{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:57:22Z","timestamp":1791511042055,"version":"4.3.4"},"reference-count":63,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T00:00:00Z","timestamp":1556841600000},"content-version":"vor","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Milton Safenowitz"},{"DOI":"10.13039\/100000971","name":"ALSA","doi-asserted-by":"publisher","award":["NS100401"],"award-info":[{"award-number":["NS100401"]}],"id":[{"id":"10.13039\/100000971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000971","name":"ALSA","doi-asserted-by":"publisher","award":["NS103360"],"award-info":[{"award-number":["NS103360"]}],"id":[{"id":"10.13039\/100000971","id-type":"DOI","asserted-by":"publisher"}]},{"name":"F31 NRSA"},{"name":"NSF GRFP (2014178388)"},{"name":"Thomas Shortman"},{"name":"Axol\u00a0Science"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01NS085207"],"award-info":[{"award-number":["R01NS085207"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01NS099320"],"award-info":[{"award-number":["R01NS099320"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P01NS09911"],"award-info":[{"award-number":["P01NS09911"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01NS094239"],"award-info":[{"award-number":["R01NS094239"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U24NS078736"],"award-info":[{"award-number":["U24NS078736"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Target ALS"},{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000971","name":"ALS Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000971","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Answer ALS"},{"name":"The Robert Packard Center for ALS Research"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01NS082563"],"award-info":[{"award-number":["R01NS082563"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS094239"],"award-info":[{"award-number":["NS094239"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30NS050274"],"award-info":[{"award-number":["P30NS050274"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000971","name":"ALSA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000971","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Target ALS"},{"name":"Robert Packard Center for ALS"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.cell.2018.03.025","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T18:27:40Z","timestamp":1522952860000},"page":"958-971.e17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":415,"title":["Stress Granule Assembly Disrupts Nucleocytoplasmic Transport"],"prefix":"10.1016","volume":"173","author":[{"given":"Ke","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Gavin","family":"Daigle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa N.","family":"Coyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan C.","family":"Grima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly E.","family":"Bowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh","family":"Wadhwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiguo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Rigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Paul","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron D.","family":"Gitler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Rothstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2018.03.025_bib1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tibs.2007.12.003","article-title":"Stress granules: the Tao of RNA triage","volume":"33","author":"Anderson","year":"2008","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.cell.2018.03.025_bib2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41593-017-0022-z","article-title":"Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in\u00a0vivo","volume":"21","author":"Apicco","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2018.03.025_bib3","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.neuron.2013.02.004","article-title":"Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD\/ALS","volume":"77","author":"Ash","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2018.03.025_bib4","doi-asserted-by":"crossref","first-page":"7193","DOI":"10.1021\/jm300713s","article-title":"Discovery of 7-methyl-5-(1-[3-(trifluoromethyl)phenyl]acetyl-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)","volume":"55","author":"Axten","year":"2012","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.cell.2018.03.025_bib5","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrm.2017.7","article-title":"Biomolecular condensates: organizers of cellular biochemistry","volume":"18","author":"Banani","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2018.03.025_bib6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nature22038","article-title":"Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice","volume":"544","author":"Becker","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.03.025_bib7","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1091\/mbc.e13-08-0506","article-title":"Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration","volume":"25","author":"Bernis","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cell.2018.03.025_bib8","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/109374000436355","article-title":"Molecular aspects of arsenic stress","volume":"3","author":"Bernstam","year":"2000","journal-title":"J.\u00a0Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.cell.2018.03.025_bib9","doi-asserted-by":"crossref","first-page":"17098","DOI":"10.1074\/jbc.M110.109439","article-title":"eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress","volume":"285","author":"Bevilacqua","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2018.03.025_bib10","doi-asserted-by":"crossref","first-page":"20877","DOI":"10.1038\/srep20877","article-title":"Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS\/FTD","volume":"6","author":"Boeynaems","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2018.03.025_bib11","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.molcel.2017.02.013","article-title":"Phase separation of C9orf72 dipeptide repeats perturbs stress granule dynamics","volume":"65","author":"Boeynaems","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cell.2018.03.025_bib12","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nsmb1229","article-title":"Structure-based design of a pathway-specific nuclear import inhibitor","volume":"14","author":"Cansizoglu","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.cell.2018.03.025_bib13","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1242\/jcs.084855","article-title":"RanGTP is required for meiotic spindle organization and the initiation of embryonic development in Drosophila","volume":"124","author":"Cesario","year":"2011","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cell.2018.03.025_bib14","doi-asserted-by":"crossref","first-page":"6600","DOI":"10.1093\/nar\/gkp717","article-title":"A role for transportin in deposition of TTP to cytoplasmic RNA granules and mRNA decay","volume":"37","author":"Chang","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2018.03.025_bib15","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/nan.12292","article-title":"Neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72 is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins","volume":"42","author":"Davidson","year":"2016","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.cell.2018.03.025_bib16","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2018.03.025_bib17","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.neuron.2013.10.015","article-title":"RNA toxicity from the ALS\/FTD C9ORF72 expansion is mitigated by antisense intervention","volume":"80","author":"Donnelly","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2018.03.025_bib18","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature09320","article-title":"Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS","volume":"466","author":"Elden","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.03.025_bib19","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1523\/JNEUROSCI.0543-14.2014","article-title":"Profilin 1 associates with stress granules and ALS-linked mutations alter stress granule dynamics","volume":"34","author":"Figley","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cell.2018.03.025_bib20","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nature14974","article-title":"GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport","volume":"525","author":"Freibaum","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.03.025_bib21","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1242\/jcs.110.11.1325","article-title":"Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-beta","volume":"110","author":"Fridell","year":"1997","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cell.2018.03.025_bib22","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.bbamcr.2010.03.020","article-title":"Identification of importin alpha1 as a novel constituent of RNA stress granules","volume":"1803","author":"Fujimura","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cell.2018.03.025_bib23","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neuron.2017.03.027","article-title":"Polyglutamine-expanded Huntingtin exacerbates age-related disruption of nuclear integrity and nucleocytoplasmic transport","volume":"94","author":"Gasset-Rosa","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2018.03.025_bib24","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1091\/mbc.e04-08-0715","article-title":"Stress granule assembly is mediated by prion-like aggregation of TIA-1","volume":"15","author":"Gilks","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cell.2018.03.025_bib25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neuron.2017.03.023","article-title":"Mutant Huntingtin disrupts the nuclear pore complex","volume":"94","author":"Grima","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2018.03.025_bib26","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nn.3953","article-title":"Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination","volume":"18","author":"Haines","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2018.03.025_bib27","doi-asserted-by":"crossref","first-page":"e1672","DOI":"10.1038\/cddis.2015.49","article-title":"Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity","volume":"6","author":"Halliday","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cell.2018.03.025_bib28","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.cell.2015.12.038","article-title":"ATPase-modulated stress granules contain a diverse proteome and substructure","volume":"164","author":"Jain","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.03.025_bib29","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/nn.4085","article-title":"Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD\/ALS","volume":"18","author":"Jovi\u010di\u0107","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cell.2018.03.025_bib30","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1083\/jcb.201508028","article-title":"G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits","volume":"212","author":"Kedersha","year":"2016","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cell.2018.03.025_bib31","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/ng.2853","article-title":"Therapeutic modulation of eIF2\u03b1 phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models","volume":"46","author":"Kim","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cell.2018.03.025_bib32","doi-asserted-by":"crossref","first-page":"C273","DOI":"10.1152\/ajpcell.00314.2002","article-title":"Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes","volume":"284","author":"Kimball","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.cell.2018.03.025_bib33","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1097\/NEN.0b013e3181bc3bec","article-title":"Nuclear contour irregularity and abnormal transporter protein distribution in anterior horn cells in amyotrophic lateral sclerosis","volume":"68","author":"Kinoshita","year":"2009","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.cell.2018.03.025_bib34","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.1254917","article-title":"Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells","volume":"345","author":"Kwon","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.03.025_bib35","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.cell.2006.05.049","article-title":"Rules for nuclear localization sequence recognition by karyopherin beta 2","volume":"126","author":"Lee","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.03.025_bib36","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.cell.2016.10.002","article-title":"C9orf72 dipeptide repeats impair the assembly, dynamics, and function of membrane-less organelles","volume":"167","author":"Lee","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.03.025_bib37","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1083\/jcb.201302044","article-title":"Stress granules as crucibles of ALS pathogenesis","volume":"201","author":"Li","year":"2013","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cell.2018.03.025_bib38","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.neuron.2017.07.025","article-title":"TIA1 mutations in amyotrophic lateral sclerosis and frontotemporal dementia promote phase separation and alter stress granule dynamics","volume":"95","author":"Mackenzie","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2018.03.025_bib39","doi-asserted-by":"crossref","first-page":"e68356","DOI":"10.1371\/journal.pone.0068356","article-title":"Identification of novel stress granule components that are involved in nuclear transport","volume":"8","author":"Mahboubi","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2018.03.025_bib40","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1126\/science.1256800","article-title":"C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins","volume":"345","author":"Mizielinska","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.03.025_bib41","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cell.2015.09.015","article-title":"Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization","volume":"163","author":"Molliex","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.03.025_bib42","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1126\/science.1232927","article-title":"The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD\/ALS","volume":"339","author":"Mori","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.03.025_bib43","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"314","author":"Neumann","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.03.025_bib44","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00401-007-0221-x","article-title":"Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration","volume":"113","author":"Neumann","year":"2007","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.cell.2018.03.025_bib45","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1091\/mbc.e06-12-1120","article-title":"Ataxin-2 interacts with the DEAD\/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules","volume":"18","author":"Nonhoff","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cell.2018.03.025_bib46","doi-asserted-by":"crossref","first-page":"16101","DOI":"10.1073\/pnas.0802647105","article-title":"Individual binding pockets of importin-beta for FG-nucleoporins have different binding properties and different sensitivities to RanGTP","volume":"105","author":"Otsuka","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2018.03.025_bib47","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.cell.2015.07.047","article-title":"A liquid-to-solid phase transition of the ALS protein FUS accelerated by disease mutation","volume":"162","author":"Patel","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.03.025_bib48","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.tcb.2016.05.004","article-title":"Principles and properties of stress granules","volume":"26","author":"Protter","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cell.2018.03.025_bib49","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2018.03.025_bib50","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1101\/gad.10.13.1608","article-title":"Regulation of mRNA export in response to stress in Saccharomyces cerevisiae","volume":"10","author":"Saavedra","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.cell.2018.03.025_bib51","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nature22044","article-title":"Antisense oligonucleotide therapy for spinocerebellar ataxia type 2","volume":"544","author":"Scoles","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.03.025_bib52","doi-asserted-by":"crossref","first-page":"E1111","DOI":"10.1073\/pnas.1620293114","article-title":"Toxic PRnpoly-dipeptides encoded by theC9orf72repeat expansion block nuclear import and export","volume":"114","author":"Shi","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2018.03.025_bib53","doi-asserted-by":"crossref","first-page":"e05033","DOI":"10.7554\/eLife.05033","article-title":"The small molecule ISRIB reverses the effects of eIF2\u03b1 phosphorylation on translation and stress granule assembly","volume":"4","author":"Sidrauski","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.cell.2018.03.025_bib54","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0074-7696(02)17012-4","article-title":"Regulation of nuclear import and export by the GTPase Ran","volume":"217","author":"Steggerda","year":"2002","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.cell.2018.03.025_bib55","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/nar\/gkr701","article-title":"IRES-mediated translation of cellular messenger RNA operates in eIF2\u03b1- independent manner during stress","volume":"40","author":"Thakor","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2018.03.025_bib56","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.neuron.2014.12.010","article-title":"Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS\/FTD form toxic nuclear aggregates that initiate in\u00a0vitro and in\u00a0vivo neuronal death","volume":"84","author":"Wen","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2018.03.025_bib57","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ymeth.2017.04.020","article-title":"Isolation of yeast and mammalian stress granule cores","volume":"126","author":"Wheeler","year":"2017","journal-title":"Methods"},{"key":"10.1016\/j.cell.2018.03.025_bib58","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1126\/science.aad2033","article-title":"Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA","volume":"351","author":"Woerner","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.03.025_bib59","doi-asserted-by":"crossref","first-page":"7778","DOI":"10.1073\/pnas.1219643110","article-title":"Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration","volume":"110","author":"Xu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2018.03.025_bib60","doi-asserted-by":"crossref","first-page":"e15878","DOI":"10.1371\/journal.pone.0015878","article-title":"The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism","volume":"5","author":"Yang","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2018.03.025_bib61","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00401-006-0130-4","article-title":"Altered distributions of nucleocytoplasmic transport-related proteins in the spinal cord of a mouse model of amyotrophic lateral sclerosis","volume":"112","author":"Zhang","year":"2006","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.cell.2018.03.025_bib62","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature14973","article-title":"The C9orf72 repeat expansion disrupts nucleocytoplasmic transport","volume":"525","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.03.025_bib63","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nn.4272","article-title":"C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins","volume":"19","author":"Zhang","year":"2016","journal-title":"Nat. Neurosci."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867418303052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867418303052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:50:00Z","timestamp":1660783800000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867418303052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0092867418303052"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2018.03.025","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732994586.793546070","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stress Granule Assembly Disrupts Nucleocytoplasmic Transport","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2018.03.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}