j.cell.2016.07.055_bib38","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/bs.apar.2015.02.004","article-title":"PfEMP1 - a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis","volume":"88","author":"Hviid","year":"2015","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.cell.2016.07.055_bib39","doi-asserted-by":"crossref","first-page":"E4","DOI":"10.1371\/journal.pbio.0020004","article-title":"Cell-passage activity is required for the malarial parasite to cross the liver sinusoidal cell layer","volume":"2","author":"Ishino","year":"2004","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cell.2016.07.055_bib40","doi-asserted-by":"crossref","first-page":"E5455","DOI":"10.1073\/pnas.1414221111","article-title":"(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium","volume":"111","author":"Jim\u00e9nez-D\u00edaz","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2016.07.055_bib41","doi-asserted-by":"crossref","first-page":"244re245","DOI":"10.1126\/scitranslmed.3008882","article-title":"Plasmodium falciparum transmission stages accumulate in the human bone marrow","volume":"6","author":"Joice","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2016.07.055_bib42","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nature12920","article-title":"A transcriptional switch underlies commitment to sexual development in malaria parasites","volume":"507","author":"Kafsack","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.07.055_bib43","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.aad3318","article-title":"Malaria parasites target the hepatocyte receptor EphA2 for successful host infection","volume":"350","author":"Kaushansky","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cell.2016.07.055_bib44","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.jmb.2010.01.040","article-title":"Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies","volume":"397","author":"Khunrae","year":"2010","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.cell.2016.07.055_bib45","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1128\/AAC.02727-13","article-title":"KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission","volume":"58","author":"Kuhen","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cell.2016.07.055_bib46","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/0140-6736(90)92827-5","article-title":"TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria","volume":"336","author":"Kwiatkowski","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2016.07.055_bib47","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1093\/cid\/cis615","article-title":"Postmortem characterization of patients with clinical diagnosis of Plasmodium vivax malaria: to what extent does this parasite kill?","volume":"55","author":"Lacerda","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.cell.2016.07.055_bib48","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/ni.f.205","article-title":"Immunity to malaria: more questions than answers","volume":"9","author":"Langhorne","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2016.07.055_bib49","doi-asserted-by":"crossref","first-page":"7703","DOI":"10.1074\/jbc.M115.698282","article-title":"Multiple Plasmodium falciparum merozoite surface protein 1 complexes mediate merozoite binding to human erythrocytes","volume":"291","author":"Lin","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2016.07.055_bib50","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0140-6736(13)62568-4","article-title":"Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria (DETECTIVE): a multicentre, double-blind, randomised, phase 2b dose-selection study","volume":"383","author":"Llanos-Cuentas","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2016.07.055_bib51","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0035-9203(97)90066-3","article-title":"The epidemiology of severe malaria in an area of low transmission in Thailand","volume":"91","author":"Luxemburger","year":"1997","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.cell.2016.07.055_bib52","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.chom.2013.04.009","article-title":"Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system","volume":"13","author":"Mantel","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2016.07.055_bib53","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.chom.2013.06.005","article-title":"A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax","volume":"14","author":"March","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2016.07.055_bib54","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1056\/NEJM199505253322102","article-title":"Indicators of life-threatening malaria in African children","volume":"332","author":"Marsh","year":"1995","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2016.07.055_bib55","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nature14412","article-title":"A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria","volume":"520","author":"Mbengue","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.07.055_bib56","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1017\/S0031182015000074","article-title":"Malaria and immunity during pregnancy and postpartum: a tale of two species","volume":"142","author":"McLean","year":"2015","journal-title":"Parasitology"},{"key":"10.1016\/j.cell.2016.07.055_bib57","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nature12782","article-title":"Targeting Plasmodium PI(4)K to eliminate malaria","volume":"504","author":"McNamara","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.07.055_bib58","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.chom.2015.02.011","article-title":"Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice","volume":"17","author":"Mikolajczak","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2016.07.055_bib59","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ng.3189","article-title":"Genetic architecture of artemisinin-resistant Plasmodium falciparum","volume":"47","author":"Miotto","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2016.07.055_bib60","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1126\/science.1260403","article-title":"Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance","volume":"347","author":"Mok","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cell.2016.07.055_bib61","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1182\/blood-2013-03-490219","article-title":"Loss of endothelial protein C receptors links coagulation and inflammation to\u00a0parasite sequestration in cerebral malaria in African children","volume":"122","author":"Moxon","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.cell.2016.07.055_bib62","doi-asserted-by":"crossref","first-page":"e3071","DOI":"10.1371\/journal.pntd.0003071","article-title":"Is Plasmodium vivax malaria a severe malaria?: a systematic review and meta-analysis","volume":"8","author":"Naing","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cell.2016.07.055_bib63","doi-asserted-by":"crossref","first-page":"8247","DOI":"10.1073\/pnas.1200472109","article-title":"Memory B cells are a more reliable archive for historical antimalarial responses than plasma antibodies in no-longer exposed children","volume":"109","author":"Ndungu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2016.07.055_bib64","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1186\/s12936-015-1008-5","article-title":"Beninese children with cerebral malaria do not develop humoral immunity against the IT4-VAR19-DC8 PfEMP1 variant linked to EPCR and brain endothelial binding","volume":"14","author":"Nunes-Silva","year":"2015","journal-title":"Malar. J."},{"key":"10.1016\/j.cell.2016.07.055_bib65","doi-asserted-by":"crossref","first-page":"247ra102","DOI":"10.1126\/scitranslmed.3008705","article-title":"New antigens for a multicomponent blood-stage malaria vaccine","volume":"6","author":"Osier","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2016.07.055_bib66","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.chom.2015.06.003","article-title":"Parasite calcineurin regulates host cell recognition and attachment by apicomplexans","volume":"18","author":"Paul","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2016.07.055_bib67","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1186\/1475-2875-13-481","article-title":"Severe vivax malaria: a systematic review and meta-analysis of clinical studies since 1900","volume":"13","author":"Rahimi","year":"2014","journal-title":"Malar. J."},{"key":"10.1016\/j.cell.2016.07.055_bib68","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1073\/pnas.1415466112","article-title":"Multiprotein complex between the GPI-anchored CyRPA with PfRH5 and PfRipr is crucial for Plasmodium falciparum erythrocyte invasion","volume":"112","author":"Reddy","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2016.07.055_bib69","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2013.04.029","article-title":"Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles","volume":"153","author":"Regev-Rudzki","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.cell.2016.07.055_bib70","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.chom.2010.12.003","article-title":"Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte","volume":"9","author":"Riglar","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2016.07.055_bib71","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nm.3083","article-title":"Immune mechanisms in malaria: new insights in vaccine development","volume":"19","author":"Riley","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2016.07.055_bib72","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.chom.2015.10.006","article-title":"Malaria sporozoites traverse host cells within transient vacuoles","volume":"18","author":"Risco-Castillo","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2016.07.055_bib73","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.chom.2008.07.012","article-title":"Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection","volume":"4","author":"Rodrigues","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2016.07.055_bib74","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/S0140-6736(11)60888-X","article-title":"Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study","volume":"378","author":"Scott","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2016.07.055_bib75","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1126\/science.1241800","article-title":"Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine","volume":"341","author":"Seder","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.cell.2016.07.055_bib76","doi-asserted-by":"crossref","first-page":"e1000746","DOI":"10.1371\/journal.ppat.1000746","article-title":"Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites","volume":"6","author":"Singh","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cell.2016.07.055_bib77","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1111\/cmi.12183","article-title":"Malaria\u2019s deadly grip: cytoadhesion of Plasmodium falciparum-infected erythrocytes","volume":"15","author":"Smith","year":"2013","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.cell.2016.07.055_bib78","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/S0140-6736(97)02038-2","article-title":"Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa","volume":"349","author":"Snow","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2016.07.055_bib79","doi-asserted-by":"crossref","first-page":"e62906","DOI":"10.1371\/journal.pone.0062906","article-title":"The open access malaria box: a drug discovery catalyst for neglected diseases","volume":"8","author":"Spangenberg","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2016.07.055_bib80","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.chom.2012.12.006","article-title":"Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials","volume":"13","author":"Spillman","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2016.07.055_bib81","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1016\/j.vaccine.2013.08.007","article-title":"First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers","volume":"31","author":"Spring","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.cell.2016.07.055_bib82","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1126\/science.1260867","article-title":"Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates","volume":"347","author":"Straimer","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cell.2016.07.055_bib83","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1126\/science.1129720","article-title":"Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids","volume":"313","author":"Sturm","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.cell.2016.07.055_bib84","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1084\/jem.20121130","article-title":"Role of host cell traversal by the malaria sporozoite during liver infection","volume":"210","author":"Tavares","year":"2013","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2016.07.055_bib85","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/nyas.12690","article-title":"The pathogenesis of pediatric cerebral malaria: eye exams, autopsies, and neuroimaging","volume":"1342","author":"Taylor","year":"2015","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.cell.2016.07.055_bib86","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pt.2011.10.002","article-title":"Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum","volume":"28","author":"Tham","year":"2012","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.cell.2016.07.055_bib87","doi-asserted-by":"crossref","first-page":"e1005343","DOI":"10.1371\/journal.ppat.1005343","article-title":"Plasmodium falciparum adhesins play an essential role in signalling and activation of invasion into human erythrocytes","volume":"11","author":"Tham","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cell.2016.07.055_bib88","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1016\/j.vaccine.2014.03.020","article-title":"A multi-stage malaria vaccine candidate targeting both transmission and asexual parasite life-cycle stages","volume":"32","author":"Theisen","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.cell.2016.07.055_bib89","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nature12216","article-title":"Severe malaria is associated with parasite binding to endothelial protein C receptor","volume":"498","author":"Turner","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.07.055_bib90","doi-asserted-by":"crossref","first-page":"5521","DOI":"10.1038\/ncomms6521","article-title":"Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum","volume":"5","author":"Vaidya","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2016.07.055_bib91","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1086\/518441","article-title":"HIV, malaria, and infant anemia as risk factors for postneonatal infant mortality among HIV-seropositive women in Kisumu, Kenya","volume":"196","author":"van Eijk","year":"2007","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.cell.2016.07.055_bib92","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1172\/JCI62684","article-title":"Complete Plasmodium falciparum liver-stage development in liver-chimeric mice","volume":"122","author":"Vaughan","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2016.07.055_bib93","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.chom.2016.06.004","article-title":"The essential invasion complex PfRh5\/PfRipr\/CyRPA is linked to injection of calcium into human erythrocytes by merozoites during invasion","volume":"20","author":"Volz","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2016.07.055_bib94","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4269\/ajtmh.14-0841","article-title":"Investigating the pathogenesis of severe malaria: a multidisciplinary and cross-geographical approach","volume":"93","author":"Wassmer","year":"2015","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.cell.2016.07.055_bib95","doi-asserted-by":"crossref","first-page":"e1004670","DOI":"10.1371\/journal.ppat.1004670","article-title":"Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes","volume":"11","author":"Weiss","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cell.2016.07.055_bib96","unstructured":"WHO (2015). The World Malaria Report http:\/\/wwwwhoint\/malaria\/publications\/world-malaria-report-2015\/report\/en\/ ISBN 978 92 4 156515 8."},{"key":"10.1016\/j.cell.2016.07.055_bib97","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/bs.apar.2015.04.001","article-title":"Development of malaria transmission-blocking vaccines: from concept to product","volume":"89","author":"Wu","year":"2015","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.cell.2016.07.055_bib98","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1093\/infdis\/jiu308","article-title":"Decreased endothelial nitric oxide\u00a0bioavailability, impaired microvascular function, and increased tissue oxygen consumption in children with falciparum malaria","volume":"210","author":"Yeo","year":"2014","journal-title":"J.\u00a0Infect. Dis."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286741631008X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009286741631008X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T06:59:41Z","timestamp":1536303581000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009286741631008X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":98,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S009286741631008X"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2016.07.055","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Malaria: Biology and Disease","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2016.07.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}