{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:42:38Z","timestamp":1791942158843,"version":"4.3.4"},"reference-count":79,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T00:00:00Z","timestamp":1509667200000},"content-version":"vor","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"NIH"},{"name":"NIDA","award":["DP1DA034990"],"award-info":[{"award-number":["DP1DA034990"]}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"crossref","award":["R01AI111809"],"award-info":[{"award-number":["R01AI111809"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000051","name":"NHGRI","doi-asserted-by":"crossref","award":["1U01HG007910"],"award-info":[{"award-number":["1U01HG007910"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000051","name":"NHGRI","doi-asserted-by":"crossref","award":["5T32AI007244-33"],"award-info":[{"award-number":["5T32AI007244-33"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006108","name":"NCATS","doi-asserted-by":"crossref","award":["UL1TR001114"],"award-info":[{"award-number":["UL1TR001114"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"crossref","award":["HHSN272201400048C"],"award-info":[{"award-number":["HHSN272201400048C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Howard Hughes Medical Investigator award"},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"crossref","award":["U19AI110818"],"award-info":[{"award-number":["U19AI110818"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100011102","name":"European Union Seventh Framework Programme","doi-asserted-by":"crossref","award":["278433-PREDEMICS"],"award-info":[{"award-number":["278433-PREDEMICS"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science Foundation","award":["DGE 1144152"],"award-info":[{"award-number":["DGE 1144152"]}]},{"name":"NIH","award":["U19AI110818"],"award-info":[{"award-number":["U19AI110818"]}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.cell.2016.10.014","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T13:46:44Z","timestamp":1478180804000},"page":"1088-1098.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":204,"title":["Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013\u20132016 Epidemic"],"prefix":"10.1016","volume":"167","author":[{"given":"William E.","family":"Diehl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron E.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan D.","family":"Grubaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Max","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyusik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pyae Phyo","family":"Kyawe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"McCauley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Donnard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"Kucukural","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"McDonel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F.","family":"Schaffner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Garber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Rambaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian G.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pardis C.","family":"Sabeti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Luban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2016.10.014_bib1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/jcc.540150503","article-title":"ICM\u2014A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation","volume":"15","author":"Abagyan","year":"1994","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.cell.2016.10.014_bib2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.virol.2016.06.011","article-title":"Virus fitness differences observed between two naturally occurring isolates of Ebola virus Makona variant using a reverse genetics approach","volume":"496","author":"Albari\u00f1o","year":"2016","journal-title":"Virology"},{"key":"10.1016\/j.cell.2016.10.014_bib3","doi-asserted-by":"crossref","first-page":"e0003652","DOI":"10.1371\/journal.pntd.0003652","article-title":"What factors might have led to the emergence of Ebola in West Africa?","volume":"9","author":"Alexander","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cell.2016.10.014_bib4","doi-asserted-by":"crossref","first-page":"vew16","DOI":"10.1093\/ve\/vew016","article-title":"Rapid outbreak sequencing of Ebola virus in Sierra Leone identifies transmission chains linked to sporadic cases","volume":"2","author":"Arias","year":"2016","journal-title":"Virus Evolution"},{"key":"10.1016\/j.cell.2016.10.014_bib5","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1056\/NEJMoa1404505","article-title":"Emergence of Zaire Ebola virus disease in Guinea","volume":"371","author":"Baize","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2016.10.014_bib6","first-page":"1","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J.\u00a0Stat. Softw."},{"key":"10.1016\/j.cell.2016.10.014_bib7","doi-asserted-by":"crossref","first-page":"e3056","DOI":"10.1371\/journal.pntd.0003056","article-title":"Outbreak of ebola virus disease in Guinea: where ecology meets economy","volume":"8","author":"Bausch","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cell.2016.10.014_bib8","doi-asserted-by":"crossref","first-page":"14849","DOI":"10.1073\/pnas.0505659102","article-title":"Cyclophilin A is required for TRIM5alpha-mediated resistance to HIV-1 in Old World monkey cells","volume":"102","author":"Berthoux","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2016.10.014_bib9","unstructured":"Bivand, R., and Lewin-Koh, N. (2016). Tools for Reading and Handling Spatial Objects [R package maptools version 0.8-39] (Comprehensive R Archive Network [CRAN]). http:\/\/r-forge.r-project.org\/projects\/maptools\/."},{"key":"10.1016\/j.cell.2016.10.014_bib10","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(77)92001-3","article-title":"Viral haemorrhagic fever in southern Sudan and northern Zaire. Preliminary studies on the aetiological agent","volume":"1","author":"Bowen","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2016.10.014_bib11","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1093\/bioinformatics\/btp348","article-title":"trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses","volume":"25","author":"Capella-Guti\u00e9rrez","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2016.10.014_bib12","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature10348","article-title":"Ebola virus entry requires the cholesterol transporter Niemann-Pick C1","volume":"477","author":"Carette","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.10.014_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature14594","article-title":"Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa","volume":"524","author":"Carroll","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.10.014_bib14","unstructured":"CDC (2016). Outbreaks Chronology: Ebola Virus Disease | Ebola Hemorrhagic Fever | CDC. http:\/\/www.cdc.gov\/vhf\/ebola\/outbreaks\/history\/chronology.html (CDC)."},{"key":"10.1016\/j.cell.2016.10.014_bib15","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1126\/science.1110656","article-title":"Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection","volume":"308","author":"Chandran","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.cell.2016.10.014_bib16","doi-asserted-by":"crossref","first-page":"6547","DOI":"10.1128\/jvi.66.11.6547-6554.1992","article-title":"Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: definition of critical amino acids involved in cell tropism","volume":"66","author":"Chesebro","year":"1992","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2016.10.014_bib17","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature10380","article-title":"Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection","volume":"477","author":"C\u00f4t\u00e9","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.10.014_bib18","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1172\/JCI83162","article-title":"Ebola viral load at diagnosis associates with patient outcome and outbreak evolution","volume":"125","author":"de La Vega","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2016.10.014_bib19","doi-asserted-by":"crossref","first-page":"11140","DOI":"10.1128\/JVI.00269-08","article-title":"Identification of postentry restrictions to Mason-Pfizer monkey virus infection in New World monkey cells","volume":"82","author":"Diehl","year":"2008","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2016.10.014_bib20","doi-asserted-by":"crossref","first-page":"e1000076","DOI":"10.1371\/journal.ppat.1000076","article-title":"The evolutionary genetics and emergence of avian influenza viruses in wild birds","volume":"4","author":"Dugan","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cell.2016.10.014_bib21","doi-asserted-by":"crossref","first-page":"8000","DOI":"10.1038\/ncomms9000","article-title":"Assessing the contribution of interferon antagonism to the virulence of West African Ebola viruses","volume":"6","author":"Dunham","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2016.10.014_bib22","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0140-6736(10)60667-8","article-title":"Ebola haemorrhagic fever","volume":"377","author":"Feldmann","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2016.10.014_bib23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0168-1702(95)00080-1","article-title":"Differentiation of filoviruses by electron microscopy","volume":"39","author":"Geisbert","year":"1995","journal-title":"Virus Res."},{"key":"10.1016\/j.cell.2016.10.014_bib24","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1016\/S0002-9440(10)63591-2","article-title":"Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection","volume":"163","author":"Geisbert","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cell.2016.10.014_bib25","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1002\/sim.3107","article-title":"Scaling regression inputs by dividing by two standard deviations","volume":"27","author":"Gelman","year":"2008","journal-title":"Stat. Med."},{"key":"10.1016\/j.cell.2016.10.014_bib26","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1126\/science.1259657","article-title":"Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak","volume":"345","author":"Gire","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.cell.2016.10.014_bib27","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.cell.2016.05.022","article-title":"Structural insights into the Niemann-Pick C1 (NPC1)-mediated cholesterol transfer and Ebola infection","volume":"165","author":"Gong","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2016.10.014_bib28","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.3201\/eid1807.111654","article-title":"Ebola virus antibodies in fruit bats, Ghana, West Africa","volume":"18","author":"Hayman","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.cell.2016.10.014_bib29","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1126\/science.1213362","article-title":"Airborne transmission of influenza A\/H5N1 virus between ferrets","volume":"336","author":"Herfst","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.cell.2016.10.014_bib30","doi-asserted-by":"crossref","first-page":"e300","DOI":"10.1371\/journal.pbio.0030300","article-title":"Whole-genome analysis of human influenza A virus reveals multiple persistent lineages and reassortment among recent H3N2 viruses","volume":"3","author":"Holmes","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cell.2016.10.014_bib31","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nature10831","article-title":"Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA\/H1N1 virus in ferrets","volume":"486","author":"Imai","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.10.014_bib32","doi-asserted-by":"crossref","first-page":"12463","DOI":"10.1128\/JVI.76.24.12463-12472.2002","article-title":"Covalent modifications of the ebola virus glycoprotein","volume":"76","author":"Jeffers","year":"2002","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2016.10.014_bib33","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0140-6736(77)92000-1","article-title":"Isolation and partial characterisation of a new virus causing acute haemorrhagic fever in Zaire","volume":"1","author":"Johnson","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2016.10.014_bib34","doi-asserted-by":"crossref","first-page":"13378","DOI":"10.1128\/JVI.01170-07","article-title":"Proteolysis of the Ebola virus glycoproteins enhances virus binding and infectivity","volume":"81","author":"Kaletsky","year":"2007","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2016.10.014_bib35","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability","volume":"30","author":"Katoh","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.cell.2016.10.014_bib36","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.3390\/v4112471","article-title":"Niemann-Pick C1 (NPC1)\/NPC1-like1 chimeras define sequences critical for NPC1's function as a flovirus entry receptor","volume":"4","author":"Krishnan","year":"2012","journal-title":"Viruses"},{"key":"10.1016\/j.cell.2016.10.014_bib37","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.3201\/eid2107.150522","article-title":"Monitoring of Ebola virus Makona evolution through establishment of advanced genomic capability in Liberia","volume":"21","author":"Kugelman","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.cell.2016.10.014_bib38","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1007\/s00705-010-0814-x","article-title":"Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations","volume":"155","author":"Kuhn","year":"2010","journal-title":"Arch. Virol."},{"key":"10.1016\/j.cell.2016.10.014_bib39","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.chom.2015.11.008","article-title":"Evolution and spread of Ebola virus in Liberia, 2014-2015","volume":"18","author":"Ladner","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2016.10.014_bib40","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nature10117","article-title":"SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx","volume":"474","author":"Laguette","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.10.014_bib41","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/438575a","article-title":"Fruit bats as reservoirs of Ebola virus","volume":"438","author":"Leroy","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.10.014_bib42","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1038\/sj.emboj.7600640","article-title":"Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2","volume":"24","author":"Li","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2016.10.014_bib43","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijid.2015.10.021","article-title":"Age and Ebola viral load correlate with mortality and survival time in 288 Ebola virus disease patients","volume":"42","author":"Li","year":"2016","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.cell.2016.10.014_bib44","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1743-422X-6-75","article-title":"Expression of Ebolavirus glycoprotein on the target cells enhances viral entry","volume":"6","author":"Manicassamy","year":"2009","journal-title":"Virol. J."},{"key":"10.1016\/j.cell.2016.10.014_bib45","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.3201\/eid2110.150259","article-title":"Delayed disease progression in cynomolgus macaques infected with Ebola virus Makona strain","volume":"21","author":"Marzi","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.cell.2016.10.014_bib46","doi-asserted-by":"crossref","first-page":"8502","DOI":"10.1128\/JVI.74.18.8502-8512.2000","article-title":"Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus hemagglutinins after their introduction into mammals","volume":"74","author":"Matrosovich","year":"2000","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2016.10.014_bib47","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/sj.gt.3301292","article-title":"Characterization of novel safe lentiviral vectors derived from simian immunodeficiency virus (SIVmac251) that efficiently transduce mature human dendritic cells","volume":"7","author":"N\u00e8gre","year":"2000","journal-title":"Gene Ther."},{"key":"10.1016\/j.cell.2016.10.014_bib48","doi-asserted-by":"crossref","first-page":"e1000012","DOI":"10.1371\/journal.ppat.1000012","article-title":"Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918","volume":"4","author":"Nelson","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cell.2016.10.014_bib49","doi-asserted-by":"crossref","first-page":"4","DOI":"10.7554\/eLife.11785","article-title":"Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats","volume":"4","author":"Ng","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.cell.2016.10.014_bib50","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.1128\/JVI.76.10.4855-4865.2002","article-title":"Ebola virus VP40 drives the formation of virus-like filamentous particles along with GP","volume":"76","author":"Noda","year":"2002","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2016.10.014_bib51","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1126\/science.1121586","article-title":"Large-scale sequence analysis of avian influenza isolates","volume":"311","author":"Obenauer","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.cell.2016.10.014_bib52","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.cell.2015.06.007","article-title":"Ebola virus epidemiology, transmission, and evolution during seven months in Sierra Leone","volume":"161","author":"Park","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2016.10.014_bib53","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1128\/MMBR.00004-08","article-title":"Cross-species virus transmission and the emergence of new epidemic diseases","volume":"72","author":"Parrish","year":"2008","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.cell.2016.10.014_bib54","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0140-6736(77)92002-5","article-title":"Isolation of Marburg-like virus from a case of haemorrhagic fever in Zaire","volume":"1","author":"Pattyn","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2016.10.014_bib55","doi-asserted-by":"crossref","first-page":"D593","DOI":"10.1093\/nar\/gkr859","article-title":"ViPR: an open bioinformatics database and analysis resource for virology research","volume":"40","author":"Pickett","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"Suppl 2","key":"10.1016\/j.cell.2016.10.014_bib56","doi-asserted-by":"crossref","first-page":"S176","DOI":"10.1086\/520541","article-title":"Spatial and temporal patterns of Zaire ebolavirus antibody prevalence in the possible reservoir bat species","volume":"196","author":"Pourrut","year":"2007","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.cell.2016.10.014_bib57","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/1471-2334-9-159","article-title":"Large serological survey showing cocirculation of Ebola and Marburg viruses in Gabonese bat populations, and a high seroprevalence of both viruses in Rousettus aegyptiacus","volume":"9","author":"Pourrut","year":"2009","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.cell.2016.10.014_bib58","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature16996","article-title":"Real-time, portable genome sequencing for Ebola surveillance","volume":"530","author":"Quick","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.10.014_bib59","unstructured":"R Core Team (2016). R: A Language and Environment for Statistical Computing."},{"key":"10.1016\/j.cell.2016.10.014_bib60","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nature06945","article-title":"The genomic and epidemiological dynamics of human influenza A virus","volume":"453","author":"Rambaut","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.10.014_bib61","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1742-4690-11-12","article-title":"Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration","volume":"11","author":"Reinhard","year":"2014","journal-title":"Retrovirology"},{"key":"10.1016\/j.cell.2016.10.014_bib62","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1126\/science.1222526","article-title":"The potential for respiratory droplet-transmissible A\/H5N1 influenza virus to evolve in a mammalian host","volume":"336","author":"Russell","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.cell.2016.10.014_bib63","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1073\/pnas.93.8.3602","article-title":"The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing","volume":"93","author":"Sanchez","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2016.10.014_bib64","doi-asserted-by":"crossref","first-page":"4174","DOI":"10.1128\/JVI.80.8.4174-4178.2006","article-title":"Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein","volume":"80","author":"Schornberg","year":"2006","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2016.10.014_bib65","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature14612","article-title":"Distinct lineages of Ebola virus in Guinea during the 2014 West African epidemic","volume":"524","author":"Simon-Loriere","year":"2015","journal-title":"Nature"},{"issue":"Suppl 3","key":"10.1016\/j.cell.2016.10.014_bib66","doi-asserted-by":"crossref","first-page":"S268","DOI":"10.1093\/infdis\/jiw145","article-title":"Ebola virus Makona shows reduced lethality in an immune-deficient mouse model","volume":"214","author":"Smither","year":"2016","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.cell.2016.10.014_bib67","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/bioinformatics\/bti191","article-title":"RAxML-III: a fast program for maximum likelihood-based inference of large phylogenetic trees","volume":"21","author":"Stamatakis","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2016.10.014_bib68","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.jmb.2005.11.002","article-title":"Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities","volume":"355","author":"Stevens","year":"2006","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.cell.2016.10.014_bib69","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1126\/science.1124513","article-title":"Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus","volume":"312","author":"Stevens","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.cell.2016.10.014_bib70","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature14490","article-title":"Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone","volume":"524","author":"Tong","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2016.10.014_bib71","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jviromet.2009.10.020","article-title":"An enzymatic virus-like particle assay for sensitive detection of virus entry","volume":"163","author":"Tscherne","year":"2010","journal-title":"J.\u00a0Virol. Methods"},{"key":"10.1016\/j.cell.2016.10.014_bib72","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.cell.2016.10.013","article-title":"Human adaptation of Ebola virus during the West African outbreak","volume":"167","author":"Urbanowicz","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2016.10.014_bib73","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1126\/science.1057269","article-title":"Recovery of infectious Ebola virus from complementary DNA: RNA editing of the GP gene and viral cytotoxicity","volume":"291","author":"Volchkov","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.cell.2016.10.014_bib74","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.cell.2015.12.044","article-title":"Ebola viral glycoprotein bound to its endosomal receptor Niemann-Pick C1","volume":"164","author":"Wang","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2016.10.014_bib75","unstructured":"WHO (2016). Ebola Situation Reports | Ebola. http:\/\/apps.who.int\/ebola\/ebola-situation-reports (WHO)."},{"key":"10.1016\/j.cell.2016.10.014_bib76","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2009"},{"key":"10.1016\/j.cell.2016.10.014_bib77","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1128\/JVI.02162-09","article-title":"Structure, receptor binding, and antigenicity of influenza virus hemagglutinins from the 1957 H2N2 pandemic","volume":"84","author":"Xu","year":"2010","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2016.10.014_bib78","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1006\/mthe.2002.0585","article-title":"Lentiviral vectors for sustained transgene expression in human bone marrow-derived stromal cells","volume":"5","author":"Zhang","year":"2002","journal-title":"Mol. Ther."},{"key":"10.1016\/j.cell.2016.10.014_bib79","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/1873-3468.12089","article-title":"Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions","volume":"590","author":"Zhao","year":"2016","journal-title":"FEBS Lett."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867416313976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867416313976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T14:42:11Z","timestamp":1712328131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867416313976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":79,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0092867416313976"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2016.10.014","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726916252.793525015","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013\u20132016 Epidemic","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2016.10.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2016.10.013","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}