{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:03:12Z","timestamp":1793070192290,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T00:00:00Z","timestamp":1555632000000},"content-version":"vor","delay-in-days":383,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["022358"],"award-info":[{"award-number":["022358"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.cell.2018.03.076","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T11:41:12Z","timestamp":1524138072000},"page":"762-775.e16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":326,"title":["GPR68 Senses Flow and Is Essential for Vascular Physiology"],"prefix":"10.1016","volume":"173","author":[{"given":"Jie","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanti","family":"Mathur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Vessi\u00e8res","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Hammack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Nonomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Favre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Grimaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Petrus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allain","family":"Francisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-li","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James K.","family":"Mainquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart M.","family":"Cahalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"Orth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Lukacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bordone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bandell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Laffitte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Henrion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardem","family":"Patapoutian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cell.2018.03.076_bib1","doi-asserted-by":"crossref","first-page":"e79985","DOI":"10.1371\/journal.pone.0079985","article-title":"Proton-sensing ovarian cancer G protein-coupled receptor 1 on dendritic cells is required for airway responses in a murine asthma model","volume":"8","author":"Aoki","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2018.03.076_bib2","first-page":"72","article-title":"Lessons from photoreceptors: turning off g-protein signaling in living cells","volume":"25","author":"Burns","year":"2010","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.cell.2018.03.076_bib3","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/cvr\/cvw172","article-title":"The angiotensin II type 2 receptor activates flow-mediated outward remodelling through T\u00a0cells-dependent interleukin-17 production","volume":"112","author":"Caillon","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.cell.2018.03.076_bib4","doi-asserted-by":"crossref","first-page":"15463","DOI":"10.1073\/pnas.0607224103","article-title":"G protein-coupled receptors sense fluid shear stress in endothelial cells","volume":"103","author":"Chachisvilis","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2018.03.076_bib5","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1073\/pnas.1614035114","article-title":"Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis","volume":"114","author":"Chen","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2018.03.076_bib6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1152\/physrev.00047.2009","article-title":"Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives","volume":"91","author":"Chiu","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cell.2018.03.076_bib7","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0092-8674(00)80299-8","article-title":"Regulation of IRK3 inward rectifier K+ channel by m1 acetylcholine receptor and intracellular magnesium","volume":"89","author":"Chuang","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.cell.2018.03.076_bib8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.1193270","article-title":"Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels","volume":"330","author":"Coste","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.03.076_bib9","doi-asserted-by":"crossref","first-page":"e0148439","DOI":"10.1371\/journal.pone.0148439","article-title":"OGR1\/GPR68 Modulates the Severity of Experimental Autoimmune Encephalomyelitis and Regulates Nitric Oxide Production by Macrophages","volume":"11","author":"D\u2019Souza","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2018.03.076_bib10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrn2993","article-title":"Molecular mechanisms of mechanotransduction in mammalian sensory neurons","volume":"12","author":"Delmas","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cell.2018.03.076_bib11","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/349588a0","article-title":"The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration","volume":"349","author":"Driscoll","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.03.076_bib12","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1093\/cvr\/cvm055","article-title":"Alteration in flow (shear stress)-induced remodelling in rat resistance arteries with aging: improvement by a treatment with hydralazine","volume":"77","author":"Dumont","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.cell.2018.03.076_bib13","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev.genet.36.061802.101708","article-title":"Genetics of sensory mechanotransduction","volume":"36","author":"Ernstrom","year":"2002","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.cell.2018.03.076_bib14","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.2337\/db11-0750","article-title":"The AGE-breaker ALT-711 restores high blood flow-dependent remodeling in mesenteric resistance arteries in a rat model of type 2 diabetes","volume":"61","author":"Freidja","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.cell.2018.03.076_bib15","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1476-5381.2009.00132.x","article-title":"Endothelial Ca+-activated K+ channels in normal and impaired EDHF-dilator responses--relevance to cardiovascular pathologies and drug discovery","volume":"157","author":"Grgic","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cell.2018.03.076_bib16","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1172\/JCI119840","article-title":"Impaired flow-induced dilation in mesenteric resistance arteries from mice lacking vimentin","volume":"100","author":"Henrion","year":"1997","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2018.03.076_bib17","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/367467a0","article-title":"Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans","volume":"367","author":"Huang","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.03.076_bib18","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature15699","article-title":"Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65","volume":"527","author":"Huang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.03.076_bib19","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1749-6632.1997.tb51984.x","article-title":"Fluid shear stress-mediated signal transduction: how do endothelial cells transduce mechanical force into biological responses?","volume":"811","author":"Ishida","year":"1997","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"10.1016\/j.cell.2018.03.076_bib20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nrm2597","article-title":"Mechanotransduction gone awry","volume":"10","author":"Jaalouk","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cell.2018.03.076_bib21","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1152\/physrev.00035.2013","article-title":"Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs","volume":"95","author":"Joyner","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cell.2018.03.076_bib22","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jmb.2004.03.016","article-title":"A combined transmembrane topology and signal peptide prediction method","volume":"338","author":"K\u00e4ll","year":"2004","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.cell.2018.03.076_bib23","doi-asserted-by":"crossref","first-page":"W429","DOI":"10.1093\/nar\/gkm256","article-title":"Advantages of combined transmembrane topology and signal peptide prediction--the Phobius web server","volume":"35","author":"K\u00e4ll","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cell.2018.03.076_bib24","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.neuron.2010.06.032","article-title":"C.\u00a0elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel","volume":"67","author":"Kang","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.cell.2018.03.076_bib25","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1093\/emboj\/18.7.1730","article-title":"Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity","volume":"18","author":"Levina","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2018.03.076_bib26","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1161\/CIRCULATIONAHA.107.763730","article-title":"Impaired tissue perfusion: a pathology common to hypertension, obesity, and diabetes mellitus","volume":"118","author":"Levy","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.cell.2018.03.076_bib27","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2018.03.076_bib28","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nature04538","article-title":"A C. elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue","volume":"440","author":"Li","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.03.076_bib29","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cell.2018.03.076_bib30","doi-asserted-by":"crossref","first-page":"e5705","DOI":"10.1371\/journal.pone.0005705","article-title":"Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1","volume":"4","author":"Li","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cell.2018.03.076_bib31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nature13701","article-title":"Piezo1 integration of vascular architecture with physiological force","volume":"515","author":"Li","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.03.076_bib32","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1097\/01.WCB.0000088764.02615.B7","article-title":"Cerebrovascular vasodilation to extraluminal acidosis occurs via combined activation of ATP-sensitive and Ca2+-activated potassium channels","volume":"23","author":"Lindauer","year":"2003","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.cell.2018.03.076_bib33","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.cell.2018.03.076_bib34","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/01.CIR.103.6.864","article-title":"Flow (shear stress)-induced endothelium-dependent dilation is altered in mice lacking the gene encoding for dystrophin","volume":"103","author":"Loufrani","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.cell.2018.03.076_bib35","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature01905","article-title":"Proton-sensing G-protein-coupled receptors","volume":"425","author":"Ludwig","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.03.076_bib36","doi-asserted-by":"crossref","first-page":"8329","DOI":"10.1038\/ncomms9329","article-title":"Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia","volume":"6","author":"Lukacs","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2018.03.076_bib37","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/HJH.0b013e32834e38a0","article-title":"Effects of diabetes and hypertension on structure and distensibilty of human small coronary arteries","volume":"30","author":"Lynch","year":"2012","journal-title":"J.\u00a0Hypertens."},{"key":"10.1016\/j.cell.2018.03.076_bib38","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1038\/emboj.2008.233","article-title":"Gq-coupled receptors as\u00a0mechanosensors mediating myogenic vasoconstriction","volume":"27","author":"Mederos y Schnitzler","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.cell.2018.03.076_bib39","doi-asserted-by":"crossref","first-page":"C467","DOI":"10.1152\/ajpcell.00117.2012","article-title":"G\u03b1q\/11-mediated intracellular calcium responses to retrograde flow in endothelial cells","volume":"303","author":"Melchior","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.cell.2018.03.076_bib40","doi-asserted-by":"crossref","first-page":"H466","DOI":"10.1152\/ajpheart.00854.2009","article-title":"TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress","volume":"298","author":"Mendoza","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.cell.2018.03.076_bib41","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1038\/nprot.2013.107","article-title":"Isolation and expansion of human and mouse brain microvascular endothelial cells","volume":"8","author":"Navone","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cell.2018.03.076_bib42","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/S0735-1097(96)00393-2","article-title":"Cardiovascular effects of exercise: role of endothelial shear stress","volume":"28","author":"Niebauer","year":"1996","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.cell.2018.03.076_bib43","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature20793","article-title":"Piezo2 senses airway stretch and mediates lung inflation-induced apnoea","volume":"541","author":"Nonomura","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.03.076_bib44","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.ajhg.2016.08.020","article-title":"Mutations in the pH-Sensing G-protein-Coupled Receptor GPR68 Cause Amelogenesis Imperfecta","volume":"99","author":"Parry","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cell.2018.03.076_bib45","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/HYPERTENSIONAHA.111.179390","article-title":"Two-pore domain K+ channels: evidence for TWIK-2 in blood pressure regulation","volume":"58","author":"Pathan","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.cell.2018.03.076_bib46","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1096\/fj.12-222299","article-title":"Shear stress activates extracellular signal-regulated kinase 1\/2 via the angiotensin II type 1 receptor","volume":"27","author":"Ramkhelawon","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.cell.2018.03.076_bib47","doi-asserted-by":"crossref","first-page":"10347","DOI":"10.1073\/pnas.1409233111","article-title":"Piezo1, a mechanically activated ion channel, is required for vascular development in mice","volume":"111","author":"Ranade","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2018.03.076_bib48","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.celrep.2015.09.072","article-title":"Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling","volume":"13","author":"Retailleau","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.cell.2018.03.076_bib49","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41467-017-00429-3","article-title":"Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance","volume":"8","author":"Rode","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cell.2018.03.076_bib50","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1542\/pir.25.10.350","article-title":"Back to basics: acidosis and alkalosis","volume":"25","author":"Schwaderer","year":"2004","journal-title":"Pediatr. Rev"},{"key":"10.1016\/j.cell.2018.03.076_bib51","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1152\/physrev.00006.2013","article-title":"Postischemic revascularization: from cellular and molecular mechanisms to clinical applications","volume":"93","author":"Silvestre","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cell.2018.03.076_bib52","doi-asserted-by":"crossref","first-page":"H1241","DOI":"10.1152\/ajpheart.00818.2011","article-title":"G protein-mediated stretch reception","volume":"302","author":"Storch","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.cell.2018.03.076_bib53","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/368265a0","article-title":"A large-conductance mechanosensitive channel in E.\u00a0coli encoded by mscL alone","volume":"368","author":"Sukharev","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.03.076_bib54","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/sj.mn.7800151","article-title":"Impaired collateral artery development in spontaneously hypertensive rats","volume":"9","author":"Tuttle","year":"2002","journal-title":"Microcirculation"},{"key":"10.1016\/j.cell.2018.03.076_bib55","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1126\/science.287.5461.2229","article-title":"A Drosophila mechanosensory transduction channel","volume":"287","author":"Walker","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.cell.2018.03.076_bib56","doi-asserted-by":"crossref","first-page":"7765","DOI":"10.1073\/pnas.141199598","article-title":"Mechanical behavior in living cells consistent with the tensegrity model","volume":"98","author":"Wang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cell.2018.03.076_bib57","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1172\/JCI87343","article-title":"Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release","volume":"126","author":"Wang","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cell.2018.03.076_bib58","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/nature13251","article-title":"Piezo2 is required for Merkel-cell mechanotransduction","volume":"509","author":"Woo","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.03.076_bib59","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature11685","article-title":"Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation","volume":"493","author":"Yan","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cell.2018.03.076_bib60","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/onc.2012.566","article-title":"Role of OGR1 in myeloid-derived cells in prostate cancer","volume":"33","author":"Yan","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.cell.2018.03.076_bib61","doi-asserted-by":"crossref","first-page":"C1391","DOI":"10.1152\/ajpcell.00549.2008","article-title":"Mechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells","volume":"296","author":"Zhang","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867418304483?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0092867418304483?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:29:53Z","timestamp":1758799793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867418304483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0092867418304483"],"URL":"https:\/\/doi.org\/10.1016\/j.cell.2018.03.076","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733073878.793545393","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.733073878.793547074","asserted-by":"object"}]},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GPR68 Senses Flow and Is Essential for Vascular Physiology","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cell.2018.03.076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}