{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:26:02Z","timestamp":1792113962229,"version":"4.4.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T00:00:00Z","timestamp":1554422400000},"content-version":"vor","delay-in-days":369,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Disease","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["U19AI082724"],"award-info":[{"award-number":["U19AI082724"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["5U19AI109946"],"award-info":[{"award-number":["5U19AI109946"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["U19AI057266"],"award-info":[{"award-number":["U19AI057266"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["U19AI109946"],"award-info":[{"award-number":["U19AI109946"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIAID Centers of Excellence for Influenza Research and Surveillance","award":["HHSN272201400005C"],"award-info":[{"award-number":["HHSN272201400005C"]}]},{"name":"NIAID Centers of Excellence for Influenza Research and Surveillance","award":["HHSN272201400008C"],"award-info":[{"award-number":["HHSN272201400008C"]}]},{"name":"CEIRS"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.cell.2018.03.030","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T18:40:09Z","timestamp":1522953609000},"page":"417-429.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":423,"title":["Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies"],"prefix":"10.1016","volume":"173","author":[{"given":"Yao-Qing","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teddy John","family":"Wohlbold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-Ying","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlynn E.","family":"Neu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongquan","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla Thatcher","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ericka","family":"Kirkpatrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Karin E.","family":"Palm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Stamper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda Yu-Ling","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Topham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Treanor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Wrammert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryna C.","family":"Eichelberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Georgiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Krammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick C.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2018.03.030_bib1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jmv.10143","article-title":"Divergent evolution of hemagglutinin and neuraminidase genes in recent influenza A:H3N2 viruses isolated in Canada","volume":"67","author":"Abed","year":"2002","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.cell.2018.03.030_bib2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1750-2659.2011.00304.x","article-title":"Influenza neuraminidase","volume":"6","author":"Air","year":"2012","journal-title":"Influenza Other Respi. Viruses"},{"key":"10.1016\/j.cell.2018.03.030_bib3","doi-asserted-by":"crossref","first-page":"14614","DOI":"10.1038\/s41598-017-14931-7","article-title":"Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain","volume":"7","author":"Anderson","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cell.2018.03.030_bib4","doi-asserted-by":"crossref","first-page":"316ra192","DOI":"10.1126\/scitranslmed.aad0522","article-title":"Immune history profoundly affects broadly protective B cell responses to influenza","volume":"7","author":"Andrews","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cell.2018.03.030_bib5","article-title":"Is It Possible to Develop a \u201cUniversal\u201d Influenza Virus Vaccine? Outflanking Antibody Immunodominance on the\u00a0Road to Universal Influenza Vaccination","author":"Angeletti","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cell.2018.03.030_bib6","doi-asserted-by":"crossref","first-page":"6516","DOI":"10.1074\/jbc.M114.622308","article-title":"Biophysical measurement of the balance of influenza a hemagglutinin and neuraminidase activities","volume":"290","author":"Benton","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cell.2018.03.030_bib7","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/jb\/mvj051","article-title":"Variation in the divalent cation requirements of influenza A virus N1 neuraminidases","volume":"139","author":"Brett","year":"2006","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.cell.2018.03.030_bib8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1128\/jvi.10.1.60-66.1972","article-title":"A 2 (N2) neuraminidase of the X-7 influenza virus recombinant: determination of molecular size and subunit composition of the active unit","volume":"10","author":"Bucher","year":"1972","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2018.03.030_bib9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1128\/jcm.24.1.157-160.1986","article-title":"Serum and nasal wash antibodies associated with resistance to experimental challenge with influenza A wild-type virus","volume":"24","author":"Clements","year":"1986","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.cell.2018.03.030_bib10","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1001\/jama.2009.294","article-title":"Infections with oseltamivir-resistant influenza A(H1N1) virus in the United States","volume":"301","author":"Dharan","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.cell.2018.03.030_bib11","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1172\/JCI84428","article-title":"Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in\u00a0vivo protection","volume":"126","author":"DiLillo","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2018.03.030_bib12","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.antiviral.2013.09.018","article-title":"Universal anti-neuraminidase antibody inhibiting all influenza A subtypes","volume":"100","author":"Doyle","year":"2013","journal-title":"Antiviral Res."},{"key":"10.1016\/j.cell.2018.03.030_bib13","first-page":"275","article-title":"Influenza neuraminidase as a vaccine antigen","volume":"386","author":"Eichelberger","year":"2015","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.cell.2018.03.030_bib14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.15585\/mmwr.mm6606a3","article-title":"Interim Estimates of 2016-17 Seasonal Influenza Vaccine Effectiveness - United States, February 2017","volume":"66","author":"Flannery","year":"2017","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.cell.2018.03.030_bib15","unstructured":"Genentech. (2016). TAMIFLU (R) (oseltamivir phosphate) prescribing. https:\/\/www.gene.com\/download\/pdf\/tamiflu_prescribing.pdf."},{"key":"10.1016\/j.cell.2018.03.030_bib16","doi-asserted-by":"crossref","first-page":"12274","DOI":"10.1128\/JVI.76.23.12274-12280.2002","article-title":"Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A\/Memphis\/31\/98)","volume":"76","author":"Gulati","year":"2002","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2018.03.030_bib17","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1172\/JCI74374","article-title":"Preexisting human antibodies neutralize recently emerged H7N9 influenza strains","volume":"125","author":"Henry Dunand","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2018.03.030_bib18","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.chom.2016.05.014","article-title":"Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection","volume":"19","author":"Henry Dunand","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.cell.2018.03.030_bib19","article-title":"Estimates of global seasonal influenza-associated respiratory mortality: a modelling study","author":"Iuliano","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2018.03.030_bib20","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1586\/erv.11.130","article-title":"Influenza viral neuraminidase: the forgotten antigen","volume":"10","author":"Johansson","year":"2011","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.cell.2018.03.030_bib21","doi-asserted-by":"crossref","first-page":"6869","DOI":"10.1073\/pnas.84.19.6869","article-title":"Antigen-presenting B cells and helper T\u00a0cells cooperatively mediate intravirionic antigenic competition between influenza A virus surface glycoproteins","volume":"84","author":"Johansson","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2018.03.030_bib22","series-title":"Fields Virology: Sixth Edition","article-title":"Parainfluenza viruses","author":"Karron","year":"2013"},{"key":"10.1016\/j.cell.2018.03.030_bib23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrd4529","article-title":"Advances in the development of influenza virus vaccines","volume":"14","author":"Krammer","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cell.2018.03.030_bib24","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1038\/nm.4224","article-title":"Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination","volume":"22","author":"Lee","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.cell.2018.03.030_bib25","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1073\/pnas.1118979109","article-title":"Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells","volume":"109","author":"Li","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2018.03.030_bib26","doi-asserted-by":"crossref","first-page":"4728","DOI":"10.1128\/JVI.03509-12","article-title":"H3N2 influenza virus infection induces broadly reactive hemagglutinin stalk antibodies in humans and mice","volume":"87","author":"Margine","year":"2013","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2018.03.030_bib27","first-page":"e51112","article-title":"Expression of functional recombinant hemagglutinin and neuraminidase proteins from the novel H7N9 influenza virus using the baculovirus expression system","author":"Margine","year":"2013","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.cell.2018.03.030_bib28","doi-asserted-by":"crossref","first-page":"12665","DOI":"10.1128\/JVI.78.22.12665-12667.2004","article-title":"Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium","volume":"78","author":"Matrosovich","year":"2004","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2018.03.030_bib29","doi-asserted-by":"crossref","first-page":"e00417","DOI":"10.1128\/mBio.00417-16","article-title":"Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A\/H1N1 Virus Healthy Human Challenge Model","volume":"7","author":"Memoli","year":"2016","journal-title":"MBio"},{"key":"10.1016\/j.cell.2018.03.030_bib30","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0140-6736(73)92196-X","article-title":"Effect of neuraminidase antibody on Hong Kong influenza","volume":"1","author":"Monto","year":"1973","journal-title":"Lancet"},{"key":"10.1016\/j.cell.2018.03.030_bib31","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/infdis\/jiv195","article-title":"Antibody to Influenza Virus Neuraminidase: An Independent Correlate of Protection","volume":"212","author":"Monto","year":"2015","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.cell.2018.03.030_bib32","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJM197206222862502","article-title":"Association of serum anti-neuraminidase antibody with resistance to influenza in man","volume":"286","author":"Murphy","year":"1972","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cell.2018.03.030_bib33","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/ni.3684","article-title":"Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins","volume":"18","author":"Nachbagauer","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cell.2018.03.030_bib34","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1128\/AAC.00581-10","article-title":"Assessment of pandemic and seasonal influenza A (H1N1) virus susceptibility to neuraminidase inhibitors in three enzyme activity inhibition assays","volume":"54","author":"Nguyen","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"issue":"Suppl 4","key":"10.1016\/j.cell.2018.03.030_bib35","doi-asserted-by":"crossref","first-page":"D17","DOI":"10.1016\/j.vaccine.2008.07.048","article-title":"Efficacy and effectiveness of influenza vaccination","volume":"26","author":"Nichol","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.cell.2018.03.030_bib36","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1099\/0022-1317-33-1-159","article-title":"Inhibition of influenza virus replication in tissue culture by 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA): mechanism of action","volume":"33","author":"Palese","year":"1976","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.cell.2018.03.030_bib37","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1083\/jcb.110.4.999","article-title":"Conversion of a class II integral membrane protein into a soluble and efficiently secreted protein: multiple intracellular and extracellular oligomeric and conformational forms","volume":"110","author":"Paterson","year":"1990","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cell.2018.03.030_bib38","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02281-16","article-title":"Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin","volume":"8","author":"Rajendran","year":"2017","journal-title":"MBio"},{"key":"10.1016\/j.cell.2018.03.030_bib39","doi-asserted-by":"crossref","first-page":"20748","DOI":"10.1073\/pnas.1113801108","article-title":"Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses","volume":"108","author":"Sandbulte","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2018.03.030_bib40","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0042-6822(78)90356-2","article-title":"Host range recombinants of fowl plague (influenza A) virus","volume":"91","author":"Scholtissek","year":"1978","journal-title":"Virology"},{"key":"10.1016\/j.cell.2018.03.030_bib41","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/jvi.2.8.778-786.1968","article-title":"Protective effects of specific immunity to viral neuraminidase on influenza virus infection of mice","volume":"2","author":"Schulman","year":"1968","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2018.03.030_bib42","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nprot.2009.3","article-title":"Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen","volume":"4","author":"Smith","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2018.03.030_bib43","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/j.vaccine.2014.01.078","article-title":"Stability of neuraminidase in inactivated influenza vaccines","volume":"32","author":"Sultana","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.cell.2018.03.030_bib44","doi-asserted-by":"crossref","first-page":"e1002249","DOI":"10.1371\/journal.ppat.1002249","article-title":"Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition","volume":"7","author":"Vavricka","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.cell.2018.03.030_bib45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/rmv.352","article-title":"Functional balance between haemagglutinin and neuraminidase in influenza virus infections","volume":"12","author":"Wagner","year":"2002","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.cell.2018.03.030_bib46","doi-asserted-by":"crossref","first-page":"9290","DOI":"10.1128\/JVI.01203-13","article-title":"Molecular basis for broad neuraminidase immunity: conserved epitopes in seasonal and pandemic H1N1 as well as H5N1 influenza viruses","volume":"87","author":"Wan","year":"2013","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.cell.2018.03.030_bib47","doi-asserted-by":"crossref","first-page":"6114","DOI":"10.1038\/ncomms7114","article-title":"Structural characterization of a protective epitope spanning A(H1N1)pdm09 influenza virus neuraminidase monomers","volume":"6","author":"Wan","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2018.03.030_bib48","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1126\/science.1086907","article-title":"Predominant autoantibody production by early human B cell precursors","volume":"301","author":"Wardemann","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.03.030_bib49","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jviromet.2015.02.014","article-title":"Optimization of an enzyme-linked lectin assay suitable for rapid antigenic characterization of the neuraminidase of human influenza A(H3N2) viruses","volume":"217","author":"Westgeest","year":"2015","journal-title":"J.\u00a0Virol. Methods"},{"key":"10.1016\/j.cell.2018.03.030_bib50","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.antiviral.2016.10.001","article-title":"An influenza A virus (H7N9) anti-neuraminidase monoclonal antibody with prophylactic and therapeutic activity in\u00a0vivo","volume":"135","author":"Wilson","year":"2016","journal-title":"Antiviral Res."},{"key":"10.1016\/j.cell.2018.03.030_bib51","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.3390\/v6062465","article-title":"In the shadow of hemagglutinin: a growing interest in influenza viral neuraminidase and its role as a vaccine antigen","volume":"6","author":"Wohlbold","year":"2014","journal-title":"Viruses"},{"key":"10.1016\/j.cell.2018.03.030_bib52","doi-asserted-by":"crossref","first-page":"e02556","DOI":"10.1128\/mBio.02556-14","article-title":"Vaccination with adjuvanted recombinant neuraminidase induces broad heterologous, but not heterosubtypic, cross-protection against influenza virus infection in mice","volume":"6","author":"Wohlbold","year":"2015","journal-title":"MBio"},{"key":"10.1016\/j.cell.2018.03.030_bib53","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s41564-017-0011-8","article-title":"Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes","volume":"2","author":"Wohlbold","year":"2017","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.cell.2018.03.030_bib54","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nature06890","article-title":"Rapid cloning of high-affinity human monoclonal antibodies against influenza virus","volume":"453","author":"Wrammert","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.03.030_bib55","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1084\/jem.20101352","article-title":"Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection","volume":"208","author":"Wrammert","year":"2011","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cell.2018.03.030_bib56","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/srep01551","article-title":"Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding","volume":"3","author":"Wu","year":"2013","journal-title":"Sci. Rep."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867418303106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867418303106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:29:06Z","timestamp":1758799746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867418303106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0092867418303106"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2018.03.030","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732983609.793545012","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2018.03.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}