{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:16:06Z","timestamp":1792286166810,"version":"4.4.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"vor","delay-in-days":373,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P01-CA129243"],"award-info":[{"award-number":["P01-CA129243"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U54-163167"],"award-info":[{"award-number":["U54-163167"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"DOD","doi-asserted-by":"publisher","award":["W81XWH-12-0074"],"award-info":[{"award-number":["W81XWH-12-0074"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alan and Sandra Gerry Metastasis Research Initiative"},{"name":"MSKCC Clinical Scholars Training Program"},{"name":"Solomon R. and Rebecca D. Baker Foundation"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.cell.2017.02.025","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T14:30:56Z","timestamp":1489156256000},"page":"1101-1113.e13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":345,"title":["Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis"],"prefix":"10.1016","volume":"168","author":[{"given":"Adrienne","family":"Boire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Shieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo G.","family":"Macalinao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Pentsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Massagu\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2017.02.025_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cell.2012.04.042","article-title":"A CXCL1 paracrine network links cancer chemoresistance and metastasis","volume":"150","author":"Acharyya","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cell.2017.02.025_bib2","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.1200\/JCO.2010.31.0805","article-title":"Plasma transforming growth factor alpha and amphiregulin protein levels in NCIC Clinical Trials Group BR.21","volume":"28","author":"Addison","year":"2010","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.cell.2017.02.025_bib3","doi-asserted-by":"crossref","first-page":"20231","DOI":"10.1074\/jbc.271.34.20231","article-title":"Molecular cloning and characterization of the human anaphylatoxin C3a receptor","volume":"271","author":"Ames","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2017.02.025_bib4","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.4049\/jimmunol.166.10.6341","article-title":"Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models","volume":"166","author":"Ames","year":"2001","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2017.02.025_bib5","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/ijc.28949","article-title":"An NMR metabolomics approach for the diagnosis of leptomeningeal carcinomatosis in lung adenocarcinoma cancer patients","volume":"136","author":"An","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cell.2017.02.025_bib6","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2017.02.025_bib7","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.15252\/embj.201591881","article-title":"Complement activation, regulation, and molecular basis for complement-related diseases","volume":"34","author":"Bajic","year":"2015","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2017.02.025_bib8","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/ki.2011.158","article-title":"Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury","volume":"80","author":"Bao","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.cell.2017.02.025_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.semcdb.2014.01.005","article-title":"Amphiregulin","volume":"28","author":"Berasain","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cell.2017.02.025_bib10","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/nature08021","article-title":"Genes that mediate breast cancer metastasis to the brain","volume":"459","author":"Bos","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.cell.2017.02.025_bib11","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.celrep.2016.10.052","article-title":"Macrophage ontogeny underlies differences in tumor-specific education in brain malignancies","volume":"17","author":"Bowman","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2017.02.025_bib12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1136\/pgmj.56.653.149","article-title":"Diffuse involvement of the leptomeninges by tumour--a clinical and pathological study of 63 cases","volume":"56","author":"Boyle","year":"1980","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.cell.2017.02.025_bib13","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jocn.2015.11.012","article-title":"Management of leptomeningeal metastases: prognostic factors and associated outcomes","volume":"27","author":"Brower","year":"2016","journal-title":"J.\u00a0Clin. Neurosci."},{"key":"10.1016\/j.cell.2017.02.025_bib14","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.ccr.2011.08.025","article-title":"Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs","volume":"20","author":"Chen","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2017.02.025_bib15","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nature18268","article-title":"Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer","volume":"533","author":"Chen","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cell.2017.02.025_bib16","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1212\/WNL.0b013e3181dc1a69","article-title":"Leptomeningeal metastases in the MRI era","volume":"74","author":"Clarke","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.cell.2017.02.025_bib17","doi-asserted-by":"crossref","first-page":"C577","DOI":"10.1152\/ajpcell.1990.259.4.C577","article-title":"A factor in serum lowers resistance and opens tight junctions of MDCK cells","volume":"259","author":"Conyers","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.cell.2017.02.025_bib18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1749-6632.2012.06526.x","article-title":"Myosin light chain kinase: pulling the strings of epithelial tight junction function","volume":"1258","author":"Cunningham","year":"2012","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.cell.2017.02.025_bib19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1081\/CNV-50458","article-title":"Leptomeningeal metastasis","volume":"23","author":"DeAngelis","year":"2005","journal-title":"Cancer Invest."},{"key":"10.1016\/j.cell.2017.02.025_bib20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2017.02.025_bib21","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.4049\/jimmunol.166.3.2025","article-title":"Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma","volume":"166","author":"Drouin","year":"2001","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2017.02.025_bib22","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1016\/S0140-6736(16)00272-5","article-title":"Primary glomerulonephritides","volume":"387","author":"Floege","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2017.02.025_bib23","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1212\/WNL.0000000000000455","article-title":"Teaching NeuroImages: leptomeningeal lung carcinoma","volume":"82","author":"Glover","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.cell.2017.02.025_bib24","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/nature05760","article-title":"Mediators of vascular remodelling co-opted for sequential steps in lung metastasis","volume":"446","author":"Gupta","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cell.2017.02.025_bib25","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/35023175","article-title":"A role for the C3a anaphylatoxin receptor in the effector phase of asthma","volume":"406","author":"Humbles","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cell.2017.02.025_bib26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1254\/jphs.09180FP","article-title":"Effect of the C3a-receptor antagonist SB 290157 on anti-OVA polyclonal antibody-induced arthritis","volume":"112","author":"Hutamekalin","year":"2010","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.cell.2017.02.025_bib27","doi-asserted-by":"crossref","first-page":"24571","DOI":"10.1074\/jbc.M202561200","article-title":"Transforming growth factor-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways","volume":"277","author":"Kakonen","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2017.02.025_bib28","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1535-6108(03)00132-6","article-title":"A multigenic program mediating breast cancer metastasis to bone","volume":"3","author":"Kang","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cell.2017.02.025_bib29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0733-8619(02)00032-4","article-title":"Leptomeningeal metastases","volume":"21","author":"Kesari","year":"2003","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.cell.2017.02.025_bib30","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.rmed.2014.01.005","article-title":"Complement components as potential therapeutic targets for asthma treatment","volume":"108","author":"Khan","year":"2014","journal-title":"Respir. Med."},{"key":"10.1016\/j.cell.2017.02.025_bib31","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/1097-0142(19830101)51:1<154::AID-CNCR2820510130>3.0.CO;2-K","article-title":"Leptomeningeal carcinomatosis. How does cancer reach the pia-arachnoid?","volume":"51","author":"Kokkoris","year":"1983","journal-title":"Cancer"},{"key":"10.1016\/j.cell.2017.02.025_bib32","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1074\/jbc.M210063200","article-title":"Vascular endothelial growth factor modulates the transendothelial migration of MDA-MB-231 breast cancer cells through regulation of brain microvascular endothelial cell permeability","volume":"278","author":"Lee","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2017.02.025_bib33","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/sj.bjc.6603770","article-title":"Alteration of the serum levels of the epidermal growth factor receptor and its ligands in patients with non-small cell lung cancer and head and neck carcinoma","volume":"96","author":"Lemos-Gonz\u00e1lez","year":"2007","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cell.2017.02.025_bib34","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cyto.2011.07.021","article-title":"Lipocalin 2 regulation and its complex role in inflammation and cancer","volume":"56","author":"Li","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.cell.2017.02.025_bib35","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0006-8993(99)02355-0","article-title":"Phorbol ester induced changes in tight and adherens junctions in the choroid plexus epithelium and in the ependyma","volume":"854","author":"Lippoldt","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.cell.2017.02.025_bib36","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.cell.2017.02.025_bib37","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cell.2016.02.025","article-title":"Metastatic latency and immune evasion through autocrine inhibition of WNT","volume":"165","author":"Malladi","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2017.02.025_bib38","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature17038","article-title":"Metastatic colonization by circulating tumour cells","volume":"529","author":"Massagu\u00e9","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cell.2017.02.025_bib39","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S1046-2023(03)00029-X","article-title":"Functional analysis of tight junctions","volume":"30","author":"Matter","year":"2003","journal-title":"Methods"},{"key":"10.1016\/j.cell.2017.02.025_bib40","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3389\/fimmu.2015.00262","article-title":"Complement system Part I - Molecular mechanisms of activation and regulation","volume":"6","author":"Merle","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cell.2017.02.025_bib41","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.4049\/jimmunol.0901468","article-title":"Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice","volume":"183","author":"Mizutani","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cell.2017.02.025_bib42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cell.2009.04.030","article-title":"WNT\/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis","volume":"138","author":"Nguyen","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.cell.2017.02.025_bib43","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/ki.1991.326","article-title":"Measurement of SC5b-9 in urine in patients with the nephrotic syndrome","volume":"40","author":"Ogrodowski","year":"1991","journal-title":"Kidney Int."},{"key":"10.1016\/j.cell.2017.02.025_bib44","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cell.2008.01.046","article-title":"TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4","volume":"133","author":"Padua","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.cell.2017.02.025_bib45","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature10138","article-title":"CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis","volume":"475","author":"Qian","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cell.2017.02.025_bib46","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.3394","article-title":"Microenvironmental regulation of tumor progression and metastasis","volume":"19","author":"Quail","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2017.02.025_bib47","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1023\/A:1006237917632","article-title":"A simple mouse model for leptomeningeal metastases and repeated intrathecal therapy","volume":"42","author":"Reijneveld","year":"1999","journal-title":"J.\u00a0Neurooncol."},{"key":"10.1016\/j.cell.2017.02.025_bib48","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrneph.2016.70","article-title":"Complement in disease: a defence system turning offensive","volume":"12","author":"Ricklin","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cell.2017.02.025_bib49","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1158\/0008-5472.CAN-16-0485","article-title":"Incipient melanoma brain metastases instigate astrogliosis and neuroinflammation","volume":"76","author":"Schwartz","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.cell.2017.02.025_bib50","first-page":"117","article-title":"Leptomeningeal metastases in breast cancer","volume":"3","author":"Scott","year":"2013","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.cell.2017.02.025_bib51","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/ncb3011","article-title":"Analysis of\u00a0tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S","volume":"16","author":"Sevenich","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cell.2017.02.025_bib52","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1007\/s11095-006-9091-5","article-title":"Micronutrient and urate transport in choroid plexus and kidney: implications for drug therapy","volume":"23","author":"Spector","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.cell.2017.02.025_bib53","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.expneurol.2015.02.032","article-title":"A balanced view of choroid plexus structure and function: focus on adult humans","volume":"267","author":"Spector","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.cell.2017.02.025_bib54","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.expneurol.2015.07.027","article-title":"A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans","volume":"273","author":"Spector","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.cell.2017.02.025_bib55","doi-asserted-by":"crossref","first-page":"495402","DOI":"10.1155\/2014\/495402","article-title":"Beta2-microglobulin as a diagnostic marker in cerebrospinal fluid: a follow-up study","volume":"2014","author":"Svato\u0148ov\u00e1","year":"2014","journal-title":"Dis. Markers"},{"key":"10.1016\/j.cell.2017.02.025_bib56","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1681\/ASN.2008040434","article-title":"C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy","volume":"20","author":"Tang","year":"2009","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.cell.2017.02.025_bib57","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00005072-197703000-00003","article-title":"Meningeal carcinomatosis: development of an experimental model","volume":"36","author":"Ushio","year":"1977","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.cell.2017.02.025_bib58","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.cell.2014.01.040","article-title":"Serpins promote cancer cell survival and vascular co-option in brain metastasis","volume":"156","author":"Valiente","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cell.2017.02.025_bib59","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11060-008-9758-3","article-title":"Prognostic factors and clinical outcomes in patients with leptomeningeal metastasis from solid tumors","volume":"93","author":"Waki","year":"2009","journal-title":"J.\u00a0Neurooncol."},{"key":"10.1016\/j.cell.2017.02.025_bib60","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2217\/fon.09.167","article-title":"Known and emerging biomarkers of leptomeningeal metastasis and its response to treatment","volume":"6","author":"Walbert","year":"2010","journal-title":"Future Oncol."},{"key":"10.1016\/j.cell.2017.02.025_bib61","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1158\/1078-0432.CCR-13-1590","article-title":"Molecular mechanisms of bone metastasis and associated muscle weakness","volume":"20","author":"Waning","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cell.2017.02.025_bib62","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nature16140","article-title":"Neutrophils support lung colonization of metastasis-initiating breast cancer cells","volume":"528","author":"Wculek","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2017.02.025_bib63","doi-asserted-by":"crossref","first-page":"11490","DOI":"10.1073\/pnas.92.25.11490","article-title":"Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity","volume":"92","author":"Wessels","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2017.02.025_bib64","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nature15376","article-title":"Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth","volume":"527","author":"Zhang","year":"2015","journal-title":"Nature"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867417302404?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867417302404?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:27:37Z","timestamp":1758799657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867417302404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0092867417302404"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2017.02.025","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727390993.793533262","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2017.02.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}